{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T17:52:09Z","timestamp":1778262729014,"version":"3.51.4"},"reference-count":71,"publisher":"The Endocrine Society","issue":"5","license":[{"start":{"date-parts":[[2021,2,15]],"date-time":"2021-02-15T00:00:00Z","timestamp":1613347200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81673272"],"award-info":[{"award-number":["81673272"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81872712"],"award-info":[{"award-number":["81872712"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007129","name":"Natural Science Foundation of Shandong Province","doi-asserted-by":"publisher","award":["ZR2019ZD02"],"award-info":[{"award-number":["ZR2019ZD02"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Young Scholars Program of Shandong University","award":["2016WLJH23"],"award-info":[{"award-number":["2016WLJH23"]}]},{"name":"Training Project for Youth Teams of Science and Technology Innovation at Xuzhou Medical University","award":["TD202008"],"award-info":[{"award-number":["TD202008"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,5,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>The association between thyroid function and dyslipidemia has been well documented in observational studies. However, observational studies are prone to confounding, making it difficult to conduct causal inference. We performed a 2-sample bidirectional Mendelian randomization (MR) using summary statistics from large-scale genome-wide association studies of thyroid stimulating hormone (TSH), free T4 (FT4), and blood lipids. We chose the inverse variance\u2013weighted (IVW) method for the main analysis, and consolidated results through various sensitivity analyses involving 6 different MR methods under different model specifications. We further conducted genetic correlation analysis and colocalization analysis to deeply reflect the causality. The IVW method showed per 1 SD increase in normal TSH was significantly associated with a 0.048 SD increase in total cholesterol (TC; P\u2005&amp;lt;\u20050.001) and a 0.032 SD increase in low-density lipoprotein cholesterol (LDL; P\u2005=\u20050.021). A 1 SD increase in normal FT4 was significantly associated with a 0.056 SD decrease in TC (P\u2005=\u20050.014) and a 0.072 SD decrease in LDL (P\u2005=\u20050.009). Neither TSH nor FT4 showed causal associations with high-density lipoprotein cholesterol and triglycerides. No significant causal effect of blood lipids on normal TSH or FT4 can be detected. All results were largely consistent when using several alternative MR methods, and were reconfirmed by both genetic correlation analysis and colocalization analysis. Our study suggested that, even within reference range, higher TSH or lower FT4 are causally associated with increased TC and LDL, whereas no reverse causal association can be found.<\/jats:p>","DOI":"10.1210\/endocr\/bqab037","type":"journal-article","created":{"date-parts":[[2021,2,15]],"date-time":"2021-02-15T14:50:48Z","timestamp":1613400648000},"source":"Crossref","is-referenced-by-count":21,"title":["Mendelian Randomization Highlights the Causal Role of Normal Thyroid Function on Blood Lipid Profiles"],"prefix":"10.1210","volume":"162","author":[{"given":"Yanjun","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Biostatistics, School of Public Health, Cheeloo College of Medicine, Shandong University, Jinan 250012, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ping","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, School of Public Health, Cheeloo College of Medicine, Shandong University, Jinan 250012, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lu","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, School of Public Health, Cheeloo College of Medicine, Shandong University, Jinan 250012, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, School of Public Health, Cheeloo College of Medicine, Shandong University, Jinan 250012, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2710-3440","authenticated-orcid":false,"given":"Ping","family":"Zeng","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics, Xuzhou Medical University, Xuzhou 221004, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3527-4488","authenticated-orcid":false,"given":"Zhongshang","family":"Yuan","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, School of Public Health, Cheeloo College of Medicine, Shandong University, Jinan 250012, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"80","published-online":{"date-parts":[[2021,2,15]]},"reference":[{"issue":"11","key":"2021121713511968700_CIT0001","doi-asserted-by":"crossref","first-page":"ITC81","DOI":"10.7326\/AITC201712050","article-title":"Dyslipidemia","volume":"167","author":"Kopin","year":"2017","journal-title":"Ann Intern Med."},{"issue":"16","key":"2021121713511968700_CIT0002","doi-asserted-by":"crossref","first-page":"1557","DOI":"10.1056\/NEJMra1806939","article-title":"Lipid management for the prevention of atherosclerotic cardiovascular disease","volume":"381","author":"Michos","year":"2019","journal-title":"N Engl J Med."},{"issue":"1","key":"2021121713511968700_CIT0003","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1007\/s11154-016-9402-z","article-title":"Dyslipidemia in patients with chronic kidney disease","volume":"18","author":"Hager","year":"2017","journal-title":"Rev Endocr Metab Disord."},{"key":"2021121713511968700_CIT0004","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.atherosclerosis.2020.03.020","article-title":"Association of blood lipid profile with incident chronic kidney disease: a Mendelian randomization study","volume":"300","author":"Zhang","year":"2020","journal-title":"Atherosclerosis."},{"issue":"8","key":"2021121713511968700_CIT0005","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1016\/j.metabol.2016.05.003","article-title":"Non-alcoholic fatty liver disease and dyslipidemia: an update","volume":"65","author":"Katsiki","year":"2016","journal-title":"Metabolism."},{"issue":"1","key":"2021121713511968700_CIT0006","doi-asserted-by":"crossref","first-page":"3957","DOI":"10.1038\/s41467-018-06467-9","article-title":"A Mendelian randomization study of the effects of blood lipids on breast cancer risk","volume":"9","author":"Nowak","year":"2018","journal-title":"Nat Commun."},{"issue":"2","key":"2021121713511968700_CIT0007","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/j.mcna.2012.01.012","article-title":"The effect of thyroid disorders on lipid levels and metabolism","volume":"96","author":"Duntas","year":"2012","journal-title":"Med Clin North Am."},{"issue":"5","key":"2021121713511968700_CIT0008","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1089\/thy.2014.0219","article-title":"Subclinical hypothyroidism might worsen the effects of aging on serum lipid profiles: a population-based case-control study","volume":"25","author":"Zhao","year":"2015","journal-title":"Thyroid."},{"issue":"8","key":"2021121713511968700_CIT0009","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1089\/thy.2016.0010","article-title":"A worthy finding: decrease in total cholesterol and low-density lipoprotein cholesterol in treated mild subclinical hypothyroidism","volume":"26","author":"Zhao","year":"2016","journal-title":"Thyroid."},{"issue":"4","key":"2021121713511968700_CIT0010","doi-asserted-by":"crossref","first-page":"500","DOI":"10.14310\/horm.2002.1707","article-title":"Thyroid hormones: a potential ally to LDL-cholesterol-lowering agents","volume":"15","author":"Duntas","year":"2016","journal-title":"Hormones (Athens)."},{"issue":"10","key":"2021121713511968700_CIT0011","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1016\/j.tem.2014.07.001","article-title":"Thyroid hormone regulation of hepatic lipid and carbohydrate metabolism","volume":"25","author":"Sinha","year":"2014","journal-title":"Trends Endocrinol Metab."},{"issue":"8","key":"2021121713511968700_CIT0012","doi-asserted-by":"crossref","first-page":"2724","DOI":"10.1210\/jc.2012-1133","article-title":"Thyroid-stimulating hormone levels within the reference range are associated with serum lipid profiles independent of thyroid hormones","volume":"97","author":"Wang","year":"2012","journal-title":"J Clin Endocrinol Metab."},{"issue":"6","key":"2021121713511968700_CIT0013","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1055\/s-0043-110142","article-title":"The association between normal range TSH and lipid profile","volume":"49","author":"Ahi","year":"2017","journal-title":"Horm Metab Res."},{"issue":"6","key":"2021121713511968700_CIT0014","doi-asserted-by":"crossref","first-page":"874","DOI":"10.1111\/cen.12216","article-title":"A cross-sectional study of the association between circulating TSH level and lipid profile in a large Spanish population","volume":"79","author":"Santos-Palacios","year":"2013","journal-title":"Clin Endocrinol (Oxf)."},{"issue":"2","key":"2021121713511968700_CIT0015","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1210\/jc.2006-1718","article-title":"Thyroid function is associated with components of the metabolic syndrome in euthyroid subjects","volume":"92","author":"Roos","year":"2007","journal-title":"J Clin Endocrinol Metab."},{"issue":"11","key":"2021121713511968700_CIT0016","doi-asserted-by":"crossref","first-page":"1566","DOI":"10.1089\/thy.2014.0103","article-title":"Serum free thyroxine concentration is associated with metabolic syndrome in euthyroid subjects","volume":"24","author":"Mehran","year":"2014","journal-title":"Thyroid."},{"issue":"6","key":"2021121713511968700_CIT0017","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1056\/NEJMp1604635","article-title":"The emergence of the randomized, controlled trial","volume":"375","author":"Bothwell","year":"2016","journal-title":"N Engl J Med."},{"issue":"9977","key":"2021121713511968700_CIT0018","doi-asserted-by":"crossref","first-page":"1502","DOI":"10.1016\/S0140-6736(15)60742-5","article-title":"The history and fate of the gold standard","volume":"385","author":"Jones","year":"2015","journal-title":"Lancet."},{"key":"2021121713511968700_CIT0019","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1146\/annurev-publhealth-031811-124606","article-title":"Causal inference in public health","volume":"34","author":"Glass","year":"2013","journal-title":"Annu Rev Public Health."},{"issue":"6","key":"2021121713511968700_CIT0020","doi-asserted-by":"crossref","first-page":"1776","DOI":"10.1093\/ije\/dyv341","article-title":"Causality and causal inference in epidemiology: the need for a pluralistic approach","volume":"45","author":"Vandenbroucke","year":"2016","journal-title":"Int J Epidemiol."},{"issue":"19","key":"2021121713511968700_CIT0021","doi-asserted-by":"crossref","first-page":"1925","DOI":"10.1001\/jama.2017.17219","article-title":"Mendelian randomization","volume":"318","author":"Emdin","year":"2017","journal-title":"JAMA."},{"issue":"18","key":"2021121713511968700_CIT0022","doi-asserted-by":"crossref","first-page":"1400","DOI":"10.1136\/heartjnl-2016-310605","article-title":"Mendelian randomisation in cardiovascular research: an introduction for clinicians","volume":"103","author":"Bennett","year":"2017","journal-title":"Heart."},{"issue":"1","key":"2021121713511968700_CIT0023","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/ije\/dyg070","article-title":"\u2018Mendelian randomization\u2019: can genetic epidemiology contribute to understanding environmental determinants of disease?","volume":"32","author":"Smith","year":"2003","journal-title":"Int J Epidemiol."},{"issue":"9501","key":"2021121713511968700_CIT0024","doi-asserted-by":"crossref","first-page":"1906","DOI":"10.1016\/S0140-6736(05)67767-7","article-title":"Nature\u2019s randomised trials","volume":"366","author":"Hingorani","year":"2005","journal-title":"Lancet."},{"issue":"4","key":"2021121713511968700_CIT0025","doi-asserted-by":"crossref","first-page":"965","DOI":"10.3945\/ajcn.115.118216","article-title":"Best (but oft-forgotten) practices: the design, analysis, and interpretation of Mendelian randomization studies","volume":"103","author":"Haycock","year":"2016","journal-title":"Am J Clin Nutr."},{"issue":"9","key":"2021121713511968700_CIT0026","doi-asserted-by":"crossref","first-page":"1339","DOI":"10.1038\/s41588-019-0481-0","article-title":"A global overview of pleiotropy and genetic architecture in complex traits","volume":"51","author":"Watanabe","year":"2019","journal-title":"Nat Genet."},{"issue":"Database issue","key":"2021121713511968700_CIT0027","doi-asserted-by":"crossref","first-page":"D1001","DOI":"10.1093\/nar\/gkt1229","article-title":"The NHGRI GWAS Catalog, a curated resource of SNP-trait associations","volume":"42","author":"Welter","year":"2014","journal-title":"Nucleic Acids Res."},{"issue":"3","key":"2021121713511968700_CIT0028","doi-asserted-by":"crossref","first-page":"908","DOI":"10.1093\/ije\/dyw127","article-title":"Commentary: two-sample Mendelian randomization: opportunities and challenges","volume":"45","author":"Lawlor","year":"2016","journal-title":"Int J Epidemiol."},{"issue":"1","key":"2021121713511968700_CIT0029","doi-asserted-by":"crossref","first-page":"3861","DOI":"10.1038\/s41467-020-17668-6","article-title":"Testing and controlling for horizontal pleiotropy with probabilistic Mendelian randomization in transcriptome-wide association studies","volume":"11","author":"Yuan","year":"2020","journal-title":"Nat Commun."},{"issue":"7","key":"2021121713511968700_CIT0030","doi-asserted-by":"crossref","first-page":"1177","DOI":"10.1093\/aje\/kwt084","article-title":"Efficient design for Mendelian randomization studies: subsample and 2-sample instrumental variable estimators","volume":"178","author":"Pierce","year":"2013","journal-title":"Am J Epidemiol."},{"issue":"7","key":"2021121713511968700_CIT0031","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1002\/gepi.21758","article-title":"Mendelian randomization analysis with multiple genetic variants using summarized data","volume":"37","author":"Burgess","year":"2013","journal-title":"Genet Epidemiol."},{"issue":"3","key":"2021121713511968700_CIT0032","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1089\/thy.2019.0167","article-title":"Hypothyroidism and kidney function: a mendelian randomization study","volume":"30","author":"Ellervik","year":"2020","journal-title":"Thyroid."},{"issue":"2","key":"2021121713511968700_CIT0033","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1001\/jamacardio.2018.4635","article-title":"Assessment of the relationship between genetic determinants of thyroid function and atrial fibrillation: a mendelian randomization study","volume":"4","author":"Ellervik","year":"2019","journal-title":"JAMA Cardiol."},{"issue":"8","key":"2021121713511968700_CIT0034","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1210\/clinem\/dgaa239","article-title":"Thyroid function affects the risk of stroke via atrial fibrillation: a mendelian randomization study","volume":"105","author":"Marouli","year":"2020","journal-title":"J Clin Endocrinol Metab"},{"key":"2021121713511968700_CIT0035","article-title":"Variation in normal range thyroid function affects serum cholesterol levels, blood pressure, and type 2 diabetes risk: a mendelian randomization study","author":"Ku\u015b","year":"2020","journal-title":"Thyroid"},{"issue":"11","key":"2021121713511968700_CIT0036","doi-asserted-by":"crossref","first-page":"1514","DOI":"10.1038\/s41588-018-0222-9","article-title":"Genetics of blood lipids among ~300,000 multi-ethnic participants of the Million Veteran Program","volume":"50","author":"Klarin","year":"2018","journal-title":"Nat Genet."},{"issue":"1","key":"2021121713511968700_CIT0037","doi-asserted-by":"crossref","first-page":"4455","DOI":"10.1038\/s41467-018-06356-1","article-title":"Genome-wide analyses identify a role for SLC17A4 and AADAT in thyroid hormone regulation","volume":"9","author":"Teumer","year":"2018","journal-title":"Nat Commun."},{"key":"2021121713511968700_CIT0038","article-title":"Data from: Mendelian randomization highlights the causal role of normal thyroid function on blood lipid profiles","author":"Wang","year":"2020","journal-title":"figshare Digital Repository"},{"issue":"11","key":"2021121713511968700_CIT0039","doi-asserted-by":"crossref","first-page":"1274","DOI":"10.1038\/ng.2797","article-title":"Discovery and refinement of loci associated with lipid levels","volume":"45","author":"Willer","year":"2013","journal-title":"Nat Genet."},{"issue":"3","key":"2021121713511968700_CIT0040","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1086\/519795","article-title":"PLINK: a tool set for whole-genome association and population-based linkage analyses","volume":"81","author":"Purcell","year":"2007","journal-title":"Am J Hum Genet."},{"issue":"7422","key":"2021121713511968700_CIT0041","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1038\/nature11632","article-title":"An integrated map of genetic variation from 1,092 human genomes","volume":"491","author":"Abecasis","year":"2012","journal-title":"Nature"},{"issue":"4","key":"2021121713511968700_CIT0042","doi-asserted-by":"crossref","first-page":"e0120758","DOI":"10.1371\/journal.pone.0120758","article-title":"A multivariate genome-wide association analysis of 10 LDL subfractions, and their response to statin treatment, in 1868 Caucasians","volume":"10","author":"Shim","year":"2015","journal-title":"Plos One."},{"issue":"5","key":"2021121713511968700_CIT0043","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1038\/s41588-018-0099-7","article-title":"Detection of widespread horizontal pleiotropy in causal relationships inferred from Mendelian randomization between complex traits and diseases","volume":"50","author":"Verbanck","year":"2018","journal-title":"Nat Genet."},{"issue":"11","key":"2021121713511968700_CIT0044","doi-asserted-by":"crossref","first-page":"1783","DOI":"10.1002\/sim.7221","article-title":"A framework for the investigation of pleiotropy in two-sample summary data Mendelian randomization","volume":"36","author":"Bowden","year":"2017","journal-title":"Stat Med."},{"issue":"4","key":"2021121713511968700_CIT0045","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1002\/gepi.21965","article-title":"Consistent estimation in mendelian randomization with some invalid instruments using a weighted median estimator","volume":"40","author":"Bowden","year":"2016","journal-title":"Genet Epidemiol."},{"issue":"3","key":"2021121713511968700_CIT0046","doi-asserted-by":"crossref","first-page":"1742","DOI":"10.1214\/19-AOS1866","article-title":"Statistical inference in two-sample summary-data Mendelian randomization using robust adjusted profile score","volume":"48","author":"Zhao","year":"2020","journal-title":"Ann Stat"},{"issue":"4","key":"2021121713511968700_CIT0047","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1002\/gepi.22295","article-title":"A comparison of robust Mendelian randomization methods using summary data","volume":"44","author":"Slob","year":"2020","journal-title":"Genet Epidemiol."},{"issue":"2","key":"2021121713511968700_CIT0048","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1093\/ije\/dyv080","article-title":"Mendelian randomization with invalid instruments: effect estimation and bias detection through Egger regression","volume":"44","author":"Bowden","year":"2015","journal-title":"Int J Epidemiol."},{"issue":"10","key":"2021121713511968700_CIT0049","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1038\/s41576-019-0137-z","article-title":"Genetic correlations of polygenic disease traits: from theory to practice","volume":"20","author":"van Rheenen","year":"2019","journal-title":"Nat Rev Genet."},{"issue":"2","key":"2021121713511968700_CIT0050","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1007\/s40471-020-00233-6","article-title":"The use of genetic correlation and mendelian randomization studies to increase our understanding of relationships between complex traits","volume":"7","author":"Kraft","year":"2020","journal-title":"Curr Epidemiol Rep."},{"issue":"12","key":"2021121713511968700_CIT0051","doi-asserted-by":"crossref","first-page":"1728","DOI":"10.1038\/s41588-018-0255-0","article-title":"Distinguishing genetic correlation from causation across 52 diseases and complex traits","volume":"50","author":"O\u2019Connor","year":"2018","journal-title":"Nat Genet."},{"issue":"11","key":"2021121713511968700_CIT0052","doi-asserted-by":"crossref","first-page":"1236","DOI":"10.1038\/ng.3406","article-title":"An atlas of genetic correlations across human diseases and traits","volume":"47","author":"Bulik-Sullivan","year":"2015","journal-title":"Nat Genet."},{"issue":"1","key":"2021121713511968700_CIT0053","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1186\/s12916-019-1448-9","article-title":"Causal association of type 2 diabetes with amyotrophic lateral sclerosis: new evidence from Mendelian randomization using GWAS summary statistics","volume":"17","author":"Zeng","year":"2019","journal-title":"BMC Med."},{"issue":"5","key":"2021121713511968700_CIT0054","doi-asserted-by":"crossref","first-page":"e1004383","DOI":"10.1371\/journal.pgen.1004383","article-title":"Bayesian test for colocalisation between pairs of genetic association studies using summary statistics","volume":"10","author":"Giambartolomei","year":"2014","journal-title":"Plos Genet."},{"key":"2021121713511968700_CIT0055","first-page":"272","article-title":"Detecting potential pleiotropy across cardiovascular and neurological diseases using univariate, bivariate, and multivariate methods on 43,870 individuals from the eMERGE network","volume":"24","author":"Zhang","year":"2019","journal-title":"Pac Symp Biocomput."},{"key":"2021121713511968700_CIT0056","article-title":"An iterative approach to detect pleiotropy and perform mendelian randomization analysis using GWAS summary statistics","author":"Zhu","year":"2020","journal-title":"Bioinformatics"},{"issue":"4","key":"2021121713511968700_CIT0057","doi-asserted-by":"crossref","first-page":"1401","DOI":"10.1002\/hep.23800","article-title":"A novel role for thyroid-stimulating hormone: up-regulation of hepatic 3-hydroxy-3-methyl-glutaryl-coenzyme A reductase expression through the cyclic adenosine monophosphate\/protein kinase A\/cyclic adenosine monophosphate-responsive element binding protein pathway","volume":"52","author":"Tian","year":"2010","journal-title":"Hepatology."},{"issue":"5","key":"2021121713511968700_CIT0058","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.1016\/j.jhep.2014.12.006","article-title":"Thyroid-stimulating hormone regulates hepatic bile acid homeostasis via SREBP-2\/HNF-4\u03b1\/CYP7A1 axis","volume":"62","author":"Song","year":"2015","journal-title":"J Hepatol."},{"issue":"5","key":"2021121713511968700_CIT0059","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1016\/j.jhep.2015.02.003","article-title":"Pituitary TSH controls bile salt synthesis","volume":"62","author":"Jansen","year":"2015","journal-title":"J Hepatol."},{"key":"2021121713511968700_CIT0060","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.metabol.2017.07.006","article-title":"Thyroid stimulating hormone exhibits the impact on LDLR\/LDL-c via up-regulating hepatic PCSK9 expression","volume":"76","author":"Gong","year":"2017","journal-title":"Metabolism."},{"key":"2021121713511968700_CIT0061","doi-asserted-by":"crossref","first-page":"S172","DOI":"10.1194\/jlr.R800091-JLR200","article-title":"PCSK9: a convertase that coordinates LDL catabolism","volume":"50 Suppl","author":"Horton","year":"2009","journal-title":"J Lipid Res."},{"issue":"47","key":"2021121713511968700_CIT0062","doi-asserted-by":"crossref","first-page":"48865","DOI":"10.1074\/jbc.M409699200","article-title":"NARC-1\/PCSK9 and its natural mutants: zymogen cleavage and effects on the low density lipoprotein (LDL) receptor and LDL cholesterol","volume":"279","author":"Benjannet","year":"2004","journal-title":"J Biol Chem."},{"issue":"5","key":"2021121713511968700_CIT0063","doi-asserted-by":"crossref","first-page":"2050","DOI":"10.1210\/jc.2018-00183","article-title":"Comprehensive metabolic profiling reveals a lipid-rich fingerprint of free thyroxine far beyond classic parameters","volume":"103","author":"Lange","year":"2018","journal-title":"J Clin Endocrinol Metab."},{"issue":"2","key":"2021121713511968700_CIT0064","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1530\/eje.0.1380141","article-title":"High serum cholesterol levels in persons with \u2018high-normal\u2019 TSH levels: should one extend the definition of subclinical hypothyroidism?","volume":"138","author":"Michalopoulou","year":"1998","journal-title":"Eur J Endocrinol."},{"issue":"5","key":"2021121713511968700_CIT0065","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1038\/nrendo.2018.10","article-title":"Direct effects of thyroid hormones on hepatic lipid metabolism","volume":"14","author":"Sinha","year":"2018","journal-title":"Nat Rev Endocrinol."},{"issue":"2","key":"2021121713511968700_CIT0066","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1152\/physrev.00030.2013","article-title":"Thyroid hormone regulation of metabolism","volume":"94","author":"Mullur","year":"2014","journal-title":"Physiol Rev."},{"issue":"9","key":"2021121713511968700_CIT0067","doi-asserted-by":"crossref","first-page":"1216","DOI":"10.1016\/j.bbalip.2007.05.001","article-title":"Activation of the hepatic LDL receptor promoter by thyroid hormone","volume":"1771","author":"Lopez","year":"2007","journal-title":"Biochim Biophys Acta."},{"issue":"3","key":"2021121713511968700_CIT0068","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/j.tem.2009.11.004","article-title":"Thyroid hormone crosstalk with nuclear receptor signaling in metabolic regulation","volume":"21","author":"Liu","year":"2010","journal-title":"Trends Endocrinol Metab."},{"issue":"36","key":"2021121713511968700_CIT0069","doi-asserted-by":"crossref","first-page":"34114","DOI":"10.1074\/jbc.M305417200","article-title":"Thyroid hormone regulation and cholesterol metabolism are connected through sterol regulatory element-binding protein-2 (SREBP-2)","volume":"278","author":"Shin","year":"2003","journal-title":"J Biol Chem."},{"issue":"1-2","key":"2021121713511968700_CIT0070","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.mce.2014.02.003","article-title":"Thyroid hormone induction of human cholesterol 7 alpha-hydroxylase (Cyp7a1) in vitro","volume":"388","author":"Lammel Lindemann","year":"2014","journal-title":"Mol Cell Endocrinol."},{"key":"2021121713511968700_CIT0071","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1146\/annurev-genom-083117-021731","article-title":"Inferring causal relationships between risk factors and outcomes from genome-wide association study data","volume":"19","author":"Burgess","year":"2018","journal-title":"Annu Rev Genomics Hum Genet."}],"container-title":["Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/endo\/advance-article-pdf\/doi\/10.1210\/endocr\/bqab037\/36264312\/bqab037.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/endo\/article-pdf\/162\/5\/bqab037\/41808561\/bqab037.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/endo\/article-pdf\/162\/5\/bqab037\/41808561\/bqab037.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,17]],"date-time":"2021-12-17T14:19:36Z","timestamp":1639750776000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/endo\/article\/doi\/10.1210\/endocr\/bqab037\/6136226"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,2,15]]},"references-count":71,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2021,5,1]]}},"URL":"https:\/\/doi.org\/10.1210\/endocr\/bqab037","relation":{},"ISSN":["0013-7227","1945-7170"],"issn-type":[{"value":"0013-7227","type":"print"},{"value":"1945-7170","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2021,5,1]]},"published":{"date-parts":[[2021,2,15]]},"article-number":"bqab037"}}