{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T05:18:42Z","timestamp":1790745522017,"version":"4.1.0"},"reference-count":54,"publisher":"The Endocrine Society","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1999,6,1]]},"DOI":"10.1210\/endo.140.6.6833","type":"journal-article","created":{"date-parts":[[2014,1,8]],"date-time":"2014-01-08T16:09:44Z","timestamp":1389197384000},"page":"2801-2813","source":"Crossref","is-referenced-by-count":42,"title":["Neonatal Estrogen Exposure Alters the Transforming Growth Factor-\u03b2 Signaling System in the Developing Rat Prostate and Blocks the Transient p21cip1\/waf1 Expression Associated with Epithelial Differentiation*"],"prefix":"10.1210","volume":"140","author":[{"given":"William Y.","family":"Chang","sequence":"first","affiliation":[{"name":"Departments of Urology (W.Y.C., L.B., C.W., G.S.P.) , University of Illinois College of Medicine, Chicago, Illinois 60612"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lynn","family":"Birch","sequence":"additional","affiliation":[{"name":"Departments of Urology (W.Y.C., L.B., C.W., G.S.P.) , University of Illinois College of Medicine, Chicago, Illinois 60612"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carl","family":"Woodham","sequence":"additional","affiliation":[{"name":"Departments of Urology (W.Y.C., L.B., C.W., G.S.P.) , University of Illinois College of Medicine, Chicago, Illinois 60612"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leslie I.","family":"Gold","sequence":"additional","affiliation":[{"name":"New York University Medical School (L.I.G.), New York, New York 10016"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gail S.","family":"Prins","sequence":"additional","affiliation":[{"name":"Departments of Urology (W.Y.C., L.B., C.W., G.S.P.) , University of Illinois College of Medicine, Chicago, Illinois 60612"},{"name":"Physiology and Biophysics (G.S.P.), University of Illinois College of Medicine, Chicago, Illinois 60612"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"80","reference":[{"key":"2019041122282580800_R1","first-page":"186","article-title":"Sex steroid imprinting of the immature prostate.","volume":"16","author":"Rajfer","year":"1978","journal-title":"Invest Urol"},{"key":"2019041122282580800_R2","first-page":"337","article-title":"Sex steroid imprinting and prostatic growth.","volume":"17","author":"Chung","year":"1980","journal-title":"Invest Urol"},{"key":"2019041122282580800_R3","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1095\/biolreprod35.1.219","article-title":"Morphometric analysis of the rat ventral prostate and seminal vesicles during prepubertal development: effects of neonatal treatment with estrogen.","volume":"35","author":"Gaytan","year":"1986","journal-title":"Biol Reprod"},{"key":"2019041122282580800_R4","doi-asserted-by":"crossref","first-page":"2387","DOI":"10.1210\/endo.132.6.8504743","article-title":"Effects of neonatal estrogen exposure on prostatic secretory genes and their correlation with androgen receptor expression in the separate prostate lobes of the adult rat.","volume":"132","author":"Prins","year":"1993","journal-title":"Endocrinology"},{"key":"2019041122282580800_R5","first-page":"247","article-title":"Developmental estrogenization of the prostate gland","volume-title":"Prostate: Basic and Clinical Aspects","author":"Prins","year":"1997"},{"key":"2019041122282580800_R6","doi-asserted-by":"crossref","first-page":"3703","DOI":"10.1210\/endo.130.6.1597166","article-title":"Neonatal estrogen exposure induces lobe-specific alterations in adult rat prostate androgen receptor expression.","volume":"130","author":"Prins","year":"1992","journal-title":"Endocrinology"},{"key":"2019041122282580800_R7","doi-asserted-by":"crossref","first-page":"1593","DOI":"10.1016\/S0022-5347(17)36458-3","article-title":"Prostatic dysplasia associated with increased expression of c-myc in neonatally estrogenized mice.","volume":"149","author":"Pylkkanen","year":"1993","journal-title":"J Urol"},{"key":"2019041122282580800_R8","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1210\/endo.140.1.6401","article-title":"Neonatal estrogen stimulates proliferation of periductal fibroblasts and alters the extracellular matrix composition in the rat prostate.","volume":"140","author":"Chang","year":"1999","journal-title":"Endocrinology"},{"key":"2019041122282580800_R9","doi-asserted-by":"crossref","first-page":"1801","DOI":"10.1210\/endo.138.5.5106","article-title":"Neonatal estrogen exposure up-regulates estrogen receptor expression in the developing and adult rat prostate lobes.","volume":"138","author":"Prins","year":"1997","journal-title":"Endocrinology"},{"key":"2019041122282580800_R10","doi-asserted-by":"crossref","first-page":"874","DOI":"10.1210\/endo.139.3.5827","article-title":"Estrogen receptor-\u03b2 messenger ribonucleic acid ontogeny in the prostate of normal and neonatally estrogenized rats.","volume":"139","author":"Prins","year":"1998","journal-title":"Endocrinology"},{"key":"2019041122282580800_R11","first-page":"79","article-title":"The cell biology of tranforming growth factor \u03b2.","volume":"1032","author":"Barnrd","year":"1990","journal-title":"Biochim Biophys Acta"},{"key":"2019041122282580800_R12","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1007\/978-3-642-49295-2_8","article-title":"The transforming growth factor-\u03b2s","volume-title":"Peptide Growth Factors and Their Receptors","author":"Roberts","year":"1990"},{"key":"2019041122282580800_R13","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1126\/science.3474783","article-title":"Reversible inhibition of mammary gland growth by transforming growth factor-\u03b2.","volume":"237","author":"Silberstein","year":"1987","journal-title":"Science"},{"key":"2019041122282580800_R14","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1165\/ajrcmb.15.3.8810636","article-title":"Keratinocyte growth factor and embryonic rat lung morphogenesis.","volume":"15","author":"Shiratori","year":"1996","journal-title":"Am J Respir Cell Mol Biol"},{"key":"2019041122282580800_R15","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1210\/endo.134.3.8119140","article-title":"Mesenchymal-epithelial interactions and transforming growth factor-\u03b2 expression during mouse prostate morphogenesis.","volume":"134","author":"Timme","year":"1994","journal-title":"Endocrinology"},{"key":"2019041122282580800_R16","doi-asserted-by":"crossref","first-page":"1378","DOI":"10.1210\/endo.139.3.5787","article-title":"Developmental and hormonal regulation of transforming growth factor-\u03b21 (TGF\u03b21), -2, and -3 gene expression in isolated prostatic epithelial and stromal cells: epidermal growth factor and TGF\u03b2 interactions.","volume":"139","author":"Itoh","year":"1998","journal-title":"Endocrinology"},{"key":"2019041122282580800_R17","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1002\/(SICI)1097-0045(19970915)33:1<64::AID-PROS11>3.0.CO;2-J","article-title":"Prostatic ductal system in rats: tissue-specific expression and regional variation in stromal distribution of transforming growth factor-\u03b21.","volume":"33","author":"Nemeth","year":"1997","journal-title":"Prostate"},{"key":"2019041122282580800_R18","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1095\/biolreprod59.1.93","article-title":"Species-specific detection of growth factor gene expression in developing murine prostatic tissue.","volume":"59","author":"Haughney","year":"1998","journal-title":"Biol Reprod"},{"key":"2019041122282580800_R19","doi-asserted-by":"crossref","first-page":"2124","DOI":"10.1210\/endo-123-4-2124","article-title":"Identification of a cellular receptor for transforming growth factor-\u03b2 in rat ventral prostate and its negative regulation by androgens.","volume":"123","author":"Kryprianou","year":"1988","journal-title":"Endocrinology"},{"key":"2019041122282580800_R20","first-page":"107","article-title":"Expression and localization of transforming growth factor-\u03b2 receptors type I and type II in the rat ventral prostate during regression.","volume":"10","author":"Kim","year":"1996","journal-title":"Mol Endocrinol"},{"key":"2019041122282580800_R21","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1007\/BF01037924","article-title":"Expression of transforming growth factor-\u03b2 receptor type I and type II in rat ventral prostate and Dunning R3327 PAP adenocarcinoma in response to castration and oestrogen treatment.","volume":"25","author":"Wilstrom","year":"1997","journal-title":"Urol Res"},{"key":"2019041122282580800_R22","doi-asserted-by":"crossref","first-page":"3737","DOI":"10.1002\/j.1460-2075.1988.tb03257.x","article-title":"A new type of transforming growth factor-\u03b2, TGF-\u03b23.","volume":"7","author":"Derynck","year":"1988","journal-title":"EMBO J"},{"key":"2019041122282580800_R23","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1089\/dna.1988.7.1","article-title":"Transforming growth factor-\u03b22, cDNA cloning and sequence analysis.","volume":"7","author":"Madisen","year":"1988","journal-title":"DNA"},{"key":"2019041122282580800_R24","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1002\/(SICI)1097-4652(199610)169:1<97::AID-JCP10>3.0.CO;2-L","article-title":"Expression of transforming growth factor \u03b21 (TGF-\u03b21), -\u03b22, and -\u03b23 by cultured human prostate cells.","volume":"169","author":"Story","year":"1996","journal-title":"J Cell Physiol"},{"key":"2019041122282580800_R25","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1007\/BF02017391","article-title":"Latency and activation in the control of TGF-\u03b2.","volume":"1","author":"Barcellos-Hoff","year":"1996","journal-title":"J Mammary Gland Biol Neoplasia"},{"key":"2019041122282580800_R26","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1007\/BF00191213","article-title":"Transforming growth factor-beta and prostate cancer.","volume":"13","author":"Steiner","year":"1995","journal-title":"World J Urol"},{"key":"2019041122282580800_R27","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1016\/0092-8674(92)90395-S","article-title":"TGF-\u03b2 signals through a heteromeric protein kinase receptor complex.","volume":"7","author":"Wrana","year":"1992","journal-title":"Cell"},{"key":"2019041122282580800_R28","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/S0959-437X(98)80069-5","article-title":"SMADS: mediators and regulators of TGF\u03b2 signaling.","volume":"8","author":"Kretzschmar","year":"1998","journal-title":"Curr Opin Gen Dev"},{"key":"2019041122282580800_R29","doi-asserted-by":"crossref","first-page":"3187","DOI":"10.1210\/endo-129-6-3187","article-title":"Androgen receptor localization in different cell types of the adult rat prostate.","volume":"129","author":"Prins","year":"1991","journal-title":"Endocrinology"},{"key":"2019041122282580800_R30","doi-asserted-by":"crossref","first-page":"3059","DOI":"10.1093\/nar\/18.10.3059","article-title":"cDNA cloning by PCR of rat transforming growth factor \u03b2-1.","volume":"18","author":"Qian","year":"1990","journal-title":"Nucleic Acids Res"},{"key":"2019041122282580800_R31","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1016\/S0021-9258(19)75757-3","article-title":"The primary structure of rat ribosomal protein L19.","volume":"262","author":"Chan","year":"1987","journal-title":"J Biol Chem"},{"key":"2019041122282580800_R32","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1083\/jcb.108.2.653","article-title":"Transforming growth factor-\u03b21: histochemical localization with antibodies to different epitopes.","volume":"108","author":"Flanders","year":"1989","journal-title":"J Cell Biol"},{"key":"2019041122282580800_R33","first-page":"1228","article-title":"Immunohistochemical detetion of active transforming growth factor-\u03b2 in situ using engineered tissue.","volume":"147","author":"Barcellos-Hoff","year":"1995","journal-title":"Am J Pathol"},{"key":"2019041122282580800_R34","doi-asserted-by":"crossref","first-page":"892","DOI":"10.1172\/JCI117045","article-title":"Transforming growth factor-\u03b2 activation in irradiated murine mammary gland.","volume":"93","author":"Barcellos-Hoff","year":"1994","journal-title":"J Clin Invest"},{"key":"2019041122282580800_R35","first-page":"156","article-title":"Analysis of TGF\u03b21, TGF\u03b22 and TGF\u03b23 immunoreactivity during ovine wound repair.","volume":"3","author":"McMullen","year":"1995","journal-title":"Wound Repair Regen"},{"key":"2019041122282580800_R36","doi-asserted-by":"crossref","first-page":"1303","DOI":"10.1210\/endo.136.3.7867585","article-title":"The developmental pattern of androgen receptor expression in rat prostate lobes is altered after neonatal exposure to estrogen.","volume":"136","author":"Prins","year":"1995","journal-title":"Endocrinology"},{"key":"2019041122282580800_R37","first-page":"1","article-title":"Overexpression of transforming growth factor (TGF) \u03b21 type II receptor restores TGF-\u03b21 sensitivity and signaling in human prostate cancer cells.","volume":"9","author":"Guo","year":"1998","journal-title":"Cell Growth Diff"},{"key":"2019041122282580800_R38","doi-asserted-by":"crossref","first-page":"3569","DOI":"10.1210\/endo.139.8.6138","article-title":"Transforming growth factor-\u03b21 induces nuclear to cytoplasmic distribution of androgen receptor and inhibits androgen response in prostate smooth muscle ells.","volume":"139","author":"Gerdes","year":"1998","journal-title":"Endocrinology"},{"key":"2019041122282580800_R39","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1126\/science.3164526","article-title":"Estrogen binding, receptor mRNA, and biologic response in osteoblast-like osteosarcoma cells.","volume":"241","author":"Komm","year":"1988","journal-title":"Science"},{"key":"2019041122282580800_R40","doi-asserted-by":"crossref","first-page":"1444","DOI":"10.1210\/endo.133.3.8365375","article-title":"Transforming growth factor-\u03b21-like immunoreactivity in the pituitary gland of the rat: effect of estrogen.","volume":"133","author":"Burns","year":"1993","journal-title":"Endocrinology"},{"key":"2019041122282580800_R41","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/0092-8674(87)90193-0","article-title":"Evidence that transforming growth factor-\u03b2 is a hormonally regulated negtive growth factor in human breast cancer cells.","volume":"48","author":"Knabbe","year":"1987","journal-title":"Cell"},{"key":"2019041122282580800_R42","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1002\/(SICI)1097-0215(19970516)71:4<573::AID-IJC11>3.0.CO;2-D","article-title":"Down-regulation of protein and mRNA expression for transforming growth factor-\u03b2 (TGF-\u03b21) type I and type II receptors in human prostate cancer.","volume":"71","author":"Guo","year":"1997","journal-title":"Int J Cancer"},{"key":"2019041122282580800_R43","doi-asserted-by":"crossref","first-page":"1831","DOI":"10.1101\/gad.9.15.1831","article-title":"Kip\/Cip and Ink4 Cdk inhibitors cooperate to induce cell cycle arrest in response to TGF-\u03b2.","volume":"9","author":"Reynisdottir","year":"1995","journal-title":"Genes Dev"},{"key":"2019041122282580800_R44","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1159\/000147793","article-title":"Epithelial development in the rat ventral prostate, anterior prostate and seminal vesicle.","volume":"155","author":"Hayward","year":"1996","journal-title":"Acta Anat"},{"key":"2019041122282580800_R45","doi-asserted-by":"crossref","first-page":"1335","DOI":"10.1128\/MCB.16.4.1335","article-title":"The cyclin-dependent kinase inhibitor p21waf-1 is required for survival of differentiating neuroblastoma cells.","volume":"16","author":"Poluha","year":"1996","journal-title":"Mol Cell Biol"},{"key":"2019041122282580800_R46","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1016\/0092-8674(95)90039-X","article-title":"Mice lacking p21cip-1\/waf-1 undergo normal development, but are defective in G1 checkpoint control.","volume":"82","author":"Deng","year":"1995","journal-title":"Cell"},{"key":"2019041122282580800_R47","doi-asserted-by":"crossref","first-page":"1024","DOI":"10.1126\/science.7863329","article-title":"p53-indenpendent expression of p21cip-1 in muscle and other terminally differentiating cell.","volume":"267","author":"Parker","year":"1995","journal-title":"Science"},{"key":"2019041122282580800_R48","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1126\/science.280.5366.1069","article-title":"Inhibitory function of p21cip-1\/waf-1 in differentiation of primary mouse keratinocytes independent of cell cycle control.","volume":"280","author":"Di Cunto","year":"1998","journal-title":"Science"},{"key":"2019041122282580800_R49","first-page":"861","article-title":"Cancer development in male reproductive tract in rats given diethylstilbestrol at neonatal age.","volume":"69","author":"Arai","year":"1978","journal-title":"Gann"},{"key":"2019041122282580800_R50","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1002\/pros.2990180204","article-title":"Regional differences in the prostate of the neonatally estrogenized mouse.","volume":"18","author":"Pylkkanen","year":"1991","journal-title":"Prostate"},{"key":"2019041122282580800_R51","first-page":"6","article-title":"Maturation arrest of stem cell differentiation is a common pathway for the cellular origin of teratocarcinomas and epithelial cancers.","volume":"70","author":"Sell","year":"1994","journal-title":"Lab Invest"},{"key":"2019041122282580800_R52","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1006\/bbrc.1996.0499","article-title":"TGF\u03b21 induces morphogenesis of branching cords by clones mammary epithelial cells at subpicomolar concentrations.","volume":"220","author":"Soriano","year":"1996","journal-title":"Biochem Biophys Res Commun"},{"key":"2019041122282580800_R53","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1006\/dbio.1996.0110","article-title":"Arrested lung morphogenesis in transgenic mice bearing an SP-C-TGF-\u03b21 chimeric gene.","volume":"175","author":"Zhou","year":"1996","journal-title":"Dev Biol"},{"key":"2019041122282580800_R54","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1146\/annurev.cb.06.110190.003121","article-title":"The transforming growth factor-\u03b2 family.","volume":"6","author":"Massague","year":"1990","journal-title":"Annu Rev Cell Biol"}],"container-title":["Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/endo\/article-pdf\/140\/6\/2801\/10382042\/endo2801.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,21]],"date-time":"2022-03-21T23:04:36Z","timestamp":1647903876000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/endo\/article\/140\/6\/2801\/2990903"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1999,6,1]]},"references-count":54,"aliases":["10.1210\/en.140.6.2801"],"journal-issue":{"issue":"6","published-print":{"date-parts":[[1999,6,1]]}},"URL":"https:\/\/doi.org\/10.1210\/endo.140.6.6833","relation":{},"ISSN":["0013-7227","1945-7170"],"issn-type":[{"value":"0013-7227","type":"print"},{"value":"1945-7170","type":"electronic"}],"subject":[],"published":{"date-parts":[[1999,6,1]]}}}