{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T21:58:31Z","timestamp":1783634311178,"version":"3.55.0"},"reference-count":44,"publisher":"The Endocrine Society","issue":"9","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1998,9,1]]},"DOI":"10.1210\/endo.139.9.6172","type":"journal-article","created":{"date-parts":[[2014,1,8]],"date-time":"2014-01-08T16:09:28Z","timestamp":1389197368000},"page":"3736-3742","source":"Crossref","is-referenced-by-count":64,"title":["Effect of the High-Affinity Estrogen Receptor Ligand ICI 182,780 on the Rat Tibia*"],"prefix":"10.1210","volume":"139","author":[{"given":"Jean D.","family":"Sibonga","sequence":"first","affiliation":[{"name":"Department of Orthopedic Research (J.D.S., H.D., R.M.H., R.T.T.), Mayo Clinic, Rochester, Minnessota 55905"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harald","family":"Dobnig","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Research (J.D.S., H.D., R.M.H., R.T.T.), Mayo Clinic, Rochester, Minnessota 55905"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryan M.","family":"Harden","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Research (J.D.S., H.D., R.M.H., R.T.T.), Mayo Clinic, Rochester, Minnessota 55905"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Russell T.","family":"Turner","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Research (J.D.S., H.D., R.M.H., R.T.T.), Mayo Clinic, Rochester, Minnessota 55905"},{"name":"Biochemistry and Molecular Biology (R.T.T.), Mayo Clinic, Rochester, Minnessota 55905"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"80","reference":[{"key":"2019041122165349700_R1","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/8756-3282(95)00291-K","article-title":"Tissue-selective actions of estrogen analogs.","volume":"17","author":"Evans","year":"1995","journal-title":"Bone [Suppl]"},{"key":"2019041122165349700_R2","doi-asserted-by":"crossref","first-page":"R7","DOI":"10.1677\/joe.0.112R007","article-title":"Steroidal pure antiestrogens","volume":"112","author":"Wakeling","year":"1987","journal-title":"J Endocrinol"},{"key":"2019041122165349700_R3","first-page":"3867","article-title":"A potent specific pure antiestrogen with clinical potential.","volume":"51","author":"Wakeling","year":"1991","journal-title":"Cancer Res"},{"key":"2019041122165349700_R4","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/BF00662395","article-title":"The future of new pure antiestrogens in clinical breast cancer.","volume":"25","author":"Wakeling","year":"1993","journal-title":"Breast Cancer Res Treat"},{"key":"2019041122165349700_R5","doi-asserted-by":"crossref","first-page":"6883","DOI":"10.1073\/pnas.87.17.6883","article-title":"Inhibition of estrogen receptor DNA binding by the\u201c pure\u201d antiestrogen ICI 163,384 appears to be mediated by impaired receptor dimerization.","volume":"87","author":"Falwell","year":"1990","journal-title":"Proc Natl Acad Sci USA"},{"key":"2019041122165349700_R6","first-page":"659","article-title":"Analysis of estrogen receptor function in vitro reveals three distinct classes of antiestrogens.","volume":"9","author":"McDonnell","year":"1995","journal-title":"Mol Endocrinol"},{"key":"2019041122165349700_R7","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1200\/JCO.1993.11.4.771","article-title":"The efficacy and cost-effectiveness of adjuvant therapy of early breast cancer in premenopausal women.","volume":"11","author":"Smith","year":"1993","journal-title":"J Clin Oncol"},{"key":"2019041122165349700_R8","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1210\/edrv-11-2-221","article-title":"Endocrine treatment of breast cancer in women.","volume":"11","author":"Santen","year":"1990","journal-title":"Endocr Rev"},{"key":"2019041122165349700_R9","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1007\/BF01806350","article-title":"Long-term adjuvant tamoxifen therapy for breast cancer.","volume":"15","author":"Jordan","year":"1990","journal-title":"Breast Cancer Res Treat"},{"key":"2019041122165349700_R10","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1200\/JCO.1989.7.6.803","article-title":"Tamoxifen therapy in premenopausal breast cancer: biology, efficacy and side effects.","volume":"7","author":"Love","year":"1989","journal-title":"J Clin Oncol"},{"key":"2019041122165349700_R11","doi-asserted-by":"crossref","first-page":"2256","DOI":"10.1016\/0959-8049(93)90218-5","article-title":"Type I IGF receptor and acquired tamoxifen resistance in oestrogen-responsive human breast cancer cells","volume":"29A","author":"Wiseman","year":"1993","journal-title":"Eur J Cancer"},{"key":"2019041122165349700_R12","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1016\/0022-4731(88)90014-3","article-title":"Novel antioestrogens without partial agonist activity.","volume":"31","author":"Wakeling","year":"1988","journal-title":"J Steroid Biochem"},{"key":"2019041122165349700_R13","first-page":"21","article-title":"Human estrogen receptor transactivational capacity is determined by both cellular and promoter context and mediated by two functionally distinct intramolecular regions.","volume":"8","author":"Tzukerman","year":"1994","journal-title":"Mol Endocrinol"},{"key":"2019041122165349700_R14","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1210\/endo.138.3.4979","article-title":"Comparison of the ligand binding specificity and transcript tissue distribution of estrogen receptors \u03b1 and \u03b2.","volume":"138","author":"Kuiper","year":"1997","journal-title":"Endocrinology"},{"key":"2019041122165349700_R15","doi-asserted-by":"crossref","first-page":"2787","DOI":"10.1210\/endo.133.6.8243306","article-title":"The estrogen antagonist ICI 182,780 reduces cancellous bone volume in female rats.","volume":"133","author":"Gallagher","year":"1993","journal-title":"Endocrinology"},{"key":"2019041122165349700_R16","first-page":"275","article-title":"Skeletal effects of estrogen.","volume":"15","author":"Turner","year":"1994","journal-title":"Endocr Rev"},{"key":"2019041122165349700_R17","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1007\/BF01807038","article-title":"Ovarian status influences the skeletal effects of tamoxifen in adult rats.","volume":"41","author":"Sibonga","year":"1996","journal-title":"Breast Cancer Res Treat"},{"key":"2019041122165349700_R18","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1002\/jbmr.5650020617","article-title":"Bone histomorphometry: standardization of nomenclature, symbols, and units.","volume":"2","author":"Parfitt","year":"1987","journal-title":"J Bone Miner Res"},{"key":"2019041122165349700_R19","doi-asserted-by":"crossref","first-page":"1396","DOI":"10.1172\/JCI111096","article-title":"Relationships between surface, volume and thickness of iliac trabecular bone in aging and osteoporosis: implications for the microanatomic and cellular mechanisms of bone loss.","volume":"72","author":"Parfitt","year":"1983","journal-title":"J Clin Invest"},{"key":"2019041122165349700_R20","doi-asserted-by":"crossref","first-page":"1552","DOI":"10.1210\/endo.138.4.5083","article-title":"Characterization of the ovariectomized rat model for the evaluation of estrogen effects on plasma cholesterol levels.","volume":"138","author":"Lundeen","year":"1997","journal-title":"Endocrinology"},{"key":"2019041122165349700_R21","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1210\/endo-115-2-507","article-title":"Evaluation of pathogenesis of skeletal changes in ovariectomized rats.","volume":"115","author":"Kalu","year":"1984","journal-title":"Endocrinology"},{"key":"2019041122165349700_R22","doi-asserted-by":"crossref","first-page":"2283","DOI":"10.1210\/endo.134.5.8156931","article-title":"The effects of raloxifene on tibia histomorphometry in ovariectomized rats.","volume":"134","author":"Evans","year":"1996","journal-title":"Endocrinology"},{"key":"2019041122165349700_R23","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1002\/jbmr.5650020206","article-title":"The effect of ovariectomy and 17\u03b2-estradiol on cortical bone histomorphometry in growing rats.","volume":"2","author":"Turner","year":"1987","journal-title":"J Bone Miner Res"},{"key":"2019041122165349700_R24","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1002\/jbmr.5650020513","article-title":"Tamoxifen prevents the skeletal effects of ovarian hormone deficiency in rats.","volume":"2","author":"Turner","year":"1987","journal-title":"J Bone Miner Res"},{"key":"2019041122165349700_R25","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/0031-9384(77)90105-6","article-title":"Central action and a special comparison of the estrogenic effects of an antiestrogen on eating and body weight.","volume":"18","author":"Roy","year":"1977","journal-title":"Physiol Behav"},{"key":"2019041122165349700_R26","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/0027-5107(95)00130-1","article-title":"Tissue-specific actions of antioestrogens.","volume":"333","author":"Wakeling","year":"1995","journal-title":"Mutat Res"},{"key":"2019041122165349700_R27","doi-asserted-by":"crossref","first-page":"1794","DOI":"10.1210\/endo.138.5.5109","article-title":"Clomiphene prevents cancellous bone loss from tibia of ovariectomized rats.","volume":"138","author":"Jimenez","year":"1997","journal-title":"Endocrinology"},{"key":"2019041122165349700_R28","doi-asserted-by":"crossref","first-page":"2435","DOI":"10.1210\/endo.136.6.7750465","article-title":"Droloxifene, a new estrogen antagonist\/agonist prevents bone loss in ovariectomized rats.","volume":"136","author":"Ke","year":"1995","journal-title":"Endocrinology"},{"key":"2019041122165349700_R29","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1007\/BF02554882","article-title":"Skeletal alterations in ovariectomized rats.","volume":"37","author":"Wronski","year":"1985","journal-title":"Calcif Tissue Int"},{"key":"2019041122165349700_R30","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/8756-3282(86)90683-6","article-title":"Histologic evidence for osteopenia and increased bone turnover in ovariectomized rats.","volume":"7","author":"Wronski","year":"1986","journal-title":"Bone"},{"key":"2019041122165349700_R31","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1002\/jbmr.5650040415","article-title":"The differential effects of gonadal insufficiency on bone histomorphometry in male and female rats.","volume":"4","author":"Turner","year":"1989","journal-title":"J Bone Miner Res"},{"key":"2019041122165349700_R32","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1002\/jbmr.5650080313","article-title":"Mechanism of action of estrogen on cancellous bone balance in tibiae of ovariectomized growing rats: inhibition of indices of formation and resorption.","volume":"8","author":"Turner","year":"1993","journal-title":"J Bone Miner Res"},{"key":"2019041122165349700_R33","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1210\/endo-123-2-681","article-title":"Estrogen treatment prevents osteopenia, and depresses bone turnover in ovariectomized rats.","volume":"123","author":"Wronski","year":"1988","journal-title":"Endocrinology"},{"key":"2019041122165349700_R34","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1210\/endo.134.1.7506213","article-title":"Reduced chondroclast differentiation results in increased cancellous bone volume in estrogen-treated growing rats.","volume":"134","author":"Turner","year":"1994","journal-title":"Endocrinology"},{"key":"2019041122165349700_R35","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1159\/000157084","article-title":"Growth plate structure and function.","volume":"7","author":"Hunziker","year":"1988","journal-title":"Pathol Immunopathol Res"},{"key":"2019041122165349700_R36","first-page":"143","article-title":"The physiological and clinical significance of bone histomorphometric data","volume-title":"Bone Histomorphometry","author":"Parfitt","year":"1983"},{"key":"2019041122165349700_R37","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1002\/(SICI)1097-0185(199609)246:1<39::AID-AR5>3.0.CO;2-A","article-title":"Trabecular and endocortical bone surfaces in the rat: modeling or remodeling?","volume":"246","author":"Erben","year":"1996","journal-title":"Anat Rec"},{"key":"2019041122165349700_R38","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/0169-6009(91)90021-Q","article-title":"Skeletal response of ovariectomized rats to low and high doses of 17\u03b2-estradiol.","volume":"14","author":"Kalu","year":"1991","journal-title":"Bone Miner"},{"key":"2019041122165349700_R39","doi-asserted-by":"crossref","first-page":"4199","DOI":"10.1073\/pnas.94.8.4199","article-title":"Estrogen regulates the rate of bone turnover but bone balance in ovariectomized rats is modulated by prevailing mechanical strain.","volume":"94","author":"Westerlind","year":"1997","journal-title":"Proc Natl Acad Sci USA"},{"key":"2019041122165349700_R40","doi-asserted-by":"crossref","first-page":"2383","DOI":"10.1016\/0024-3205(84)90446-6","article-title":"Mechanisms of hormone action: parallels in receptor-mediated signal propagation for steroid and receptor-mediated signal propagation for steroid and peptide effectors.","volume":"35","author":"Szego","year":"1984","journal-title":"Life Sci"},{"key":"2019041122165349700_R41","first-page":"547","article-title":"Estrogen results in rapid, differential regulation of immediate response, growth factor, and matrix protein genes in bone and uterus of growing rats","author":"Kidder"},{"key":"2019041122165349700_R42","doi-asserted-by":"crossref","first-page":"1508","DOI":"10.1126\/science.277.5331.1508","article-title":"Differential ligand activation of estrogen receptors Er\u03b1 and Er\u03b2 at AP1 sites.","volume":"277","author":"Paech","year":"1997","journal-title":"Science"},{"key":"2019041122165349700_R43","doi-asserted-by":"crossref","first-page":"1222","DOI":"10.1126\/science.273.5279.1222","article-title":"Identification of an estrogen response element activated by metabolites of 17\u03b2-estradiol and raloxifene.","volume":"273","author":"Yang","year":"1996","journal-title":"Science"},{"key":"2019041122165349700_R44","doi-asserted-by":"crossref","first-page":"2581","DOI":"10.1073\/pnas.94.6.2581","article-title":"The quinone reductase gene: a unique estrogen receptor-regulated gene that is activated by antiestrogens.","volume":"94","author":"Montano","year":"1997","journal-title":"Proc Natl Acad Sci USA"}],"container-title":["Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/endo\/article-pdf\/139\/9\/3736\/10348893\/endo3736.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,4,12]],"date-time":"2019-04-12T16:20:23Z","timestamp":1555086023000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/endo\/article\/139\/9\/3736\/2986946"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1998,9,1]]},"references-count":44,"aliases":["10.1210\/en.139.9.3736"],"journal-issue":{"issue":"9","published-print":{"date-parts":[[1998,9,1]]}},"URL":"https:\/\/doi.org\/10.1210\/endo.139.9.6172","relation":{},"ISSN":["0013-7227","1945-7170"],"issn-type":[{"value":"0013-7227","type":"print"},{"value":"1945-7170","type":"electronic"}],"subject":[],"published":{"date-parts":[[1998,9,1]]}}}