{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T22:59:14Z","timestamp":1791068354755,"version":"4.1.0"},"reference-count":40,"publisher":"The Endocrine Society","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1999,10,1]]},"DOI":"10.1210\/endo.140.10.7036","type":"journal-article","created":{"date-parts":[[2014,1,8]],"date-time":"2014-01-08T16:09:28Z","timestamp":1389197368000},"page":"4683-4690","source":"Crossref","is-referenced-by-count":136,"title":["A Role for Interleukin-6 in Parathyroid Hormone-Induced Bone Resorption in Vivo1"],"prefix":"10.1210","volume":"140","author":[{"given":"Andrew","family":"Grey","sequence":"first","affiliation":[{"name":"Section of Endocrinology (A.G., M.-A.M., U.M., B.-H.S., K.I.), Yale University School of Medicine, New Haven, Connecticut 06520-8020"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary-Ann","family":"Mitnick","sequence":"additional","affiliation":[{"name":"Section of Endocrinology (A.G., M.-A.M., U.M., B.-H.S., K.I.), Yale University School of Medicine, New Haven, Connecticut 06520-8020"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Urszula","family":"Masiukiewicz","sequence":"additional","affiliation":[{"name":"Section of Endocrinology (A.G., M.-A.M., U.M., B.-H.S., K.I.), Yale University School of Medicine, New Haven, Connecticut 06520-8020"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ben-Hua","family":"Sun","sequence":"additional","affiliation":[{"name":"Section of Endocrinology (A.G., M.-A.M., U.M., B.-H.S., K.I.), Yale University School of Medicine, New Haven, Connecticut 06520-8020"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stuart","family":"Rudikoff","sequence":"additional","affiliation":[{"name":"Laboratory of Genetics (S.R.), National Cancer Institute, Bethesda, Maryland 20892"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert L.","family":"Jilka","sequence":"additional","affiliation":[{"name":"University of Arkansas for Medical Sciences (R.J., S.M.), Little Rock, Arkansas 72205"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stavros C.","family":"Manolagas","sequence":"additional","affiliation":[{"name":"University of Arkansas for Medical Sciences (R.J., S.M.), Little Rock, Arkansas 72205"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karl","family":"Insogna","sequence":"additional","affiliation":[{"name":"Section of Endocrinology (A.G., M.-A.M., U.M., B.-H.S., K.I.), Yale University School of Medicine, New Haven, Connecticut 06520-8020"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"80","reference":[{"key":"2019041121312975900_R1","first-page":"15","author":"Brown","year":"1994"},{"key":"2019041121312975900_R2","doi-asserted-by":"crossref","first-page":"1676","DOI":"10.1056\/NEJM198606263142605","article-title":"Involutional osteoporosis.","volume":"314","author":"Riggs","year":"1986","journal-title":"N Engl J Med"},{"key":"2019041121312975900_R3","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1002\/jbmr.5650060205","article-title":"Interrelationship among vitamin D metabolism, true calcium absorption, parathyroid function and age in women: evidence of an age-related intestinal resistance to 1,25-(OH)D action.","volume":"6","author":"Eastell","year":"1991","journal-title":"J Bone Miner Res"},{"key":"2019041121312975900_R4","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1046\/j.1365-2265.1996.744565.x","article-title":"Accelerated bone loss in postmenopausal women with primary hyperparathyroidism.","volume":"44","author":"Grey","year":"1996","journal-title":"Clin Endocrinol (Oxf)"},{"key":"2019041121312975900_R5","first-page":"3487","article-title":"Longitudinal changes in bone mineral density and bone turnover in postmenopausal women with primary hyperparathyroidism.","volume":"81","author":"Guo","year":"1996","journal-title":"J Clin Endocrinol Metab"},{"key":"2019041121312975900_R6","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/S0950-351X(97)80537-X","article-title":"The skeletal effects of primary hyperparathyroidism.","volume":"11","author":"Grey","year":"1997","journal-title":"Bailliere\u2019s Clin Endocrinol Metab"},{"key":"2019041121312975900_R7","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1210\/endo-118-2-824","article-title":"Osteoblastic cells mediate osteoclastic responsiveness to parathyroid hormone.","volume":"118","author":"McSheehy","year":"1986","journal-title":"Endocrinology"},{"key":"2019041121312975900_R8","doi-asserted-by":"crossref","first-page":"1474","DOI":"10.1002\/jbmr.5650111014","article-title":"Colony stimulating factor-1 plays a role in osteoclast formation and function in bone resorption induced by parathyroid hormone and parathyroid hormone-related protein.","volume":"11","author":"Weir","year":"1996","journal-title":"J Bone Miner Res"},{"key":"2019041121312975900_R9","doi-asserted-by":"crossref","first-page":"2581","DOI":"10.1084\/jem.183.6.2581","article-title":"The role of gp130-mediated signals in osteoclast development: regulation of interleukin-11 production by osteoblasts and distribution of its receptor in bone marrow cultures.","volume":"183","author":"Romas","year":"1996","journal-title":"J Exp Med"},{"key":"2019041121312975900_R10","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1210\/endo.136.2.7835281","article-title":"Cytokine and hormonal stimulation of human osteosarcoma interleukin-11 production.","volume":"136","author":"Elias","year":"1995","journal-title":"Endocrinology"},{"key":"2019041121312975900_R11","doi-asserted-by":"crossref","first-page":"3597","DOI":"10.1073\/pnas.95.7.3597","article-title":"Osteoclast differentiation factor is a ligand for osteoprotegerin\/osteoclastogenesis-inhibitory factor and is identical to TRANCE\/RANKL.","volume":"95","author":"Yasuda","year":"1998","journal-title":"Proc Natl Acad Sci USA"},{"key":"2019041121312975900_R12","doi-asserted-by":"crossref","first-page":"4743","DOI":"10.1210\/endo.139.11.6433","article-title":"Osteotropic agents regulate the expression of osteoclast differentiation factor and osteoprotegerin in osteoblastic stromal cells.","volume":"139","author":"Horwood","year":"1998","journal-title":"Endocrinology"},{"key":"2019041121312975900_R13","doi-asserted-by":"crossref","first-page":"1546","DOI":"10.1016\/0006-291X(89)90851-6","article-title":"Parathyroid hormone (PTH) and PTH-like protein (PLP) stimulate interleukin-6 production by osteogenic cells: a possible role of interleukin-6 in osteoclastogenesis.","volume":"162","author":"Lowik","year":"1989","journal-title":"Biochem Biophys Res Commun"},{"key":"2019041121312975900_R14","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1002\/jbmr.5650040422","article-title":"Interleukin-6 is produced by bone and modulated by parathyroid hormone.","volume":"4","author":"Feyen","year":"1989","journal-title":"J Bone Miner Res"},{"key":"2019041121312975900_R15","doi-asserted-by":"crossref","first-page":"3297","DOI":"10.4049\/jimmunol.145.10.3297","article-title":"IL-6 is produced by osteoblasts and induces bone resorption.","volume":"145","author":"Ishimi","year":"1990","journal-title":"J Immunol"},{"key":"2019041121312975900_R16","first-page":"471","author":"Horowitz","year":"1990"},{"key":"2019041121312975900_R17","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1016\/0006-291X(91)91360-O","article-title":"Effect of parathyroid hormone on release of interleukin 1 and interleukin 6 from cultured mouse osteoblastic cells.","volume":"179","author":"Li","year":"1991","journal-title":"Biochem Biophys Res Commun"},{"key":"2019041121312975900_R18","doi-asserted-by":"crossref","first-page":"1163","DOI":"10.1002\/jbmr.5650081003","article-title":"Regulation of cytokine expression in osteoblasts by parathyroid hormone: rapid stimulation of interleukin-6 and leukemia inhibitory factor mRNA.","volume":"8","author":"Greenfield","year":"1993","journal-title":"J Bone Miner Res"},{"key":"2019041121312975900_R19","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1002\/jbmr.5650080706","article-title":"Stimulation of interleukin-6 production by either calcitonin gene-related peptide or parathyroid hormone in two phenotypically distinct bone marrow-derived murine stromal cell lines.","volume":"8","author":"Sakagami","year":"1993","journal-title":"J Bone Miner Res"},{"key":"2019041121312975900_R20","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1016\/8756-3282(95)00332-2","article-title":"In vivo, human parathyroid hormone fragment (hPTH 1\u201334) transiently stimulates immediate early response gene expression, but not proliferation, in trabecular bone cells of young rats.","volume":"17","author":"Onyia","year":"1995","journal-title":"Bone"},{"key":"2019041121312975900_R21","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1002\/jbmr.5650070502","article-title":"Interleukin-6: an osteotropic factor?","volume":"7","author":"Roodman","year":"1992","journal-title":"J Bone Miner Res"},{"key":"2019041121312975900_R22","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1126\/science.1621100","article-title":"Increased osteoclast development after estrogen loss: mediation by interleukin-6.","volume":"257","author":"Jilka","year":"1992","journal-title":"Science"},{"key":"2019041121312975900_R23","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.1002\/j.1460-2075.1994.tb06368.x","article-title":"Interleukin-6 deficient mice are protected from bone loss caused by estrogen depletion.","volume":"13","author":"Poli","year":"1994","journal-title":"EMBO J"},{"key":"2019041121312975900_R24","doi-asserted-by":"crossref","first-page":"1238","DOI":"10.1172\/JCI118157","article-title":"Adenyl cyclase and interleukin 6 are downstream effectors of parathyroid hormone resulting in stimulation of bone resorption.","volume":"96","author":"Greenfield","year":"1995","journal-title":"J Clin Invest"},{"key":"2019041121312975900_R25","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1002\/jbmr.5650110606","article-title":"In vivo demonstration that parathyroid hormone and parathyroid hormone-related protein stimulate expression by osteoblasts of interleukin-6 and leukemia inhibitory factor.","volume":"11","author":"Pollock","year":"1996","journal-title":"J Bone Miner Res"},{"key":"2019041121312975900_R26","first-page":"3450","article-title":"Circulating levels of interleukin-6 and tumor necrosis factor-\u03b1 are elevated in primary hyperparathyroidism, and correlate with markers of bone resorption.","volume":"81","author":"Grey","year":"1996","journal-title":"J Clin Endocrinol Metab"},{"key":"2019041121312975900_R27","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1038\/368339a0","article-title":"Impaired immune and acute-phase responses in interleukin-6-deficient mice.","volume":"368","author":"Kopf","year":"1994","journal-title":"Nature"},{"key":"2019041121312975900_R28","first-page":"500","article-title":"Estrogen loss upregulates hematopoiesis in the mouse: a mediating role of IL-6.","volume":"23","author":"Jilka","year":"1995","journal-title":"Exp Hematol"},{"key":"2019041121312975900_R29","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1002\/jbmr.5650110403","article-title":"Sequential effects of chronic human PTH (1\u201384) treatment of estrogen-deficiency osteopenia in the rat.","volume":"11","author":"Mitlak","year":"1996","journal-title":"J Bone Miner Res"},{"key":"2019041121312975900_R30","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1002\/jbmr.5650110715","article-title":"Effects of hysterectomy on bone in intact rats, ovariectomized rats, and ovariectomized rats treated with estrogen.","volume":"11","author":"Goulding","year":"1996","journal-title":"J Bone Miner Res"},{"key":"2019041121312975900_R31","first-page":"333","article-title":"Molecular basis and clinical applications of biological markers of bone turnover.","volume":"17","author":"Calvo","year":"1996","journal-title":"Endocr Rev"},{"key":"2019041121312975900_R32","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1002\/jbmr.5650080407","article-title":"High-dose estrogen inhibits bone resorption and stimulates bone formation in the ovariectomized mouse.","volume":"8","author":"Bain","year":"1993","journal-title":"J Bone Miner Res"},{"key":"2019041121312975900_R33","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1007\/BF02409454","article-title":"Role of osteoblasts in hormonal control of bone resorption - a hypothesis.","volume":"33","author":"Rodan","year":"1981","journal-title":"Calcif Tissue Int"},{"key":"2019041121312975900_R34","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/S0169-6009(08)80149-3","article-title":"Endogenous production of tumor necrosis factor by primary cultures of murine calvarial cells: influence on IL-6 production and osteoclast development.","volume":"24","author":"Passeri","year":"1994","journal-title":"Bone Miner"},{"key":"2019041121312975900_R35","doi-asserted-by":"crossref","first-page":"4056","DOI":"10.1210\/endo.136.9.7649114","article-title":"Production of interleukin-6 in human osteoblasts and human bone marrow stromal cells: evidence that induction by interleukin-1 and tumor necrosis factor-\u03b1 is not regulated by ovarian steroids.","volume":"136","author":"Rifas","year":"1995","journal-title":"Endocrinology"},{"key":"2019041121312975900_R36","doi-asserted-by":"crossref","first-page":"11924","DOI":"10.1073\/pnas.90.24.11924","article-title":"Soluble interleukin-6 receptor triggers osteoclast formation by interleukin-6.","volume":"90","author":"Tamura","year":"1993","journal-title":"Proc Natl Acad Sci USA"},{"key":"2019041121312975900_R37","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1210\/endo.133.2.8393771","article-title":"Parathyroid hormone (PTH)\/PTH-related peptide receptor messenger ribonucleic acids are widely distributed in rat tissues.","volume":"133","author":"Urena","year":"1993","journal-title":"Endocrinology"},{"key":"2019041121312975900_R38","author":"Mitnick","year":"1998"},{"key":"2019041121312975900_R39","doi-asserted-by":"crossref","first-page":"1399","DOI":"10.1084\/jem.183.4.1399","article-title":"The function of the soluble interleukin 6 (IL-6) receptor in vivo: sensitization of human soluble IL-6 receptor transgenic mice towards IL-6 and prolongation of the plasma half-life of IL-6.","volume":"183","author":"Peters","year":"1996","journal-title":"J Exp Med"},{"key":"2019041121312975900_R40","doi-asserted-by":"crossref","first-page":"127","DOI":"10.7326\/0003-4819-128-2-199801150-00009","article-title":"Endocrine and metabolic actions of interleukin-6, pp 128\u2013130. In: Papanicolaou DA (moderator) The Pathophysiologic Roles of Interleukin-6 in Human Disease.","volume":"128","author":"Papanicolaou","year":"1998","journal-title":"Ann Intern Med"}],"container-title":["Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/endo\/article-pdf\/140\/10\/4683\/10380476\/endo4683.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,7,9]],"date-time":"2023-07-09T14:42:33Z","timestamp":1688913753000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/endo\/article\/140\/10\/4683\/2990777"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1999,10,1]]},"references-count":40,"aliases":["10.1210\/en.140.10.4683"],"journal-issue":{"issue":"10","published-print":{"date-parts":[[1999,10,1]]}},"URL":"https:\/\/doi.org\/10.1210\/endo.140.10.7036","relation":{},"ISSN":["0013-7227","1945-7170"],"issn-type":[{"value":"0013-7227","type":"print"},{"value":"1945-7170","type":"electronic"}],"subject":[],"published":{"date-parts":[[1999,10,1]]}}}