{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T18:15:40Z","timestamp":1789236940954,"version":"build-2803163510"},"reference-count":39,"publisher":"The Endocrine Society","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1999,3,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>This study is designed to clarify the role of an orphan nuclear hormone receptor, ROR\u03b1, on thyroid hormone (TH) receptor (TR)-mediated transcription on a TH-response element (TRE). A transient transfection study using various TREs [i.e., F2 (chick lysozyme TRE), DR4 (direct repeat), and palindrome TRE] and TR and ROR\u03b11 was performed. When ROR\u03b11 and TR were cotransfected into CV1 cells, ROR\u03b11 enhanced the transactivation by liganded-TR on all TREs tested without an effect on basal repression by unliganded TR. By electrophoretic mobility shift assay, on the other hand, although ROR\u03b1 bound to all TREs tested as a monomer, no (or weak) TR and ROR\u03b11 heterodimer formation was observed on various TREs except when a putative ROR-response element was present. The transactivation by ROR\u03b11 on a ROR-response element, which does not contain a TRE, was not enhanced by TR. The effect of ROR\u03b11 on the TREs is unique, because, whereas other nuclear hormone receptors (such as vitamin D receptor) may competitively bind to TRE to exert dominant negative function, ROR\u03b11 augmented TR action. These results indicate that ROR\u03b11 may modify the effect of liganded TR on TH-responsive genes. Because TR and ROR\u03b1 are coexpressed in cerebellar Purkinje cells, and perinatal hypothyroid animals and ROR\u03b1-disrupted animals show similar abnormalities of this cell type, cross-talk between these two receptors may play a critical role in Purkinje cell differentiation.<\/jats:p>","DOI":"10.1210\/endo.140.3.6562","type":"journal-article","created":{"date-parts":[[2014,1,8]],"date-time":"2014-01-08T11:10:12Z","timestamp":1389179412000},"page":"1356-1364","source":"Crossref","is-referenced-by-count":31,"title":["ROR\u03b1 Augments Thyroid Hormone Receptor-Mediated Transcriptional Activation*"],"prefix":"10.1210","volume":"140","author":[{"given":"Noriyuki","family":"Koibuchi","sequence":"first","affiliation":[{"name":"Division of Genetics, Department of Medicine, Brigham and Women\u2019s Hospital and Harvard Medical School, Boston, Massachusetts 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