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A key participant in adipose tissue homeostasis that has only recently captured broad scientific attention is the lymphatic vasculature. The lymphatic system\u2019s role in lipid trafficking and mediating inflammation makes it a natural partner in regulating adipose tissue, and evidence supporting a bidirectional relationship between lymphatics and adipose tissue has accumulated in recent years. Obesity is now understood to impair lymphatic function, whereas altered lymphatic function results in aberrant adipose tissue deposition, though the molecular mechanisms governing these phenomena have yet to be fully elucidated. We will review our current understanding of the relationship between adipose tissue and the lymphatic system here, focusing on known mechanisms of lymphatic-adipose crosstalk.<\/jats:p>","DOI":"10.1210\/endocr\/bqab224","type":"journal-article","created":{"date-parts":[[2021,10,31]],"date-time":"2021-10-31T09:26:42Z","timestamp":1635672402000},"source":"Crossref","is-referenced-by-count":25,"title":["Crosstalk Between Adipose and Lymphatics in Health and Disease"],"prefix":"10.1210","volume":"163","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4321-3992","authenticated-orcid":false,"given":"Gregory P","family":"Westcott","sequence":"first","affiliation":[{"name":"Division of Endocrinology, Diabetes, and Metabolism, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA"},{"name":"Joslin Diabetes Center, Boston, MA 02215, USA"},{"name":"Harvard Medical School, Boston, MA 02215, 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