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As in mammals, the inhibin-specific \u03b1 subunit (INHA\/Inha\/inha) has also been characterized in teleosts; however, its functions and physiological importance in fish reproduction remain unknown. Using CRISPR\/Cas9 method, we generated an inha-deficient zebrafish line and analyzed its reproductive performance. As expected, pituitary expression of fshb increased significantly in both the young and the adult inha mutant. The expression of lhb also increased in the mutant, but only in sexually mature adults. Interestingly, the expression of activin \u03b2A (inhbaa) increased significantly in both the ovary and the testis of inha mutant, and the expression of ovarian aromatase (cyp19a1a) also increased dramatically in the mutant ovary. The juvenile female mutant showed clear signs of early follicle activation or precocious puberty onset. However, the adult female mutant was infertile with follicles arrested at the full-grown stage without final oocyte maturation and ovulation. Although follicle growth was normal overall in the mutant, the size and distribution of yolk granules in oocytes were distinct and some follicles showed granulosa cell hypertrophy. In contrast to females, inha-null males showed normal spermatogenesis and fertility. As reported in mammals, we also found sporadic tumor formation in inha mutants. Taken together, our study not only confirmed some conserved roles of inhibin across vertebrates, such as inhibition of FSH biosynthesis and tumor formation, but also revealed novel aspects of inhibin functions such as disruption of folliculogenesis and female infertility but no obvious involvement in spermatogenesis in fish.<\/jats:p>","DOI":"10.1210\/endocr\/bqaa184","type":"journal-article","created":{"date-parts":[[2020,10,12]],"date-time":"2020-10-12T19:26:15Z","timestamp":1602530775000},"source":"Crossref","is-referenced-by-count":23,"title":["Loss of Inhibin Advances Follicle Activation and Female Puberty Onset but Blocks Oocyte Maturation in Zebrafish"],"prefix":"10.1210","volume":"161","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9838-0499","authenticated-orcid":false,"given":"Huijie","family":"Lu","sequence":"first","affiliation":[{"name":"Centre of Reproduction, Development and Aging (CRDA), Faculty of Health Sciences, University of Macau, Taipa, Macau, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cheng","family":"Zhao","sequence":"additional","affiliation":[{"name":"Centre of Reproduction, Development and Aging (CRDA), Faculty of Health Sciences, University of Macau, Taipa, Macau, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bo","family":"Zhu","sequence":"additional","affiliation":[{"name":"Centre of Reproduction, Development and Aging (CRDA), Faculty of Health Sciences, University of Macau, Taipa, Macau, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhiwei","family":"Zhang","sequence":"additional","affiliation":[{"name":"Centre of Reproduction, Development and Aging (CRDA), Faculty of Health Sciences, University of Macau, Taipa, Macau, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4296-1585","authenticated-orcid":false,"given":"Wei","family":"Ge","sequence":"additional","affiliation":[{"name":"Centre of Reproduction, Development and Aging (CRDA), Faculty of Health Sciences, University of Macau, Taipa, Macau, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"80","published-online":{"date-parts":[[2020,10,12]]},"reference":[{"issue":"1957","key":"2021121718174543100_CIT0001","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1126\/science.76.1957.19","article-title":"Dual endocrine activity of the testes","volume":"76","author":"McCullagh","year":"1932","journal-title":"Science."},{"issue":"21","key":"2021121718174543100_CIT0002","doi-asserted-by":"crossref","first-page":"7217","DOI":"10.1073\/pnas.82.21.7217","article-title":"Isolation and partial characterization of a Mr 32,000 protein with inhibin activity from porcine follicular fluid","volume":"82","author":"Ling","year":"1985","journal-title":"Proc Natl Acad Sci U S 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