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Here we review those diverse actions, the physiological relevance of which had remained unestablished until recently. With the identification of a CARTp receptor, GPR160, the physiologic importance and therapeutic potential of CARTp or analogs are being revealed. Not only is the CARTp-GPR160 interaction essential for the circadian regulation of appetite and thirst but also for the transmission of nerve injury-induced pain. Molecular approaches now are uncovering additional physiologically relevant actions and the development of acute tissue-specific gene compromise approaches may reveal even more physiologically relevant actions of this pluripotent ligand\/receptor pair.<\/jats:p>","DOI":"10.1210\/endocr\/bqab108","type":"journal-article","created":{"date-parts":[[2021,5,27]],"date-time":"2021-05-27T22:03:49Z","timestamp":1622153029000},"source":"Crossref","is-referenced-by-count":8,"title":["Overcoming Stress, Hunger, and Pain: Cocaine- and Amphetamine-Regulated Transcript Peptide\u2019s Promise"],"prefix":"10.1210","volume":"162","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0560-4447","authenticated-orcid":false,"given":"Willis K","family":"Samson","sequence":"first","affiliation":[{"name":"Department of Pharmacology and Physiology and Henry and Amelia Nasrallah Center for Neuroscience Saint Louis University School of Medicine, St Louis, MO 63104, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela","family":"Salvemini","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Physiology and Henry and Amelia Nasrallah Center for Neuroscience Saint Louis University School of Medicine, St Louis, MO 63104, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gina L C","family":"Yosten","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Physiology and Henry and Amelia Nasrallah Center for Neuroscience Saint Louis University School of Medicine, St Louis, MO 63104, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"80","published-online":{"date-parts":[[2021,5,27]]},"reference":[{"issue":"2","key":"2021121717593098800_CIT0001","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/0378-1119(96)88651-3","article-title":"Characterization of the human cDNA and genomic DNA encoding CART: a cocaine- and 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