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The effect of alternate promoter architecture on transcription bursting is not known. We studied the human prolactin (hPRL) gene that contains 2 promoters, a pituitary-specific promoter that requires the transcription factor Pit-1 and displays dramatic transcriptional bursting activity and an alternate upstream promoter that is active in nonpituitary tissues. We studied large hPRL genomic fragments with luciferase reporters, and used bacterial artificial chromosome recombineering to manipulate critical promoter regions. Stochastic switch mathematical modelling of single-cell time-lapse luminescence image data revealed that the Pit-1\u2013dependent promoter showed longer, higher-amplitude transcriptional bursts. Knockdown studies confirmed that the presence of Pit-1 stabilized and prolonged periods of active transcription. Pit-1 therefore plays an active role in establishing the timing of transcription cycles, in addition to its cell-specific functions.<\/jats:p>","DOI":"10.1210\/endocr\/bqaa249","type":"journal-article","created":{"date-parts":[[2021,1,3]],"date-time":"2021-01-03T11:20:09Z","timestamp":1609672809000},"source":"Crossref","is-referenced-by-count":7,"title":["Transcription Factor Pit-1 Affects Transcriptional Timing in the Dual-Promoter Human Prolactin Gene"],"prefix":"10.1210","volume":"162","author":[{"given":"Anne V","family":"McNamara","sequence":"first","affiliation":[{"name":"Systems Microscopy Centre, Division of Molecular and Cellular Function, School of Biological Sciences, Faculty Biology, Medicine & Health, Manchester Academic Health Sciences Centre, University of Manchester, Manchester, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raheela","family":"Awais","sequence":"additional","affiliation":[{"name":"School of Life Sciences, University of Liverpool, 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