{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T10:45:34Z","timestamp":1788864334286,"version":"build-2803163510"},"reference-count":41,"publisher":"The Endocrine Society","issue":"10","license":[{"start":{"date-parts":[[2020,8,18]],"date-time":"2020-08-18T00:00:00Z","timestamp":1597708800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"Connecticut Stem Cell Research Fund","award":["12-SCA-YALE-23"],"award-info":[{"award-number":["12-SCA-YALE-23"]}]},{"name":"Connecticut Regenerative Medicine Research Fund","award":["15-RMB-YALE-18"],"award-info":[{"award-number":["15-RMB-YALE-18"]}]},{"name":"Women\u2019s Health Research"},{"name":"CHOP Research Institute"},{"name":"Aileen K. and Brian L. 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We have established a highly reproducible directed differentiation approach leading to PTH-expressing cells from human embryonic stem cells and induced pluripotent stem cells. We accomplished this through the comparison of multiple different basal media, the inclusion of the CDK inhibitor PD0332991 in both definitive endoderm and anterior foregut endoderm stages, and a 2-stage pharyngeal endoderm series. This is the first protocol to reproducibly establish PTH-expressing cells from human pluripotent stem cells and represents a first step toward the development of functional parathyroid cells with broad applicability for medicinal and scientific investigation.<\/jats:p>","DOI":"10.1210\/endocr\/bqaa141","type":"journal-article","created":{"date-parts":[[2020,8,18]],"date-time":"2020-08-18T20:46:08Z","timestamp":1597783568000},"source":"Crossref","is-referenced-by-count":21,"title":["Differentiation of PTH-Expressing Cells From Human Pluripotent Stem Cells"],"prefix":"10.1210","volume":"161","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3164-4605","authenticated-orcid":false,"given":"Betty R","family":"Lawton","sequence":"first","affiliation":[{"name":"Department of Laboratory Medicine, Yale Stem Cell Center, Yale University, New Haven, 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