{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T22:10:40Z","timestamp":1783635040037,"version":"3.55.0"},"reference-count":53,"publisher":"The Endocrine Society","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2001,1,1]]},"DOI":"10.1210\/endo.142.1.7893","type":"journal-article","created":{"date-parts":[[2014,1,8]],"date-time":"2014-01-08T16:11:14Z","timestamp":1389197474000},"page":"359-369","source":"Crossref","is-referenced-by-count":47,"title":["Developmental Exposure to Estrogens Alters Epithelial Cell Adhesion and Gap Junction Proteins in the Adult Rat Prostate**Supported by NIDDK Grants 40890 and 09873, NCI CA-73769, DOD (DAMD17\u201300-1\u20130032), VA Merit Review Award, and a travel scholarship from AESCA GmbH. Traiskirchen, Austria and AstraZeneca GmbH, Vienna, Austria."],"prefix":"10.1210","volume":"142","author":[{"given":"Helga","family":"Habermann","sequence":"first","affiliation":[{"name":"Department of Urology (H.H.), University of Graz, Austria;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William Y.","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Urology (W.Y.C., L.B., G.S.P.), University of Illinois, Chicago, Illinois 60612;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lynn","family":"Birch","sequence":"additional","affiliation":[{"name":"Department of Urology (W.Y.C., L.B., G.S.P.), University of Illinois, Chicago, Illinois 60612;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Parmender","family":"Mehta","sequence":"additional","affiliation":[{"name":"Department of Medicine and Sylvester Comprehensive Cancer Center (P.M.), University of Miami School of Medicine, Florida 33136"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gail S.","family":"Prins","sequence":"additional","affiliation":[{"name":"Department of Urology (W.Y.C., L.B., G.S.P.), University of Illinois, Chicago, Illinois 60612;"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"80","reference":[{"key":"2019041121181079700_R1","first-page":"186","article-title":"Sex steroid imprinting of the immature prostate.","volume":"16","author":"Rajfer","year":"1978","journal-title":"Invest Urol"},{"key":"2019041121181079700_R2","doi-asserted-by":"crossref","first-page":"1136","DOI":"10.1016\/S0022-5347(17)45239-6","article-title":"The differential effects of neonatal androgen, estrogen and progesterone on adult rat prostate growth.","volume":"136","author":"Naslund","year":"1986","journal-title":"J Urol"},{"key":"2019041121181079700_R3","doi-asserted-by":"crossref","first-page":"3703","DOI":"10.1210\/endo.130.6.1597166","article-title":"Neonatal estrogen exposure induces lobe-specific alterations in adult rat prostate androgen receptor expression.","volume":"130","author":"Prins","year":"1992","journal-title":"Endocrinology"},{"key":"2019041121181079700_R4","doi-asserted-by":"crossref","first-page":"2387","DOI":"10.1210\/endo.132.6.8504743","article-title":"Effects of neonatal estrogen exposure on prostatic secretory genes and their correlation with androgen receptor expression in the separate prostate lobes of the adult rat.","volume":"132","author":"Prins","year":"1993","journal-title":"Endocrinology"},{"key":"2019041121181079700_R5","first-page":"247","article-title":"Developmental estrogenization of the prostate gland.","volume-title":"Prostate: Basic and Clinical Aspects.","author":"Prins","year":"1997"},{"key":"2019041121181079700_R6","doi-asserted-by":"crossref","first-page":"1593","DOI":"10.1016\/S0022-5347(17)36458-3","article-title":"Prostatic dysplasia associated with increased expression of C-MYC in neonatally estrogenized mice.","volume":"149","author":"Pylkkanen","year":"1993","journal-title":"J Urol"},{"key":"2019041121181079700_R7","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1002\/pros.2990240204","article-title":"Developmental estrogenization and prostatic neoplasia.","volume":"24","author":"Santti","year":"1994","journal-title":"Prostate"},{"key":"2019041121181079700_R8","doi-asserted-by":"crossref","first-page":"1801","DOI":"10.1210\/endo.138.5.5106","article-title":"Neonatal estrogen exposure up-regulates estrogen receptor expression in the developing and adult rat prostate lobes.","volume":"138","author":"Prins","year":"1997","journal-title":"Endocrinology"},{"key":"2019041121181079700_R9","doi-asserted-by":"crossref","first-page":"874","DOI":"10.1210\/endo.139.3.5827","article-title":"Estrogen receptor-\u03b2 messenger ribonucleic acid ontogeny in the prostate of normal and neonatally estrogenized rats.","volume":"139","author":"Prins","year":"1998","journal-title":"Endocrinology"},{"key":"2019041121181079700_R10","doi-asserted-by":"crossref","first-page":"1303","DOI":"10.1210\/endo.136.3.7867585","article-title":"The developmental pattern of androgen receptor expression in rat prostate lobes is altered after neonatal exposure to estrogen.","volume":"136","author":"Prins","year":"1995","journal-title":"Endocrinology"},{"key":"2019041121181079700_R11","doi-asserted-by":"crossref","first-page":"2801","DOI":"10.1210\/endo.140.6.6833","article-title":"Neonatal estrogen exposure alters the transforming growth factor-\u03b2 signaling system in the developing rat prostate and blocks the transient p21cip1\/wafl expression associated with epithelial differentiation.","volume":"140","author":"Chang","year":"1999","journal-title":"Endocrinology"},{"key":"2019041121181079700_R12","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1210\/endo.140.1.6401","article-title":"Neonatal estrogen stimulates proliferation of periductal fibroblasts and alters the extracellular matrix composition in the rat prostate.","volume":"140","author":"Chang","year":"1999","journal-title":"Endocrinology"},{"key":"2019041121181079700_R13","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1016\/S0955-0674(96)80108-6","article-title":"Desmosomes: differentiation, development, dynamics and disease.","volume":"8","author":"Garrod","year":"1996","journal-title":"Curr Opin Cell Biol"},{"key":"2019041121181079700_R14","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1432-1033.1996.0001q.x","article-title":"Connections with connexins: the molecular basis of direct intercellular signaling.","volume":"238","author":"Bruzzone","year":"1996","journal-title":"Eur J Biochem"},{"key":"2019041121181079700_R15","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/0166-2236(89)90150-1","article-title":"Gap junctional communication and development.","volume":"12","author":"Guthrie","year":"1989","journal-title":"Trends Neurosci"},{"key":"2019041121181079700_R16","first-page":"216","article-title":"The role of gap junctional intercellular communication in neoplasia.","volume":"24","author":"Ruch","year":"1994","journal-title":"Ann Clin Lab Sci"},{"key":"2019041121181079700_R17","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1159\/000147751","article-title":"Molecular interactions in the submembrane plaque of cell-cell and cell-matrix adhesions.","volume":"154","author":"Geiger","year":"1995","journal-title":"Acta Anat"},{"key":"2019041121181079700_R18","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1146\/annurev.bi.65.070196.002355","article-title":"Connexins, connexons, and intercellular communication.","volume":"65","author":"Goodenough","year":"1996","journal-title":"Annu Rev Biochem"},{"key":"2019041121181079700_R19","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1002\/(SICI)1097-4644(19960616)61:4<514::AID-JCB4>3.0.CO;2-R","article-title":"Cadherin-catenin complex: protein interactions and their implications for cadherin function.","volume":"61","author":"Aberle","year":"1996","journal-title":"J Cell Biochem"},{"key":"2019041121181079700_R20","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1016\/S0955-0674(97)80122-6","article-title":"Cadherins, catenins and APC protein: interplay between cytoskeletal complexes and signaling pathways.","volume":"5","author":"Barth","year":"1997","journal-title":"Curr Opin Cell Biol"},{"key":"2019041121181079700_R21","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1146\/annurev.ph.47.030185.001535","article-title":"The role of gap junctions in development.","volume":"47","author":"Caveney","year":"1985","journal-title":"Annu Rev Physiol"},{"key":"2019041121181079700_R22","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1242\/dev.114.1.203","article-title":"Spatial and temporal patterns of distribution of the gap junction protein connexin43 during mouse gastrulation and organogenesis.","volume":"114","author":"Yancey","year":"1992","journal-title":"Development"},{"key":"2019041121181079700_R23","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1002\/aja.1001940403","article-title":"Connexin 43 expression in the mouse embryo: localization of transcripts within developmentally significant domains.","volume":"194","author":"Ruangvoravat","year":"1992","journal-title":"Dev Dynam"},{"key":"2019041121181079700_R24","doi-asserted-by":"crossref","first-page":"2371","DOI":"10.1210\/endo.133.5.8404689","article-title":"Differential expression of gap junction connexins in endocrine and exocrine glands.","volume":"133","author":"Meda","year":"1993","journal-title":"Endocrinology"},{"key":"2019041121181079700_R25","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1002\/(SICI)1520-6408(1999)24:1\/2<91::AID-DVG10>3.0.CO;2-#","article-title":"Suppression of human prostate cancer cell growth by forced expression of connexin genes.","volume":"110","author":"Mehta","year":"1999","journal-title":"Dev Genet"},{"key":"2019041121181079700_R26","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1002\/(SICI)1098-2744(199601)15:1<18::AID-MC4>3.0.CO;2-O","article-title":"Gap-junctional communication in normal and neoplastic prostate epithelial cells and its regulation by cAMP.","volume":"15","author":"Mehta","year":"1996","journal-title":"Mol Carcinog"},{"key":"2019041121181079700_R27","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1006\/bbrc.1996.1468","article-title":"Reduced connexin 43 expression in high grade, human prostatic adenocarcinoma cells.","volume":"227","author":"Tsai","year":"1996","journal-title":"Biochem Biophy Res Commun"},{"key":"2019041121181079700_R28","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1098\/rspb.1994.0018","article-title":"The connexin43 gene is responsive to oestrogen.","volume":"255","author":"Yu","year":"1994","journal-title":"Proc R Soc Lond B"},{"key":"2019041121181079700_R29","doi-asserted-by":"crossref","first-page":"2380","DOI":"10.1210\/endo.132.6.8389279","article-title":"Increased expression of connexin-43 in the rat myometrium during labor is associated with an increase in the plasma estrogen:progesterone ratio.","volume":"132","author":"Lye","year":"1993","journal-title":"Endocrinology"},{"key":"2019041121181079700_R30","doi-asserted-by":"crossref","first-page":"3571","DOI":"10.1210\/endo.136.8.7628395","article-title":"Increase in messenger ribonucleic acid encoding the myometrial gap junction protein, connexin-43, requires protein synthesis and is associated with increased expression of the activator protein-1 c-fos.","volume":"136","author":"Piersanti","year":"1995","journal-title":"Endocrinology"},{"key":"2019041121181079700_R31","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/0896-6273(91)90241-Q","article-title":"Gap junctions: new tools, new answers, new questions.","volume":"6","author":"Bennett","year":"1991","journal-title":"Neuron"},{"key":"2019041121181079700_R32","volume-title":"Developmental Biology","author":"Gilbert","year":"1994"},{"key":"2019041121181079700_R33","first-page":"2916","article-title":"Decreased expression of E-cadherin in the progression of rat prostatic cancer.","volume":"52","author":"Bussemakers","year":"1992","journal-title":"Cancer Res"},{"key":"2019041121181079700_R34","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1006\/dbio.1994.1002","article-title":"Expression of the connexin43 gap junctional protein in tissues at the tip of the chick limb bud is related to the epithelial-mesenchymal interactions that mediate morphogenesis.","volume":"161","author":"Green","year":"1994","journal-title":"Dev Biol"},{"key":"2019041121181079700_R35","first-page":"1215","article-title":"Consistent expression of an epithelial cell adhesion molecule (C-CAM) during human prostate development and loss of expression in prostate cancer: implication as a tumor suppressor.","volume":"55","author":"Kleinerman","year":"1995","journal-title":"Cancer Res"},{"key":"2019041121181079700_R36","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/0092-8674(91)90143-M","article-title":"Genetic manipulation of e-cadherin expression by epithelial tumor cells reveals an invasion suppressor role.","volume":"66","author":"Vleminckz","year":"1991","journal-title":"Cell"},{"key":"2019041121181079700_R37","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1093\/carcin\/14.5.1073","article-title":"Gap junction protein gene suppresses tumorigenicity.","volume":"14","author":"Rose","year":"1993","journal-title":"Carcinogenesis"},{"key":"2019041121181079700_R38","first-page":"2831","article-title":"Application of a tumor suppressor (C-CAM1)-expressing recombinant adenovirus in androgen-independent human prostate cancer therapy: a preclincial study.","volume":"55","author":"Kleinerman","year":"1995","journal-title":"Cancer Res"},{"key":"2019041121181079700_R39","doi-asserted-by":"crossref","first-page":"3187","DOI":"10.1210\/endo-129-6-3187","article-title":"Androgen receptor localization in different cell types of the adult rat prostate.","volume":"129","author":"Prins","year":"1991","journal-title":"Endocrinology"},{"key":"2019041121181079700_R40","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1111\/j.1464-410X.1991.tb15394.x","article-title":"Relationship between clinical stage and histological zone of origin in early prostate cancer: morphometric analysis.","volume":"68","author":"Greene","year":"1991","journal-title":"Br J Urol"},{"key":"2019041121181079700_R41","first-page":"2128","article-title":"Cadherin cell adhesion molecules in human epithelial tissues and carcinomas.","volume":"49","author":"Shimoyama","year":"1989","journal-title":"Cancer Res"},{"key":"2019041121181079700_R42","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.1083\/jcb.138.5.1125","article-title":"Fibroblast growth factor 4 directs gap junction expression in the mesenchyme of the vertebrate limb bud.","volume":"138","author":"Makarenkova","year":"1997","journal-title":"J Cell Biol"},{"key":"2019041121181079700_R43","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1242\/dev.108.4.623","article-title":"The role of gap junctions in patterning of the chick limb bud.","volume":"108","author":"Allen","year":"1990","journal-title":"Development"},{"key":"2019041121181079700_R44","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1242\/dev.116.3.639","article-title":"Multiple gap junction genes are utilized during rat skin and hair development.","volume":"116","author":"Risek","year":"1992","journal-title":"Development"},{"key":"2019041121181079700_R45","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1006\/dbio.1994.1190","article-title":"Developmental regulation and structural organization of connexins in epidermal gap junctions.","volume":"164","author":"Risek","year":"1994","journal-title":"Dev Biol"},{"key":"2019041121181079700_R46","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1007\/BF01994355","article-title":"Incorporation of the gene for a cell-cell channel protein into transformed cells leads to normalization of growth.","volume":"124","author":"Mehta","year":"1991","journal-title":"J Membr Biol"},{"key":"2019041121181079700_R47","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/0014-4827(92)90346-A","article-title":"The hepatocyte-specific phenotype of murine liver cells correlates with high expression of connexin32 and connexin26 but very low expression of connexin43.","volume":"201","author":"Stutenkemper","year":"1992","journal-title":"Exp Cell Res"},{"key":"2019041121181079700_R48","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1006\/dbio.1996.0318","article-title":"Cell contact-dependent signaling.","volume":"180","author":"Fagotto","year":"1996","journal-title":"Dev Biol"},{"key":"2019041121181079700_R49","doi-asserted-by":"crossref","first-page":"2077","DOI":"10.1083\/jcb.111.5.2077","article-title":"Differential phosphorylation of the gap junction protein connexin43 in junctional communication-competent and -deficient cell lines.","volume":"111","author":"Musil","year":"1990","journal-title":"J Cell Biol"},{"key":"2019041121181079700_R50","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1007\/BF00689788","article-title":"Decreased expression of the intercellular adhesion molecule E-cadherin in prostate cancer: biological significance and clinical implications.","volume":"12","author":"Giroldi","year":"1993","journal-title":"Cancer Metastasis Rev"},{"key":"2019041121181079700_R51","first-page":"5104","article-title":"Expression of the cellular adhesion molecule E-cadherin is reduced or absent in high-grade prostate cancer.","volume":"52","author":"Umbas","year":"1992","journal-title":"Cancer Res"},{"key":"2019041121181079700_R52","doi-asserted-by":"crossref","first-page":"1817","DOI":"10.1083\/jcb.107.5.1817","article-title":"Topological distribution of two connexin 32 antigenic sites in intact and split rodent hepatocyte gap junctions.","volume":"107","author":"Goodenough","year":"1988","journal-title":"J Cell Biol"},{"key":"2019041121181079700_R53","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1091\/mbc.3.8.839","article-title":"transcription of the gene for the gap junctional protein connexin 43 and expression of functional cell-to-cell channels are regulated by cAMP.","volume":"3","author":"Mehta","year":"1992","journal-title":"Mol Biol Cell"}],"container-title":["Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/endo\/article-pdf\/142\/1\/359\/10365341\/endo0359.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,21]],"date-time":"2022-03-21T23:17:43Z","timestamp":1647904663000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/endo\/article\/142\/1\/359\/2989035"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,1,1]]},"references-count":53,"aliases":["10.1210\/en.142.1.359"],"journal-issue":{"issue":"1","published-print":{"date-parts":[[2001,1,1]]}},"URL":"https:\/\/doi.org\/10.1210\/endo.142.1.7893","relation":{},"ISSN":["0013-7227","1945-7170"],"issn-type":[{"value":"0013-7227","type":"print"},{"value":"1945-7170","type":"electronic"}],"subject":[],"published":{"date-parts":[[2001,1,1]]}}}