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TRH (0.1 \u03bcg) or the somatostatin subtype 5-preferring analog, BIM-23052 (1 \u03bcg), injected intracisternally increased basal gastric emptying by 34% and 47%, respectively. TRHr antisense, which had no effect on basal emptying, blocked TRH action but did not influence that of BIM-23052. Cold exposure increased gastric emptying by 64%, and the response was inhibited by vagotomy, atropine (0.1 mg\/kg, ip), and TRHr antisense (intracisternally). Saline or mismatched oligodeoxynucleotides, injected intracisternally under similar conditions, did not alter the enhanced gastric emptying induced by cold or intracisternal injection of TRH or BIM-23052. These results indicate that TRH receptor activation in the brain stem mediates acute cold-induced vagal cholinergic stimulation of gastric transit, and that medullary TRH may play a role in the autonomic visceral responses to acute cold.<\/jats:p>","DOI":"10.1210\/endo.139.9.6195","type":"journal-article","created":{"date-parts":[[2014,1,8]],"date-time":"2014-01-08T16:09:28Z","timestamp":1389197368000},"page":"3730-3735","source":"Crossref","is-referenced-by-count":21,"title":["Intracisternal Antisense Oligodeoxynucleotides to the Thyrotropin-Releasing Hormone Receptor Blocked Vagal-Dependent Stimulation of Gastric Emptying Induced by Acute Cold in Rats*"],"prefix":"10.1210","volume":"139","author":[{"given":"V.","family":"Martinez","sequence":"first","affiliation":[{"name":"CURE: Digestive Diseases Research Center, West Los Angeles Veterans Administration Medical Center, and the Department of Medicine, Digestive Disease Division, and Brain Research Institute, University of California School of Medicine, Los Angeles, California 90073"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. 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