{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T10:00:38Z","timestamp":1791021638958,"version":"4.1.0"},"reference-count":42,"publisher":"The Endocrine Society","issue":"12","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2000,12,1]]},"DOI":"10.1210\/endo.141.12.7837","type":"journal-article","created":{"date-parts":[[2014,1,8]],"date-time":"2014-01-08T16:10:53Z","timestamp":1389197453000},"page":"4698-4710","source":"Crossref","is-referenced-by-count":191,"title":["A Small Composite Probasin Promoter Confers High Levels of Prostate-Specific Gene Expression through Regulation by Androgens and Glucocorticoids in Vitro and in Vivo**This work was supported by R01-DK-55748 from the NIH and the Frances Williams Preston Laboratories of the T. J. Martell Foundation. Transgenic mice were bred by the Transgenic Core\/ES Cell Shared Resource of the Vanderbilt-Ingram Cancer Center (NCI Grant 2P30-CA-68485\u201305)."],"prefix":"10.1210","volume":"141","author":[{"given":"JianFeng","family":"Zhang","sequence":"first","affiliation":[{"name":"Departments of Urologic Surgery (J.Z., T.Z.T., S.K., R.J.M.) Nashville, Tennessee 37232"},{"name":"Cell Biology (J.Z., S.K., R.J.M.), Nashville, Tennessee 37232"},{"name":"The Vanderbilt Prostate Cancer Center (J.Z., T.Z.T., S.K., R.J.M.), Nashville, Tennessee 37232"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tania Z.","family":"Thomas","sequence":"additional","affiliation":[{"name":"Departments of Urologic Surgery (J.Z., T.Z.T., S.K., R.J.M.) Nashville, Tennessee 37232"},{"name":"The Vanderbilt Prostate Cancer Center (J.Z., T.Z.T., S.K., R.J.M.), Nashville, Tennessee 37232"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan","family":"Kasper","sequence":"additional","affiliation":[{"name":"Departments of Urologic Surgery (J.Z., T.Z.T., S.K., R.J.M.) Nashville, Tennessee 37232"},{"name":"Cell Biology (J.Z., S.K., R.J.M.), Nashville, Tennessee 37232"},{"name":"The Vanderbilt Prostate Cancer Center (J.Z., T.Z.T., S.K., R.J.M.), Nashville, Tennessee 37232"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert J.","family":"Matusik","sequence":"additional","affiliation":[{"name":"Departments of Urologic Surgery (J.Z., T.Z.T., S.K., R.J.M.) Nashville, Tennessee 37232"},{"name":"Cell Biology (J.Z., S.K., R.J.M.), Nashville, Tennessee 37232"},{"name":"The Vanderbilt Prostate Cancer Center (J.Z., T.Z.T., S.K., R.J.M.), Nashville, Tennessee 37232"},{"name":"Center for Reproductive Biology Research (R.J.M.), Nashville, Tennessee 37232"},{"name":"The Vanderbilt-Ingram Cancer Center (R.J.M.), Nashville, Tennessee 37232"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"80","reference":[{"key":"2019041121293398000_R1","first-page":"95","article-title":"Androgen receptor mutants that affect normal growth and development.","volume":"14","author":"Brinkmann","year":"1992","journal-title":"Cancer Surv"},{"key":"2019041121293398000_R2","first-page":"1566","article-title":"Increased androgen receptor activity and altered c-myc expression in prostate cancer cells after long-term androgen deprivation.","volume":"54","author":"Kokontis","year":"1994","journal-title":"Cancer Res"},{"key":"2019041121293398000_R3","doi-asserted-by":"crossref","first-page":"7871","DOI":"10.1073\/pnas.84.22.7871","article-title":"A DNA sequence of 15 base pairs is sufficient to mediate both glucocorticoid and progesterone induction of gene expression.","volume":"84","author":"Shrahle","year":"1987","journal-title":"Proc Natl Acad Sci USA"},{"key":"2019041121293398000_R4","doi-asserted-by":"crossref","first-page":"5263","DOI":"10.1093\/nar\/16.12.5263","article-title":"Characterization of response elements for androgens, glucocorticoids and progestins in mouse mammary tumour virus.","volume":"16","author":"Ham","year":"1988","journal-title":"Nucleic Acids Res"},{"key":"2019041121293398000_R5","doi-asserted-by":"crossref","first-page":"10731","DOI":"10.1016\/S0021-9258(17)44517-0","article-title":"Characterization and cloning of rat dorsal prostate mRNAs. Androgen regulation of two closely related abundant mRNAs.","volume":"258","author":"Dodd","year":"1983","journal-title":"J Biol Chem"},{"key":"2019041121293398000_R6","first-page":"23","article-title":"Characterization of two cis-acting elements involved in the androgen regulation of the probasin gene.","volume":"7","author":"Rennie","year":"1993","journal-title":"Mol Endocrinol"},{"key":"2019041121293398000_R7","first-page":"230","article-title":"The rat probasin gene promoter directs hormonally and developmentally regulated expression of a heterologous gene specifically to the prostate in transgenic mice.","volume":"8","author":"Greenberg","year":"1994","journal-title":"Mol Endocrinol"},{"key":"2019041121293398000_R8","doi-asserted-by":"crossref","first-page":"7843","DOI":"10.1073\/pnas.86.20.7843","article-title":"Regulation of a bifunctional mRNA results in synthesis of secreted and nuclear probasin.","volume":"86","author":"Spence","year":"1989","journal-title":"Proc Natl Acad Sci USA"},{"key":"2019041121293398000_R9","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1016\/0006-291X(82)91725-9","article-title":"Isolation and characterization of androgen-dependent non-histone chromosomal protein from dorsolateral prostate of rats.","volume":"109","author":"Matuo","year":"1982","journal-title":"Biochem Biophys Res Commun"},{"key":"2019041121293398000_R10","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1139\/o86-083","article-title":"Regulation of prostatic genes: role of androgens and zinc in gene expression.","volume":"64","author":"Matusik","year":"1986","journal-title":"Biochem Cell Biol"},{"key":"2019041121293398000_R11","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/BF00235188","article-title":"Post-castration rebound of an androgen regulated prostatic gene.","volume":"84","author":"Sweetland","year":"1988","journal-title":"Mol Cell Biochem"},{"key":"2019041121293398000_R12","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1677\/jme.0.0220313","article-title":"Selective activation of the probasin androgen responsive region by steroid hormones.","volume":"22","author":"Kasper","year":"1999","journal-title":"J Mol Endocrinol"},{"key":"2019041121293398000_R13","doi-asserted-by":"crossref","first-page":"31763","DOI":"10.1016\/S0021-9258(18)31761-7","article-title":"Cooperative binding of androgen receptors to two DNA sequences is required for androgen induction of the probasin gene.","volume":"269","author":"Kasper","year":"1994","journal-title":"J Biol Chem"},{"key":"2019041121293398000_R14","doi-asserted-by":"crossref","first-page":"19013","DOI":"10.1074\/jbc.271.32.19013","article-title":"The androgen-specific probasin response element 2 interacts differentially with androgen and glucocorticoid receptors.","volume":"271","author":"Claessens","year":"1996","journal-title":"J Biol Chem"},{"key":"2019041121293398000_R15","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1042\/bj3410515","article-title":"Differential DNA binding by the androgen and glucocorticoid receptors involves the second Zn-finger and a C-terminal extension of the DNA- binding domains.","volume":"341","author":"Schoenmakers","year":"1999","journal-title":"Biochem J"},{"key":"2019041121293398000_R16","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1002\/(SICI)1097-0045(19970701)32:2<129::AID-PROS8>3.0.CO;2-H","article-title":"A large fragment of the probasin promoter targets high levels of transgene expression to the prostate of transgenic mice.","volume":"32","author":"Yan","year":"1997","journal-title":"Prostate"},{"key":"2019041121293398000_R17","article-title":"Molecular Cloning: A Laboratory Manual.","volume-title":"Cold Spring Harbor Laboratory Press,","author":"Sambrook","year":"1989"},{"key":"2019041121293398000_R18","doi-asserted-by":"crossref","first-page":"8282","DOI":"10.1074\/jbc.274.12.8282","article-title":"A 5-kilobase pair promoter fragment of the murine epididymal retinoic acid-binding protein gene drives the tissue-specific, cell-specific, and androgen-regulated expression of a foreign gene in the epididymis of transgenic mice.","volume":"274","author":"Lareyre","year":"1999","journal-title":"J Biol Chem"},{"key":"2019041121293398000_R19","doi-asserted-by":"crossref","first-page":"1256","DOI":"10.1210\/mend.11.9.9974","volume":"11","author":"Cleutjens","journal-title":"Mol Endocrinol"},{"key":"2019041121293398000_R20","doi-asserted-by":"crossref","first-page":"6369","DOI":"10.1073\/pnas.94.12.6369","article-title":"Tissue-specific expression of the human prostate-specific antigen gene in transgenic mice: implications for tolerance and immunotherapy.","volume":"94","author":"Wei","year":"1997","journal-title":"Proc Natl Acad Sci USA"},{"key":"2019041121293398000_R21","first-page":"283","article-title":"Transgenic mice carrying a PSArasT24 hybrid gene develop salivary gland and GI tract neoplasms.","volume":"72","author":"Schaffner","year":"1995","journal-title":"Lab Invest"},{"key":"2019041121293398000_R22","doi-asserted-by":"crossref","first-page":"2063","DOI":"10.1210\/endo.140.5.6696","article-title":"Identification of the deoxyribonucleic acid-binding site of a regulatory protein involved in prostate-specific and androgen receptor-dependent gene expression.","volume":"140","author":"Patrikainen","year":"1999","journal-title":"Endocrinology"},{"key":"2019041121293398000_R23","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1002\/(SICI)1097-0045(19980401)35:1<18::AID-PROS3>3.0.CO;2-D","article-title":"Relative activity and specificity of promoters from prostate-expressed genes.","volume":"35","author":"Brookes","year":"1998","journal-title":"Prostate"},{"key":"2019041121293398000_R24","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1038\/ng0198-56","article-title":"Repeat-induced gene silencing in mammals.","volume":"18","author":"Garrick","year":"1998","journal-title":"Nat Genet"},{"key":"2019041121293398000_R25","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1002\/(SICI)1521-1878(199807)20:7<532::AID-BIES3>3.0.CO;2-M","article-title":"Conspiracy of silence among repeated transgenes.","volume":"20","author":"Henikoff","year":"1998","journal-title":"BioEssays"},{"key":"2019041121293398000_R26","doi-asserted-by":"crossref","first-page":"3439","DOI":"10.1073\/pnas.92.8.3439","article-title":"Prostate cancer in a transgenic mouse.","volume":"92","author":"Greenberg","year":"1995","journal-title":"Proc Natl Acad Sci USA"},{"key":"2019041121293398000_R27","first-page":"23","article-title":"RasT24 driven by a probasin promoter induces prostatic hyperplasia in transgenic mice.","volume":"2","author":"Barrios","year":"1996","journal-title":"Transgenics"},{"key":"2019041121293398000_R28","first-page":"319","article-title":"Development, progression and androgen-dependence of prostate tumors in transgenic: a model for prostate cancer.","volume":"78","author":"Kasper","year":"1998","journal-title":"Lab Invest"},{"key":"2019041121293398000_R29","doi-asserted-by":"crossref","first-page":"12290","DOI":"10.1074\/jbc.275.16.12290","article-title":"Differences in DNA binding characteristics of the androgen and glucocorticoid receptors can determine hormone-specific responses.","volume":"275","author":"Schoenmakers","year":"2000","journal-title":"J Biol Chem"},{"key":"2019041121293398000_R30","doi-asserted-by":"crossref","first-page":"25756","DOI":"10.1074\/jbc.274.36.25756","article-title":"Cooperative assembly of androgen receptor into a nucleoprotein complex that regulates the prostate-specific antigen enhancer.","volume":"274","author":"Huang","year":"1999","journal-title":"J Biol Chem"},{"key":"2019041121293398000_R31","doi-asserted-by":"crossref","first-page":"1393","DOI":"10.1056\/NEJM199505253322101","article-title":"Mutation of the androgen-receptor gene in metastatic androgen- independent prostate cancer.","volume":"332","author":"Taplin","year":"1995","journal-title":"N Engl J Med"},{"key":"2019041121293398000_R32","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1016\/S0022-5347(17)36163-3","article-title":"Prostate specific antigen decline after antiandrogen withdrawal: the flutamide withdrawal syndrome.","volume":"149","author":"Kelly","year":"1993","journal-title":"J Urol"},{"key":"2019041121293398000_R33","first-page":"1541","article-title":"Mutant androgen receptor detected in an advanced-stage prostatic carcinoma is activated by adrenal androgens and progesterone.","volume":"12","author":"Culig","year":"1993","journal-title":"Mol Endocrinol"},{"key":"2019041121293398000_R34","doi-asserted-by":"crossref","first-page":"6319","DOI":"10.1073\/pnas.89.14.6319","article-title":"Androgen receptor gene mutations in human prostate cancer.","volume":"89","author":"Newmark","year":"1992","journal-title":"Proc Natl Acad Sci USA"},{"key":"2019041121293398000_R35","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1016\/0960-0760(92)90401-4","article-title":"The androgen receptor in LNCaP cells contains a mutation in the ligand binding domain which affects steroid binding characteristics and response to antiandrogens.","volume":"41","author":"Veldscholte","year":"1992","journal-title":"J Steroid Biochem Mol Biol"},{"key":"2019041121293398000_R36","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1006\/bbrc.1994.1011","article-title":"Microsatellite mutation (CAG24\u219218) in the androgen receptor gene in human prostate cancer.","volume":"198","author":"Schoenberg","year":"1994","journal-title":"Biochem Biophys Res Commun"},{"key":"2019041121293398000_R37","first-page":"277","article-title":"Mutations in the androgen receptor gene are associated with progression of human prostate cancer to androgen independence.","volume":"2","author":"Tilley","year":"1996","journal-title":"Clin Cancer Res"},{"key":"2019041121293398000_R38","first-page":"2861","article-title":"Frequent detection of codon 877 mutation in the androgen receptor gene in advanced prostate cancers.","volume":"54","author":"Gaddipati","year":"1994","journal-title":"Cancer Res"},{"key":"2019041121293398000_R39","first-page":"342","article-title":"Genetic changes in primary and recurrent prostate cancer by comparative genomic hybridization.","volume":"55","author":"Visakorpi","year":"1995","journal-title":"Cancer Res"},{"key":"2019041121293398000_R40","first-page":"314","article-title":"Androgen receptor gene amplification: a possible molecular mechanism for androgen deprivation therapy failure in prostate cancer.","volume":"57","author":"Koivisto","year":"1997","journal-title":"Cancer Res"},{"key":"2019041121293398000_R41","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/S0090-4295(96)80011-2","article-title":"Hormone and antihormone withdrawal: implications for the management of androgen-independent prostate cancer.","volume":"47","author":"Scher","year":"1996","journal-title":"Urology"},{"key":"2019041121293398000_R42","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/S0090-4295(99)80182-4","article-title":"Hormone-refractory (D3) prostate cancer: refining the concept.","volume":"46","author":"Scher","year":"1995","journal-title":"Urology"}],"container-title":["Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/endo\/article-pdf\/141\/12\/4698\/10361562\/endo4698.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,21]],"date-time":"2022-03-21T23:15:28Z","timestamp":1647904528000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/endo\/article\/141\/12\/4698\/2988549"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,12,1]]},"references-count":42,"aliases":["10.1210\/en.141.12.4698"],"journal-issue":{"issue":"12","published-print":{"date-parts":[[2000,12,1]]}},"URL":"https:\/\/doi.org\/10.1210\/endo.141.12.7837","relation":{},"ISSN":["0013-7227","1945-7170"],"issn-type":[{"value":"0013-7227","type":"print"},{"value":"1945-7170","type":"electronic"}],"subject":[],"published":{"date-parts":[[2000,12,1]]}}}