{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T08:45:36Z","timestamp":1767861936656,"version":"3.49.0"},"reference-count":51,"publisher":"The Endocrine Society","issue":"8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1997,8,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>In this study, prostaglandin (PG) F2\u03b1 was found to activate mitogen-activated protein (MAP) kinase and MAP kinase kinase (MEK) in cultured rat puerperal uterine myometrial cells. PGF2\u03b1 stimulation also led to an increase in phosphorylation of raf-1, son of sevenless (SOS), and Shc. Furthermore, we examined the mechanism by which PGF2\u03b1 induced MAP kinase phosphorylation. Both pertussis toxin (10 ng\/ml), which inactivates Gi\/Go proteins, and expression of a peptide derived from the carboxyl terminus of the \u03b2-adrenergic receptor kinase 1 (\u03b2ARK1), which specifically blocks signaling mediated by the \u03b2\u03b3 subunits of G proteins, blocked the PGF2\u03b1-induced activation of MAP kinase. Ritodrine (1 \u03bcm), which is known to relax uterine muscle contraction, attenuated PGF2\u03b1-induced tyrosine phosphorylation of MAP kinase. Moreover, to examine the role of MAP kinase pathway in uterine contraction, an inhibitor of MEK activity, PD098059, was used. Although MEK inhibitor had no effect on PGF2\u03b1-induced calcium mobilization, this inhibitor partially inhibited PGF2\u03b1-induced uterine contraction. These results provide evidence that PGF2\u03b1 stimulates the MAP kinase signaling pathway in cultured rat puerperal uterine myometrial cells through G\u03b2\u03b3 protein, suggesting that this new pathway may play an important role in the biological action of PGF2\u03b1 on these cells.<\/jats:p>","DOI":"10.1210\/endo.138.8.5305","type":"journal-article","created":{"date-parts":[[2014,1,8]],"date-time":"2014-01-08T16:09:00Z","timestamp":1389197340000},"page":"3103-3111","source":"Crossref","is-referenced-by-count":42,"title":["Role of Mitogen-Activated Protein Kinase Pathway in Prostaglandin F2\u03b1-Induced Rat Puerperal Uterine Contraction"],"prefix":"10.1210","volume":"138","author":[{"given":"Masahide","family":"Ohmichi","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology, Osaka University Medical School (M.O., K.K., A.K., K.M., H.I., T.K., A.M., Y.M.), 2\u20132, Yamadaoka, Suita-shi, Osaka 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