{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T11:50:02Z","timestamp":1790423402256,"version":"4.1.0"},"reference-count":159,"publisher":"The Endocrine Society","issue":"5","license":[{"start":{"date-parts":[[2021,2,18]],"date-time":"2021-02-18T00:00:00Z","timestamp":1613606400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Integrative Pharmacological Science Training Program","award":["2T32-GM092715-06"],"award-info":[{"award-number":["2T32-GM092715-06"]}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["R01-DK103808"],"award-info":[{"award-number":["R01-DK103808"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,5,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The small peptide neurotensin (Nts) is implicated in myriad processes including analgesia, thermoregulation, reward, arousal, blood pressure, and modulation of feeding and body weight. Alterations in Nts have recently been described in individuals with obesity or eating disorders, suggesting that disrupted Nts signaling may contribute to body weight disturbance. Curiously, Nts mediates seemingly opposing regulation of body weight via different tissues. Peripherally acting Nts promotes fat absorption and weight gain, whereas central Nts signaling suppresses feeding and weight gain. Thus, because Nts is pleiotropic, a location-based approach must be used to understand its contributions to disordered body weight and whether the Nts system might be leveraged to improve metabolic health. Here we review the role of Nts signaling in the brain to understand the sites, receptors, and mechanisms by which Nts can promote behaviors that modify body weight. New techniques permitting site-specific modulation of Nts and Nts receptor\u2013expressing cells suggest that, even in the brain, not all Nts circuitry exerts the same function. Intriguingly, there may be dedicated brain regions and circuits via which Nts specifically suppresses feeding behavior and weight gain vs other Nts-attributed physiology. Defining the central mechanisms by which Nts signaling modifies body weight may suggest strategies to correct disrupted energy balance, as needed to address overweight, obesity, and eating disorders.<\/jats:p>","DOI":"10.1210\/endocr\/bqab038","type":"journal-article","created":{"date-parts":[[2021,2,18]],"date-time":"2021-02-18T11:00:02Z","timestamp":1613646002000},"source":"Crossref","is-referenced-by-count":58,"title":["The Role of Central Neurotensin in Regulating Feeding and Body Weight"],"prefix":"10.1210","volume":"162","author":[{"given":"Jariel","family":"Ramirez-Virella","sequence":"first","affiliation":[{"name":"Neuroscience Program, Michigan State University, East Lansing, Michigan, USA"},{"name":"Department of Pharmacology and Toxicology, Michigan State University, East Lansing, Michigan, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4823-4346","authenticated-orcid":false,"given":"Gina M","family":"Leinninger","sequence":"additional","affiliation":[{"name":"Neuroscience Program, Michigan State University, East Lansing, Michigan, USA"},{"name":"Department of Physiology, Michigan State University, East Lansing, Michigan, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"80","published-online":{"date-parts":[[2021,2,18]]},"reference":[{"issue":"3","key":"2021121713512068900_CIT0001","doi-asserted-by":"crossref","first-page":"900","DOI":"10.1016\/j.bbadis.2017.12.036","article-title":"Role of central neurotensin in regulating feeding: implications for the development and treatment of body weight disorders","volume":"1864","author":"Schroeder","year":"2018","journal-title":"Biochim Biophys Acta Mol Basis Dis."},{"key":"2021121713512068900_CIT0002","doi-asserted-by":"crossref","first-page":"108005","DOI":"10.1016\/j.neuropharm.2020.108005","article-title":"Neurotensin in reward processes","volume":"167","author":"Torruella-Su\u00e1rez","year":"2020","journal-title":"Neuropharmacology."},{"key":"2021121713512068900_CIT0003","doi-asserted-by":"crossref","first-page":"36","DOI":"10.3389\/fendo.2013.00036","article-title":"Diverse roles of neurotensin agonists in the central nervous system","volume":"4","author":"Boules","year":"2013","journal-title":"Front Endocrinol (Lausanne)."},{"issue":"11","key":"2021121713512068900_CIT0004","doi-asserted-by":"crossref","first-page":"3116","DOI":"10.1016\/j.celrep.2017.11.068","article-title":"Lateral hypothalamic neurotensin neurons orchestrate dual weight loss behaviors via distinct mechanisms","volume":"21","author":"Woodworth","year":"2017","journal-title":"Cell Rep."},{"issue":"3","key":"2021121713512068900_CIT0005","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1038\/nn.4487","article-title":"Hormonal gain control of a medial preoptic area social reward circuit","volume":"20","author":"McHenry","year":"2017","journal-title":"Nat Neurosci."},{"issue":"3","key":"2021121713512068900_CIT0006","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1523\/JNEUROSCI.1466-19.2019","article-title":"Manipulations of central amygdala neurotensin neurons alter the consumption of ethanol and sweet fluids in mice","volume":"40","author":"Torruella-Su\u00e1rez","year":"2020","journal-title":"J Neurosci."},{"issue":"4","key":"2021121713512068900_CIT0007","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1016\/j.neuron.2019.08.026","article-title":"Control of non-REM sleep by midbrain neurotensinergic neurons","volume":"104","author":"Zhong","year":"2019","journal-title":"Neuron."},{"key":"2021121713512068900_CIT0008","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.neuropharm.2018.09.038","article-title":"Activation of lateral hypothalamic area neurotensin-expressing neurons promotes drinking","volume":"154","author":"Kurt","year":"2019","journal-title":"Neuropharmacology."},{"issue":"7603","key":"2021121713512068900_CIT0009","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1038\/nature17662","article-title":"An obligatory role for neurotensin in high-fat-diet-induced obesity","volume":"533","author":"Li","year":"2016","journal-title":"Nature."},{"issue":"19","key":"2021121713512068900_CIT0010","doi-asserted-by":"crossref","first-page":"6854","DOI":"10.1016\/S0021-9258(19)43429-7","article-title":"The isolation of a new hypotensive peptide, neurotensin, from bovine hypothalami","volume":"248","author":"Carraway","year":"1973","journal-title":"J Biol Chem."},{"issue":"22","key":"2021121713512068900_CIT0011","doi-asserted-by":"crossref","first-page":"7045","DOI":"10.1016\/S0021-9258(17)32938-1","article-title":"Characterization of radioimmunoassayable neurotensin in the rat. 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