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Their bioavailability is determined by specific transporter proteins at the cell surface. The TH-specific transporter monocarboxylate transporter 8 (MCT8) was recently reported as a regulator of bone mass in mice. Given that high systemic triiodothyronine (T3) levels in Mct8 knockout (KO) mice are still able to cause trabecular bone loss, alternative TH transporters must substitute for MCT8 function in bone. In this study, we analyzed the skeletal phenotypes of male Oatp1c1 KO and Mct10 KO mice, which are euthyroid, and male Mct8\/Oatp1c1 and Mct8\/Mct10 double KO mice, which have elevated circulating T3 levels, to unravel the role of TH transport in bone. MicroCT analysis showed no significant trabecular bone changes in Oatp1c1 KO mice at 4 weeks and 16 weeks of age compared with wild-type littermate controls, whereas 16-week-old Mct8\/Oatp1c1 double KO animals displayed trabecular bone loss. At 12 weeks, Mct10 KO mice, but not Mct8\/Mct10 double KO mice, had decreased trabecular femoral bone volume with reduced osteoblast numbers. By contrast, lack of Mct10 in 24-week-old mice led to trabecular bone gain at the femur with increased osteoblast numbers and decreased osteoclast numbers whereas Mct8\/Mct10 double KO did not alter bone mass. Neither Mct10 nor Mct8\/Mct10 deletion affected vertebral bone structures at both ages. In vitro, osteoblast differentiation and activity were impaired by Mct10 and Mct8\/Mct10-deficiency. These data demonstrate that MCT10, but not OATP1C1, is a site- and age-dependent regulator of bone mass and turnover in male mice.<\/jats:p>","DOI":"10.1210\/endocr\/bqab218","type":"journal-article","created":{"date-parts":[[2021,10,21]],"date-time":"2021-10-21T00:32:15Z","timestamp":1634776335000},"source":"Crossref","is-referenced-by-count":11,"title":["The Thyroid Hormone Transporter MCT10 Is a Novel Regulator of Trabecular Bone Mass and Bone Turnover in Male Mice"],"prefix":"10.1210","volume":"163","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1059-5506","authenticated-orcid":false,"given":"Franziska","family":"Lademann","sequence":"first","affiliation":[{"name":"Department of Medicine III and Center for Healthy Aging, Technische Universit\u00e4t Dresden, D-01307 Dresden, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6072-142X","authenticated-orcid":false,"given":"Steffen","family":"Mayerl","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, University of Duisburg-Essen, University Hospital Essen, D-45147 Essen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Tsourdi","sequence":"additional","affiliation":[{"name":"Department of Medicine III and Center for Healthy Aging, Technische Universit\u00e4t Dresden, D-01307 Dresden, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francois","family":"Verrey","sequence":"additional","affiliation":[{"name":"Institute of Physiology, University of Zurich, CH-8057 Zurich, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victoria D","family":"Leitch","sequence":"additional","affiliation":[{"name":"Molecular Endocrinology Laboratory, Department of Metabolism, Digestion and Reproduction, Imperial College London, London SW7 2AZ, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Graham R","family":"Williams","sequence":"additional","affiliation":[{"name":"Molecular Endocrinology Laboratory, Department of Metabolism, Digestion and Reproduction, Imperial College London, London SW7 2AZ, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J H Duncan","family":"Bassett","sequence":"additional","affiliation":[{"name":"Molecular Endocrinology Laboratory, Department of Metabolism, Digestion and Reproduction, Imperial College London, London SW7 2AZ, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorenz C","family":"Hofbauer","sequence":"additional","affiliation":[{"name":"Department of Medicine III and Center for Healthy Aging, Technische Universit\u00e4t Dresden, D-01307 Dresden, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heike","family":"Heuer","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, University of Duisburg-Essen, University Hospital Essen, D-45147 Essen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4067-6799","authenticated-orcid":false,"given":"Martina","family":"Rauner","sequence":"additional","affiliation":[{"name":"Department of Medicine III and Center for Healthy Aging, Technische Universit\u00e4t Dresden, D-01307 Dresden, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"80","published-online":{"date-parts":[[2021,10,20]]},"reference":[{"issue":"2","key":"2021111800233215500_CIT0001","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1210\/er.2015-1106","article-title":"Role of thyroid hormones in skeletal development and bone 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