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Growing epidemiological evidence suggests that PBDEs alter cardiovascular function. The goal of this study was to examine the effects of BDE-47 on adrenal corticosteroid pathways that play vital roles in cardiovascular homeostasis and pathophysiology. The effect of BDE-47 on aldosterone and cortisol secretion was characterized in a human adrenocortical cell line. HAC15 cells were exposed to various concentrations of BDE-47 (1 nM to 100 \u03bcM). Cell viability, corticosteroid secretion, gene expression of enzymes involved in corticosteroid synthesis, and metabolic activity was examined. Additionally, Sprague Dawley male rats were orally exposed to BDE-47 (10 or 100 \u00b5g\/kg), 5 days per week for 16 weeks. Organ weights and plasma corticosteroid levels were measured. In HAC15 cells, basal and stimulated aldosterone and cortisol secretion was significantly increased by BDE-47. Gene expression of several enzymes involved in corticosteroid synthesis and mitochondrial metabolism also increased. In Sprague Dawley rats, adrenal but not heart, kidney, or liver weights, were significantly increased in BDE-47 treatment groups. Plasma corticosterone levels were significantly increased in the 100 \u00b5g BDE-47\/kg treatment group. No change in plasma aldosterone levels were observed with BDE-47 exposure. These data indicate that BDE-47 disrupts the regulation of corticosteroid secretion and provides further evidence that PBDEs are potential endocrine disruptors. Future studies will determine the underlying molecular mechanism of altered corticosteroid production and examine whether these alterations result in underlying cardiovascular disease in our rodent model of 16-week BDE-47 exposure.<\/jats:p>","DOI":"10.1210\/endocr\/bqab160","type":"journal-article","created":{"date-parts":[[2021,8,9]],"date-time":"2021-08-09T20:45:36Z","timestamp":1628541936000},"source":"Crossref","is-referenced-by-count":18,"title":["Adrenal Corticosteroid Perturbation by the Endocrine Disruptor BDE-47 in a Human Adrenocortical Cell Line and Male Rats"],"prefix":"10.1210","volume":"162","author":[{"given":"Benjamin M","family":"Dungar","sequence":"first","affiliation":[{"name":"Department of Pharmacology, College of Graduate Studies, Midwestern University, Downers Grove, IL 60515, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chad D","family":"Schupbach","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, College of Graduate Studies, Midwestern University, Downers Grove, IL 60515, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessie R","family":"Jacobson","sequence":"additional","affiliation":[{"name":"Chicago College of Osteopathic Medicine, Midwestern University, Downers Grove, IL 60515, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0474-443X","authenticated-orcid":false,"given":"Phillip G","family":"Kopf","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, College of Graduate Studies, Midwestern University, Downers Grove, IL 60515, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"80","published-online":{"date-parts":[[2021,8,9]]},"reference":[{"issue":"4","key":"2021101307533394800_CIT0001","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1210\/er.2009-0002","article-title":"Endocrine-disrupting chemicals: an Endocrine Society scientific statement","volume":"30","author":"Diamanti-Kandarakis","year":"2009","journal-title":"Endocr Rev."},{"key":"2021101307533394800_CIT0002","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1146\/annurev-physiol-012110-142200","article-title":"Endocrine disruptors: from endocrine to metabolic disruption","volume":"73","author":"Casals-Casas","year":"2011","journal-title":"Annu Rev Physiol."},{"issue":"1","key":"2021101307533394800_CIT0003","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1289\/ehp.6559","article-title":"Brominated flame retardants: cause for concern?","volume":"112","author":"Birnbaum","year":"2004","journal-title":"Environ Health Perspect."},{"issue":"4","key":"2021101307533394800_CIT0004","doi-asserted-by":"crossref","first-page":"281","DOI":"10.3121\/cmr.1.4.281","article-title":"Polybrominated diphenyl ethers (PBDEs): new pollutants-old diseases","volume":"1","author":"Siddiqi","year":"2003","journal-title":"Clin Med Res."},{"issue":"2","key":"2021101307533394800_CIT0005","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/j.ijheh.2015.11.001","article-title":"Levels of persistent contaminants in relation to fish consumption among older male anglers in Wisconsin","volume":"219","author":"Christensen","year":"2016","journal-title":"Int J Hyg Environ Health."},{"issue":"6","key":"2021101307533394800_CIT0006","doi-asserted-by":"crossref","first-page":"1780","DOI":"10.1021\/jf035310q","article-title":"Time trend investigation of PCBs, PBDEs, and organochlorine pesticides in selected n-3 polyunsaturated fatty acid rich dietary fish oil and vegetable oil supplements; nutritional relevance for human essential n-3 fatty acid requirements","volume":"52","author":"Jacobs","year":"2004","journal-title":"J Agric Food Chem."},{"key":"2021101307533394800_CIT0007","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.envint.2012.05.006","article-title":"Polybrominated diphenyl ethers in maternal serum, umbilical cord serum, colostrum and mature breast milk. 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