{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T14:17:45Z","timestamp":1791901065449,"version":"4.3.4"},"reference-count":72,"publisher":"The Endocrine Society","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2002,6,1]]},"DOI":"10.1210\/endo.143.6.8864","type":"journal-article","created":{"date-parts":[[2014,1,8]],"date-time":"2014-01-08T16:12:02Z","timestamp":1389197522000},"page":"2019-2024","source":"Crossref","is-referenced-by-count":89,"title":["Perspective: Genetic Defects in the Etiology of Congenital Hypothyroidism"],"prefix":"10.1210","volume":"143","author":[{"given":"Peter","family":"Kopp","sequence":"first","affiliation":[{"name":"Division of Endocrinology, Metabolism & Molecular Medicine, Northwestern University, Chicago, Illinois 60611"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"80","reference":[{"key":"2019041121213837800_R1","first-page":"1095","article-title":"Effects of neonatal screening for hypothyroidism: prevention of mental retardation by treatment before clinical manifestation.","volume":"2","year":"1981","journal-title":"Lancet"},{"key":"2019041121213837800_R2","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1097\/00008480-200108000-00013","article-title":"Genetic regulation of thyroid development.","volume":"13","author":"Gillam","year":"2001","journal-title":"Curr Opin Pediatr"},{"key":"2019041121213837800_R3","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1097\/00008480-200108000-00014","article-title":"Genetic defects in thyroid hormone synthesis.","volume":"13","author":"Gillam","year":"2001","journal-title":"Curr Opin Pediatr"},{"key":"2019041121213837800_R4","doi-asserted-by":"crossref","first-page":"2009","DOI":"10.1210\/jcem.86.5.7501","article-title":"Nineteen years of national screening for congenital hypothyroidism: familial cases with thyroid dysgenesis suggest the involvement of genetic factors.","volume":"86","author":"Castanet","year":"2001","journal-title":"J Clin Endocrinol Metab"},{"key":"2019041121213837800_R5","doi-asserted-by":"crossref","first-page":"2502","DOI":"10.1210\/jcem.84.7.5831","article-title":"A search for the possible molecular mechanisms of thyroid dysgenesis: sex ratios and associated malformations.","volume":"84","author":"Devos","year":"1999","journal-title":"J Clin Endocrinol Metab"},{"key":"2019041121213837800_R6","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1136\/adc.57.11.877","article-title":"Congenital isolated thyrotrophin releasing hormone deficiency.","volume":"57","author":"Niimi","year":"1982","journal-title":"Arch Dis Child"},{"key":"2019041121213837800_R7","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1007\/BF03348429","article-title":"Hypothalamic hypothyroidism due to isolated thyrotropin-releasing hormone (TRH) deficiency.","volume":"7","author":"Katakami","year":"1984","journal-title":"J Endocrinol Invest"},{"key":"2019041121213837800_R8","doi-asserted-by":"crossref","first-page":"10862","DOI":"10.1073\/pnas.94.20.10862","article-title":"Tertiary hypothyroidism and hyperglycemia in mice with targeted disruption of the thyrotropin-releasing hormone gene.","volume":"94","author":"Yamada","year":"1997","journal-title":"Proc Natl Acad Sci USA"},{"key":"2019041121213837800_R9","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.1056\/NEJM198504253121703","article-title":"Decreased receptor binding of biologically inactive thyrotropin in central hypothyroidism. Effect of treatment with thyrotropin-releasing hormone.","volume":"312","author":"Beck-Peccoz","year":"1985","journal-title":"N Engl J Med"},{"key":"2019041121213837800_R10","first-page":"1361","article-title":"A novel mechanism for isolated central hypothyroidism: inactivating mutations in the thyrotropin-releasing hormone receptor gene.","volume":"82","author":"Collu","year":"1997","journal-title":"J Clin Endocrinol Metab"},{"key":"2019041121213837800_R11","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1210\/jcem-71-4-792","article-title":"Deoxyribonucleic acid analysis of five families with familial inherited thyroid stimulating hormone deficiency.","volume":"71","author":"Hayashizaki","year":"1990","journal-title":"J Clin Endocrinol Metab"},{"key":"2019041121213837800_R12","first-page":"336","article-title":"Congenital secondary hypothyroidism caused by exon skipping due to a homozygous donor splice site mutation in the TSH\u03b2-subunit gene.","volume":"87","author":"Pohlenz","year":"2002","journal-title":"J Clin Endocrinol Metab"},{"key":"2019041121213837800_R13","doi-asserted-by":"crossref","first-page":"1250","DOI":"10.1172\/JCI118540","article-title":"A circulating, biologically inactive thyrotropin caused by a mutation in the beta subunit gene.","volume":"97","author":"Medeiros-Neto","year":"1996","journal-title":"J Clin Invest"},{"key":"2019041121213837800_R14","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1126\/science.257.5073.1115","article-title":"A mutation in the POU-homeodomain of Pit-1 responsible for combined pituitary hormone deficiency.","volume":"257","author":"Radovick","year":"1992","journal-title":"Science"},{"key":"2019041121213837800_R15","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1038\/ng0298-147","article-title":"Mutations in PROP1 cause familial combined pituitary hormone deficiency.","volume":"18","author":"Wu","year":"1998","journal-title":"Nat Genet"},{"key":"2019041121213837800_R16","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1038\/76041","article-title":"Mutations in LHX3 result in a new syndrome revealed by combined pituitary hormone deficiency.","volume":"25","author":"Netchine","year":"2000","journal-title":"Nat Genet"},{"key":"2019041121213837800_R17","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1038\/477","article-title":"Mutations in the homeobox gene HESX1\/Hesx1 associated with septo-optic dysplasia in human and mouse.","volume":"19","author":"Dattani","year":"1998","journal-title":"Nat Genet"},{"key":"2019041121213837800_R18","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1093\/hmg\/10.1.39","article-title":"Heterozygous HESX1 mutations associated with isolated congenital pituitary hypoplasia and septo-optic dysplasia.","volume":"10","author":"Thomas","year":"2001","journal-title":"Hum Mol Genet"},{"key":"2019041121213837800_R19","first-page":"3727","article-title":"Phenotypic variability in familial combined pituitary hormone deficiency caused by a PROP1 gene mutation resulting in the substitution of Arg\u2013>Cys at codon 120 (R120C).","volume":"83","author":"Flu\u0308ck","year":"1998","journal-title":"J Clin Endocrinol Metab"},{"key":"2019041121213837800_R20","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1038\/ng0598-83","article-title":"PAX8 mutations associated with congenital hypothyroidism caused by thyroid agenesis.","volume":"19","author":"Macchia","year":"1998","journal-title":"Nat Genet"},{"key":"2019041121213837800_R21","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1038\/ng0598-87","article-title":"Follicular cells of the thyroid gland require Pax8 gene function.","volume":"19","author":"Mansouri","year":"1998","journal-title":"Nat Genet"},{"key":"2019041121213837800_R22","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1038\/1294","article-title":"Mutation of the gene encoding human TTF-2 associated with thyroid agenesis, cleft palate and choanal atresia.","volume":"19","author":"Clifton-Bligh","year":"1998","journal-title":"Nat Genet"},{"key":"2019041121213837800_R23","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1038\/1289","article-title":"A mouse model for hereditary thyroid dysgenesis and cleft palate.","volume":"19","author":"De Felice","year":"1998","journal-title":"Nat Genet"},{"key":"2019041121213837800_R24","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/0167-4781(94)90176-7","article-title":"Thyroid-specific gene expression.","volume":"1218","author":"Damante","year":"1994","journal-title":"Biochim Biophys Acta"},{"key":"2019041121213837800_R25","first-page":"234","article-title":"Autosomal dominant transmission of congenital thyroid hypoplasia due to loss-of-function mutation of PAX8.","volume":"86","author":"Vilain","year":"2001","journal-title":"J Clin Endocrinol Metab"},{"key":"2019041121213837800_R26","doi-asserted-by":"crossref","first-page":"3962","DOI":"10.1210\/jcem.86.8.7765","article-title":"A novel mutation (Q40P) in PAX8 associated with congenital hypothyroidism and thyroid hypoplasia: evidence for phenotypic variability in mother and child.","volume":"86","author":"Congdon","year":"2001","journal-title":"J Clin Endocrinol Metab"},{"key":"2019041121213837800_R27","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1136\/jmg.26.1.49","article-title":"Congenital hypothyroidism, spiky hair, and cleft palate.","volume":"26","author":"Bamforth","year":"1989","journal-title":"J Med Genet"},{"key":"2019041121213837800_R28","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1093\/emboj\/16.11.3185","article-title":"TTF-2, a new forkhead protein, shows a temporal expression in the developing thyroid which is consistent with a role in controlling the onset of differentiation.","volume":"16","author":"Zannini","year":"1997","journal-title":"EMBO J"},{"key":"2019041121213837800_R29","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1101\/gad.10.1.60","article-title":"The T\/ebp null mouse: thyroid-specific enhancer-binding protein is essential for the organogenesis of the thyroid, lung, ventral forebrain, and pituitary.","volume":"10","author":"Kimura","year":"1996","journal-title":"Genes Dev"},{"key":"2019041121213837800_R30","doi-asserted-by":"crossref","first-page":"1317","DOI":"10.1056\/NEJM199804303381817","article-title":"Deletion of thyroid transcription factor-1 gene in an infant with neonatal thyroid dysfunction and respiratory failure.","volume":"338","author":"Devriendt","year":"1998","journal-title":"N Engl J Med"},{"key":"2019041121213837800_R31","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1067\/mpd.2000.107111","article-title":"Deletion of NKX2.1 gene encoding thyroid transcription factor-1 in two siblings with hypothyroidism and respiratory failure.","volume":"137","author":"Iwatani","year":"2000","journal-title":"J Pediatr"},{"key":"2019041121213837800_R32","unstructured":"Pohlenz J, Dumitrescu A, Zundel D, Martine U, Schonberger W, Refetoff S, Hyperthyrotropinemia, respiratory distress and ataxia associated with a mutation in the thyroid transcription factor 1 (TTF-1) gene. Program of the 83rd Annual Meeting of The Endocrine Society, Denver, Colorado, 2001 (Abstract OR43-3)"},{"key":"2019041121213837800_R33","unstructured":"Schuetz BR, Krude H, Biebermann H, von Moers A, Schnabel D, Toennies H, Schwarz S, Neitzel H, Grueters A, Loss of fuction mutations in the NKX2\u20131 gene define a new syndrome with CNS, thyroid and lung impairment. Program of the 83rd Annual Meeting of The Endocrine Society, Denver, Colorado, 2001 (Abstract OR59-3)"},{"key":"2019041121213837800_R34","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1056\/NEJM199501193320305","article-title":"Resistance to thyrotropin caused by mutations in the thyrotropin-receptor gene.","volume":"332","author":"Sunthornthepvarakul","year":"1995","journal-title":"N Engl J Med"},{"key":"2019041121213837800_R35","doi-asserted-by":"crossref","first-page":"3018","DOI":"10.1172\/JCI119497","article-title":"Familial congenital hypotyroidism due to inactivating mutation of the thyrotropin receptor causing profound hypoplasia of the thyroid gland.","volume":"99","author":"Abramowicz","year":"1997","journal-title":"J Clin Invest"},{"key":"2019041121213837800_R36","first-page":"97","article-title":"Resistance to thyrotropin and other abnormabilities of the thyrotropin receptor.","volume":"51","author":"Refetoff","year":"1996","journal-title":"Recent Prog Hormone Res"},{"key":"2019041121213837800_R37","doi-asserted-by":"crossref","first-page":"1301","DOI":"10.1007\/PL00000941","article-title":"The TSH receptor and its role in thyroid disease.","volume":"58","author":"Kopp","year":"2001","journal-title":"Cell Mol Life Sci"},{"key":"2019041121213837800_R38","first-page":"129","article-title":"Identification of a point mutation in the thyrotropin receptor of the hyt\/hyt hypothyroid mouse.","volume":"8","author":"Stein","year":"1994","journal-title":"Mol Endocrinol"},{"key":"2019041121213837800_R39","first-page":"675","article-title":"Endocrine manifestations of stimulatory G protein \u03b1-subunit mutations and the role of genomic imprinting.","volume":"22","author":"Weinstein","year":"2001","journal-title":"Endocr Rev"},{"key":"2019041121213837800_R40","first-page":"3933","article-title":"Resistance to thyrotropin (TSH) in three families is not associated with mutations in the TSH receptor or TSH.","volume":"82","author":"Xie","year":"1997","journal-title":"J Clin Endocrinol Metab"},{"key":"2019041121213837800_R41","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1038\/379458a0","article-title":"Cloning and characterization of the thyroid iodide transporter.","volume":"379","author":"Dai","year":"1996","journal-title":"Nature"},{"key":"2019041121213837800_R42","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1006\/bbrc.1996.1358","article-title":"Cloning of the human sodium iodide symporter.","volume":"226","author":"Smanik","year":"1996","journal-title":"Biochem Biophys Res Commun"},{"key":"2019041121213837800_R43","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1152\/physrev.2000.80.3.1083","article-title":"Molecular analysis of the sodium\/iodide symporter: impact on thyroid and extrathyroid pathophysiology.","volume":"80","author":"De la Vieja","year":"2000","journal-title":"Physiol Rev"},{"key":"2019041121213837800_R44","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1038\/ng1297-411","article-title":"Pendred syndrome is caused by mutations in a putative sulphate transporter gene (PDS).","volume":"17","author":"Everett","year":"1997","journal-title":"Nat Genet"},{"key":"2019041121213837800_R45","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1210\/endo.141.2.7303","article-title":"Pendrin, the protein encoded by the Pendred syndrome gene (PDS), is an apical porter of iodide in the thyroid and is regulated by thyroglobulin in FRTL-5 cells.","volume":"141","author":"Royaux","year":"2000","journal-title":"Endocrinology"},{"key":"2019041121213837800_R46","unstructured":"Gillam M, Karamanoglu Arseven O, Rutishauser J, Waeber Stephan C, Kopp P, Functional characterization of pendrin and two naturally occurring mutants: evidence for pendrin-mediated iodide efflux. Proc 73rd Annual Meeting of the American Thyroid Association, Washington DC, 2001 (Abstract 196), p 265"},{"key":"2019041121213837800_R47","first-page":"1","article-title":"Clinical and molecular analysis of three Mexican families with Pendred\u2019s syndrome.","volume":"144","author":"Gonzalez Trevino","year":"2001","journal-title":"Eur J Endocrinol"},{"key":"2019041121213837800_R48","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1046\/j.1365-2265.1996.714536.x","article-title":"Thyroid peroxidase: evidence for disease gene exclusion in Pendred\u2019s syndrome.","volume":"44","author":"Gausden","year":"1996","journal-title":"Clin Endocrinol"},{"key":"2019041121213837800_R49","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1093\/hmg\/10.2.153","article-title":"Targeted disruption of mouse Pds provides insight about the inner-ear defects encountered in Pendred syndrome.","volume":"10","author":"Everett","year":"2001","journal-title":"Hum Mol Genet"},{"key":"2019041121213837800_R50","doi-asserted-by":"crossref","first-page":"1200","DOI":"10.1172\/JCI115981","article-title":"Identification of a mutation in the coding sequence of the human thyroid peroxidase gene causing congenital goiter.","volume":"90","author":"Abramowicz","year":"1992","journal-title":"J Clin Invest"},{"key":"2019041121213837800_R51","first-page":"1061","article-title":"Two different mutations in the thyroid peroxidase gene of a large inbred Amish kindred: power and limits of homozygosity mapping.","volume":"84","author":"Pannain","year":"1999","journal-title":"J Clin Endocrinol Metab"},{"key":"2019041121213837800_R52","doi-asserted-by":"crossref","first-page":"3708","DOI":"10.1210\/jcem.85.10.6878","article-title":"Two decades of screening for congenital hypothyroidism in The Netherlands: TPO gene mutations in total iodide organification defects (an update).","volume":"85","author":"Bakker","year":"2000","journal-title":"J Clin Endocrinol Metab"},{"key":"2019041121213837800_R53","doi-asserted-by":"crossref","first-page":"37265","DOI":"10.1074\/jbc.274.52.37265","article-title":"Purification of a novel flavoprotein involved in the thyroid NADPH oxidase. Cloning of the porcine and human cDNAs.","volume":"274","author":"Dupuy","year":"1999","journal-title":"J Biol Chem"},{"key":"2019041121213837800_R54","doi-asserted-by":"crossref","first-page":"23227","DOI":"10.1074\/jbc.M000916200","article-title":"Cloning of two human thyroid cDNAs encoding new members of the NADPH oxidase family.","volume":"275","author":"De Deken","year":"2000","journal-title":"J Biol Chem"},{"key":"2019041121213837800_R55","unstructured":"Moreno JC, Bikker H, de Randamie J, Wiedijk BM, van Trotsenburg P, Kempers MJ, Vulsma T, de Vijlder JJM, Ris-Stalpers C 2000 Mutations in the ThOX2 gene in patients with congenital hypothyroidism due to iodide organification defects. Endocr J 47(Suppl):107 (Abstract 008)"},{"key":"2019041121213837800_R56","doi-asserted-by":"crossref","first-page":"4843","DOI":"10.1210\/jcem.86.10.7934","article-title":"Goiter and hypothyroidism in two siblings due to impaired Ca+2\/NAD(P)H-dependent H2O2-generating activity.","volume":"86","author":"Figueiredo","year":"2001","journal-title":"J Clin Endocrinol Metab"},{"key":"2019041121213837800_R57","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1530\/eje.0.1450485","article-title":"Genomic organization of the human thyroglobulin gene: the complete intron-exon structure.","volume":"145","author":"Mendive","year":"2001","journal-title":"Eur J Endocrinol"},{"key":"2019041121213837800_R58","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1677\/joe.0.1700307","article-title":"Up to date with human thyroglobulin.","volume":"170","author":"Graaf","year":"2001","journal-title":"J Endocrinol"},{"key":"2019041121213837800_R59","first-page":"165","article-title":"Defective thyroglobulin synthesis and secretion causing goiter and hypothyroidism.","volume":"14","author":"Medeiros-Neto","year":"1993","journal-title":"Endocr Rev"},{"key":"2019041121213837800_R60","first-page":"36","article-title":"Autosomal dominant inheritance of a thyroglobulin abnormality suggests cooperation of subunits in hormone formation.","volume":"44","author":"De Vijlder","year":"1983","journal-title":"Ann Endocrinol"},{"key":"2019041121213837800_R61","first-page":"173","article-title":"Endocrinopathies in the family of endoplasmic reticulum (ER) storage diseases: disorders of protein trafficking and the role of ER molecular chaperones.","volume":"19","author":"Kim","year":"1998","journal-title":"Endocr Rev"},{"key":"2019041121213837800_R62","doi-asserted-by":"crossref","first-page":"4050","DOI":"10.1210\/endo.141.11.7794","article-title":"A novel missense mutation (G2320R) in thyroglobulin causes hypothyroidism in rdw rats.","volume":"141","author":"Hishinuma","year":"2000","journal-title":"Endocrinology"},{"key":"2019041121213837800_R63","doi-asserted-by":"crossref","first-page":"1944","DOI":"10.1210\/mend.14.12.0571","article-title":"A missense mutation G2320R in the thyroglobulin gene causes non-goitrous congenital primary hypothyroidism in the WIC-rdw rat.","volume":"14","author":"Kim","year":"2000","journal-title":"Mol Endocrinol"},{"key":"2019041121213837800_R64","first-page":"139","author":"Medeiros-Neto","year":"1994"},{"key":"2019041121213837800_R65","first-page":"348","article-title":"The syndromes of resistance to thyroid hormone.","volume":"14","author":"Refetoff","year":"1993","journal-title":"Endocr Rev"},{"key":"2019041121213837800_R66","doi-asserted-by":"crossref","unstructured":"Weiss RE, Refetoff S 2000 Resistance to thyroid hormone. Rev Endocr Metab Disord 1(1\u20132):97\u2013108","DOI":"10.1023\/A:1010072605757"},{"key":"2019041121213837800_R67","doi-asserted-by":"crossref","first-page":"572","DOI":"10.7326\/0003-4819-123-8-199510150-00002","article-title":"Genetic and clinical features of 42 kindreds with resistance to thyroid hormone.","volume":"123","author":"Brucker-Davis","year":"1995","journal-title":"Ann Int Med"},{"key":"2019041121213837800_R68","first-page":"49","article-title":"Recessive inheritance of thyroid hormone resistance caused by complete deletion of the protein-coding region of the thyroid hormone receptor-\u03b2 gene.","volume":"74","author":"Takeda","year":"1992","journal-title":"J Clin Endocrinol Metab"},{"key":"2019041121213837800_R69","first-page":"4196","article-title":"Dominant inheritance of resistance to thyroid hormone not linked to defects in the thyroid hormone receptor \u03b1 or \u03b2 genes may be due to a defective co-factor.","volume":"81","author":"Weiss","year":"1996","journal-title":"J Clin Endocrinol Metab"},{"key":"2019041121213837800_R70","first-page":"3919","article-title":"Five new families with resistance to thyroid hormone not caused by mutations in the thyroid hormone receptor \u03b2 gene.","volume":"84","author":"Pohlenz","year":"1999","journal-title":"J Clin Endocrinol Metab"},{"key":"2019041121213837800_R71","doi-asserted-by":"crossref","first-page":"2245","DOI":"10.1001\/jama.1990.03450170093029","article-title":"Neonatal detection of generalized resistance to thyroid hormone.","volume":"264","author":"Weiss","year":"1990","journal-title":"JAMA"},{"key":"2019041121213837800_R72","first-page":"1","article-title":"Management of patients with resistance to thyroid hormone.","volume":"12","author":"Weiss","year":"1999","journal-title":"Thyroid Today"}],"container-title":["Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/endo\/article-pdf\/143\/6\/2019\/10367350\/endo2019.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,4,12]],"date-time":"2019-04-12T08:50:34Z","timestamp":1555059034000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/endo\/article\/143\/6\/2019\/2989288"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,6,1]]},"references-count":72,"aliases":["10.1210\/en.143.6.2019"],"journal-issue":{"issue":"6","published-print":{"date-parts":[[2002,6,1]]}},"URL":"https:\/\/doi.org\/10.1210\/endo.143.6.8864","relation":{},"ISSN":["0013-7227","1945-7170"],"issn-type":[{"value":"0013-7227","type":"print"},{"value":"1945-7170","type":"electronic"}],"subject":[],"published":{"date-parts":[[2002,6,1]]}}}