{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T12:51:07Z","timestamp":1790859067405,"version":"4.1.0"},"reference-count":50,"publisher":"The Endocrine Society","issue":"9","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2000,9,1]]},"DOI":"10.1210\/endo.141.9.7647","type":"journal-article","created":{"date-parts":[[2014,1,8]],"date-time":"2014-01-08T16:11:02Z","timestamp":1389197462000},"page":"3485-3492","source":"Crossref","is-referenced-by-count":8,"title":["Accumulation of Synaptosomal-Associated Protein of 25 kDa (SNAP-25) and Other Proteins Associated with the Secretory Pathway in GH4C1 Cells Upon Treatment with Estradiol, Insulin, and Epidermal Growth Factor*"],"prefix":"10.1210","volume":"141","author":[{"given":"Min S.","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Pharmacology, Yale University School of Medicine (M.S.L., Y.L.Z., Z.S., H.R.), New Haven, Connecticut 06510"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong Lian","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Yale University School of Medicine (M.S.L., Y.L.Z., Z.S., H.R.), New Haven, Connecticut 06510"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenyu","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Yale University School of Medicine (M.S.L., Y.L.Z., Z.S., H.R.), New Haven, Connecticut 06510"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harrison","family":"Rhee","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Yale University School of Medicine (M.S.L., Y.L.Z., Z.S., H.R.), New Haven, Connecticut 06510"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Jeromin","sequence":"additional","affiliation":[{"name":"Department of Samuel Lunenfeld Research Institute, Mount Sinai Hospital (A.J., J.R.), Toronto, Ontario, Canada J5G 1X5"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Roder","sequence":"additional","affiliation":[{"name":"Department of Samuel Lunenfeld Research Institute, Mount Sinai Hospital (A.J., J.R.), Toronto, Ontario, Canada J5G 1X5"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Priscilla S.","family":"Dannies","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"80","reference":[{"key":"2019041123175563300_R1","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1096\/fasebj.8.2.7907072","article-title":"A role for synaptic vesicles in non-neuronal cells: clues from pancreatic \u03b2 cells and from chromaffin cells.","volume":"8","author":"Thomas-Reetz","year":"1994","journal-title":"FASEB J"},{"key":"2019041123175563300_R2","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/S0301-0082(99)00004-0","article-title":"The concept of a calcium sensor in transmitter release.","volume":"59","author":"Bennett","year":"1999","journal-title":"Prog Neurobiol"},{"key":"2019041123175563300_R3","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1038\/370191a0","article-title":"Vesicle fusion from yeast to man.","volume":"370","author":"Ferro-Novick","year":"1994","journal-title":"Nature"},{"key":"2019041123175563300_R4","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1016\/S0024-3205(97)01156-9","article-title":"Synaptobrevin isoforms in secretory granules and synaptic-like microvesicles in anterior pituitary cells.","volume":"62","author":"Majo","year":"1998","journal-title":"Life Sci"},{"key":"2019041123175563300_R5","doi-asserted-by":"crossref","first-page":"R5","DOI":"10.1677\/joe.0.153R005","article-title":"Involvement of SNAP-25 in TRH-induced exocytosis in pituitary GH4C1 cells","volume":"153","author":"Masumoto","year":"1997","journal-title":"J Endocrinol"},{"key":"2019041123175563300_R6","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1083\/jcb.140.2.305","article-title":"Expression of Rab3D N135I inhibits regulated secretion of ACTH in AtT-20 cells.","volume":"140","author":"Baldini","year":"1998","journal-title":"J Cell Biol"},{"key":"2019041123175563300_R7","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1210\/mend.13.2.0228","article-title":"Subcellular distribution and function of Rab3A, B, C, and D isoforms in insulin-secreting cells.","volume":"13","author":"Iezzi","year":"1999","journal-title":"Mol Endocrinol"},{"key":"2019041123175563300_R8","first-page":"351","article-title":"Expression of synaptosomal-associated protein SNAP-25 in endocrine anterior pituitary cells.","volume":"69","author":"Aguado","year":"1996","journal-title":"Eur J Cell Biol"},{"key":"2019041123175563300_R9","doi-asserted-by":"crossref","first-page":"5885","DOI":"10.1093\/emboj\/18.21.5885","article-title":"Disruption of Rab3-calmodulin interaction, but not other effector interactions, prevents rab3 inhibition of exocytosis.","volume":"18","author":"Coppola","year":"1999","journal-title":"EMBO J"},{"key":"2019041123175563300_R10","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1677\/joe.0.1570267","article-title":"Rab3B is essential for GnRH-induced gonadotrophin release from anterior pituitary cells.","volume":"157","author":"Tasaka","year":"1998","journal-title":"J Endocrinol"},{"key":"2019041123175563300_R11","first-page":"3","article-title":"Protein hormone storage in secretory granules: mechanisms for concentration and sorting.","volume":"20","author":"Dannies","year":"1999","journal-title":"Endocr Rev"},{"key":"2019041123175563300_R12","doi-asserted-by":"crossref","first-page":"2273","DOI":"10.1083\/jcb.103.6.2273","article-title":"Conversion of proinsulin to insulin occurs coordinately with acidification of maturing secretory vesicles.","volume":"103","author":"Orci","year":"1986","journal-title":"J Cell Biol"},{"key":"2019041123175563300_R13","doi-asserted-by":"crossref","first-page":"1543","DOI":"10.1210\/endo-119-4-1543","article-title":"Hormonal induction of secretory granules in a pituitary tumor cell line.","volume":"119","author":"Scammell","year":"1986","journal-title":"Endocrinology"},{"key":"2019041123175563300_R14","doi-asserted-by":"crossref","first-page":"3183","DOI":"10.4049\/jimmunol.152.6.3183","article-title":"Islet cell antigen 512 is a diabetes-specific islet autoantigen related to protein tyrosine phosphatases.","volume":"152","author":"Rabin","year":"1994","journal-title":"J Immunol"},{"key":"2019041123175563300_R15","doi-asserted-by":"crossref","first-page":"2102","DOI":"10.1002\/j.1460-2075.1996.tb00564.x","article-title":"ICA 512, an autoantigen of type I diabetes, is an intrinsic membrane protein of neurosecretory granules.","volume":"15","author":"Solimena","year":"1996","journal-title":"EMBO J"},{"key":"2019041123175563300_R16","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1089\/dna.1994.13.505","article-title":"Molecular cloning and identification of a receptor-type protein tyrosine phosphatase, IA-2, from human insulinoma.","volume":"13","author":"Lan","year":"1994","journal-title":"DNA Cell Biol"},{"key":"2019041123175563300_R17","doi-asserted-by":"crossref","first-page":"2727","DOI":"10.1210\/endo.139.6.6039","article-title":"Stabilization of the receptor protein tyrosine phosphatase-like protein ICA512 in GH4C1 cells upon treatment with estradiol, insulin, and epidermal growth factor.","volume":"139","author":"Lee","year":"1998","journal-title":"Endocrinology"},{"key":"2019041123175563300_R18","first-page":"409","article-title":"Hormonal regulation of prolactin storage in a clonal strain of rat pituitary tumor cells.","volume":"55","author":"Kiino","year":"1982","journal-title":"Yale J Biol Med"},{"key":"2019041123175563300_R19","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1083\/jcb.115.3.625","article-title":"Association of Rab3A with synaptic vesicles at late stages of the secretory pathway.","volume":"115","author":"Matteoli","year":"1991","journal-title":"J Cell Biol"},{"key":"2019041123175563300_R20","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1126\/science.1589771","article-title":"Synaptotagmin: a calcium sensor on the synaptic vesicle surface.","volume":"256","author":"Brose","year":"1992","journal-title":"Science"},{"key":"2019041123175563300_R21","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1083\/jcb.129.1.219","article-title":"Cellubrevin and synaptobrevins: similar subcellular localization and biochemical properties in PC12 cells.","volume":"129","author":"Chilcote","year":"1995","journal-title":"J Cell Biol"},{"key":"2019041123175563300_R22","doi-asserted-by":"crossref","first-page":"2373","DOI":"10.1128\/JVI.72.3.2373-2387.1998","article-title":"African swine fever virus is wrapped by the endoplasmic reticulum.","volume":"72","author":"Rouiller","year":"1998","journal-title":"J Virol"},{"key":"2019041123175563300_R23","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1210\/mend-4-7-1017","article-title":"Prolactin and insulin are targeted to the regulated pathway in GH4C1 cells, but their storage is differentially regulated.","volume":"4","author":"Reaves","year":"1990","journal-title":"Mol Endocrinol"},{"key":"2019041123175563300_R24","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1089\/dna.1988.7.261","article-title":"p1B15: a cDNA clone of the rat mRNA encoding cyclophilin.","volume":"7","author":"Danielson","year":"1988","journal-title":"DNA"},{"key":"2019041123175563300_R25","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/S0167-4889(98)00050-0","article-title":"Rab proteins.","volume":"1404","author":"Martinez","year":"1998","journal-title":"Biochim Biophys Acta"},{"key":"2019041123175563300_R26","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1016\/S0955-0674(97)80025-7","article-title":"The diversity of Rab proteins in vesicle transport.","volume":"9","author":"Novick","year":"1997","journal-title":"Curr Opin Cell Biol"},{"key":"2019041123175563300_R27","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1159\/000126994","article-title":"Differential distribution of synaptotagmin I and rab3 in the anterior pituitary of four mammalian species.","volume":"62","author":"Redecker","year":"1995","journal-title":"Neuroendocrinology"},{"key":"2019041123175563300_R28","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1038\/364540a0","article-title":"Inhibition of Rab3B expression attenuates Ca(2+)-dependent exocytosis in rat anterior pituitary cells.","volume":"364","author":"Lledo","year":"1993","journal-title":"Nature"},{"key":"2019041123175563300_R29","doi-asserted-by":"crossref","first-page":"4906","DOI":"10.1523\/JNEUROSCI.15-07-04906.1995","article-title":"Cellular localization of synaptotagmin I, II, and III mRNAs in the central nervous system and pituitary and adrenal glands of the rat.","volume":"15","author":"Marqueze","year":"1995","journal-title":"J Neurosci"},{"key":"2019041123175563300_R30","doi-asserted-by":"crossref","first-page":"5344","DOI":"10.1210\/endo.137.12.8940356","article-title":"Molecular components of the exocytotic machinery in the rat pituitary gland.","volume":"137","author":"Jacobsson","year":"1996","journal-title":"Endocrinology"},{"key":"2019041123175563300_R31","doi-asserted-by":"crossref","first-page":"11675","DOI":"10.1016\/S0021-9258(17)32622-4","article-title":"Synaptotagmin III is a novel isoform of rat synaptotagmin expressed in endocrine and neuronal cells.","volume":"269","author":"Mizuta","year":"1994","journal-title":"J Biol Chem"},{"key":"2019041123175563300_R32","doi-asserted-by":"crossref","first-page":"1922","DOI":"10.1523\/JNEUROSCI.19-06-01922.1999","article-title":"The synaptophysin-synaptobrevin complex: a hallmark of synaptic vesicle maturation.","volume":"19","author":"Becher","year":"1999","journal-title":"J Neurosci"},{"key":"2019041123175563300_R33","doi-asserted-by":"crossref","first-page":"22768","DOI":"10.1074\/jbc.273.35.22768","article-title":"Neuronal Ca2+ sensor 1, the mammalian homologue of frequenin, is expressed in chromaffin and PC12 cells and regulates neurosecretion from dense-core granules.","volume":"273","author":"McFerran","year":"1998","journal-title":"J Biol Chem"},{"key":"2019041123175563300_R34","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/0896-6273(93)90267-U","article-title":"Frequenin\u2013a novel calcium-binding protein that modulates synaptic efficacy in the Drosophila nervous system.","volume":"11","author":"Pongs","year":"1993","journal-title":"Neuron"},{"key":"2019041123175563300_R35","doi-asserted-by":"crossref","first-page":"1688","DOI":"10.1056\/NEJM199812033392307","article-title":"Folding of secretory and membrane proteins.","volume":"339","author":"Kuznetsov","year":"1998","journal-title":"N Engl J Med"},{"key":"2019041123175563300_R36","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1042\/bj3000871","article-title":"The characterization of a cyclophilin-type peptidyl prolyl cis-trans-isomerase from the endoplasmic-reticulum lumen.","volume":"300","author":"Bose","year":"1994","journal-title":"Biochem J"},{"key":"2019041123175563300_R37","doi-asserted-by":"crossref","first-page":"1903","DOI":"10.1073\/pnas.88.5.1903","article-title":"Human cyclophilin B: a second cyclophilin gene encodes a peptidyl-prolyl isomerase with a signal sequence.","volume":"88","author":"Price","year":"1991","journal-title":"Proc Natl Acad Sci USA"},{"key":"2019041123175563300_R38","doi-asserted-by":"crossref","first-page":"1264","DOI":"10.1210\/endo-109-4-1264","article-title":"Insulin and 17\u03b2-estradiol increase the intracellular prolactin content of GH4C1 cells.","volume":"109","author":"Kiino","year":"1981","journal-title":"Endocrinology"},{"key":"2019041123175563300_R39","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/S0962-8924(98)01267-7","article-title":"The unfolded protein response: an intracellular signalling pathway with many surprising features.","volume":"8","author":"Sidrauski","year":"1998","journal-title":"Trends Cell Biol"},{"key":"2019041123175563300_R40","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1083\/jcb.85.3.786","article-title":"Epidermal growth factor and thyrotropin-releasing hormone act similarly on a clonal pituitary cell strain. Modulation of hormone production and inhbition of cell proliferation.","volume":"85","author":"Schonbrunn","year":"1980","journal-title":"J Cell Biol"},{"key":"2019041123175563300_R41","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1146\/annurev.bi.39.070170.004433","article-title":"Control of enzyme levels in animal tissues.","volume":"39","author":"Schimke","year":"1970","journal-title":"Annu Rev Biochem"},{"key":"2019041123175563300_R42","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1046\/j.1365-2826.1998.00178.x","article-title":"Estrogen down-regulates mRNA encoding the exocytotic protein SNAP-25 in the rat pituitary gland.","volume":"10","author":"Jacobsson","year":"1998","journal-title":"J Neuroendocrinol"},{"key":"2019041123175563300_R43","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1677\/joe.0.1610323","article-title":"Exocytotic protein components in rat pituitary gland after long-term estrogen administration.","volume":"161","author":"Majo","year":"1999","journal-title":"J Endocrinol"},{"key":"2019041123175563300_R44","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1002\/(SICI)1096-9896(199712)183:4<440::AID-PATH953>3.0.CO;2-#","article-title":"Immunocytochemical analysis of the synaptic proteins SNAP-25 and Rab3A in human pituitary adenomas. Overexpression of SNAP-25 in the mammmosomatotroph lineages.","volume":"183","author":"Majo","year":"1997","journal-title":"J Pathol"},{"key":"2019041123175563300_R45","doi-asserted-by":"crossref","first-page":"1943","DOI":"10.1210\/endo.134.4.8137763","article-title":"Cytochemical detection of gonadotropin-releasing hormone-binding sites on rat pituitary cells with luteinizing hormone, follicle-stimulating hormone, and growth hormone antigens during diestrous up-regulation.","volume":"134","author":"Childs","year":"1994","journal-title":"Endocrinology"},{"key":"2019041123175563300_R46","doi-asserted-by":"crossref","first-page":"3048","DOI":"10.1210\/endo.130.5.1572312","article-title":"Follistatin gene expression in the pituitary: localization in gonadotropes and folliculostellate cells in diestrous rats.","volume":"130","author":"Kaiser","year":"1992","journal-title":"Endocrinology"},{"key":"2019041123175563300_R47","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1210\/endo-117-1-418","article-title":"Cultures of GH3 cells are functionally heterogeneous: thyrotropin-releasing hormone, estradiol and cortisol cause reciprocal shifts in the proportions of growth hormone and prolactin secretors.","volume":"117","author":"Boockfor","year":"1985","journal-title":"Endocrinology"},{"key":"2019041123175563300_R48","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0303-7207(92)90227-W","article-title":"Single and dual hormone secretors in GH3 cultures respond differently to hypothalamic factors.","volume":"87","author":"Mogg","year":"1992","journal-title":"Mol Cell Endocrinol"},{"key":"2019041123175563300_R49","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1677\/joe.0.1400455","article-title":"Secretory characteristics and phenotypic plasticity of growth hormone- and prolactin-producing cell lines.","volume":"140","author":"Kineman","year":"1994","journal-title":"J Endocrinol"},{"key":"2019041123175563300_R50","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1007\/s004410050021","article-title":"Epidermal growth factor, insulin, and estrogen stimulate development of prolactin-secreting cells in cultures of GH3 cells.","volume":"299","author":"Kakeya","year":"2000","journal-title":"Cell Tissue Res"}],"container-title":["Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/endo\/article-pdf\/141\/9\/3485\/10366552\/endo3485.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,7,9]],"date-time":"2023-07-09T14:45:18Z","timestamp":1688913918000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/endo\/article\/141\/9\/3485\/2989186"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,9,1]]},"references-count":50,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2000,9,1]]}},"URL":"https:\/\/doi.org\/10.1210\/endo.141.9.7647","relation":{},"ISSN":["0013-7227","1945-7170"],"issn-type":[{"value":"0013-7227","type":"print"},{"value":"1945-7170","type":"electronic"}],"subject":[],"published":{"date-parts":[[2000,9,1]]}}}