{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T17:43:22Z","timestamp":1791481402419,"version":"4.3.4"},"reference-count":51,"publisher":"The Endocrine Society","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1999,11,1]]},"DOI":"10.1210\/endo.140.11.7121","type":"journal-article","created":{"date-parts":[[2014,1,8]],"date-time":"2014-01-08T16:09:42Z","timestamp":1389197382000},"page":"5112-5119","source":"Crossref","is-referenced-by-count":52,"title":["Hypertension Associated with Decreased Testosterone Levels in Natriuretic Peptide Receptor-A Gene-Knockout and Gene-Duplicated Mutant Mouse Models1"],"prefix":"10.1210","volume":"140","author":[{"given":"Kailash N.","family":"Pandey","sequence":"first","affiliation":[{"name":"Department of Physiology, Tulane University School of Medicine (K.N.P.), New Orleans, Louisiana 70112"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paula M.","family":"Oliver","sequence":"additional","affiliation":[{"name":"The Department of Pathology, University of North Carolina (P.M.O., N.M., O.S.), Chapel Hill, North Carolina 27599"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nobuyo","family":"Maeda","sequence":"additional","affiliation":[{"name":"The Department of Pathology, University of North Carolina (P.M.O., N.M., O.S.), Chapel Hill, North Carolina 27599"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oliver","family":"Smithies","sequence":"additional","affiliation":[{"name":"The Department of Pathology, University of North Carolina (P.M.O., N.M., O.S.), Chapel Hill, North Carolina 27599"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"80","reference":[{"key":"2019041200380200100_R1","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/0024-3205(81)90370-2","article-title":"A rapid and potent natriuretic response to intravenous injection of atrial myocardial extract in rats.","volume":"28","author":"deBold","year":"1981","journal-title":"Life Sci"},{"key":"2019041200380200100_R2","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1038\/309717a0","article-title":"Purification, sequencing and synthesis of natriuretic and vasoactive rat atrial peptide.","volume":"309","author":"Atlas","year":"1984","journal-title":"Nature"},{"key":"2019041200380200100_R3","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1038\/309722a0","article-title":"Structure of rat atrial natriuretic factor precursor deduced from cDNA sequence.","volume":"309","author":"Maki","year":"1984","journal-title":"Nature"},{"key":"2019041200380200100_R4","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1016\/S0031-6997(25)00429-6","article-title":"Atrial natriuretic factor receptor and signal transduction.","volume":"45","author":"Anand-Srivastava","year":"1993","journal-title":"Pharmacol Rev"},{"key":"2019041200380200100_R5","first-page":"255","author":"Pandey","year":"1996"},{"key":"2019041200380200100_R6","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1056\/NEJM199807303390507","article-title":"Natriuretic peptides.","volume":"339","author":"Levin","year":"1998","journal-title":"N Engl J Med"},{"key":"2019041200380200100_R7","doi-asserted-by":"crossref","first-page":"3043","DOI":"10.1016\/S0021-9258(18)94025-1","article-title":"Atrial natriuretic factor.","volume":"264","author":"Inagami","year":"1989","journal-title":"J Biol Chem"},{"key":"2019041200380200100_R8","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1152\/physrev.1990.70.3.665","article-title":"Diverse biological actions of atrial natriuretic peptide.","volume":"70","author":"Brenner","year":"1990","journal-title":"Physiol Rev"},{"key":"2019041200380200100_R9","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1126\/science.1672777","article-title":"Selective activation of the B-natriuretic peptide receptor by C-type natriuretic peptide (CNP).","volume":"252","author":"Koller","year":"1991","journal-title":"Science"},{"key":"2019041200380200100_R10","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0092-8674(92)90258-E","article-title":"Guanylyl cyclase receptors and their endocrine, paracrine and autocrine ligands.","volume":"71","author":"Garbers","year":"1992","journal-title":"Cell"},{"key":"2019041200380200100_R11","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1210\/edrv-15-2-135","article-title":"The family of guanylyl cyclase receptors and their ligands.","volume":"15","author":"Drewett","year":"1994","journal-title":"Endocr Rev"},{"key":"2019041200380200100_R12","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1146\/annurev.ph.54.030192.000303","article-title":"Receptors for atrial natriuretic factor.","volume":"54","author":"Maack","year":"1992","journal-title":"Annu Rev Physiol"},{"key":"2019041200380200100_R13","first-page":"171","author":"Pandey","year":"1997"},{"key":"2019041200380200100_R14","doi-asserted-by":"crossref","first-page":"8467","DOI":"10.1021\/bi00374a022","article-title":"Atrial natriuretic factor receptor on cultured Leydig tumor cells: ligand binding and photoaffinity labeling.","volume":"25","author":"Pandey","year":"1986","journal-title":"Biochemisty"},{"key":"2019041200380200100_R15","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1016\/0006-291X(86)90295-0","article-title":"Atrial natriuretic factor regulates steroidogenic responsiveness and cyclic nucleotide levels in mouse Leydig cells in vitro.","volume":"138","author":"Pandey","year":"1986","journal-title":"Biochem Biophys Res Commun"},{"key":"2019041200380200100_R16","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/0014-5793(86)80659-7","article-title":"Testosterone production by mouse Leydig cells is stimulated in vitro by atrial natriuretic factor.","volume":"202","author":"Mukhopadhyay","year":"1986","journal-title":"FEBS Lett"},{"key":"2019041200380200100_R17","doi-asserted-by":"crossref","first-page":"12342","DOI":"10.1016\/S0021-9258(19)38352-8","article-title":"Molecular cloning and expression of murine guanylate cyclase\/atrial natriuretic factor receptor cDNA.","volume":"265","author":"Pandey","year":"1990","journal-title":"J Biol Chem"},{"key":"2019041200380200100_R18","doi-asserted-by":"crossref","first-page":"1195","DOI":"10.1210\/endo-121-3-1195","article-title":"Specific receptor-mediated stimulation of progesterone secretion and cGMP accumulation by rat atrial natriuretic factor in cultured human granulosa-lutein (G-L) cells.","volume":"121","author":"Pandey","year":"1987","journal-title":"Endocrinology"},{"key":"2019041200380200100_R19","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1210\/endo.132.2.8425488","article-title":"The atrial natriuretic peptide system in rat ovaries.","volume":"132","author":"Gutkowska","year":"1993","journal-title":"Endocrinology"},{"key":"2019041200380200100_R20","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/0014-2999(85)90595-3","article-title":"Atrial natriuretic factor stimulates testosterone production by mouse interstitial cells.","volume":"115","author":"Bex","year":"1985","journal-title":"Eur J Pharmacol"},{"key":"2019041200380200100_R21","doi-asserted-by":"crossref","first-page":"253","DOI":"10.3109\/01485018708986825","article-title":"Specific binding and steroidogenic effects of atrial natriuretic factor in Leydig cells of rats.","volume":"19","author":"Foresta","year":"1987","journal-title":"Arch Androl"},{"key":"2019041200380200100_R22","doi-asserted-by":"crossref","first-page":"2141","DOI":"10.1210\/endo.133.5.8404664","article-title":"Receptor-mediated stimulatory effect of atrial natriuretic factor, brain natriuretic peptide and C-type natriuretic peptide in stimulation of testosterone production in purified mouse Leydig cells: activation of cholesterol side-chain cleavage enzyme.","volume":"133","author":"Khurana","year":"1993","journal-title":"Endocrinology"},{"key":"2019041200380200100_R23","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1161\/01.HYP.28.5.847","article-title":"Differential expression and autoradiographic localization of atrial natriuretic peptide receptor in spontaneously hypertensive and normotensive rat testes.","volume":"28","author":"Kapasi","year":"1996","journal-title":"Hypertension"},{"key":"2019041200380200100_R24","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1097\/00004872-199307000-00003","article-title":"Sex hormones and homeostatic risk factors for coronary heart disease in men with hypertension.","volume":"11","author":"Phillips","year":"1993","journal-title":"J Hypertens"},{"key":"2019041200380200100_R25","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1161\/01.HYP.28.5.859","article-title":"Erectile dysfunction in hypertensive subjects.","volume":"28","author":"Jaffe","year":"1996","journal-title":"Hypertension"},{"key":"2019041200380200100_R26","first-page":"755","article-title":"Low testosterone and insulin resistance in hypertension-prone men.","volume":"10","author":"Endre","year":"1996","journal-title":"J Hum Hypertens"},{"key":"2019041200380200100_R27","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1210\/endo.132.2.8425480","article-title":"Endothelin-1 promotes steroidogenesis and stimulates protooncogene expression in transformed murine Leydig cells.","volume":"132","author":"Ergul a, Glassberg","year":"1993","journal-title":"Endocrinology"},{"key":"2019041200380200100_R28","doi-asserted-by":"crossref","first-page":"14730","DOI":"10.1073\/pnas.94.26.14730","article-title":"Hypertension, cardiac hypertrophy, and sudden death in mice lacking natriuretic peptide receptor-A.","volume":"94","author":"Oliver","year":"1997","journal-title":"Proc Natl Acad Sci USA"},{"key":"2019041200380200100_R29","doi-asserted-by":"crossref","first-page":"2547","DOI":"10.1073\/pnas.95.5.2547","article-title":"Natriuretic peptide receptor 1 expression influences blood pressures of mice in a dose-dependent manner.","volume":"95","author":"Oliver","year":"1998","journal-title":"Proc Natl Acad Sci USA"},{"key":"2019041200380200100_R30","doi-asserted-by":"crossref","first-page":"3612","DOI":"10.1073\/pnas.91.9.3612","article-title":"Targeted gene duplication and disruption for analyzing quantitative genetic traits in mice.","volume":"91","author":"Smithies","year":"1995","journal-title":"Proc Natl Acad Sci USA"},{"key":"2019041200380200100_R31","doi-asserted-by":"crossref","first-page":"5266","DOI":"10.1073\/pnas.92.12.5266","article-title":"Gene targeting approaches to complex genetic diseases: Atherosclerosis and essential hypertension.","volume":"92","author":"Smithies","year":"1995","journal-title":"Proc Natl Acad Sci USA"},{"key":"2019041200380200100_R32","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1038\/380149a0","article-title":"A comprehensive genetic map of the mouse genome.","volume":"380","author":"Deitrich","year":"1996","journal-title":"Nature"},{"key":"2019041200380200100_R33","doi-asserted-by":"crossref","first-page":"4382","DOI":"10.1016\/S0021-9258(18)53621-8","article-title":"Stoichiometric analysis of internalization, recycling and redistribution of photoaffinity labeled guanylyl cyclase\/atrial natriuretic factor receptors in cultured murine Leydig tumor cells.","volume":"268","author":"Pandey","year":"1993","journal-title":"J Biol Chem"},{"key":"2019041200380200100_R34","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/0167-4889(94)90113-9","article-title":"Modulation of guanylate cyclase-coupled atrial natriuretic factor receptor activity by mastoparan and G-proteins.","volume":"1224","author":"Khurana","year":"1994","journal-title":"Biochim Biohys Acta"},{"key":"2019041200380200100_R35","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1006\/abbi.1995.1052","article-title":"Catalytic activation of guanylate cyclase\/atrial natriuretic factor receptor by combined effects of ANP and GTP\u03b3S in plasma membranes of Leydig cells.","volume":"316","author":"Khurana","year":"1995","journal-title":"Arch Biochem Biophys"},{"key":"2019041200380200100_R36","first-page":"903","article-title":"Effects of an Igf gene null mutation on mouse reproduction.","volume":"10","author":"Baker","year":"1996","journal-title":"Mol Endocrinol"},{"key":"2019041200380200100_R37","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1210\/jcem-72-2-392","article-title":"Stimulatory effects of alpha-hANP on testosterone secretion in man.","volume":"72","author":"Foresta","year":"1991","journal-title":"J Clin Endrocrinol Metab"},{"key":"2019041200380200100_R38","doi-asserted-by":"crossref","first-page":"3444","DOI":"10.1073\/pnas.83.10.3444","article-title":"Effect of atrial natriuretic peptide on gonadotropin release in superfused rat pituitary cells.","volume":"83","author":"Horvath","year":"1986","journal-title":"Proc Natl Acad Sci USA"},{"key":"2019041200380200100_R39","doi-asserted-by":"crossref","first-page":"11391","DOI":"10.1073\/pnas.89.23.11391","article-title":"The role of endogenous atrial natriuretic peptide in resting and stress-induced release of corticotropin, prolactin, growth hormone, and thyroid-stimulating hormone.","volume":"89","author":"Franci","year":"1992","journal-title":"Proc Natl Acad Sci USA"},{"key":"2019041200380200100_R40","doi-asserted-by":"crossref","first-page":"23064","DOI":"10.1074\/jbc.272.37.23064","article-title":"the guanylyl cyclase-deficient mouse defines differential pathways of natriuretic peptide signaling.","volume":"272","author":"Lopez","year":"1997","journal-title":"J Biol Chem"},{"key":"2019041200380200100_R41","first-page":"4324","article-title":"Natriuretic peptides in the human testis: Evidence for a potential role of C-type natriuretic peptide in Leydig cells.","volume":"81","author":"Middendorff","year":"1996","journal-title":"J Clin Endocrinol Metab"},{"key":"2019041200380200100_R42","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1007\/978-1-4615-5913-9_21","article-title":"New aspects of Leydig cell function.","volume":"424","author":"Middendorff","year":"1997","journal-title":"Adv Exp Med Biol"},{"key":"2019041200380200100_R43","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1016\/S0006-291X(05)81312-9","article-title":"Atrial natriuretic factor in mammalian testes. Immunological detection in spermatozoa.","volume":"180","author":"Pandey","year":"1991","journal-title":"Biochem Biophys Res Commun"},{"key":"2019041200380200100_R44","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1042\/bj2390463","article-title":"Steroidogenic effect of atrial natriuretic factor in isolated mouse Leydig cells is medicated by cyclic GMP.","volume":"239","author":"Mukhopadhyay","year":"1986","journal-title":"Biochem J"},{"key":"2019041200380200100_R45","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/S0021-9258(17)42597-X","article-title":"Atrial natriuretic factor selectively activates particulate guanylate cyclase and elevates cyclic GMP in rat tissue.","volume":"259","author":"Waldman","year":"1984","journal-title":"J Biol Chem"},{"key":"2019041200380200100_R46","doi-asserted-by":"crossref","first-page":"3721","DOI":"10.1016\/S0021-9258(17)34861-5","article-title":"Action of choleragen and gonadotropin in isolated Leydig cells.","volume":"253","author":"Dufau","year":"1978","journal-title":"J Biol Chem"},{"key":"2019041200380200100_R47","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1016\/0014-5793(79)80416-0","article-title":"Maximal steroidogenic capacity of mouse Leydig cells.","volume":"107","author":"Schumacher","year":"1979","journal-title":"FEBS Lett"},{"key":"2019041200380200100_R48","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/0303-7207(82)90060-0","article-title":"Stimulation and inhibition by LHRH analogues of cultured rat Leydig cell function and lack of effect on mouse Leydig cells.","volume":"27","author":"Hunter","year":"1982","journal-title":"Mol Cell Endocrinol"},{"key":"2019041200380200100_R49","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1080\/07435809009033009","article-title":"Effects of acute and chronic treatments with atrial natriuretic factor (ANF) on the Leydig cells of the rat testis.","volume":"16","author":"Mazzocchi","year":"1990","journal-title":"Endocr Res"},{"key":"2019041200380200100_R50","doi-asserted-by":"crossref","first-page":"181","DOI":"10.3109\/01485018808986740","article-title":"Effects of atrial natriuretic factor (ANF) on rat testicular steroidogenesis in vitro.","volume":"21","author":"Foresta","year":"1988","journal-title":"Arch Androl"},{"key":"2019041200380200100_R51","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1530\/acta.0.1280274","article-title":"The role of calcium ions in rat Leydig cell steroidogenesis induced by atrial natriuretic peptide.","volume":"128","author":"Foresta","year":"1993","journal-title":"Acta Endocrinol (Copenh)"}],"container-title":["Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/endo\/article-pdf\/140\/11\/5112\/10379287\/endo5112.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T11:54:06Z","timestamp":1746100446000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/endo\/article\/140\/11\/5112\/2990681"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1999,11,1]]},"references-count":51,"journal-issue":{"issue":"11","published-print":{"date-parts":[[1999,11,1]]}},"URL":"https:\/\/doi.org\/10.1210\/endo.140.11.7121","relation":{},"ISSN":["0013-7227","1945-7170"],"issn-type":[{"value":"0013-7227","type":"print"},{"value":"1945-7170","type":"electronic"}],"subject":[],"published":{"date-parts":[[1999,11,1]]}}}