{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T15:51:51Z","timestamp":1783525911016,"version":"3.55.0"},"reference-count":74,"publisher":"The Endocrine Society","issue":"11","license":[{"start":{"date-parts":[[2021,8,13]],"date-time":"2021-08-13T00:00:00Z","timestamp":1628812800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001804","name":"Canada Research Chairs Program","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100001804","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Qu\u00e9bec Network on Drug Research"},{"name":"Cardiometabolic health, Diabetes and Obesity Research Network"},{"name":"Foundation of the Qu\u00e9bec Heart and Lung Institute"},{"DOI":"10.13039\/501100010785","name":"Canada First Research Excellence Fund","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100010785","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Fonds de recherche et d\u2019enseignement"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,11,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>The brain influences liver metabolism through many neuroendocrine and autonomic mechanisms that have evolved to protect the organism against starvation and hypoglycemia. Unfortunately, this effective way of preventing death has become dysregulated in modern obesogenic environments, although the pathophysiological mechanisms behind metabolic dyshomeostasis are still unclear. In this Mini-Review, we provide our thoughts regarding obesity and type 2 diabetes as diseases of the autonomic nervous system. We discuss the pathophysiological mechanisms that alter the autonomic brain-liver communication in these diseases, and how they could represent important targets to prevent or treat metabolic dysfunctions. We discuss how sympathetic hyperactivity to the liver may represent an early event in the progression of metabolic diseases and could progressively lead to hepatic neuropathy. We hope that this discussion will inspire and help to frame a model based on better understanding of the chronology of autonomic dysfunctions in the liver, enabling the application of the right strategy at the right time.<\/jats:p>","DOI":"10.1210\/endocr\/bqab164","type":"journal-article","created":{"date-parts":[[2021,8,13]],"date-time":"2021-08-13T16:41:42Z","timestamp":1628872902000},"source":"Crossref","is-referenced-by-count":19,"title":["Pathophysiological Mechanisms That Alter the Autonomic Brain-Liver Communication in Metabolic Diseases"],"prefix":"10.1210","volume":"162","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5431-6903","authenticated-orcid":false,"given":"Anisia","family":"Silva","sequence":"first","affiliation":[{"name":"Faculty of Pharmacy, Universit\u00e9 Laval, Qu\u00e9bec City, QC G1V 0A6, Canada"},{"name":"Quebec Heart and Lung Institute, Qu\u00e9bec City, QC G1V 4G5, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6939-6136","authenticated-orcid":false,"given":"Alexandre","family":"Caron","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy, Universit\u00e9 Laval, Qu\u00e9bec City, QC G1V 0A6, Canada"},{"name":"Quebec Heart and Lung Institute, Qu\u00e9bec City, QC G1V 4G5, Canada"},{"name":"Montreal Diabetes Research Center, Montreal, QC H2X 0A9, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"80","published-online":{"date-parts":[[2021,8,13]]},"reference":[{"issue":"4","key":"2021101307532268100_CIT0001","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1016\/j.bbadis.2010.01.006","article-title":"The role of the autonomic nervous liver innervation in the control of energy metabolism","volume":"1802","author":"Yi","year":"2010","journal-title":"Biochim Biophys 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