{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T02:34:13Z","timestamp":1790735653347,"version":"4.1.0"},"reference-count":166,"publisher":"The Endocrine Society","issue":"8","license":[{"start":{"date-parts":[[2021,4,30]],"date-time":"2021-04-30T00:00:00Z","timestamp":1619740800000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["R01CA196639"],"award-info":[{"award-number":["R01CA196639"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000069","name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","doi-asserted-by":"publisher","award":["K01AR064315"],"award-info":[{"award-number":["K01AR064315"]}],"id":[{"id":"10.13039\/100000069","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Karl Potach Foundation"},{"DOI":"10.13039\/100000968","name":"American Heart Association","doi-asserted-by":"publisher","award":["18IPA34110189"],"award-info":[{"award-number":["18IPA34110189"]}],"id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,8,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Breast cancer is a highly heterogeneous disease, encompassing many subtypes that have distinct origins, behaviors, and prognoses. Although traditionally seen as a genetic disease, breast cancer is now also known to involve epigenetic abnormalities. Epigenetic regulators, such as DNA methyltransferases and histone-modifying enzymes, play essential roles in gene regulation and cancer development. Dysregulation of epigenetic regulator activity has been causally linked with breast cancer pathogenesis. Hairless (HR) encodes a 130-kDa transcription factor that is essential for development and tissue homeostasis. Its role in transcription regulation is partly mediated by its interaction with multiple nuclear receptors, including thyroid hormone receptor, retinoic acid receptor-related orphan receptors, and vitamin D receptor. HR has been studied primarily in epidermal development and homeostasis. Hr-mutant mice are highly susceptible to ultraviolet- or carcinogen-induced skin tumors. Besides its putative tumor suppressor function in skin, loss of HR function has also been implicated in increased leukemia susceptibility and promotes the growth of melanoma and brain cancer cells. HR has also been demonstrated to function as a histone H3 lysine 9 demethylase. Recent genomics studies have identified HR mutations in a variety of human cancers, including breast cancer. The anticancer function and mechanism of action by HR in mammary tissue remains to be investigated. Here, we review the emerging role of HR, its histone demethylase activity and histone methylation in breast cancer development, and potential for epigenetic therapy.<\/jats:p>","DOI":"10.1210\/endocr\/bqab088","type":"journal-article","created":{"date-parts":[[2021,4,30]],"date-time":"2021-04-30T00:05:59Z","timestamp":1619741159000},"source":"Crossref","is-referenced-by-count":13,"title":["Control of Breast Cancer Pathogenesis by Histone Methylation and the Hairless Histone Demethylase"],"prefix":"10.1210","volume":"162","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7330-1627","authenticated-orcid":false,"given":"Megan H","family":"Trager","sequence":"first","affiliation":[{"name":"Columbia University Vagelos College of Physicians and Surgeons, New York, New York 10032, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bindeshwar","family":"Sah","sequence":"additional","affiliation":[{"name":"The Hormel Institute, University of Minnesota, Austin, Minnesota 55912, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhongming","family":"Chen","sequence":"additional","affiliation":[{"name":"The Hormel Institute, University of Minnesota, Austin, Minnesota 55912, USA"},{"name":"Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota 55912, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7245-355X","authenticated-orcid":false,"given":"Liang","family":"Liu","sequence":"additional","affiliation":[{"name":"The Hormel Institute, University of Minnesota, Austin, Minnesota 55912, USA"},{"name":"Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota 55912, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"80","published-online":{"date-parts":[[2021,4,29]]},"reference":[{"issue":"1","key":"2021121717503841500_CIT0001","doi-asserted-by":"crossref","first-page":"7","DOI":"10.3322\/caac.21590","article-title":"Cancer statistics, 2020","volume":"70","author":"Siegel","year":"2020","journal-title":"CA Cancer J Clin."},{"key":"2021121717503841500_CIT0002","doi-asserted-by":"crossref","first-page":"227","DOI":"10.3389\/fmed.2017.00227","article-title":"Tumor heterogeneity in breast cancer","volume":"4","author":"Turashvili","year":"2017","journal-title":"Front Med (Lausanne)."},{"key":"2021121717503841500_CIT0003","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.semcdb.2016.08.025","article-title":"Molecular heterogeneity in breast cancer: state of the science and implications for patient care","volume":"64","author":"Ellsworth","year":"2017","journal-title":"Semin Cell Dev Biol."},{"key":"2021121717503841500_CIT0004","doi-asserted-by":"crossref","first-page":"4809183","DOI":"10.1155\/2018\/4809183","article-title":"Precision medicine for breast cancer: the paths to truly individualized diagnosis and treatment","volume":"2018","author":"Harris","year":"2018","journal-title":"Int J Breast Cancer."},{"issue":"16","key":"2021121717503841500_CIT0005","doi-asserted-by":"crossref","first-page":"3131","DOI":"10.7150\/jca.18457","article-title":"Breast cancer cell line classification and its relevance with breast tumor subtyping","volume":"8","author":"Dai","year":"2017","journal-title":"J Cancer."},{"issue":"6797","key":"2021121717503841500_CIT0006","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1038\/35021093","article-title":"Molecular portraits of human breast tumours","volume":"406","author":"Perou","year":"2000","journal-title":"Nature."},{"issue":"10","key":"2021121717503841500_CIT0007","doi-asserted-by":"crossref","first-page":"1497","DOI":"10.1016\/j.molonc.2016.09.003","article-title":"Dysregulation of histone methyltransferases in breast cancer\u2014opportunities for new targeted therapies?","volume":"10","author":"Michalak","year":"2016","journal-title":"Mol Oncol."},{"key":"2021121717503841500_CIT0008","doi-asserted-by":"crossref","first-page":"e51480","DOI":"10.7554\/eLife.51480","article-title":"Novel insights into breast cancer copy number genetic heterogeneity revealed by single-cell genome sequencing","volume":"9","author":"Baslan","year":"2020","journal-title":"Elife."},{"issue":"1","key":"2021121717503841500_CIT0009","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1158\/2159-8290.CD-12-0462","article-title":"The genomic landscape of breast cancer as a therapeutic roadmap","volume":"3","author":"Ellis","year":"2013","journal-title":"Cancer Discov."},{"key":"2021121717503841500_CIT0010","doi-asserted-by":"crossref","first-page":"747318","DOI":"10.1155\/2013\/747318","article-title":"Hereditary breast cancer: the era of new susceptibility genes","volume":"2013","author":"Apostolou","year":"2013","journal-title":"Biomed Res Int."},{"issue":"6348","key":"2021121717503841500_CIT0011","doi-asserted-by":"crossref","first-page":"eaal2380","DOI":"10.1126\/science.aal2380","article-title":"Epigenetic plasticity and the hallmarks of cancer","volume":"357","author":"Flavahan","year":"2017","journal-title":"Science."},{"issue":"2","key":"2021121717503841500_CIT0012","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/j.semcdb.2009.10.007","article-title":"Histone methyltransferases in cancer","volume":"21","author":"Albert","year":"2010","journal-title":"Semin Cell Dev Biol."},{"issue":"11","key":"2021121717503841500_CIT0013","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1016\/j.tcb.2010.08.011","article-title":"Histone demethylases in development and disease","volume":"20","author":"Pedersen","year":"2010","journal-title":"Trends Cell Biol."},{"issue":"2","key":"2021121717503841500_CIT0014","first-page":"34","article-title":"Histone demethylases and their roles in cancer epigenetics","volume":"1","author":"D\u2019Oto","year":"2016","journal-title":"J Med Oncol Ther."},{"issue":"3","key":"2021121717503841500_CIT0015","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1038\/s41568-019-0109-9","article-title":"Epigenetic therapy in immune-oncology","volume":"19","author":"Jones","year":"2019","journal-title":"Nat Rev Cancer."},{"issue":"7","key":"2021121717503841500_CIT0016","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1056\/NEJMra1805035","article-title":"Epigenetic therapies for cancer","volume":"383","author":"Bates","year":"2020","journal-title":"N Engl J Med."},{"issue":"2","key":"2021121717503841500_CIT0017","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1038\/nm.4257","article-title":"Targeting the histone methyltransferase G9A activates imprinted genes and improves survival of a mouse model of Prader-Willi syndrome","volume":"23","author":"Kim","year":"2017","journal-title":"Nat Med."},{"issue":"4","key":"2021121717503841500_CIT0018","doi-asserted-by":"crossref","first-page":"1596","DOI":"10.1021\/jm501234a","article-title":"Selective inhibitors of protein methyltransferases","volume":"58","author":"Kaniskan","year":"2015","journal-title":"J Med Chem."},{"issue":"1","key":"2021121717503841500_CIT0019","doi-asserted-by":"crossref","first-page":"4559","DOI":"10.1038\/s41467-018-07077-1","article-title":"H3K9 methyltransferases and demethylases control lung tumor-propagating cells and lung cancer progression","volume":"9","author":"Rowbotham","year":"2018","journal-title":"Nat Commun."},{"issue":"8","key":"2021121717503841500_CIT0020","doi-asserted-by":"crossref","first-page":"1076","DOI":"10.1038\/s41401-018-0205-5","article-title":"Inhibition of G9A by a small molecule inhibitor, UNC0642, induces apoptosis of human bladder cancer cells","volume":"40","author":"Cao","year":"2019","journal-title":"Acta Pharmacol Sin."},{"issue":"5","key":"2021121717503841500_CIT0021","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1097\/PPO.0000000000000283","article-title":"Targeting histone methylation in cancer","volume":"23","author":"McCabe","year":"2017","journal-title":"Cancer J."},{"issue":"5532","key":"2021121717503841500_CIT0022","doi-asserted-by":"crossref","first-page":"1074","DOI":"10.1126\/science.1063127","article-title":"Translating the histone code","volume":"293","author":"Jenuwein","year":"2001","journal-title":"Science."},{"issue":"4","key":"2021121717503841500_CIT0023","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1016\/j.cell.2007.01.033","article-title":"The mammalian epigenome","volume":"128","author":"Bernstein","year":"2007","journal-title":"Cell."},{"issue":"7","key":"2021121717503841500_CIT0024","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1038\/nrc2876","article-title":"Covalent histone modifications\u2014miswritten, misinterpreted and mis-erased in human cancers","volume":"10","author":"Chi","year":"2010","journal-title":"Nat Rev Cancer."},{"issue":"9","key":"2021121717503841500_CIT0025","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1101\/gad.1652908","article-title":"Erasing the methyl mark: histone demethylases at the center of cellular differentiation and disease","volume":"22","author":"Cloos","year":"2008","journal-title":"Genes Dev."},{"issue":"5","key":"2021121717503841500_CIT0026","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1038\/nrg.2016.13","article-title":"Epigenetic modulators, modifiers and mediators in cancer aetiology and progression","volume":"17","author":"Feinberg","year":"2016","journal-title":"Nat Rev Genet."},{"issue":"5","key":"2021121717503841500_CIT0027","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1038\/nrg3173","article-title":"Histone methylation: a dynamic mark in health, disease and inheritance","volume":"13","author":"Greer","year":"2012","journal-title":"Nat Rev Genet."},{"issue":"1","key":"2021121717503841500_CIT0028","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.molcel.2016.11.003","article-title":"Arginine methylation: the coming of age","volume":"65","author":"Blanc","year":"2017","journal-title":"Mol Cell."},{"issue":"1","key":"2021121717503841500_CIT0029","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.annemergmed.2011.10.003","article-title":"Update on emerging infections: news from the Centers for Disease Control and Prevention. Notes from the field: fatal fungal soft-tissue infections after a tornado\u2014Joplin, Missouri, 2011","volume":"59","author":"Green","year":"2012","journal-title":"Ann Emerg Med."},{"issue":"4","key":"2021121717503841500_CIT0030","doi-asserted-by":"crossref","first-page":"e324","DOI":"10.1038\/emm.2017.11","article-title":"Writing, erasing and reading histone lysine methylations","volume":"49","author":"Hyun","year":"2017","journal-title":"Exp Mol Med."},{"issue":"4","key":"2021121717503841500_CIT0031","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1016\/j.cell.2007.05.009","article-title":"High-resolution profiling of histone methylations in the human genome","volume":"129","author":"Barski","year":"2007","journal-title":"Cell."},{"issue":"4","key":"2021121717503841500_CIT0032","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1016\/j.cell.2007.02.005","article-title":"Chromatin modifications and their function","volume":"128","author":"Kouzarides","year":"2007","journal-title":"Cell."},{"issue":"24","key":"2021121717503841500_CIT0033","doi-asserted-by":"crossref","first-page":"9185","DOI":"10.1128\/MCB.01529-06","article-title":"Profile of histone lysine methylation across transcribed mammalian chromatin","volume":"26","author":"Vakoc","year":"2006","journal-title":"Mol Cell Biol."},{"issue":"8","key":"2021121717503841500_CIT0034","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1101\/gad.2027411","article-title":"H3K9 methyltransferase G9A and the related molecule GLP","volume":"25","author":"Shinkai","year":"2011","journal-title":"Genes Dev."},{"issue":"4","key":"2021121717503841500_CIT0035","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1038\/cr.2011.42","article-title":"Readers of histone modifications","volume":"21","author":"Yun","year":"2011","journal-title":"Cell Res."},{"issue":"12","key":"2021121717503841500_CIT0036","doi-asserted-by":"crossref","first-page":"1218","DOI":"10.1038\/nsmb.2436","article-title":"Perceiving the epigenetic landscape through histone readers","volume":"19","author":"Musselman","year":"2012","journal-title":"Nat Struct Mol Biol."},{"issue":"11","key":"2021121717503841500_CIT0037","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1016\/j.tem.2016.06.008","article-title":"The emerging role of epigenetics in inflammation and immunometabolism","volume":"27","author":"Raghuraman","year":"2016","journal-title":"Trends Endocrinol Metab."},{"issue":"10","key":"2021121717503841500_CIT0038","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1038\/nrrheum.2017.147","article-title":"New insights into the epigenetics of inflammatory rheumatic diseases","volume":"13","author":"Ballestar","year":"2017","journal-title":"Nat Rev Rheumatol."},{"issue":"6824","key":"2021121717503841500_CIT0039","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1038\/35065138","article-title":"Selective recognition of methylated lysine 9 on histone H3 by the HP1 chromo domain","volume":"410","author":"Bannister","year":"2001","journal-title":"Nature."},{"issue":"7","key":"2021121717503841500_CIT0040","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1038\/embor.2009.90","article-title":"The HP1\u03b1-CAF1-SetDB1-containing complex provides H3K9me1 for Suv39-mediated K9me3 in pericentric heterochromatin","volume":"10","author":"Loyola","year":"2009","journal-title":"EMBO Rep."},{"issue":"14","key":"2021121717503841500_CIT0041","doi-asserted-by":"crossref","first-page":"1779","DOI":"10.1101\/gad.989402","article-title":"G9A histone methyltransferase plays a dominant role in euchromatic histone H3 lysine 9 methylation and is essential for early embryogenesis","volume":"16","author":"Tachibana","year":"2002","journal-title":"Genes Dev."},{"issue":"3","key":"2021121717503841500_CIT0042","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1016\/j.molcel.2007.01.017","article-title":"Reversal of H3K9me2 by a small-molecule inhibitor for the G9A histone methyltransferase","volume":"25","author":"Kubicek","year":"2007","journal-title":"Mol Cell."},{"issue":"5","key":"2021121717503841500_CIT0043","doi-asserted-by":"crossref","first-page":"948","DOI":"10.1016\/j.cell.2012.06.048","article-title":"Prdm3 and Prdm16 are H3K9me1 methyltransferases required for mammalian heterochromatin integrity","volume":"150","author":"Pinheiro","year":"2012","journal-title":"Cell."},{"issue":"7100","key":"2021121717503841500_CIT0044","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1038\/nature04837","article-title":"The putative oncogene GASC1 demethylates tri- and dimethylated lysine 9 on histone H3","volume":"442","author":"Cloos","year":"2006","journal-title":"Nature."},{"issue":"9","key":"2021121717503841500_CIT0045","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1038\/nrg1945","article-title":"JmjC-domain-containing proteins and histone demethylation","volume":"7","author":"Klose","year":"2006","journal-title":"Nat Rev Genet."},{"issue":"7100","key":"2021121717503841500_CIT0046","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1038\/nature04853","article-title":"The transcriptional repressor JHDM3A demethylates trimethyl histone H3 lysine 9 and lysine 36","volume":"442","author":"Klose","year":"2006","journal-title":"Nature."},{"issue":"3","key":"2021121717503841500_CIT0047","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1016\/j.cell.2006.03.027","article-title":"JHDM2A, a JmjC-containing H3K9 demethylase, facilitates transcription activation by androgen receptor","volume":"125","author":"Yamane","year":"2006","journal-title":"Cell."},{"issue":"7166","key":"2021121717503841500_CIT0048","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1038\/nature06236","article-title":"Histone demethylase JHDM2A is critical for Tnp1 and Prm1 transcription and spermatogenesis","volume":"450","author":"Okada","year":"2007","journal-title":"Nature."},{"issue":"1","key":"2021121717503841500_CIT0049","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1038\/nsmb.1753","article-title":"Enzymatic and structural insights for substrate specificity of a family of jumonji histone lysine demethylases","volume":"17","author":"Horton","year":"2010","journal-title":"Nat Struct Mol Biol."},{"issue":"1","key":"2021121717503841500_CIT0050","first-page":"75","article-title":"Histone lysine methylation and demethylation pathways in cancer","volume":"1815","author":"Varier","year":"2011","journal-title":"Biochim Biophys Acta."},{"key":"2021121717503841500_CIT0051","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1038\/s41392-019-0095-0","article-title":"Targeting epigenetic regulators for cancer therapy: mechanisms and advances in clinical trials","volume":"4","author":"Cheng","year":"2019","journal-title":"Signal Transduct Target Ther."},{"issue":"1","key":"2021121717503841500_CIT0052","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1186\/s13045-019-0811-9","article-title":"LSD1\/KDM1A inhibitors in clinical trials: advances and prospects","volume":"12","author":"Fang","year":"2019","journal-title":"J Hematol Oncol."},{"issue":"44","key":"2021121717503841500_CIT0053","doi-asserted-by":"crossref","first-page":"7017","DOI":"10.1038\/s41388-019-0923-2","article-title":"LSD1 suppresses invasion, migration and metastasis of luminal breast cancer cells via activation of GATA3 and repression of TRIM37 expression","volume":"38","author":"Hu","year":"2019","journal-title":"Oncogene."},{"issue":"1","key":"2021121717503841500_CIT0054","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1038\/s41467-017-00350-9","article-title":"G9A regulates breast cancer growth by modulating iron homeostasis through the repression of ferroxidase hephaestin","volume":"8","author":"Wang","year":"2017","journal-title":"Nat Commun."},{"issue":"24","key":"2021121717503841500_CIT0055","doi-asserted-by":"crossref","first-page":"5621","DOI":"10.1128\/MCB.00465-10","article-title":"Pygo2 associates with MLL2 histone methyltransferase and GCN5 histone acetyltransferase complexes to augment Wnt target gene expression and breast cancer stem-like cell expansion","volume":"30","author":"Chen","year":"2010","journal-title":"Mol Cell Biol."},{"issue":"6","key":"2021121717503841500_CIT0056","doi-asserted-by":"crossref","first-page":"1705","DOI":"10.1158\/0008-5472.CAN-13-1896","article-title":"UTX and MLL4 coordinately regulate transcriptional programs for cell proliferation and invasiveness in breast cancer cells","volume":"74","author":"Kim","year":"2014","journal-title":"Cancer Res."},{"issue":"3","key":"2021121717503841500_CIT0057","doi-asserted-by":"crossref","first-page":"1278","DOI":"10.1093\/nar\/gky1221","article-title":"SMYD3 promotes the epithelial-mesenchymal transition in breast cancer","volume":"47","author":"Fenizia","year":"2019","journal-title":"Nucleic Acids Res."},{"key":"2021121717503841500_CIT0058","doi-asserted-by":"crossref","first-page":"7821","DOI":"10.1038\/ncomms8821","article-title":"DOT1L cooperates with the c-Myc-p300 complex to epigenetically derepress CDH1 transcription factors in breast cancer progression","volume":"6","author":"Cho","year":"2015","journal-title":"Nat Commun."},{"issue":"2","key":"2021121717503841500_CIT0059","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/j.canlet.2016.04.008","article-title":"MiR-502\/SET8 regulatory circuit in pathobiology of breast cancer","volume":"376","author":"Liu","year":"2016","journal-title":"Cancer Lett."},{"issue":"10","key":"2021121717503841500_CIT0060","doi-asserted-by":"crossref","first-page":"4313","DOI":"10.1096\/fj.15-273540","article-title":"SET7\/9 regulates cancer cell proliferation by influencing \u03b2-catenin stability","volume":"29","author":"Shen","year":"2015","journal-title":"FASEB J."},{"issue":"47","key":"2021121717503841500_CIT0061","doi-asserted-by":"crossref","first-page":"6143","DOI":"10.1038\/onc.2016.154","article-title":"Tumor suppressor SET9 guides the epigenetic plasticity of breast cancer cells and serves as an early-stage biomarker for predicting metastasis","volume":"35","author":"Montenegro","year":"2016","journal-title":"Oncogene."},{"issue":"11","key":"2021121717503841500_CIT0062","doi-asserted-by":"crossref","first-page":"2185","DOI":"10.1093\/annonc\/mdu391","article-title":"High protein expression of EZH2 is related to unfavorable outcome to tamoxifen in metastatic breast cancer","volume":"25","author":"Reijm","year":"2014","journal-title":"Ann Oncol."},{"issue":"1","key":"2021121717503841500_CIT0063","doi-asserted-by":"crossref","first-page":"65","DOI":"10.4161\/cbt.5.1.2288","article-title":"Loss of DNA methylation and histone H4 lysine 20 trimethylation in human breast cancer cells is associated with aberrant expression of DNA methyltransferase 1, Suv4-20h2 histone methyltransferase and methyl-binding proteins","volume":"5","author":"Tryndyak","year":"2006","journal-title":"Cancer Biol Ther."},{"issue":"7","key":"2021121717503841500_CIT0064","doi-asserted-by":"crossref","first-page":"1699","DOI":"10.1158\/1078-0432.CCR-15-1772","article-title":"mTOR inhibitors suppress homologous recombination repair and synergize with PARP inhibitors via regulating SUV39H1 in BRCA-proficient triple-negative breast cancer","volume":"22","author":"Mo","year":"2016","journal-title":"Clin Cancer Res."},{"issue":"11","key":"2021121717503841500_CIT0065","doi-asserted-by":"crossref","first-page":"4606","DOI":"10.1096\/fj.13-236851","article-title":"Prolyl isomerase Pin1 negatively regulates the stability of SUV39H1 to promote tumorigenesis in breast cancer","volume":"27","author":"Khanal","year":"2013","journal-title":"FASEB J."},{"issue":"2","key":"2021121717503841500_CIT0066","doi-asserted-by":"crossref","first-page":"139","DOI":"10.5483\/BMBRep.2019.52.2.235","article-title":"SETDB1 regulates SMAD7 expression for breast cancer metastasis","volume":"52","author":"Ryu","year":"2019","journal-title":"BMB Rep."},{"issue":"47","key":"2021121717503841500_CIT0067","doi-asserted-by":"crossref","first-page":"81737","DOI":"10.18632\/oncotarget.19387","article-title":"Functional characterization of lysine-specific demethylase 2 (LSD2\/KDM1B) in breast cancer progression","volume":"8","author":"Chen","year":"2017","journal-title":"Oncotarget."},{"issue":"8","key":"2021121717503841500_CIT0068","doi-asserted-by":"crossref","first-page":"e369","DOI":"10.1038\/oncsis.2017.71","article-title":"Lysine demethylase KDM2A inhibits TET2 to promote DNA methylation and silencing of tumor suppressor genes in breast cancer","volume":"6","author":"Chen","year":"2017","journal-title":"Oncogenesis."},{"issue":"14","key":"2021121717503841500_CIT0069","doi-asserted-by":"crossref","first-page":"3935","DOI":"10.1158\/0008-5472.CAN-13-2733","article-title":"NDY1\/KDM2B functions as a master regulator of polycomb complexes and controls self-renewal of breast cancer stem cells","volume":"74","author":"Kottakis","year":"2014","journal-title":"Cancer Res."},{"issue":"1","key":"2021121717503841500_CIT0070","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1093\/nar\/gku1298","article-title":"The histone demethylase enzyme KDM3A is a key estrogen receptor regulator in breast cancer","volume":"43","author":"Wade","year":"2015","journal-title":"Nucleic Acids Res."},{"issue":"11","key":"2021121717503841500_CIT0071","doi-asserted-by":"crossref","first-page":"2833","DOI":"10.1084\/jem.20180439","article-title":"KDM4B-regulated unfolded protein response as a therapeutic vulnerability in PTEN-deficient breast cancer","volume":"215","author":"Wang","year":"2018","journal-title":"J Exp Med."},{"issue":"49","key":"2021121717503841500_CIT0072","doi-asserted-by":"crossref","first-page":"E3367","DOI":"10.1073\/pnas.1217394109","article-title":"Histone demethylase JMJD2C is a coactivator for hypoxia-inducible factor 1 that is required for breast cancer progression","volume":"109","author":"Luo","year":"2012","journal-title":"Proc Natl Acad Sci U S A."},{"issue":"40","key":"2021121717503841500_CIT0073","doi-asserted-by":"crossref","first-page":"13091","DOI":"10.1002\/anie.201807305","article-title":"Selective inhibition of lysine-specific demethylase 5A (KDM5A) using a Rhodium(III) complex for triple-negative breast cancer therapy","volume":"57","author":"Yang","year":"2018","journal-title":"Angew Chem Int Ed Engl."},{"issue":"9","key":"2021121717503841500_CIT0074","doi-asserted-by":"crossref","first-page":"1973","DOI":"10.1158\/1535-7163.MCT-17-0802","article-title":"KDM6B counteracts EZH2-mediated suppression of IGFBP5 to confer resistance to PI3K\/AKT inhibitor treatment in breast cancer","volume":"17","author":"Wang","year":"2018","journal-title":"Mol Cancer Ther."},{"issue":"21","key":"2021121717503841500_CIT0075","doi-asserted-by":"crossref","first-page":"9671","DOI":"10.1073\/pnas.1000401107","article-title":"KDM8, a H3K36me2 histone demethylase that acts in the cyclin A1 coding region to regulate cancer cell proliferation","volume":"107","author":"Hsia","year":"2010","journal-title":"Proc Natl Acad Sci U S A."},{"issue":"9","key":"2021121717503841500_CIT0076","first-page":"10325","article-title":"Overexpression of histone demethylase JMJD5 promotes metastasis and indicates a poor prognosis in breast cancer","volume":"8","author":"Zhao","year":"2015","journal-title":"Int J Clin Exp Pathol."},{"issue":"1","key":"2021121717503841500_CIT0077","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1186\/s12943-017-0673-0","article-title":"In vitro downregulated hypoxia transcriptome is associated with poor prognosis in breast cancer","volume":"16","author":"Abu-Jamous","year":"2017","journal-title":"Mol Cancer."},{"issue":"1","key":"2021121717503841500_CIT0078","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1038\/onc.2016.186","article-title":"Functional interaction of histone deacetylase 5 (HDAC5) and lysine-specific demethylase 1 (LSD1) promotes breast cancer progression","volume":"36","author":"Cao","year":"2017","journal-title":"Oncogene."},{"issue":"4","key":"2021121717503841500_CIT0079","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1016\/j.cell.2009.05.050","article-title":"LSD1 is a subunit of the NuRD complex and targets the metastasis programs in breast cancer","volume":"138","author":"Wang","year":"2009","journal-title":"Cell."},{"issue":"3","key":"2021121717503841500_CIT0080","doi-asserted-by":"crossref","first-page":"R56","DOI":"10.1186\/bcr3667","article-title":"JMJD2A contributes to breast cancer progression through transcriptional repression of the tumor suppressor ARHI","volume":"16","author":"Li","year":"2014","journal-title":"Breast Cancer Res."},{"issue":"5","key":"2021121717503841500_CIT0081","doi-asserted-by":"crossref","first-page":"1619","DOI":"10.2353\/ajpath.2009.080874","article-title":"Global levels of histone modifications predict prognosis in different cancers","volume":"174","author":"Seligson","year":"2009","journal-title":"Am J Pathol."},{"issue":"7046","key":"2021121717503841500_CIT0082","doi-asserted-by":"crossref","first-page":"1262","DOI":"10.1038\/nature03672","article-title":"Global histone modification patterns predict risk of prostate cancer recurrence","volume":"435","author":"Seligson","year":"2005","journal-title":"Nature."},{"issue":"8","key":"2021121717503841500_CIT0083","doi-asserted-by":"crossref","first-page":"1358","DOI":"10.1200\/JCO.2009.24.5639","article-title":"Cellular histone modification patterns predict prognosis and treatment response in resectable pancreatic adenocarcinoma: results from RTOG 9704","volume":"28","author":"Manuyakorn","year":"2010","journal-title":"J Clin Oncol."},{"issue":"2","key":"2021121717503841500_CIT0084","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.humpath.2009.08.007","article-title":"H3K4 dimethylation in hepatocellular carcinoma is rare compared with other hepatobiliary and gastrointestinal carcinomas and correlates with expression of the methylase Ash2 and the demethylase LSD1","volume":"41","author":"Magerl","year":"2010","journal-title":"Hum Pathol."},{"issue":"9","key":"2021121717503841500_CIT0085","doi-asserted-by":"crossref","first-page":"3802","DOI":"10.1158\/0008-5472.CAN-08-3907","article-title":"Global histone modifications in breast cancer correlate with tumor phenotypes, prognostic factors, and patient outcome","volume":"69","author":"Elsheikh","year":"2009","journal-title":"Cancer Res."},{"issue":"20","key":"2021121717503841500_CIT0086","doi-asserted-by":"crossref","first-page":"2687","DOI":"10.1101\/gad.916701","article-title":"The hairless gene mutated in congenital hair loss disorders encodes a novel nuclear receptor corepressor","volume":"15","author":"Potter","year":"2001","journal-title":"Genes Dev."},{"key":"2021121717503841500_CIT0087","doi-asserted-by":"crossref","first-page":"e010","DOI":"10.1621\/nrs.07010","article-title":"Hairless is a nuclear receptor corepressor essential for skin function","volume":"7","author":"Thompson","year":"2009","journal-title":"Nucl Recept Signal."},{"issue":"5351","key":"2021121717503841500_CIT0088","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1126\/science.279.5351.720","article-title":"Alopecia universalis associated with a mutation in the human hairless gene","volume":"279","author":"Ahmad","year":"1998","journal-title":"Science."},{"issue":"3","key":"2021121717503841500_CIT0089","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1038\/sj.jidsp.5640220","article-title":"The molecular basis of congenital atrichia in humans and mice: mutations in the hairless gene","volume":"4","author":"Ahmad","year":"1999","journal-title":"J Investig Dermatol Symp Proc."},{"issue":"5","key":"2021121717503841500_CIT0090","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1111\/j.1600-0625.1998.tb00298.x-i1","article-title":"Molecular basis for the rhino Yurlovo (hrrhY) phenotype: severe skin abnormalities and female reproductive defects associated with an insertion in the hairless gene","volume":"7","author":"Panteleyev","year":"1998","journal-title":"Exp Dermatol."},{"issue":"17","key":"2021121717503841500_CIT0091","doi-asserted-by":"crossref","first-page":"4189","DOI":"10.1242\/dev.01303","article-title":"The co-repressor hairless has a role in epithelial cell differentiation in the skin","volume":"131","author":"Zarach","year":"2004","journal-title":"Development."},{"issue":"1","key":"2021121717503841500_CIT0092","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.jdermsci.2008.08.012","article-title":"The hairless mouse in skin research","volume":"53","author":"Benavides","year":"2009","journal-title":"J Dermatol Sci."},{"issue":"41","key":"2021121717503841500_CIT0093","doi-asserted-by":"crossref","first-page":"14653","DOI":"10.1073\/pnas.0507609102","article-title":"Hairless triggers reactivation of hair growth by promoting Wnt signaling","volume":"102","author":"Beaudoin","year":"2005","journal-title":"Proc Natl Acad Sci U S A."},{"issue":"4","key":"2021121717503841500_CIT0094","doi-asserted-by":"crossref","first-page":"984","DOI":"10.1086\/302069","article-title":"A missense mutation in the zinc-finger domain of the human hairless gene underlies congenital atrichia in a family of Irish travellers","volume":"63","author":"Ahmad","year":"1998","journal-title":"Am J Hum Genet."},{"issue":"11","key":"2021121717503841500_CIT0095","doi-asserted-by":"crossref","first-page":"1671","DOI":"10.1093\/hmg\/7.11.1671","article-title":"Cloning, genomic organization, alternative transcripts and mutational analysis of the gene responsible for autosomal recessive universal congenital alopecia","volume":"7","author":"Cichon","year":"1998","journal-title":"Hum Mol Genet."},{"issue":"5","key":"2021121717503841500_CIT0096","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1002\/(SICI)1096-8628(19981228)80:5<546::AID-AJMG28>3.0.CO;2-I","article-title":"Atrichia with papular lesions maps to 8p in the region containing the human hairless gene","volume":"80","author":"Sprecher","year":"1998","journal-title":"Am J Med Genet."},{"issue":"1","key":"2021121717503841500_CIT0097","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1002\/jcb.26164","article-title":"Human hairless protein roles in skin\/hair and emerging connections to brain and other cancers","volume":"119","author":"Maatough","year":"2018","journal-title":"J Cell Biochem."},{"issue":"3","key":"2021121717503841500_CIT0098","first-page":"1116","article-title":"Presence of 1,25-dihydroxyvitamin D3 receptors in established human cancer cell lines in culture","volume":"42","author":"Frampton","year":"1982","journal-title":"Cancer Res."},{"issue":"1-2","key":"2021121717503841500_CIT0099","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1023\/A:1021343825552","article-title":"Analysis of vitamin D-receptor (VDR) and retinoid X-receptor \u03b1 in breast cancer","volume":"34","author":"Friedrich","year":"2002","journal-title":"Histochem J."},{"issue":"1","key":"2021121717503841500_CIT0100","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1186\/s13058-019-1169-1","article-title":"Vitamin D receptor expression in invasive breast tumors and breast cancer survival","volume":"21","author":"Huss","year":"2019","journal-title":"Breast Cancer Res."},{"issue":"2","key":"2021121717503841500_CIT0101","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1369\/0022155411429155","article-title":"The association between vitamin D receptor expression and prolonged overall survival in breast cancer","volume":"60","author":"Ditsch","year":"2012","journal-title":"J Histochem Cytochem."},{"issue":"1","key":"2021121717503841500_CIT0102","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1007\/s10549-014-3235-9","article-title":"Thyroid hormone receptor \u03b1 in breast cancer: prognostic and therapeutic implications","volume":"149","author":"Jerzak","year":"2015","journal-title":"Breast Cancer Res Treat."},{"issue":"16","key":"2021121717503841500_CIT0103","doi-asserted-by":"crossref","first-page":"8527","DOI":"10.1073\/pnas.94.16.8527","article-title":"The product of a thyroid hormone-responsive gene interacts with thyroid hormone receptors","volume":"94","author":"Thompson","year":"1997","journal-title":"Proc Natl Acad Sci U S A."},{"issue":"11","key":"2021121717503841500_CIT0104","doi-asserted-by":"crossref","first-page":"2547","DOI":"10.1210\/me.2002-0115","article-title":"The thyroid hormone-regulated corepressor hairless associates with histone deacetylases in neonatal rat brain","volume":"16","author":"Potter","year":"2002","journal-title":"Mol Endocrinol."},{"issue":"1","key":"2021121717503841500_CIT0105","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1038\/s41388-018-0414-x","article-title":"KDM8\/JMJD5 as a dual coactivator of AR and PKM2 integrates AR\/EZH2 network and tumor metabolism in CRPC","volume":"38","author":"Wang","year":"2019","journal-title":"Oncogene."},{"issue":"2","key":"2021121717503841500_CIT0106","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1038\/s41591-020-01168-7","article-title":"The androgen receptor is a tumor suppressor in estrogen receptor-positive breast cancer","volume":"27","author":"Hickey","year":"2021","journal-title":"Nat Med."},{"issue":"1","key":"2021121717503841500_CIT0107","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1210\/me.2013-1247","article-title":"Minireview: conversing with chromatin: the language of nuclear receptors","volume":"28","author":"Biddie","year":"2014","journal-title":"Mol Endocrinol."},{"issue":"13","key":"2021121717503841500_CIT0108","doi-asserted-by":"crossref","first-page":"21918","DOI":"10.18632\/oncotarget.15747","article-title":"JMJD3 suppresses stem cell-like characteristics in breast cancer cells by downregulation of Oct4 independently of its demethylase activity","volume":"8","author":"Xun","year":"2017","journal-title":"Oncotarget."},{"issue":"1","key":"2021121717503841500_CIT0109","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1002\/jcb.27408","article-title":"Hairless regulates p53 target genes to exert tumor suppressive functions in glioblastoma","volume":"120","author":"Brook","year":"2019","journal-title":"J Cell Biochem."},{"issue":"13","key":"2021121717503841500_CIT0110","doi-asserted-by":"crossref","first-page":"2025","DOI":"10.1210\/mend.11.13.0028","article-title":"Characterization of receptor interaction and transcriptional repression by the corepressor SMRT","volume":"11","author":"Li","year":"1997","journal-title":"Mol Endocrinol."},{"issue":"13","key":"2021121717503841500_CIT0111","doi-asserted-by":"crossref","first-page":"1876","DOI":"10.1096\/fj.99-0943rev","article-title":"Co-repressors 2000","volume":"14","author":"Burke","year":"2000","journal-title":"FASEB J."},{"issue":"2","key":"2021121717503841500_CIT0112","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1101\/gad.14.2.121","article-title":"The coregulator exchange in transcriptional functions of nuclear receptors","volume":"14","author":"Glass","year":"2000","journal-title":"Genes Dev."},{"issue":"2","key":"2021121717503841500_CIT0113","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1002\/jcb.25641","article-title":"The mammalian hairless protein as a DNA binding phosphoprotein","volume":"118","author":"Brook","year":"2017","journal-title":"J Cell Biochem."},{"issue":"4","key":"2021121717503841500_CIT0114","doi-asserted-by":"crossref","first-page":"1534","DOI":"10.1096\/fj.13-237677","article-title":"Hairless is a histone H3K9 demethylase","volume":"28","author":"Liu","year":"2014","journal-title":"FASEB J."},{"key":"2021121717503841500_CIT0115","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1146\/annurev.biochem.78.070907.103946","article-title":"Reversal of histone methylation: biochemical and molecular mechanisms of histone demethylases","volume":"79","author":"Mosammaparast","year":"2010","journal-title":"Annu Rev Biochem."},{"issue":"2","key":"2021121717503841500_CIT0116","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1007\/s002399910012","article-title":"Molecular evolution of the GATA family of transcription factors: conservation within the DNA-binding domain","volume":"50","author":"Lowry","year":"2000","journal-title":"J Mol Evol."},{"issue":"4","key":"2021121717503841500_CIT0117","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1248\/bpb.35.582","article-title":"Hairless modulates ligand-dependent activation of the vitamin D receptor-retinoid X receptor heterodimer","volume":"35","author":"Chuma","year":"2012","journal-title":"Biol Pharm Bull."},{"issue":"8","key":"2021121717503841500_CIT0118","doi-asserted-by":"crossref","first-page":"2354","DOI":"10.1158\/1535-7163.MCT-10-0207","article-title":"Immune competency of a hairless mouse strain for improved preclinical studies in genetically engineered mice","volume":"9","author":"Schaffer","year":"2010","journal-title":"Mol Cancer Ther."},{"issue":"3","key":"2021121717503841500_CIT0119","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/0092-8674(88)90201-2","article-title":"Role of endogenous retroviruses as mutagens: the hairless mutation of mice","volume":"54","author":"Stoye","year":"1988","journal-title":"Cell."},{"issue":"5","key":"2021121717503841500_CIT0120","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1111\/j.1600-0625.1998.tb00300.x-i1","article-title":"Molecular basis of a novel rhino (hrrhChr) phenotype: a nonsense mutation in the mouse hairless gene","volume":"7","author":"Ahmad","year":"1998","journal-title":"Exp Dermatol."},{"issue":"3","key":"2021121717503841500_CIT0121","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1006\/geno.1998.5495","article-title":"Molecular basis for the rhino (hrrh-8J) phenotype: a nonsense mutation in the mouse hairless gene","volume":"53","author":"Ahmad","year":"1998","journal-title":"Genomics."},{"issue":"4","key":"2021121717503841500_CIT0122","first-page":"1238","article-title":"The sensitivity of the skin of hairless mice to chemical carcinogenesis","volume":"36","author":"Iversen","year":"1976","journal-title":"Cancer Res."},{"issue":"6","key":"2021121717503841500_CIT0123","doi-asserted-by":"crossref","first-page":"e39691","DOI":"10.1371\/journal.pone.0039691","article-title":"Loss of hairless confers susceptibility to UVB-induced tumorigenesis via disruption of NF-kappaB signaling","volume":"7","author":"Kim","year":"2012","journal-title":"PloS One."},{"issue":"10","key":"2021121717503841500_CIT0124","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1111\/exd.14174","article-title":"Biomarker function of HMGA2 in ultraviolet-induced skin cancer development","volume":"29","author":"Ha","year":"2020","journal-title":"Exp Dermatol."},{"issue":"5","key":"2021121717503841500_CIT0125","doi-asserted-by":"crossref","first-page":"2516","DOI":"10.3892\/or.2016.4683","article-title":"Chemically induced skin carcinogenesis: updates in experimental models (review)","volume":"35","author":"Neagu","year":"2016","journal-title":"Oncol Rep."},{"issue":"7447","key":"2021121717503841500_CIT0126","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1038\/nature12113","article-title":"Integrated genomic characterization of endometrial carcinoma","volume":"497","author":"Kandoth","year":"2013","journal-title":"Nature."},{"issue":"5","key":"2021121717503841500_CIT0127","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1158\/2159-8290.CD-12-0095","article-title":"The cBio Cancer Genomics Portal: an open platform for exploring multidimensional cancer genomics data","volume":"2","author":"Cerami","year":"2012","journal-title":"Cancer Discov."},{"issue":"4","key":"2021121717503841500_CIT0128","doi-asserted-by":"crossref","first-page":"572","DOI":"10.18632\/oncotarget.964","article-title":"Exomic sequencing of four rare central nervous system tumor types","volume":"4","author":"Bettegowda","year":"2013","journal-title":"Oncotarget."},{"issue":"2","key":"2021121717503841500_CIT0129","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1016\/j.cell.2015.09.033","article-title":"Comprehensive molecular portraits of invasive lobular breast cancer","volume":"163","author":"Ciriello","year":"2015","journal-title":"Cell."},{"issue":"5","key":"2021121717503841500_CIT0130","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.1016\/j.cell.2015.05.001","article-title":"Integrative clinical genomics of advanced prostate cancer","volume":"161","author":"Robinson","year":"2015","journal-title":"Cell."},{"issue":"7391","key":"2021121717503841500_CIT0131","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1038\/nature11003","article-title":"The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity","volume":"483","author":"Barretina","year":"2012","journal-title":"Nature."},{"key":"2021121717503841500_CIT0132","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1186\/s12864-016-2911-z","article-title":"Comprehensive comparison of molecular portraits between cell lines and tumors in breast cancer","volume":"17","author":"Jiang","year":"2016","journal-title":"BMC Genom."},{"issue":"5","key":"2021121717503841500_CIT0133","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1016\/j.ccell.2016.04.003","article-title":"Loss of chromosome 8p governs tumor progression and drug response by altering lipid metabolism","volume":"29","author":"Cai","year":"2016","journal-title":"Cancer Cell."},{"issue":"8","key":"2021121717503841500_CIT0134","doi-asserted-by":"crossref","first-page":"1239","DOI":"10.1038\/cdd.2015.53","article-title":"TP53: an oncogene in disguise","volume":"22","author":"Soussi","year":"2015","journal-title":"Cell Death Differ."},{"issue":"18","key":"2021121717503841500_CIT0135","doi-asserted-by":"crossref","first-page":"3681","DOI":"10.1128\/MCB.00673-12","article-title":"Negative regulation of JAK2 by H3K9 methyltransferase G9A in leukemia","volume":"32","author":"Son","year":"2012","journal-title":"Mol Cell Biol."},{"issue":"13","key":"2021121717503841500_CIT0136","doi-asserted-by":"crossref","first-page":"9636","DOI":"10.1074\/jbc.M109.062588","article-title":"G9A and Glp methylate lysine 373 in the tumor suppressor p53","volume":"285","author":"Huang","year":"2010","journal-title":"J Biol Chem."},{"issue":"7605","key":"2021121717503841500_CIT0137","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1038\/nature17676","article-title":"Landscape of somatic mutations in 560 breast cancer whole-genome sequences","volume":"534","author":"Nik-Zainal","year":"2016","journal-title":"Nature."},{"issue":"5","key":"2021121717503841500_CIT0138","doi-asserted-by":"crossref","first-page":"359","DOI":"10.3109\/07853890.2015.1043140","article-title":"Epigenetic mechanisms and therapeutic targets of chemotherapy resistance in epithelial ovarian cancer","volume":"47","author":"Borley","year":"2015","journal-title":"Ann Med."},{"issue":"6","key":"2021121717503841500_CIT0139","doi-asserted-by":"crossref","first-page":"675","DOI":"10.2217\/epi.12.64","article-title":"Chromatin landscape and endocrine response in breast cancer","volume":"4","author":"Magnani","year":"2012","journal-title":"Epigenomics."},{"issue":"4","key":"2021121717503841500_CIT0140","doi-asserted-by":"crossref","first-page":"2466","DOI":"10.18632\/oncotarget.2967","article-title":"Genetic alterations of histone lysine methyltransferases and their significance in breast cancer","volume":"6","author":"Liu","year":"2014","journal-title":"Oncotarget."},{"issue":"2","key":"2021121717503841500_CIT0141","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1038\/s41576-018-0074-2","article-title":"Clinical epigenetics: seizing opportunities for translation","volume":"20","author":"Berdasco","year":"2019","journal-title":"Nat Rev Genet."},{"issue":"1","key":"2021121717503841500_CIT0142","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1186\/s13148-019-0776-0","article-title":"The timeline of epigenetic drug discovery: from reality to dreams","volume":"11","author":"Ganesan","year":"2019","journal-title":"Clin Epigenetics."},{"issue":"11","key":"2021121717503841500_CIT0143","doi-asserted-by":"crossref","first-page":"2691","DOI":"10.1158\/1078-0432.CCR-16-1729","article-title":"Combination epigenetic therapy in advanced breast cancer with 5-azacitidine and entinostat: a phase II National Cancer Institute\/Stand Up to Cancer Study","volume":"23","author":"Connolly","year":"2017","journal-title":"Clin Cancer Res."},{"key":"2021121717503841500_CIT0144","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1186\/s13148-017-0358-y","article-title":"Epi-drugs in combination with immunotherapy: a new avenue to improve anticancer efficacy","volume":"9","author":"Mazzone","year":"2017","journal-title":"Clin Epigenetics."},{"issue":"11","key":"2021121717503841500_CIT0145","doi-asserted-by":"crossref","first-page":"1463","DOI":"10.1016\/j.chembiol.2014.09.017","article-title":"EZH2 inhibitor efficacy in non-Hodgkin\u2019s lymphoma does not require suppression of H3K27 monomethylation","volume":"21","author":"Bradley","year":"2014","journal-title":"Chem Biol."},{"issue":"2","key":"2021121717503841500_CIT0146","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1038\/nm.4036","article-title":"Targeting EZH2 in cancer","volume":"22","author":"Kim","year":"2016","journal-title":"Nat Med."},{"issue":"3","key":"2021121717503841500_CIT0147","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/j.celrep.2014.12.028","article-title":"Prolonged Ezh2 depletion in glioblastoma causes a robust switch in cell fate resulting in tumor progression","volume":"10","author":"de Vries","year":"2015","journal-title":"Cell Rep."},{"issue":"24","key":"2021121717503841500_CIT0148","doi-asserted-by":"crossref","first-page":"2661","DOI":"10.1182\/blood-2017-12-818948","article-title":"The DOT1L inhibitor pinometostat reduces H3K79 methylation and has modest clinical activity in adult acute leukemia","volume":"131","author":"Stein","year":"2018","journal-title":"Blood."},{"issue":"4","key":"2021121717503841500_CIT0149","doi-asserted-by":"crossref","first-page":"1469","DOI":"10.1172\/JCI57349","article-title":"G9A interacts with Snail and is critical for Snail-mediated E-cadherin repression in human breast cancer","volume":"122","author":"Dong","year":"2012","journal-title":"J Clin Invest."},{"issue":"1","key":"2021121717503841500_CIT0150","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1038\/sj.onc.1209763","article-title":"5-Aza-2\u2032-deoxycytidine-mediated reductions in G9A histone methyltransferase and histone H3 K9 di-methylation levels are linked to tumor suppressor gene reactivation","volume":"26","author":"Wozniak","year":"2007","journal-title":"Oncogene."},{"issue":"5","key":"2021121717503841500_CIT0151","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1016\/j.febslet.2014.01.039","article-title":"H3K9 histone methyltransferase G9A-mediated transcriptional activation of p21","volume":"588","author":"Oh","year":"2014","journal-title":"FEBS Lett."},{"issue":"6","key":"2021121717503841500_CIT0152","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1016\/j.ccell.2015.04.011","article-title":"Dysfunction of the reciprocal feedback loop between GATA3- and ZEB2-nucleated repression programs contributes to breast cancer metastasis","volume":"27","author":"Si","year":"2015","journal-title":"Cancer Cell."},{"issue":"3","key":"2021121717503841500_CIT0153","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1038\/nchembio721","article-title":"Identification of a specific inhibitor of the histone methyltransferase SU(VAR)3-9","volume":"1","author":"Greiner","year":"2005","journal-title":"Nat Chem Biol."},{"issue":"3","key":"2021121717503841500_CIT0154","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1038\/nsmb.1560","article-title":"Structural basis for G9A-like protein lysine methyltransferase inhibition by BIX-01294","volume":"16","author":"Chang","year":"2009","journal-title":"Nat Struct Mol Biol."},{"issue":"24","key":"2021121717503841500_CIT0155","doi-asserted-by":"crossref","first-page":"7950","DOI":"10.1021\/jm901543m","article-title":"Discovery of a 2,4-diamino-7-aminoalkoxyquinazoline as a potent and selective inhibitor of histone lysine methyltransferase G9A","volume":"52","author":"Liu","year":"2009","journal-title":"J Med Chem."},{"issue":"15","key":"2021121717503841500_CIT0156","doi-asserted-by":"crossref","first-page":"5844","DOI":"10.1021\/jm100478y","article-title":"Protein lysine methyltransferase G9A inhibitors: design, synthesis, and structure activity relationships of 2,4-diamino-7-aminoalkoxy-quinazolines","volume":"53","author":"Liu","year":"2010","journal-title":"J Med Chem."},{"issue":"1","key":"2021121717503841500_CIT0157","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jmb.2010.04.048","article-title":"Adding a lysine mimic in the design of potent inhibitors of histone lysine methyltransferases","volume":"400","author":"Chang","year":"2010","journal-title":"J Mol Biol."},{"issue":"8","key":"2021121717503841500_CIT0158","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1038\/nchembio.599","article-title":"A chemical probe selectively inhibits G9A and GLP methyltransferase activity in cells","volume":"7","author":"Vedadi","year":"2011","journal-title":"Nat Chem Biol."},{"issue":"21","key":"2021121717503841500_CIT0159","doi-asserted-by":"crossref","first-page":"8931","DOI":"10.1021\/jm401480r","article-title":"Discovery of an in vivo chemical probe of the lysine methyltransferases G9A and GLP","volume":"56","author":"Liu","year":"2013","journal-title":"J Med Chem."},{"issue":"3","key":"2021121717503841500_CIT0160","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1002\/cmdc.201300450","article-title":"A chemical tool for in vitro and in vivo precipitation of lysine methyltransferase G9A","volume":"9","author":"Konze","year":"2014","journal-title":"ChemMedChem."},{"issue":"7","key":"2021121717503841500_CIT0161","doi-asserted-by":"crossref","first-page":"1152","DOI":"10.1021\/cb300139y","article-title":"A small-molecule probe of the histone methyltransferase G9A induces cellular senescence in pancreatic adenocarcinoma","volume":"7","author":"Yuan","year":"2012","journal-title":"ACS Chem Biol."},{"issue":"2","key":"2021121717503841500_CIT0162","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1021\/ml400496h","article-title":"Discovery and development of potent and selective inhibitors of histone methyltransferase G9A","volume":"5","author":"Sweis","year":"2014","journal-title":"ACS Med Chem Lett."},{"issue":"1","key":"2021121717503841500_CIT0163","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1021\/jm4012802","article-title":"Pan-histone demethylase inhibitors simultaneously targeting Jumonji C and lysine-specific demethylases display high anticancer activities","volume":"57","author":"Rotili","year":"2014","journal-title":"J Med Chem."},{"issue":"12","key":"2021121717503841500_CIT0164","doi-asserted-by":"crossref","first-page":"2027","DOI":"10.3390\/cancers11122027","article-title":"Inhibition of histone demethylases LSD1 and UTX regulates ER\u03b1 signaling in breast cancer","volume":"11","author":"Benedetti","year":"2019","journal-title":"Cancers (Basel)."},{"issue":"9","key":"2021121717503841500_CIT0165","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1158\/1541-7786.MCR-12-0567","article-title":"Towards sustained silencing of HER2\/neu in cancer by epigenetic editing","volume":"11","author":"Falahi","year":"2013","journal-title":"Mol Cancer Res."},{"issue":"43","key":"2021121717503841500_CIT0166","doi-asserted-by":"crossref","first-page":"5427","DOI":"10.1038\/onc.2014.470","article-title":"Stable oncogenic silencing in vivo by programmable and targeted de novo DNA methylation in breast cancer","volume":"34","author":"Stolzenburg","year":"2015","journal-title":"Oncogene."}],"container-title":["Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/endo\/advance-article-pdf\/doi\/10.1210\/endocr\/bqab088\/37611892\/bqab088.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/endo\/article-pdf\/162\/8\/bqab088\/41810233\/bqab088.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/endo\/article-pdf\/162\/8\/bqab088\/41810233\/bqab088.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,17]],"date-time":"2021-12-17T19:17:13Z","timestamp":1639768633000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/endo\/article\/doi\/10.1210\/endocr\/bqab088\/6259332"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,4,29]]},"references-count":166,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2021,8,1]]}},"URL":"https:\/\/doi.org\/10.1210\/endocr\/bqab088","relation":{},"ISSN":["0013-7227","1945-7170"],"issn-type":[{"value":"0013-7227","type":"print"},{"value":"1945-7170","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2021,8,1]]},"published":{"date-parts":[[2021,4,29]]},"article-number":"bqab088"}}