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It not only controls the sleep\u2013wake and feeding\u2013fasting cycles but also coordinates and maintains the required reproductive activities in the body. Physiologically, the reproductive processes are governed by the hypothalamic\u2013pituitary\u2013gonadal (HPG) axis in a time-dependent manner. The HPG axis releases hormones, generates female characteristics, and achieves fertility. Conversely, an abnormal daily rhythm caused by aberrant clock genes or abnormal environmental stimuli contributes to disorders of the female reproductive system, such as polycystic ovarian syndrome and premature ovarian insufficiency. Therefore, breaking the \u201ctime code\u201d of the female reproductive system is crucial. In this paper, we review the interplay between circadian clocks and the female reproductive system and present its regulatory principles, moving from normal physiology regulation to disease etiology.<\/jats:p>","DOI":"10.1210\/endocr\/bqab117","type":"journal-article","created":{"date-parts":[[2021,6,14]],"date-time":"2021-06-14T13:28:00Z","timestamp":1623677280000},"source":"Crossref","is-referenced-by-count":79,"title":["Circadian Rhythms Within the Female HPG Axis: From Physiology to Etiology"],"prefix":"10.1210","volume":"162","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8305-9715","authenticated-orcid":false,"given":"Shuyi","family":"Shao","sequence":"first","affiliation":[{"name":"Obstetrics and Gynecology Hospital, Fudan University, Shanghai, 200011, China"},{"name":"The Shanghai Key Laboratory of Female Reproductive Endocrine-Related Diseases, Shanghai, 200011, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huanqiang","family":"Zhao","sequence":"additional","affiliation":[{"name":"Obstetrics and Gynecology Hospital, Fudan University, Shanghai, 200011, China"},{"name":"The Shanghai Key Laboratory of Female Reproductive Endocrine-Related Diseases, Shanghai, 200011, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiying","family":"Lu","sequence":"additional","affiliation":[{"name":"Obstetrics and Gynecology Hospital, Fudan University, Shanghai, 200011, China"},{"name":"The Shanghai Key Laboratory of Female Reproductive Endocrine-Related Diseases, Shanghai, 200011, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaohong","family":"Lei","sequence":"additional","affiliation":[{"name":"Obstetrics and Gynecology Hospital, Fudan University, Shanghai, 200011, China"},{"name":"The Shanghai Key Laboratory of Female Reproductive Endocrine-Related Diseases, Shanghai, 200011, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3853-5070","authenticated-orcid":false,"given":"Ying","family":"Zhang","sequence":"additional","affiliation":[{"name":"Obstetrics and Gynecology Hospital, Fudan University, Shanghai, 200011, China"},{"name":"The Shanghai Key Laboratory of Female Reproductive Endocrine-Related Diseases, Shanghai, 200011, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"80","published-online":{"date-parts":[[2021,6,14]]},"reference":[{"issue":"2","key":"2021121717594570800_CIT0001","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1210\/jcem-54-2-241","article-title":"Maturation of the hypothalamo-pituitary-ovarian axis in adolescent girls","volume":"54","author":"Lemarchand-B\u00e9raud","year":"1982","journal-title":"J Clin Endocrinol 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