{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T16:58:20Z","timestamp":1785862700541,"version":"3.56.0"},"reference-count":37,"publisher":"The Endocrine Society","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1997,10,1]]},"DOI":"10.1210\/endo.138.10.5264","type":"journal-article","created":{"date-parts":[[2014,1,8]],"date-time":"2014-01-08T11:08:39Z","timestamp":1389179319000},"page":"4081-4085","source":"Crossref","is-referenced-by-count":16,"title":["Chronic Low Dose Islet Amyloid Polypeptide Infusion Reduces Food Intake, But Does Not Influence Glucose Metabolism, in Unrestrained Conscious Rats: Studies Using a Novel Aortic Catheterization Technique*"],"prefix":"10.1210","volume":"138","author":[{"given":"Urban","family":"Arnelo","sequence":"first","affiliation":[{"name":"Arvid Wretlind Laboratory for Metabolic Research, Department of Surgery, Karolinska Institutet at Huddinge University Hospital (U.A., J.P., J.L., C.A.), S-141 86 Huddinge, Sweden"},{"name":"Department of Biomedical Sciences, Creighton University School of Medicine (U.A., R.D.R., T.E.A.), Omaha, Nebraska 68178"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johan","family":"Permert","sequence":"additional","affiliation":[{"name":"Arvid Wretlind Laboratory for Metabolic Research, Department of Surgery, Karolinska Institutet at Huddinge University Hospital (U.A., J.P., J.L., C.A.), S-141 86 Huddinge, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jo\u0308rgen","family":"Larsson","sequence":"additional","affiliation":[{"name":"Arvid Wretlind Laboratory for Metabolic Research, Department of Surgery, Karolinska Institutet at Huddinge University Hospital (U.A., J.P., J.L., C.A.), S-141 86 Huddinge, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roger D.","family":"Reidelberger","sequence":"additional","affiliation":[{"name":"Research Service (151), Department of Veteran Affairs Medical Center (R.D.R.), Omaha, Nebraska 68105"},{"name":"Department of Biomedical Sciences, Creighton University School of Medicine (U.A., R.D.R., T.E.A.), Omaha, Nebraska 68178"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catarina","family":"Arnelo","sequence":"additional","affiliation":[{"name":"Arvid Wretlind Laboratory for Metabolic Research, Department of Surgery, Karolinska Institutet at Huddinge University Hospital (U.A., J.P., J.L., C.A.), S-141 86 Huddinge, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas E.","family":"Adrian","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, Creighton University School of Medicine (U.A., R.D.R., T.E.A.), Omaha, Nebraska 68178"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"80","reference":[{"key":"2019041122090352900_R1","doi-asserted-by":"crossref","first-page":"3881","DOI":"10.1073\/pnas.84.11.3881","article-title":"Amyloid fibrils in human insulinoma islets of Langerhans of the diabetic cat are derived from the neuropeptide like protein also present in normal islet cells.","volume":"84","author":"Westermark","year":"1987","journal-title":"Proc Natl Acad Sci USA"},{"key":"2019041122090352900_R2","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1016\/0006-291X(86)90708-4","article-title":"A novel peptide in the calcitonin gene related family as an amyloid fibril protein in the endocrine pancreas.","volume":"140","author":"Westermark","year":"1986","journal-title":"Biochem Biophys Res Commun"},{"key":"2019041122090352900_R3","doi-asserted-by":"crossref","first-page":"8628","DOI":"10.1073\/pnas.84.23.8628","article-title":"Purification and characterization of a peptide from amyloid-rich pancreases of type 2 diabetic patients.","volume":"84","author":"Cooper","year":"1987","journal-title":"Proc Natl Acad Sci USA"},{"key":"2019041122090352900_R4","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1007\/BF00285291","article-title":"Co-localization of islet amyloid polypeptide and insulin and the B cell secretory granules of the human pancreatic islets.","volume":"32","author":"Lukinius","year":"1989","journal-title":"Diabetologia"},{"key":"2019041122090352900_R5","doi-asserted-by":"crossref","first-page":"634","DOI":"10.2337\/diab.39.5.634","article-title":"Evidence of cosecretion of islet amyloid polypeptide and insulin by \u03b2-cells.","volume":"39","author":"Kahn","year":"1990","journal-title":"Diabetes"},{"key":"2019041122090352900_R6","doi-asserted-by":"crossref","first-page":"639","DOI":"10.2337\/diab.39.5.639","article-title":"Islet amyloid polypeptide response to glucose, insulin and somatostatin analogue administration.","volume":"39","author":"Mitsukawa","year":"1990","journal-title":"Diabetes"},{"key":"2019041122090352900_R7","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1016\/0006-291X(90)90389-5","article-title":"Islet amyloid polypeptide, a novel pancreatic peptide, is a circulating hormone secreted under glucose stimulation.","volume":"169","author":"Nakazato","year":"1990","journal-title":"Biochem Biophys Res Commun"},{"key":"2019041122090352900_R8","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/0140-6736(90)90197-D","article-title":"Islet-amyloid polypeptide in human plasma.","volume":"335","author":"van Jaarsveld","year":"1990","journal-title":"Lancet"},{"key":"2019041122090352900_R9","doi-asserted-by":"crossref","first-page":"752","DOI":"10.2337\/diab.39.6.752","article-title":"Effects of meal ingestion on plasma amylin concentration in NIDDM and nondiabetic humans.","volume":"39","author":"Butler","year":"1990","journal-title":"Diabetes"},{"key":"2019041122090352900_R10","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1056\/NEJM199402033300503","article-title":"Islet amyloid polypeptide in patients with pancreatic cancer patients and diabetes.","volume":"330","author":"Permert","year":"1994","journal-title":"N Engl J Med"},{"key":"2019041122090352900_R11","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1056\/NEJM194610312351805","article-title":"The diagnosis of cancer of the pancreas.","volume":"235","author":"Ingelfinger","year":"1946","journal-title":"N Engl J Med"},{"key":"2019041122090352900_R12","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1007\/BF01072886","article-title":"A prospective study of glucose tolerance, insulin, C-peptide, and glucagon responses in patients with pancreatic carcinoma.","volume":"23","author":"Schwartz","year":"1978","journal-title":"Am J Dig Dis"},{"key":"2019041122090352900_R13","first-page":"101","article-title":"Pancreatic cancer is associated with impaired glucose metabolism.","volume":"159","author":"Permert","year":"1993","journal-title":"Eur J Surg"},{"key":"2019041122090352900_R14","first-page":"R1654","article-title":"Chronic infusion of islet amyloid polypeptide causes anorexia in rats.","volume":"271","author":"Arnelo","journal-title":"Am J Physiol"},{"key":"2019041122090352900_R15","first-page":"155","article-title":"Long-term intravenous infusion. In: Myers RD (ed) Methods in Psychobiology.","volume":"2","author":"Weeks","year":"1972","journal-title":"Academic Press, London, vol"},{"key":"2019041122090352900_R16","first-page":"215","article-title":"Catheterisation of the jugular vein","author":"Waynforth","year":"1992","journal-title":"In: Waynforth HB, Flecknell PA (eds) Experimental and Surgical Technique in the Rat. Academic Press, London, pp"},{"key":"2019041122090352900_R17","doi-asserted-by":"crossref","first-page":"83","DOI":"10.3109\/00365529609031632","article-title":"Effects of acute and chronic infusion of islet amyloid polypeptide on food intake in rats.","volume":"31","author":"Arnelo","year":"1996","journal-title":"Scand J Gastroenterol"},{"key":"2019041122090352900_R18","first-page":"E214","article-title":"Glucose clamp technique: a method for quantifying insulin secretion and resistance","volume":"237","author":"DeFronzo","year":"1979","journal-title":"Am J Physiol"},{"key":"2019041122090352900_R19","doi-asserted-by":"crossref","first-page":"885","DOI":"10.2337\/diab.37.7.885","article-title":"Glucose transport is rate limiting for skeletal muscle glucose metabolism in normal and STZ-induced diabetic rats.","volume":"37","author":"Ziel","year":"1988","journal-title":"Diabetes"},{"key":"2019041122090352900_R20","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1016\/0006-8993(91)91644-G","article-title":"Anorexia following the intrahypothalamic administration of amylin.","volume":"539","author":"Chance","year":"1991","journal-title":"Brain Res"},{"key":"2019041122090352900_R21","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/0167-0115(95)00009-Z","article-title":"In vivo central actions of rat amylin.","volume":"56","author":"Bouali","year":"1995","journal-title":"Regul Pept"},{"key":"2019041122090352900_R22","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1016\/0196-9781(94)00203-I","article-title":"Subdiaphragmatic vagotomy does not influence the anorectic effect of amylin.","volume":"16","author":"Lutz","year":"1995","journal-title":"Peptides"},{"key":"2019041122090352900_R23","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1007\/BF00401833","article-title":"Gastric emptying is accelerated in diabetic BB rats and is slowed by subcutaneous injections of amylin.","volume":"38","author":"Young","year":"1995","journal-title":"Diabetologia"},{"key":"2019041122090352900_R24","doi-asserted-by":"crossref","first-page":"260","DOI":"10.2337\/diab.39.2.260","article-title":"Induction of insulin resistance in vivo by amylin and calcitonin gene-related peptide.","volume":"39","author":"Molina","year":"1990","journal-title":"Diabetes"},{"key":"2019041122090352900_R25","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1007\/BF00401051","article-title":"Islet amyloid polypeptide amide causes peripheral insulin resistance in vivo in dogs.","volume":"33","author":"Sowa","year":"1990","journal-title":"Diabetologia"},{"key":"2019041122090352900_R26","first-page":"1032","article-title":"Very high concentrations of islet amyloid polypeptide are necessary to alter the insulin response to intravenous glucose in man.","volume":"74","author":"Bretherton-Watt","year":"1992","journal-title":"J Clin Endocrinol Metab"},{"key":"2019041122090352900_R27","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1530\/acta.0.1290360","article-title":"Insulin resistance caused by amylin in conscious rats is independent of induced hypocalcemia and fades during long-term exposure.","volume":"129","author":"Fu\u0308rnsinn","year":"1993","journal-title":"Acta Endocrinol (Copenh)"},{"key":"2019041122090352900_R28","doi-asserted-by":"crossref","first-page":"568","DOI":"10.2337\/diab.40.5.568","article-title":"In vivo insulin resistance induced by amylin primarily through inhibition of insulin-stimulated glucogen synthesis in skeletal muscle.","volume":"40","author":"Frontoni","year":"1991","journal-title":"Diabetes"},{"key":"2019041122090352900_R29","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1016\/0006-291X(90)92053-3","article-title":"The putative hormone islet amyloid polypeptide (IAPP) induces impaired glucose tolerance in cats.","volume":"167","author":"Johnson","year":"1990","journal-title":"Biochem Biophys Res Commun"},{"key":"2019041122090352900_R30","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/0168-8227(92)90142-E","article-title":"Homologous islet amyloid polypeptide: effects on plasma levels of glucagon, insulin and glucose in the mouse.","volume":"18","author":"Panagiotidis","year":"1992","journal-title":"Diabetes Res Clin Pract"},{"key":"2019041122090352900_R31","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1038\/335632a0","volume":"335","author":"Leighton","journal-title":"Nature"},{"key":"2019041122090352900_R32","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/0168-8227(92)90016-K","article-title":"Effects of aging on plasma islet amyloid polypeptide basal level and response to oral glucose load.","volume":"15","author":"Mitsukawa","year":"1992","journal-title":"Diabetes Res Clin Pract"},{"key":"2019041122090352900_R33","doi-asserted-by":"crossref","first-page":"321","DOI":"10.3109\/07435809209111040","article-title":"Induction of acute hyperglycemia, hyperlactemia and hypocalcemia in fed and fasted BALB\/c mice by intravenous amylin injection.","volume":"18","author":"Wang","year":"1992","journal-title":"Endocr Res"},{"key":"2019041122090352900_R34","doi-asserted-by":"crossref","first-page":"1288","DOI":"10.1016\/0006-291X(91)92078-X","article-title":"Amylin is more potent and more effective than glucagon in raising plasma glucose concentration in fasted, anesthetized rats.","volume":"181","author":"Wang","year":"1991","journal-title":"Biochem Biophys Res Commun"},{"key":"2019041122090352900_R35","first-page":"E943","article-title":"Response to intravenous injection of amylin and glucagon in fasted, fed, and hypoglycemic rats","volume":"264","author":"Young","year":"1993","journal-title":"Am J Physiol"},{"key":"2019041122090352900_R36","doi-asserted-by":"crossref","first-page":"1717","DOI":"10.1016\/0024-3205(93)90480-Q","article-title":"Dose response characteristics for the hyperglycemic, hyperlactemic, hypotensive and hypocalcemic actions of amylin and calcitonin gene-related peptide-I (CGRP\u03b1) in the fasted, anesthetized rat.","volume":"52","author":"Young","year":"1993","journal-title":"Life Sci"},{"key":"2019041122090352900_R37","first-page":"E457","article-title":"Effects of amylin on glucose metabolism and glycogenolysis in vivo and in vitro","volume":"259","author":"Young","year":"1990","journal-title":"Am J Physiol"}],"container-title":["Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/endo\/article-pdf\/138\/10\/4081\/10352895\/endo4081.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,4,12]],"date-time":"2019-04-12T10:55:27Z","timestamp":1555066527000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/endo\/article\/138\/10\/4081\/2987470"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1997,10,1]]},"references-count":37,"journal-issue":{"issue":"10","published-print":{"date-parts":[[1997,10,1]]}},"URL":"https:\/\/doi.org\/10.1210\/endo.138.10.5264","relation":{},"ISSN":["0013-7227","1945-7170"],"issn-type":[{"value":"0013-7227","type":"print"},{"value":"1945-7170","type":"electronic"}],"subject":[],"published":{"date-parts":[[1997,10,1]]}}}