{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T22:26:55Z","timestamp":1758925615897},"reference-count":39,"publisher":"The Endocrine Society","issue":"7","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1999,7,1]]},"DOI":"10.1210\/endo.140.7.6849","type":"journal-article","created":{"date-parts":[[2014,1,8]],"date-time":"2014-01-08T16:10:08Z","timestamp":1389197408000},"page":"3025-3033","source":"Crossref","is-referenced-by-count":9,"title":["\u03b1-Latrotoxin Stimulates Inward Current, Rise in Cytosolic Calcium Concentration, and Exocytosis in at Pituitary Gonadotropes*"],"prefix":"10.1210","volume":"140","author":[{"given":"Frederick W.","family":"Tse","sequence":"first","affiliation":[{"name":"Department of Pharmacology and Division of Neuroscience, University of Alberta, Edmonton, Alberta, Canada T6G 2H7"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amy","family":"Tse","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Division of Neuroscience, University of Alberta, Edmonton, Alberta, Canada T6G 2H7"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"80","reference":[{"key":"2019041121180130200_R1","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/0163-7258(89)90024-7","article-title":"\u03b1-Latrotoxin and related toxins.","volume":"42","author":"Rosenthal","year":"1989","journal-title":"Pharmacol Ther"},{"key":"2019041121180130200_R2","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1038\/353065a0","article-title":"Binding of synaptotagmin to the\u03b1 -latrotoxin receptor implicates both in synaptic vesicle exocytosis.","volume":"353","author":"Petrenko","year":"1991","journal-title":"Nature"},{"key":"2019041121180130200_R3","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1126\/science.1621094","article-title":"Neurexins: synaptic cell surface proteins related to the\u03b1 -latrotoxin receptor and laminin.","volume":"257","author":"Ushkaryov","year":"1992","journal-title":"Science"},{"key":"2019041121180130200_R4","doi-asserted-by":"crossref","first-page":"21504","DOI":"10.1074\/jbc.272.34.21504","article-title":"\u03b1-latrotoxin receptor, latrophilin, is a novel member of the secretin family of G protein-coupled receptors.","volume":"272","author":"Lelianova","year":"1997","journal-title":"J Biol Chem"},{"key":"2019041121180130200_R5","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1016\/S0896-6273(00)80332-3","article-title":"\u03b1-Latrotoxin stimulates exocytosis by the interaction with a neuronal G-protein-coupled receptor.","volume":"18","author":"Krasnoperov","year":"1997","journal-title":"Neuron"},{"key":"2019041121180130200_R6","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1126\/science.948756","article-title":"Black widow spider venom: effect of purified toxin on lipid bilayer membranes.","volume":"193","author":"Finkelstein","year":"1976","journal-title":"Science"},{"key":"2019041121180130200_R7","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1007\/BF00211072","article-title":"\u03b1-Latrotoxin channels in neuroblastoma cells.","volume":"138","author":"Hurlbut","year":"1994","journal-title":"J Membr Biol"},{"key":"2019041121180130200_R8","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1007\/s004240050232","article-title":"Single-cell measurements of quantal secretion induced by \u03b1-latrotoxin from rat adrenal chromaffin cells: dependence on extracellular Ca2+.","volume":"432","author":"Barnett","year":"1996","journal-title":"Pflugers Arch"},{"key":"2019041121180130200_R9","doi-asserted-by":"crossref","first-page":"6113","DOI":"10.1523\/JNEUROSCI.18-16-06113.1998","article-title":"\u03b1-Latrotoxin alters spontaneous and depolarization-evoked quantal release from rat adrenal chromaffin cells: evidence for multiple modes of action.","volume":"18","author":"Liu","year":"1998","journal-title":"J Neurosci"},{"key":"2019041121180130200_R10","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1111\/j.1469-7793.1997.481bj.x","article-title":"Drastic facilitation by \u03b1-latrotoxin of bovine chromaffin cell exocytosis without measurable enhancement of Ca2+ entry or [Ca2+]i.","volume":"502","author":"Michelena","year":"1997","journal-title":"J Physiol"},{"key":"2019041121180130200_R11","doi-asserted-by":"crossref","first-page":"2914","DOI":"10.1523\/JNEUROSCI.18-08-02914.1998","article-title":"A Ca2+-independent receptor for\u03b1 -latrotoxin, CIRL, mediates effects on secretion via multiple mechanisms.","volume":"18","author":"Bittner","year":"1998","journal-title":"J Neurosci"},{"key":"2019041121180130200_R12","doi-asserted-by":"crossref","first-page":"3909","DOI":"10.1093\/emboj\/17.14.3909","article-title":"Vesicle exocytosis stimulated by \u03b1-latrotoxin is mediated by latrophilin and requires both external and stored Ca2+.","volume":"17","author":"Davletov","year":"1998","journal-title":"EMBO J"},{"key":"2019041121180130200_R13","doi-asserted-by":"crossref","first-page":"32715","DOI":"10.1074\/jbc.273.49.32715","article-title":"\u03b1-Latrotoxin receptor CIRL\/latrophilin 1(CL1) defines an unusual family of ubiquitous G-protein-linked receptors.","volume":"273","author":"Sugita","year":"1998","journal-title":"J Biol Chem"},{"key":"2019041121180130200_R14","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1093\/emboj\/17.3.648","article-title":"Ca2+-independent insulin exocytosis induced by\u03b1 -latrotoxin requires latrophilin, a G protein-coupled receptor.","volume":"17","author":"Lang","year":"1998","journal-title":"EMBO J"},{"key":"2019041121180130200_R15","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1126\/science.8385366","article-title":"Rhythmic exocytosis stimulated by GnRH-induced calcium oscillations in rat gonadotropes.","volume":"260","author":"Tse","year":"1993","journal-title":"Science"},{"key":"2019041121180130200_R16","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1042\/bj2750399","article-title":"Inhibition of luteinizing-hormone exocytosis by guanosine 5\u2032-\u03b3-thio-triphosphate reveals involvement of GTP-binding protein distal to second-messenger generation.","volume":"275","author":"Van der Merwe","year":"1991","journal-title":"Biochem J"},{"key":"2019041121180130200_R17","first-page":"95","article-title":"G-protein activation stimulates Ca2+-independent exocytosis in pituitary gonadotrophs.","volume":"23","author":"Tse","year":"1997","journal-title":"Soci Neurosci Abstr"},{"key":"2019041121180130200_R18","first-page":"95","article-title":"\u03b1-latrotoxin stimulates inward current, intracellular [Ca2+]i elevation and exocytosis in pituitary gonadotrophs.","volume":"23","author":"Tse","year":"1997","journal-title":"Soc Neurosci Abstr"},{"key":"2019041121180130200_R19","first-page":"85","article-title":"Patch clamping studies on identified pituitary gonadotropes in vitro. In: Levine JE (ed) Pulsatility in Neuroendocrine Systems, Methods in Neurosciences.","volume":"20","author":"Tse","year":"1994","journal-title":"Academic Press, Orlando, vol"},{"key":"2019041121180130200_R20","doi-asserted-by":"crossref","first-page":"2484","DOI":"10.1210\/endo-115-6-2484","article-title":"Detection of LH release from individual pituitary cells by the reverse hemolytic plaque assay.","volume":"115","author":"Smith","year":"1984","journal-title":"Endocrinology"},{"key":"2019041121180130200_R21","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1126\/science.1734523","article-title":"GnRH-induced Ca oscillations and rhythmic hyperpolarizations of pituitary gonadotropes.","volume":"255","author":"Tse","year":"1992","journal-title":"Science"},{"key":"2019041121180130200_R22","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1113\/jphysiol.1994.sp020212","article-title":"Calcium homeostasis in identified rat gonadotrophs.","volume":"477","author":"Tse","year":"1994","journal-title":"J Physiol"},{"key":"2019041121180130200_R23","doi-asserted-by":"crossref","first-page":"3440","DOI":"10.1016\/S0021-9258(19)83641-4","article-title":"A new generation of Ca2+ indicators with greatly improved fluorescence properties.","volume":"260","author":"Grynkiewicz","year":"1985","journal-title":"J Biol Chem"},{"key":"2019041121180130200_R24","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0079-6107(82)90011-6","article-title":"Measurement of Ca2+ concentrations in living cells.","volume":"40","author":"Blinks","year":"1982","journal-title":"Prog Biophys Mol Biol"},{"key":"2019041121180130200_R25","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1007\/BF00656997","article-title":"Improved patch-clamp techniques for high resolution current recording from cells and cell-free membrane patches.","volume":"391","author":"Hamill","year":"1981","journal-title":"Pflugers Arch"},{"key":"2019041121180130200_R26","doi-asserted-by":"crossref","first-page":"1559","DOI":"10.1111\/j.1471-4159.1982.tb06633.x","article-title":"Studies on \u03b1-latrotoxin receptors in rat brain synapotosomes: correlation between toxin binding and stimulation of transmitter release.","volume":"38","author":"Meldolesi","year":"1982","journal-title":"J Neurochem"},{"key":"2019041121180130200_R27","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1073\/pnas.81.2.620","article-title":"Free cytoplasmic Ca2+ and neurotransmitter release: studies on PC12 cells and synaptosomes exposed to \u03b1-latrotoxin.","volume":"81","author":"Meldolesi","year":"1984","journal-title":"Proc Natl Acad Sci USA"},{"key":"2019041121180130200_R28","doi-asserted-by":"crossref","first-page":"7924","DOI":"10.1073\/pnas.79.24.7924","article-title":"\u03b1-Latrotoxin of black widow spider venom depolarizes the plasma membrane, induces massive calcium influx, and stimulates transmitter release in guinea pig brain synaptosomes.","volume":"79","author":"Nicholls","year":"1982","journal-title":"Proc Natl Acad Sci USA"},{"key":"2019041121180130200_R29","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/0896-6273(93)90277-X","article-title":"Fractional contribution of calcium to the cation current through glutamate receptor channels.","volume":"11","author":"Schneggenburger","year":"1993","journal-title":"Neuron"},{"key":"2019041121180130200_R30","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1007\/BF00374879","article-title":"Calcium permeability of nicotinic acetylcholine receptor channels in bovine adrenal chromaffin cells.","volume":"425","author":"Zhou","year":"1993","journal-title":"Pflugers Arch"},{"key":"2019041121180130200_R31","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1146\/annurev.biochem.66.1.475","article-title":"Regulation of eukaryotic phosphatidylinositol-specific phospholipase C and phospholipase D.","volume":"66","author":"Singer","year":"1997","journal-title":"Annu Rev Biochem"},{"key":"2019041121180130200_R32","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1016\/0006-291X(84)90215-8","article-title":"\u03b1-Latrotoxin of black widow spider venom binds to a specific receptor coupled to phosphoinositide breakdown in PC12 cells.","volume":"121","author":"Vicentini","year":"1984","journal-title":"Biochem Biophys Res Commun"},{"key":"2019041121180130200_R33","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/0165-6147(94)90074-4","article-title":"The pharmacology of Ca2+-release channels.","volume":"15","author":"Ehrlich","year":"1994","journal-title":"Trends Pharmacol Sci"},{"key":"2019041121180130200_R34","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/S0896-6273(01)80051-9","article-title":"Local calcium gradients generated by release from intracellular calcium stores regulate exocytosis in pituitary gonadotropes.","volume":"18","author":"Tse","year":"1997","journal-title":"Neuron"},{"key":"2019041121180130200_R35","doi-asserted-by":"crossref","first-page":"1496","DOI":"10.1523\/JNEUROSCI.11-06-01496.1991","article-title":"Alien intracellular calcium chelators attenuate neurotransmitter release at the squid giant synapse.","volume":"11","author":"Adler","year":"1991","journal-title":"J Neurosci"},{"key":"2019041121180130200_R36","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1073\/pnas.76.2.991","article-title":"Action of black widow spider venom on quantized release of acetylcholine at the frog neuromuscular junction: dependence upon external Mg2+.","volume":"76","author":"Misler","year":"1979","journal-title":"Proc Natl Acad Sci USA"},{"key":"2019041121180130200_R37","doi-asserted-by":"crossref","first-page":"3149","DOI":"10.1152\/jn.1996.76.5.3149","article-title":"Calcium-independent actions of \u03b1-latrotoxin on spontaneous and evoked synaptic transmission in the hippocampus.","volume":"76","author":"Capogna","year":"1996","journal-title":"J Neurophys"},{"key":"2019041121180130200_R38","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/0014-5793(94)01069-2","article-title":"Synaptotagmin I is essential for Ca2+-independent release of neurotransmitter induced by\u03b1 -latrotoxin.","volume":"353","author":"Shoji-kasai","year":"1994","journal-title":"FEBS Lett"},{"key":"2019041121180130200_R39","doi-asserted-by":"crossref","first-page":"5344","DOI":"10.1210\/endo.137.12.8940356","article-title":"Molecular components of the exocytotic machinery in the rat pituitary gland.","volume":"137","author":"Jacobsson","year":"1996","journal-title":"Endocrinology"}],"container-title":["Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/endo\/article-pdf\/140\/7\/3025\/10377303\/endo3025.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,21]],"date-time":"2022-03-21T23:06:09Z","timestamp":1647903969000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/endo\/article\/140\/7\/3025\/2990522"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1999,7,1]]},"references-count":39,"journal-issue":{"issue":"7","published-print":{"date-parts":[[1999,7,1]]}},"URL":"https:\/\/doi.org\/10.1210\/endo.140.7.6849","relation":{},"ISSN":["0013-7227","1945-7170"],"issn-type":[{"value":"0013-7227","type":"print"},{"value":"1945-7170","type":"electronic"}],"subject":[],"published":{"date-parts":[[1999,7,1]]}}}