{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T17:21:22Z","timestamp":1791134482938,"version":"4.1.0"},"reference-count":37,"publisher":"The Endocrine Society","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2001,6,1]]},"DOI":"10.1210\/endo.142.6.8198","type":"journal-article","created":{"date-parts":[[2014,1,8]],"date-time":"2014-01-08T11:11:46Z","timestamp":1389179506000},"page":"2586-2592","source":"Crossref","is-referenced-by-count":24,"title":["Central Melanocortin Receptors Mediate Changes in Food Intake in the Rhesus Macaque*"],"prefix":"10.1210","volume":"142","author":[{"given":"Frank H.","family":"Koegler","sequence":"first","affiliation":[{"name":"Divisions of Reproductive Biology (F.H.K., A.S., J.L.C.), Oregon Regional Primate Research Center,, Beaverton, Oregon 97006"},{"name":"Neuroscience (F.H.K., K.L.G., A.S., M.S.S., J.L.C.), Oregon Regional Primate Research Center,, Beaverton, Oregon 97006"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin L.","family":"Grove","sequence":"additional","affiliation":[{"name":"Neuroscience (F.H.K., K.L.G., A.S., M.S.S., J.L.C.), Oregon Regional Primate Research Center,, Beaverton, Oregon 97006"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Schiffmacher","sequence":"additional","affiliation":[{"name":"Divisions of Reproductive Biology (F.H.K., A.S., J.L.C.), Oregon Regional Primate Research Center,, Beaverton, Oregon 97006"},{"name":"Neuroscience (F.H.K., K.L.G., A.S., M.S.S., J.L.C.), Oregon Regional Primate Research Center,, Beaverton, Oregon 97006"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. Susan","family":"Smith","sequence":"additional","affiliation":[{"name":"Neuroscience (F.H.K., K.L.G., A.S., M.S.S., J.L.C.), Oregon Regional Primate Research Center,, Beaverton, Oregon 97006"},{"name":"Department of Physiology and Pharmacology, Oregon Health Sciences University (M.S.S., J.L.C.), Beaverton, Oregon 97006"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Judy L.","family":"Cameron","sequence":"additional","affiliation":[{"name":"Divisions of Reproductive Biology (F.H.K., A.S., J.L.C.), Oregon Regional Primate Research Center,, Beaverton, Oregon 97006"},{"name":"Neuroscience (F.H.K., K.L.G., A.S., M.S.S., J.L.C.), Oregon Regional Primate Research Center,, Beaverton, Oregon 97006"},{"name":"Department of Physiology and Pharmacology, Oregon Health Sciences University (M.S.S., J.L.C.), Beaverton, Oregon 97006"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"80","reference":[{"key":"2019041121411027400_R1","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1016\/0361-9230(84)90237-5","article-title":"Proopiomelanocortin peptide immunocytochemistry in rhesus monkey brain.","volume":"13","author":"Khachaturian","year":"1984","journal-title":"Brain Res Bull"},{"key":"2019041121411027400_R2","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1159\/000126324","article-title":"Short-term starvation decreases POMC mRNA but does not alter GnRH mRNA in the brain of adult male rats.","volume":"56","author":"Bergendahl","year":"1992","journal-title":"Neuroendocrinology"},{"key":"2019041121411027400_R3","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1159\/000125626","article-title":"Altered expression of hypothalamic neuropeptide mRNAs in food-restricted and food-deprived rats.","volume":"52","author":"Brady","year":"1990","journal-title":"Neuroendocrinology"},{"key":"2019041121411027400_R4","doi-asserted-by":"crossref","first-page":"2362","DOI":"10.1523\/JNEUROSCI.19-06-02362.1999","article-title":"Role of the CNS melanocortin system in the response to overfeeding.","volume":"19","author":"Hagan","year":"1999","journal-title":"J Neurosci"},{"key":"2019041121411027400_R5","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.1038\/12506","article-title":"Obesity in the mouse model of pro-opiomelanocortin deficiency responds to peripheral melanocortin.","volume":"5","author":"Yaswen","year":"1999","journal-title":"Nat Med"},{"key":"2019041121411027400_R6","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1038\/509","article-title":"Severe early-onset obesity, adrenal insufficiency and red hair pigmentation caused by POMC mutations in humans.","volume":"19","author":"Krude","year":"1998","journal-title":"Nat Genet"},{"key":"2019041121411027400_R7","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1038\/385165a0","article-title":"Role of melanocortinergic neurons in feeding and the agouti obesity syndrome.","volume":"385","author":"Fan","year":"1997","journal-title":"Nature"},{"key":"2019041121411027400_R8","doi-asserted-by":"crossref","first-page":"3442","DOI":"10.1523\/JNEUROSCI.20-09-03442.2000","article-title":"A novel selective melanocortin-4 receptor agonist reduces food intake in rats and mice without producing aversive consequences.","volume":"20","author":"Benoit","year":"2000","journal-title":"J Neurosci"},{"key":"2019041121411027400_R9","first-page":"R248","article-title":"Central infusion of melanocortin agonist MTII in rats: assessment of c-Fos expression and taste aversion","volume":"274","author":"Thiele","year":"1998","journal-title":"Am J Physiol"},{"key":"2019041121411027400_R10","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/S0092-8674(00)81865-6","article-title":"Targeted disruption of the melanocortin-4 receptor results in obesity in mice.","volume":"88","author":"Huszar","year":"1997","journal-title":"Cell"},{"key":"2019041121411027400_R11","doi-asserted-by":"crossref","first-page":"3518","DOI":"10.1210\/endo.141.9.7791","article-title":"A unique metabolic syndrome causes obesity in the melanocortin-3 receptor-deficient mouse.","volume":"141","author":"Butler","year":"2000","journal-title":"Endocrinology"},{"key":"2019041121411027400_R12","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1038\/79254","article-title":"Inactivation of the mouse melanocortin-3 receptor results in increased fat mass and reduced lean body mass.","volume":"26","author":"Chen","year":"2000","journal-title":"Nat Genet"},{"key":"2019041121411027400_R13","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1038\/371799a0","article-title":"Agouti protein is an antagonist of the melanocyte-stimulating-hormone receptor.","volume":"371","author":"Lu","year":"1994","journal-title":"Nature"},{"key":"2019041121411027400_R14","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1006\/bbrc.1997.7200","article-title":"ART (protein product of agouti-related transcript) as an antagonist of MC-3 and MC-4 receptors.","volume":"237","author":"Fong","year":"1997","journal-title":"Biochem Biophys Res Commun"},{"key":"2019041121411027400_R15","doi-asserted-by":"crossref","first-page":"4428","DOI":"10.1210\/endo.139.10.6332","article-title":"A C-terminal fragment of agouti-related protein increases feeding and antagonizes the effect of\u03b1 -melanocyte stimulating hormone in vivo.","volume":"139","author":"Rossi","year":"1998","journal-title":"Endocrinology"},{"key":"2019041121411027400_R16","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1038\/ng1197-273","article-title":"Overexpression of Agrt leads to obesity in transgenic mice.","volume":"17","author":"Graham","year":"1997","journal-title":"Nat Genet"},{"key":"2019041121411027400_R17","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1038\/1082","article-title":"Coexpression of Agrp and NPY in fasting-activated hypothalamic neurons.","volume":"1","author":"Hahn","year":"1998","journal-title":"Nat Neurosci"},{"key":"2019041121411027400_R18","doi-asserted-by":"crossref","first-page":"15043","DOI":"10.1073\/pnas.95.25.15043","article-title":"The neuropeptide Y\/agouti gene-related protein (AGRP) brain circuitry in normal, anorectic, and monosodium glutamate-treated mice.","volume":"95","author":"Broberger","year":"1998","journal-title":"Proc Natl Acad Sci USA"},{"key":"2019041121411027400_R19","doi-asserted-by":"crossref","first-page":"1408","DOI":"10.1210\/endo.140.3.6544","article-title":"Characterization of the neuroanatomical distribution of agouti-related protein immunoreactivity in the rhesus monkey and the rat.","volume":"140","author":"Haskell-Luevano","year":"1999","journal-title":"Endocrinology"},{"key":"2019041121411027400_R20","first-page":"2596","article-title":"Hypophysiotropic thyrotropin-releasing hormone-synthesizing neurons in the human hypothalamus are innervated by neuropeptide Y, agouti-related protein, and\u03b1 -melanocyte-stimulating hormone.","volume":"85","author":"Mihaly","year":"2000","journal-title":"J Clin Endocrinol Metab"},{"key":"2019041121411027400_R21","doi-asserted-by":"crossref","first-page":"1532","DOI":"10.1210\/endo-128-3-1532","article-title":"Suppression of pulsatile luteinizing hormone and testosterone secretion during short term food restriction in the adult male rhesus monkey (Macaca mulatta).","volume":"128","author":"Cameron","year":"1991","journal-title":"Endocrinology"},{"key":"2019041121411027400_R22","first-page":"3781","article-title":"Activation of central neuropeptide Y Y1 receptors potently stimulates food intake in male rhesus monkeys.","volume":"84","author":"Larsen","year":"1999","journal-title":"J Clin Endocrinol Metab"},{"key":"2019041121411027400_R23","doi-asserted-by":"crossref","first-page":"4652","DOI":"10.1210\/endo.139.11.6297","article-title":"The stimulatory effect of leptin on the neuroendocrine reproductive axis of the monkey.","volume":"139","author":"Finn","year":"1998","journal-title":"Endocrinology"},{"key":"2019041121411027400_R24","first-page":"1298","article-title":"Localization of the melanocortin-4 receptor (MC4-R) in neuroendocrine and autonomic control circuits in the brain.","volume":"8","author":"Mountjoy","year":"1994","journal-title":"Mol Endocrinol"},{"key":"2019041121411027400_R25","doi-asserted-by":"crossref","first-page":"177","DOI":"10.2337\/diabetes.49.2.177","article-title":"Hypothalamic localization of the feeding effect of agouti-related peptide and \u03b1-melanocyte-stimulating hormone.","volume":"49","author":"Kim","year":"2000","journal-title":"Diabetes"},{"key":"2019041121411027400_R26","doi-asserted-by":"crossref","first-page":"R47","DOI":"10.1152\/ajpregu.2000.279.1.R47","article-title":"Long-term orexigenic effects of AgRP-(83\u2013132) involve mechanisms other than melanocortin receptor blockade","volume":"279","author":"Hagan","year":"2000","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"2019041121411027400_R27","doi-asserted-by":"crossref","first-page":"1195","DOI":"10.1016\/S0092-8674(05)80067-4","article-title":"Molecular characterization of the mouse agouti locus.","volume":"71","author":"Bultman","year":"1992","journal-title":"Cell"},{"key":"2019041121411027400_R28","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1126\/science.278.5335.135","article-title":"Antagonism of central melanocortin receptors in vitro and in vivo by agouti-related protein.","volume":"278","author":"Ollmann","year":"1997","journal-title":"Science"},{"key":"2019041121411027400_R29","first-page":"R695","article-title":"Effect of intracerebroventricular MSH on food intake, adiposity, c-Fos induction, and neuropeptide expression","volume":"279","author":"McMinn","year":"2000","journal-title":"Am J Physiol"},{"key":"2019041121411027400_R30","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1159\/000061016","article-title":"Hypothalamic neuropeptide Y and its neuroendocrine regulation by leptin.","volume":"26","author":"Widdowson","year":"2000","journal-title":"Front Horm Res"},{"key":"2019041121411027400_R31","doi-asserted-by":"crossref","first-page":"2635","DOI":"10.1016\/0024-3205(84)90032-8","article-title":"Neuropeptide Y: stimulation of feeding and drinking by injection into the paraventricular nucleus.","volume":"35","author":"Stanley","year":"1984","journal-title":"Life Sci"},{"key":"2019041121411027400_R32","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1054\/npep.1999.0055","article-title":"Two important systems in energy homeostasis: melanocortins and melanin-concentrating hormone.","volume":"33","author":"Tritos","year":"1999","journal-title":"Neuropeptides"},{"key":"2019041121411027400_R33","doi-asserted-by":"crossref","first-page":"222","DOI":"10.3109\/07853890008998829","article-title":"Separate systems for serotonin and leptin in appetite control.","volume":"32","author":"Halford","year":"2000","journal-title":"Ann Med"},{"key":"2019041121411027400_R34","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1054\/npep.1999.0051","article-title":"Cholecystokinin: proofs and prospects for involvement in control of food intake and body weight.","volume":"33","author":"Ritter","year":"1999","journal-title":"Neuropeptides"},{"key":"2019041121411027400_R35","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1006\/frne.2000.0197","article-title":"Leptin regulation of neuroendocrine systems.","volume":"21","author":"Ahima","year":"2000","journal-title":"Front Neuroendocrinol"},{"key":"2019041121411027400_R36","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1006\/hbeh.2000.1588","article-title":"CNS melanocortin system involvement in the regulation of food intake","volume":"37","author":"Benoit","year":"2000","journal-title":"Horm Behav."},{"key":"2019041121411027400_R37","volume-title":"The Rhesus Monkey Brain in Stereotaxic Coordinates","author":"Paxinos","year":"2000"}],"container-title":["Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/endo\/article-pdf\/142\/6\/2586\/10369936\/endo2586.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,4,12]],"date-time":"2019-04-12T06:45:45Z","timestamp":1555051545000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/endo\/article\/142\/6\/2586\/2989614"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,6,1]]},"references-count":37,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2001,6,1]]}},"URL":"https:\/\/doi.org\/10.1210\/endo.142.6.8198","relation":{},"ISSN":["0013-7227","1945-7170"],"issn-type":[{"value":"0013-7227","type":"print"},{"value":"1945-7170","type":"electronic"}],"subject":[],"published":{"date-parts":[[2001,6,1]]}}}