{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,27]],"date-time":"2025-12-27T21:10:39Z","timestamp":1766869839603,"version":"3.41.2"},"reference-count":54,"publisher":"The Endocrine Society","issue":"8","license":[{"start":{"date-parts":[[2020,6,4]],"date-time":"2020-06-04T00:00:00Z","timestamp":1591228800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["2018R1C1B5084422"],"award-info":[{"award-number":["2018R1C1B5084422"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003710","name":"Korea Health Industry Development Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003710","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003625","name":"Ministry of Health and Welfare","doi-asserted-by":"publisher","award":["HI14C3417"],"award-info":[{"award-number":["HI14C3417"]}],"id":[{"id":"10.13039\/501100003625","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,8,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Autoimmune thyroid disease (AITD) is predominant in females and has been focused on the sexual diploid in immune response. The IL-1 receptor-associated kinase 1 (IRAK1) gene on the X chromosome was recently suggested as strong autoimmune disease-susceptible loci, second to the major histocompatibility complex region. We investigated the frequency of IRAK1 single-nucleotide polymorphisms (SNPs) in children with AITD. In this study, we observed that SNPs of IRAK1 including rs3027898, rs1059703, and rs1059702 in 115 Korean AITD pediatric patients (Graves\u2019 disease = 74 [females = 52\/males = 22]; Hashimoto disease [HD] = 41 [females = 38\/males = 3]; thyroid-associated ophthalmopathy [TAO] = 40 (females = 27\/males = 13); without TAO = 75 (females = 63\/males = 12); total males = 25, total females = 90; mean age = 11.9 years) and 204 healthy Korean individuals (males = 104\/females = 100). The data from cases and controls were analyzed from separate sex-stratified or all combined by \u03c7\u200a2 test for categorical variables and Student t test for numerical variables. Our study revealed that SNPs of IRAK1-associated HD and without TAO but Graves\u2019 disease and TAO were not found significant. When cases and controls were analyzed by separate sex, we found that rs3027898 AA, rs1059703 AA, and rs1059702 GG showed disease susceptibility in female AITD, HD, and without TAO. Also, all rs3027898, rs1059703, and rs1059702 were found to be in strong linkage disequilibrium (D\u2032 = 0.96-0.98, r2 = 0.83\u20130.97). The haplotype of 3 SNPs was higher in AITD than in controls (CGA, r2 = 5.42, P = 0.019). Our results suggest that IRAK1 polymorphisms may contribute to the pathogenesis of HD, AITD, and without thyroid-associated ophthalmopathy for females.<\/jats:p>","DOI":"10.1210\/endocr\/bqaa088","type":"journal-article","created":{"date-parts":[[2020,6,5]],"date-time":"2020-06-05T05:47:02Z","timestamp":1591336022000},"source":"Crossref","is-referenced-by-count":11,"title":["Polymorphisms of IRAK1 Gene on X Chromosome Is Associated with Hashimoto Thyroiditis in Korean Children"],"prefix":"10.1210","volume":"161","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5797-4197","authenticated-orcid":false,"given":"Hye-Ri","family":"Shin","sequence":"first","affiliation":[{"name":"Catholic Hematopoietic Stem Cell Bank, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0918-0565","authenticated-orcid":false,"given":"Won Kyoung","family":"Cho","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, College of Medicine, St. Vincent\u2019s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"In-Cheol","family":"Baek","sequence":"additional","affiliation":[{"name":"Catholic Hematopoietic Stem Cell Bank, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Na Yeong","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, College of Medicine, St. Vincent\u2019s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoon Ji","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, College of Medicine, Seoul St. Mary\u2019s Hospital, The Catholic University of Korea, Seoul, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seul Ki","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, College of Medicine, Seoul St. Mary\u2019s Hospital, The Catholic University of Korea, Seoul, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Moon Bae","family":"Ahn","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, College of Medicine, Seoul St. Mary\u2019s Hospital, The Catholic University of Korea, Seoul, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Byung-Kyu","family":"Suh","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, College of Medicine, Seoul St. Mary\u2019s Hospital, The Catholic University of Korea, Seoul, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tai-Gyu","family":"Kim","sequence":"additional","affiliation":[{"name":"Catholic Hematopoietic Stem Cell Bank, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea"},{"name":"Department of Microbiology, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"80","published-online":{"date-parts":[[2020,6,4]]},"reference":[{"issue":"26","key":"2021121822271363800_CIT0001","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1556\/OH.2012.29370","article-title":"[The role of hereditary and environmental factors in autoimmune thyroid diseases]","volume":"153","author":"Bal\u00e1zs","year":"2012","journal-title":"Orv Hetil."},{"issue":"9","key":"2021121822271363800_CIT0002","doi-asserted-by":"crossref","first-page":"2496","DOI":"10.1038\/bjc.2013.597","article-title":"Cancer risk in patients with Hashimoto\u2019s thyroiditis: a nationwide cohort study","volume":"109","author":"Chen","year":"2013","journal-title":"Br J Cancer."},{"key":"2021121822271363800_CIT0003","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.jprot.2017.09.001","article-title":"Thyroid-associated orbitopathy and tears: a proteomics study","volume":"170","author":"Kishazi","year":"2018","journal-title":"J Proteomics."},{"issue":"4","key":"2021121822271363800_CIT0004","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/j.jaapos.2017.12.002","article-title":"Management of graves myopathy: thyroid-associated orbitopathy: when should we operate?","volume":"22","author":"Seiff","year":"2018","journal-title":"J Aapos."},{"issue":"1","key":"2021121822271363800_CIT0005","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1111\/cei.12395","article-title":"Thyroid-associated orbitopathy is linked to gastrointestinal autoimmunity","volume":"178","author":"Ponto","year":"2014","journal-title":"Clin Exp Immunol."},{"issue":"7","key":"2021121822271363800_CIT0006","doi-asserted-by":"crossref","first-page":"820","DOI":"10.1093\/ecco-jcc\/jjx023","article-title":"X chromosome-wide association study identifies a susceptibility locus for inflammatory bowel disease in Koreans","volume":"11","author":"Lee","year":"2017","journal-title":"J Crohns Colitis."},{"issue":"9","key":"2021121822271363800_CIT0007","doi-asserted-by":"crossref","first-page":"1018","DOI":"10.1038\/nm.3933","article-title":"Meta-analysis of shared genetic architecture across ten pediatric autoimmune diseases","volume":"21","author":"Li","year":"2015","journal-title":"Nat Med."},{"issue":"10-11","key":"2021121822271363800_CIT0008","doi-asserted-by":"crossref","first-page":"3260","DOI":"10.1177\/0962280218799532","article-title":"A robust and powerful test for case-control genetic association study on X chromosome","volume":"28","author":"Wang","year":"2019","journal-title":"Stat Methods Med Res."},{"issue":"4","key":"2021121822271363800_CIT0009","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1097\/SHK.0000000000000764","article-title":"Trauma-induced acute X chromosome skewing in white blood cells represents an immuno-modulatory mechanism unique to females and a likely contributor to sex-based outcome differences","volume":"47","author":"Pena","year":"2017","journal-title":"Shock."},{"issue":"15","key":"2021121822271363800_CIT0010","doi-asserted-by":"crossref","first-page":"6256","DOI":"10.1073\/pnas.0901181106","article-title":"Identification of IRAK1 as a risk gene with critical role in the pathogenesis of systemic lupus erythematosus","volume":"106","author":"Jacob","year":"2009","journal-title":"Proc Natl Acad Sci U S A."},{"issue":"3","key":"2021121822271363800_CIT0011","doi-asserted-by":"crossref","first-page":"335","DOI":"10.3892\/br.2017.855","article-title":"Association between interleukin-1 receptor associated kinase 1 rs3027898 A\/C gene polymorphism and rheumatoid arthritis","volume":"6","author":"Atabaki","year":"2017","journal-title":"Biomed Rep."},{"issue":"8","key":"2021121822271363800_CIT0012","doi-asserted-by":"crossref","first-page":"1303","DOI":"10.1007\/s00296-017-3722-5","article-title":"The status of pulmonary fibrosis in systemic sclerosis is associated with IRF5, STAT4, IRAK1, and CTGF polymorphisms","volume":"37","author":"Zhao","year":"2017","journal-title":"Rheumatol Int."},{"issue":"3","key":"2021121822271363800_CIT0013","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1136\/annrheumdis-2012-201851","article-title":"Fine mapping of Xq28: both MECP2 and IRAK1 contribute to risk for systemic lupus erythematosus in multiple ancestral groups","volume":"72","author":"Kaufman","year":"2013","journal-title":"Ann Rheum Dis."},{"issue":"11","key":"2021121822271363800_CIT0014","doi-asserted-by":"crossref","DOI":"10.3390\/ijms17111852","article-title":"X-Linked miRNAs associated with gender differences in rheumatoid arthritis","volume":"17","author":"Khalifa","year":"2016","journal-title":"Int J Mol Sci"},{"issue":"2","key":"2021121822271363800_CIT0015","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1002\/ajmg.a.33198","article-title":"Four unrelated patients with Lubs X-linked mental retardation syndrome and different Xq28 duplications","volume":"152A","author":"Bartsch","year":"2010","journal-title":"Am J Med Genet A."},{"key":"2021121822271363800_CIT0016","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1016\/j.mce.2014.10.013","article-title":"Variants in IRAK1-MECP2 region confer susceptibility to autoimmune thyroid diseases","volume":"399","author":"Song","year":"2015","journal-title":"Mol Cell Endocrinol."},{"issue":"6","key":"2021121822271363800_CIT0017","doi-asserted-by":"crossref","first-page":"614","DOI":"10.3855\/jidc.6776","article-title":"Susceptibility of autoimmune diseases in three polymorphisms of infection-associated gene IRAK1","volume":"9","author":"Li","year":"2015","journal-title":"J Infect Dev Ctries."},{"issue":"8","key":"2021121822271363800_CIT0018","doi-asserted-by":"crossref","DOI":"10.3390\/ijms17081369","article-title":"TNFSF4 gene variations are related to early-onset autoimmune thyroid diseases and hypothyroidism of hashimoto\u2019s thyroiditis","volume":"17","author":"Song","year":"2016","journal-title":"Int J Mol Sci"},{"issue":"1","key":"2021121822271363800_CIT0019","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1097\/CCO.0000000000000150","article-title":"Association of Hashimoto\u2019s thyroiditis and thyroid cancer","volume":"27","author":"Noureldine","year":"2015","journal-title":"Curr Opin Oncol."},{"key":"2021121822271363800_CIT0020"},{"key":"2021121822271363800_CIT0021"},{"key":"2021121822271363800_CIT0022"},{"issue":"1","key":"2021121822271363800_CIT0023","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1111\/cxo.12472","article-title":"Thyroid eye disease: a review","volume":"100","author":"Weiler","year":"2017","journal-title":"Clin Exp Optom."},{"key":"2021121822271363800_CIT0024","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.yexmp.2018.11.004","article-title":"Molecular biomarkers of Graves\u2019 ophthalmopathy","volume":"106","author":"Longo","year":"2019","journal-title":"Exp Mol Pathol."},{"issue":"5","key":"2021121822271363800_CIT0025","doi-asserted-by":"crossref","first-page":"e0216941","DOI":"10.1371\/journal.pone.0216941","article-title":"HLA alleles, especially amino-acid signatures of HLA-DPB1, might contribute to the molecular pathogenesis of early-onset autoimmune thyroid disease","volume":"14","author":"Shin","year":"2019","journal-title":"Plos One."},{"issue":"6","key":"2021121822271363800_CIT0026","doi-asserted-by":"crossref","first-page":"e37","DOI":"10.1093\/nar\/gku1341","article-title":"Insight into biases and sequencing errors for amplicon sequencing with the Illumina MiSeq platform","volume":"43","author":"Schirmer","year":"2015","journal-title":"Nucleic Acids Res."},{"issue":"17","key":"2021121822271363800_CIT0027","doi-asserted-by":"crossref","first-page":"5112","DOI":"10.1128\/AEM.01043-13","article-title":"Development of a dual-index sequencing strategy and curation pipeline for analyzing amplicon sequence data on the MiSeq Illumina sequencing platform","volume":"79","author":"Kozich","year":"2013","journal-title":"Appl Environ Microbiol."},{"key":"2021121822271363800_CIT0028","doi-asserted-by":"crossref","first-page":"e7786","DOI":"10.7717\/peerj.7786","article-title":"Adapterama II: universal amplicon sequencing on Illumina platforms (TaggiMatrix)","volume":"7","author":"Glenn","year":"2019","journal-title":"Peerj."},{"key":"2021121822271363800_CIT0029","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.fsigen.2017.01.011","article-title":"Developmental validation of the MiSeq FGx forensic genomics system for targeted next generation sequencing in forensic DNA casework and database laboratories","volume":"28","author":"J\u00e4ger","year":"2017","journal-title":"Forensic Sci Int Genet."},{"issue":"8","key":"2021121822271363800_CIT0030","doi-asserted-by":"crossref","first-page":"e105592","DOI":"10.1371\/journal.pone.0105592","article-title":"Development of a prokaryotic universal primer for simultaneous analysis of bacteria and Archaea using next-generation sequencing","volume":"9","author":"Takahashi","year":"2014","journal-title":"Plos One."},{"key":"2021121822271363800_CIT0031","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1007\/978-1-4939-7471-9_12","article-title":"MiSeq: a next generation sequencing platform for genomic analysis","volume":"1706","author":"Ravi","year":"2018","journal-title":"Methods Mol Biol."},{"issue":"7","key":"2021121822271363800_CIT0032","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1002\/humu.22332","article-title":"Targeted next-generation sequencing can replace Sanger sequencing in clinical diagnostics","volume":"34","author":"Sikkema-Raddatz","year":"2013","journal-title":"Hum Mutat."},{"issue":"1","key":"2021121822271363800_CIT0033","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1038\/nbt.1754","article-title":"Integrative genomics viewer","volume":"29","author":"Robinson","year":"2011","journal-title":"Nat Biotechnol."},{"issue":"10","key":"2021121822271363800_CIT0034","doi-asserted-by":"crossref","first-page":"1577","DOI":"10.1093\/bioinformatics\/btv024","article-title":"Ultrafast SNP analysis using the Burrows-Wheeler transform of short-read data","volume":"31","author":"Kimura","year":"2015","journal-title":"Bioinformatics."},{"issue":"2","key":"2021121822271363800_CIT0035","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1186\/gb4161","article-title":"Dissemination of scientific software with Galaxy ToolShed","volume":"15","author":"Blankenberg","year":"2014","journal-title":"Genome Biol."},{"issue":"6","key":"2021121822271363800_CIT0036","doi-asserted-by":"crossref","first-page":"e183567","DOI":"10.1001\/jamanetworkopen.2018.3567","article-title":"Risk of thyroxine-treated autoimmune thyroid disease associated with disease onset in patients with rheumatoid arthritis","volume":"1","author":"Waldenlind","year":"2018","journal-title":"JAMA Netw Open."},{"issue":"1","key":"2021121822271363800_CIT0037","doi-asserted-by":"crossref","first-page":"7","DOI":"10.3340\/jkns.2012.52.1.7","article-title":"Association study of fibroblast growth factor 2 and fibroblast growth factor receptors gene polymorphism in korean ossification of the posterior longitudinal ligament patients","volume":"52","author":"Jun","year":"2012","journal-title":"J Korean Neurosurg Soc."},{"issue":"6","key":"2021121822271363800_CIT0038","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1038\/hdy.2016.20","article-title":"Testing for Hardy-Weinberg equilibrium at biallelic genetic markers on the X chromosome","volume":"116","author":"Graffelman","year":"2016","journal-title":"Heredity (Edinb)."},{"key":"2021121822271363800_CIT0039"},{"issue":"4","key":"2021121822271363800_CIT0040","doi-asserted-by":"crossref","first-page":"E514","DOI":"10.1073\/pnas.1620139114","article-title":"Inherited human IRAK-1 deficiency selectively impairs TLR signaling in fibroblasts","volume":"114","author":"Della Mina","year":"2017","journal-title":"Proc Natl Acad Sci U S A."},{"issue":"70","key":"2021121822271363800_CIT0041","doi-asserted-by":"crossref","first-page":"33416","DOI":"10.18632\/oncotarget.26058","article-title":"Inhibition of interleukin-1 receptor-associated kinase 1 (IRAK1) as a therapeutic strategy","volume":"9","author":"Singer","year":"2018","journal-title":"Oncotarget."},{"issue":"7","key":"2021121822271363800_CIT0042","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1038\/s10038-019-0613-5","article-title":"IRAK2 and TLR10 confer risk of Hashimoto\u2019s disease: a genetic association study based on the Han Chinese population","volume":"64","author":"Li","year":"2019","journal-title":"J Hum Genet."},{"issue":"5","key":"2021121822271363800_CIT0043","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1080\/08820139.2018.1458105","article-title":"Upregulated IL-1 receptor-associated kinase 1 (IRAK1) in systemic lupus erythematosus: IRAK1 inhibition represses Th17 differentiation with therapeutic potential","volume":"47","author":"Zhou","year":"2018","journal-title":"Immunol Invest."},{"key":"2021121822271363800_CIT0044","doi-asserted-by":"crossref","first-page":"2304218","DOI":"10.1155\/2017\/2304218","article-title":"Association of polymorphisms in toll-like receptors 4 and 9 with autoimmune thyroid disease in Korean pediatric patients","volume":"2017","author":"Cho","year":"2017","journal-title":"Int J Endocrinol."},{"issue":"2","key":"2021121822271363800_CIT0045","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1159\/000360149","article-title":"Gender-specific effects on immune response and cardiac function after trauma hemorrhage and sepsis","volume":"30","author":"Albertsmeier","year":"2014","journal-title":"Viszeralmedizin."},{"issue":"1","key":"2021121822271363800_CIT0046","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1186\/2042-6410-5-3","article-title":"Influence of sex differences on microRNA gene regulation in disease","volume":"5","author":"Sharma","year":"2014","journal-title":"Biol Sex Differ."},{"issue":"13","key":"2021121822271363800_CIT0047","doi-asserted-by":"crossref","first-page":"e100","DOI":"10.1182\/blood-2011-11-390351","article-title":"Methylation of AR locus does not always reflect X chromosome inactivation state","volume":"119","author":"Swierczek","year":"2012","journal-title":"Blood."},{"issue":"12","key":"2021121822271363800_CIT0048","doi-asserted-by":"crossref","first-page":"e113036","DOI":"10.1371\/journal.pone.0113036","article-title":"Characterization of X chromosome inactivation using integrated analysis of whole-exome and mRNA sequencing","volume":"9","author":"Szelinger","year":"2014","journal-title":"Plos One."},{"issue":"4","key":"2021121822271363800_CIT0049","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1007\/s12041-015-0574-1","article-title":"X-chromosome inactivation and escape","volume":"94","author":"Disteche","year":"2015","journal-title":"J Genet."},{"issue":"1","key":"2021121822271363800_CIT0050","doi-asserted-by":"crossref","first-page":"6868","DOI":"10.1038\/s41598-019-43376-3","article-title":"rs2267531, a promoter SNP within glypican-3 gene in the X chromosome, is associated with hepatocellular carcinoma in Egyptians","volume":"9","author":"Motawi","year":"2019","journal-title":"Sci Rep."},{"issue":"2","key":"2021121822271363800_CIT0051","doi-asserted-by":"crossref","first-page":"e0212344","DOI":"10.1371\/journal.pone.0212344","article-title":"Testing for goodness rather than lack of fit of an X-chromosomal SNP to the Hardy-Weinberg model","volume":"14","author":"Wellek","year":"2019","journal-title":"Plos One."},{"issue":"2","key":"2021121822271363800_CIT0052","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1089\/thy.2014.0135","article-title":"Association of Toll-like receptor 10 polymorphisms with autoimmune thyroid disease in Korean children","volume":"25","author":"Cho","year":"2015","journal-title":"Thyroid."},{"issue":"7","key":"2021121822271363800_CIT0053","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1007\/s00393-014-1493-x","article-title":"The association between susceptibility to inflammatory arthritis and miR-146a, miR-499 and IRAK1 polymorphisms. A meta-analysis","volume":"74","author":"Song","year":"2015","journal-title":"Z Rheumatol."},{"issue":"9","key":"2021121822271363800_CIT0054","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1007\/s00011-019-01263-7","article-title":"Common variants of genes encoding TLR4 and TLR4 pathway members TIRAP and IRAK1 are effective on MCP1, IL6, IL1\u03b2, and TNF\u03b1 levels in type 2 diabetes and insulin resistance","volume":"68","author":"Degirmenci","year":"2019","journal-title":"Inflamm Res."}],"container-title":["Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/endo\/advance-article-pdf\/doi\/10.1210\/endocr\/bqaa088\/33345855\/bqaa088.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/endo\/article-pdf\/161\/8\/bqaa088\/41815188\/endo_161_8_bqaa088.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/endo\/article-pdf\/161\/8\/bqaa088\/41815188\/endo_161_8_bqaa088.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,18]],"date-time":"2021-12-18T22:27:43Z","timestamp":1639866463000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/endo\/article\/doi\/10.1210\/endocr\/bqaa088\/5851529"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,6,4]]},"references-count":54,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2020,8,1]]}},"URL":"https:\/\/doi.org\/10.1210\/endocr\/bqaa088","relation":{},"ISSN":["0013-7227","1945-7170"],"issn-type":[{"type":"print","value":"0013-7227"},{"type":"electronic","value":"1945-7170"}],"subject":[],"published-other":{"date-parts":[[2020,8]]},"published":{"date-parts":[[2020,6,4]]},"article-number":"bqaa088"}}