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Steroidogenic tissues such as the adrenal gland are particularly enriched in cholesteryl esters of long-chain polyunsaturated fatty acids, which constitute an important pool supplying cholesterol for steroid synthesis. The current studies addressed whether ACSL4 is required for normal steroidogenesis. CYP11A1 promoter\u2012mediated Cre was used to generate steroid tissue\u2012specific ACSL4 knockout (KO) mice. Results demonstrated that ACSL4 plays an important role in adrenal cholesteryl ester formation, as well as in determining the fatty acyl composition of adrenal cholesteryl esters, with ACSL4 deficiency leading to reductions in cholesteryl ester storage and alterations in cholesteryl ester composition. Statistically significant reductions in corticosterone and testosterone production, but not progesterone production, were observed in vivo, and these deficits were accentuated in ex vivo and in vitro studies of isolated steroid tissues and cells from ACSL4-deficient mice. However, these effects on steroid production appear to be due to reductions in cholesteryl ester stores rather than disturbances in signaling pathways. We conclude that ACSL4 is dispensable for normal steroidogenesis.<\/jats:p>","DOI":"10.1210\/en.2019-00464","type":"journal-article","created":{"date-parts":[[2019,8,27]],"date-time":"2019-08-27T13:04:50Z","timestamp":1566911090000},"page":"2517-2528","source":"Crossref","is-referenced-by-count":27,"title":["Tissue-Specific Ablation of ACSL4 Results in Disturbed Steroidogenesis"],"prefix":"10.1210","volume":"160","author":[{"given":"Wei","family":"Wang","sequence":"first","affiliation":[{"name":"Division of Endocrinology, Gerontology, and Metabolism, Stanford University School of Medicine, Palo Alto, California"},{"name":"Veterans Affairs Palo Alto Health Care System, Palo Alto, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao","family":"Hao","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, Gerontology, and Metabolism, Stanford University School of Medicine, Palo Alto, California"},{"name":"Veterans Affairs Palo Alto Health Care 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