{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,31]],"date-time":"2026-01-31T04:29:12Z","timestamp":1769833752838,"version":"3.49.0"},"reference-count":64,"publisher":"The Endocrine Society","issue":"2","license":[{"start":{"date-parts":[[2021,12,11]],"date-time":"2021-12-11T00:00:00Z","timestamp":1639180800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["R01 DK055704"],"award-info":[{"award-number":["R01 DK055704"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["R01 DK114054"],"award-info":[{"award-number":["R01 DK114054"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,2,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Intrauterine growth restriction (IUGR) leads to the development of type 2 diabetes in adulthood, and the permanent alterations in gene expression implicate an epigenetic mechanism. Using a rat model of IUGR, we performed TrueSeq-HELP Tagging to assess the association of DNA methylation changes and gene dysregulation in islets. We identified 511 differentially methylated regions (DMRs) and 4377 significantly altered single CpG sites. Integrating the methylome and our published transcriptome data sets resulted in the identification of pathways critical for islet function. The identified DMRs were enriched with transcription factor binding motifs, such as Elk1, Etv1, Foxa1, Foxa2, Pax7, Stat3, Hnf1, and AR. In silico analysis of 3-dimensional chromosomal interactions using human pancreas and islet Hi-C data sets identified interactions between 14 highly conserved DMRs and 35 genes with significant expression changes at an early age, many of which persisted in adult islets. In adult islets, there were far more interactions between DMRs and genes with significant expression changes identified with Hi-C, and most of them were critical to islet metabolism and insulin secretion. The methylome was integrated with our published genome-wide histone modification data sets from IUGR islets, resulting in further characterization of important regulatory regions of the genome altered by IUGR containing both significant changes in DNA methylation and specific histone marks. We identified novel regulatory regions in islets after exposure to IUGR, suggesting that epigenetic changes at key transcription factor binding motifs and other gene regulatory regions may contribute to gene dysregulation and an abnormal islet phenotype in IUGR rats.<\/jats:p>","DOI":"10.1210\/endocr\/bqab251","type":"journal-article","created":{"date-parts":[[2021,12,11]],"date-time":"2021-12-11T14:04:25Z","timestamp":1639231465000},"source":"Crossref","is-referenced-by-count":4,"title":["Identification of Novel Regulatory Regions Induced by Intrauterine Growth Restriction in Rat Islets"],"prefix":"10.1210","volume":"163","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2764-1794","authenticated-orcid":false,"given":"Yu-Chin","family":"Lien","sequence":"first","affiliation":[{"name":"Center for Research on Reproduction and Women\u2019s Health, Perelman School of Medicine, the University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA"},{"name":"Division of Neonatology, Department of Pediatrics, Children\u2019s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sara E","family":"Pinney","sequence":"additional","affiliation":[{"name":"Center for Research on Reproduction and Women\u2019s Health, Perelman School of Medicine, the University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA"},{"name":"Division Endocrinology and Diabetes, Children\u2019s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA"},{"name":"Perlman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xueqing Maggie","family":"Lu","sequence":"additional","affiliation":[{"name":"Institute for Biomedical Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2901-8904","authenticated-orcid":false,"given":"Rebecca A","family":"Simmons","sequence":"additional","affiliation":[{"name":"Center for Research on Reproduction and Women\u2019s Health, Perelman School of Medicine, the University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA"},{"name":"Division of Neonatology, Department of Pediatrics, Children\u2019s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA"},{"name":"Perlman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"80","published-online":{"date-parts":[[2021,12,11]]},"reference":[{"issue":"24","key":"2022010917551397200_CIT0001","doi-asserted-by":"crossref","first-page":"2886","DOI":"10.1001\/jama.2008.886","article-title":"Birth weight and risk of type 2 diabetes: a systematic review","volume":"300","author":"Whincup","year":"2008","journal-title":"JAMA."},{"issue":"10","key":"2022010917551397200_CIT0002","doi-asserted-by":"crossref","first-page":"2279","DOI":"10.2337\/diabetes.50.10.2279","article-title":"Intrauterine growth retardation leads to the development of type 2 diabetes in the rat","volume":"50","author":"Simmons","year":"2001","journal-title":"Diabetes."},{"issue":"10","key":"2022010917551397200_CIT0003","doi-asserted-by":"crossref","first-page":"970","DOI":"10.1016\/0026-0495(86)90064-8","article-title":"Altered gas exchange, limited glucose and branched chain amino acids, and hypoinsulinism retard fetal growth in the rat","volume":"35","author":"Ogata","year":"1986","journal-title":"Metabolism."},{"issue":"5","key":"2022010917551397200_CIT0004","doi-asserted-by":"crossref","first-page":"1672","DOI":"10.2337\/db13-1226","article-title":"Neutralizing Th2 inflammation in neonatal islets prevents \u03b2-cell failure in adult IUGR rats","volume":"63","author":"Jaeckle Santos","year":"2014","journal-title":"Diabetes."},{"issue":"3","key":"2022010917551397200_CIT0005","doi-asserted-by":"crossref","first-page":"734","DOI":"10.2337\/diabetes.52.3.734","article-title":"Neonatal exendin-4 prevents the development of diabetes in the intrauterine growth retarded rat","volume":"52","author":"Stoffers","year":"2003","journal-title":"Diabetes."},{"issue":"1","key":"2022010917551397200_CIT0006","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1203\/PDR.0b013e3181a282a5","article-title":"Exendin-4 normalizes islet vascularity in intrauterine growth restricted rats: potential role of VEGF","volume":"66","author":"Ham","year":"2009","journal-title":"Pediatr Res."},{"issue":"2","key":"2022010917551397200_CIT0007","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1210\/en.2017-00888","article-title":"Transcriptomic analysis reveals novel mechanisms mediating islet dysfunction in the intrauterine growth-restricted rat","volume":"159","author":"Rashid","year":"2018","journal-title":"Endocrinology."},{"issue":"5","key":"2022010917551397200_CIT0008","doi-asserted-by":"crossref","first-page":"1028","DOI":"10.1016\/j.cmet.2019.03.009","article-title":"Epigenetics in human obesity and type 2 diabetes","volume":"29","author":"Ling","year":"2019","journal-title":"Cell Metab."},{"issue":"20","key":"2022010917551397200_CIT0009","doi-asserted-by":"crossref","first-page":"15111","DOI":"10.1074\/jbc.M109.095133","article-title":"Experimental intrauterine growth restriction induces alterations in DNA methylation and gene expression in pancreatic islets of rats","volume":"285","author":"Thompson","year":"2010","journal-title":"J Biol Chem."},{"issue":"6","key":"2022010917551397200_CIT0010","doi-asserted-by":"crossref","first-page":"1435","DOI":"10.3390\/cells9061435","article-title":"Altered transcription factor binding and gene bivalency in islets of intrauterine growth retarded rats","volume":"9","author":"Lien","year":"2020","journal-title":"Cells."},{"key":"2022010917551397200_CIT0011","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1007\/978-1-4939-7481-8_11","article-title":"The HELP-based DNA methylation assays","volume":"1708","author":"Greally","year":"2018","journal-title":"Methods Mol Biol."},{"key":"2022010917551397200_CIT0012","article-title":"Supplementary data for: \u201cIdentification of novel regulatory regions induced by intrauterine growth restriction in rat islets.\u201d","author":"Lien","year":"2021","journal-title":"Figshare"},{"issue":"1","key":"2022010917551397200_CIT0013","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1186\/s12859-018-2037-1","article-title":"Defiant: (DMRs: easy, fast, identification and ANnoTation) identifies differentially methylated regions from iron-deficient rat hippocampus","volume":"19","author":"Condon","year":"2018","journal-title":"BMC Bioinformatics."},{"issue":"4","key":"2022010917551397200_CIT0014","first-page":"656","article-title":"BLAT\u2013the BLAST-like alignment tool","volume":"12","author":"Kent","year":"2002","journal-title":"Genome Res."},{"issue":"8","key":"2022010917551397200_CIT0015","doi-asserted-by":"crossref","first-page":"2042","DOI":"10.1016\/j.celrep.2016.10.061","article-title":"A compendium of chromatin contact maps reveals spatially active regions in the human genome","volume":"17","author":"Schmitt","year":"2016","journal-title":"Cell Rep."},{"issue":"5950","key":"2022010917551397200_CIT0016","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1126\/science.1181369","article-title":"Comprehensive mapping of long-range interactions reveals folding principles of the human genome","volume":"326","author":"Lieberman-Aiden","year":"2009","journal-title":"Science."},{"issue":"1","key":"2022010917551397200_CIT0017","doi-asserted-by":"crossref","first-page":"2078","DOI":"10.1038\/s41467-019-09975-4","article-title":"Pancreatic islet chromatin accessibility and conformation reveals distal enhancer networks of type 2 diabetes risk","volume":"10","author":"Greenwald","year":"2019","journal-title":"Nat Commun."},{"issue":"3","key":"2022010917551397200_CIT0018","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1016\/j.celrep.2018.12.083","article-title":"Multiomic profiling identifies cis-regulatory networks underlying human pancreatic \u03b2 cell identity and function","volume":"26","author":"Lawlor","year":"2019","journal-title":"Cell Rep."},{"issue":"7","key":"2022010917551397200_CIT0019","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1038\/s41588-019-0457-0","article-title":"Human pancreatic islet three-dimensional chromatin architecture provides insights into the genetics of type 2 diabetes","volume":"51","author":"Miguel-Escalada","year":"2019","journal-title":"Nat Genet."},{"issue":"6","key":"2022010917551397200_CIT0020","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1093\/bioinformatics\/btq033","article-title":"BEDTools: a flexible suite of utilities for comparing genomic features","volume":"26","author":"Quinlan","year":"2010","journal-title":"Bioinformatics."},{"issue":"9","key":"2022010917551397200_CIT0021","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1186\/s13059-014-0469-0","article-title":"Global loss of DNA methylation uncovers intronic enhancers in genes showing expression changes","volume":"15","author":"Blattler","year":"2014","journal-title":"Genome Biol."},{"issue":"7","key":"2022010917551397200_CIT0022","doi-asserted-by":"crossref","first-page":"3498","DOI":"10.1093\/nar\/gkv153","article-title":"A diverse epigenetic landscape at human exons with implication for expression","volume":"43","author":"Singer","year":"2015","journal-title":"Nucleic Acids Res."},{"issue":"11","key":"2022010917551397200_CIT0023","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.2337\/diab.44.11.1285","article-title":"Phosphofructokinase isozymes in pancreatic islets and clonal beta-cells (INS-1)","volume":"44","author":"Yaney","year":"1995","journal-title":"Diabetes."},{"key":"2022010917551397200_CIT0024","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.peptides.2015.07.008","article-title":"Altered serotonin (5-HT) 1D and 2A receptor expression may contribute to defective insulin and glucagon secretion in human type 2 diabetes","volume":"71","author":"Bennet","year":"2015","journal-title":"Peptides."},{"issue":"2","key":"2022010917551397200_CIT0025","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1172\/JCI45096","article-title":"\u03b13(V) collagen is critical for glucose homeostasis in mice due to effects in pancreatic islets and peripheral tissues","volume":"121","author":"Huang","year":"2011","journal-title":"J Clin Invest."},{"issue":"Pt 21","key":"2022010917551397200_CIT0026","first-page":"5084","article-title":"Role of phosphodiesterases in the shaping of sub-plasma-membrane cAMP oscillations and pulsatile insulin secretion","volume":"125","author":"Tian","year":"2012","journal-title":"J Cell Sci."},{"issue":"5","key":"2022010917551397200_CIT0027","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1210\/me.2016-1021","article-title":"Research resource: roles for calcium\/calmodulin-dependent protein kinase 2 (CaMKK2) in systems metabolism","volume":"30","author":"Marcelo","year":"2016","journal-title":"Mol Endocrinol."},{"issue":"17","key":"2022010917551397200_CIT0028","doi-asserted-by":"crossref","first-page":"6049","DOI":"10.1128\/MCB.23.17.6049-6062.2003","article-title":"Members of the large Maf transcription family regulate insulin gene transcription in islet beta cells","volume":"23","author":"Matsuoka","year":"2003","journal-title":"Mol Cell Biol."},{"issue":"4","key":"2022010917551397200_CIT0029","doi-asserted-by":"crossref","first-page":"1074","DOI":"10.2337\/db16-0996","article-title":"Whole-genome bisulfite sequencing of human pancreatic islets reveals novel differentially methylated regions in type 2 diabetes pathogenesis","volume":"66","author":"Volkov","year":"2017","journal-title":"Diabetes."},{"issue":"5","key":"2022010917551397200_CIT0030","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.3390\/nu11051191","article-title":"Dysregulation of neuronal genes by fetal-neonatal iron deficiency anemia is associated with altered DNA methylation in the rat hippocampus","volume":"11","author":"Lien","year":"2019","journal-title":"Nutrients."},{"issue":"2","key":"2022010917551397200_CIT0031","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1210\/clinem\/dgz037","article-title":"In utero bisphenol a exposure is linked with sex specific changes in the transcriptome and methylome of human amniocytes","volume":"105","author":"Bansal","year":"2020","journal-title":"J Clin Endocrinol Metab."},{"issue":"10","key":"2022010917551397200_CIT0032","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1080\/15592294.2015.1084462","article-title":"Integrative analysis of methylome and transcriptome in human blood identifies extensive sex- and immune cell-specific differentially methylated regions","volume":"10","author":"Mamrut","year":"2015","journal-title":"Epigenetics."},{"issue":"4","key":"2022010917551397200_CIT0033","doi-asserted-by":"crossref","first-page":"e95875","DOI":"10.1371\/journal.pone.0095875","article-title":"The DNA methylome and transcriptome of different brain regions in schizophrenia and bipolar disorder","volume":"9","author":"Xiao","year":"2014","journal-title":"PLoS One."},{"issue":"1","key":"2022010917551397200_CIT0034","doi-asserted-by":"crossref","first-page":"E15","DOI":"10.1152\/ajpendo.00424.2017","article-title":"Epigenetics and developmental origins of diabetes: correlation or causation?","volume":"315","author":"Bansal","year":"2018","journal-title":"Am J Physiol Endocrinol Metab."},{"issue":"6","key":"2022010917551397200_CIT0035","first-page":"2316","article-title":"Development of type 2 diabetes following intrauterine growth retardation in rats is associated with progressive epigenetic silencing of Pdx1","volume":"118","author":"Park","year":"2008","journal-title":"J Clin Invest."},{"issue":"10","key":"2022010917551397200_CIT0036","doi-asserted-by":"crossref","first-page":"2606","DOI":"10.1007\/s00125-011-2250-1","article-title":"Exendin-4 increases histone acetylase activity and reverses epigenetic modifications that silence Pdx1 in the intrauterine growth retarded rat","volume":"54","author":"Pinney","year":"2011","journal-title":"Diabetologia."},{"issue":"8","key":"2022010917551397200_CIT0037","doi-asserted-by":"crossref","first-page":"1594","DOI":"10.1210\/me.2009-0513","article-title":"Foxa1 and Foxa2 maintain the metabolic and secretory features of the mature \u03b2-cell","volume":"24","author":"Gao","year":"2010","journal-title":"Mol Endocrinol."},{"issue":"24","key":"2022010917551397200_CIT0038","doi-asserted-by":"crossref","first-page":"3435","DOI":"10.1101\/gad.1752608","article-title":"Dynamic regulation of Pdx1 enhancers by Foxa1 and Foxa2 is essential for pancreas development","volume":"22","author":"Gao","year":"2008","journal-title":"Genes Dev."},{"issue":"13","key":"2022010917551397200_CIT0039","doi-asserted-by":"crossref","first-page":"1706","DOI":"10.1101\/gad.901601","article-title":"Tissue-specific deletion of Foxa2 in pancreatic beta cells results in hyperinsulinemic hypoglycemia","volume":"15","author":"Sund","year":"2001","journal-title":"Genes Dev."},{"issue":"4","key":"2022010917551397200_CIT0040","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.1016\/j.bbrc.2004.05.095","article-title":"Insulin secretory defects and impaired islet architecture in pancreatic beta-cell-specific STAT3 knockout mice","volume":"319","author":"Gorogawa","year":"2004","journal-title":"Biochem Biophys Res Commun."},{"issue":"5","key":"2022010917551397200_CIT0041","doi-asserted-by":"crossref","first-page":"2050","DOI":"10.1210\/en.2009-1199","article-title":"Glucose intolerance and impaired insulin secretion in pancreas-specific signal transducer and activator of transcription-3 knockout mice are associated with microvascular alterations in the pancreas","volume":"151","author":"Kostromina","year":"2010","journal-title":"Endocrinology."},{"issue":"6","key":"2022010917551397200_CIT0042","doi-asserted-by":"crossref","first-page":"e2272","DOI":"10.1038\/cddis.2016.171","article-title":"STAT3 modulates \u03b2-cell cycling in injured mouse pancreas and protects against DNA damage","volume":"7","author":"De Groef","year":"2016","journal-title":"Cell Death Dis."},{"issue":"4","key":"2022010917551397200_CIT0043","doi-asserted-by":"crossref","first-page":"726","DOI":"10.2337\/diab.46.4.726","article-title":"Novel MODY3 mutations in the hepatocyte nuclear factor-1alpha gene: evidence for a hyperexcitability of pancreatic beta-cells to intravenous secretagogues in a glucose-tolerant carrier of a P447L mutation","volume":"46","author":"Hansen","year":"1997","journal-title":"Diabetes."},{"issue":"11","key":"2022010917551397200_CIT0044","doi-asserted-by":"crossref","first-page":"2472","DOI":"10.2337\/diabetes.50.11.2472","article-title":"Loss of HNF-1alpha function in mice leads to abnormal expression of genes involved in pancreatic islet development and metabolism","volume":"50","author":"Shih","year":"2001","journal-title":"Diabetes."},{"issue":"10","key":"2022010917551397200_CIT0045","doi-asserted-by":"crossref","first-page":"2215","DOI":"10.1172\/JCI2548","article-title":"Defective insulin secretion in hepatocyte nuclear factor 1alpha-deficient mice","volume":"101","author":"Pontoglio","year":"1998","journal-title":"J Clin Invest."},{"issue":"38","key":"2022010917551397200_CIT0046","doi-asserted-by":"crossref","first-page":"24457","DOI":"10.1074\/jbc.273.38.24457","article-title":"Defective pancreatic beta-cell glycolytic signaling in hepatocyte nuclear factor-1alpha-deficient mice","volume":"273","author":"Dukes","year":"1998","journal-title":"J Biol Chem."},{"key":"2022010917551397200_CIT0047","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.molmet.2018.07.007","article-title":"A PDX1-ATF transcriptional complex governs \u03b2 cell survival during stress","volume":"17","author":"Juliana","year":"2018","journal-title":"Mol Metab."},{"issue":"12","key":"2022010917551397200_CIT0048","doi-asserted-by":"crossref","first-page":"3402","DOI":"10.2337\/diabetes.54.12.3402","article-title":"The HMG box transcription factor Sox4 contributes to the development of the endocrine pancreas","volume":"54","author":"Wilson","year":"2005","journal-title":"Diabetes."},{"issue":"8","key":"2022010917551397200_CIT0049","doi-asserted-by":"crossref","first-page":"2234","DOI":"10.2337\/db07-0337","article-title":"Role of the transcription factor Sox4 in insulin secretion and impaired glucose tolerance","volume":"57","author":"Goldsworthy","year":"2008","journal-title":"Diabetes."},{"issue":"5","key":"2022010917551397200_CIT0050","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1007\/s00125-015-3507-x","article-title":"SOX4 cooperates with neurogenin 3 to regulate endocrine pancreas formation in mouse models","volume":"58","author":"Xu","year":"2015","journal-title":"Diabetologia."},{"issue":"55","key":"2022010917551397200_CIT0051","doi-asserted-by":"crossref","first-page":"6432","DOI":"10.1038\/sj.onc.1204039","article-title":"Expression and function of Ets transcription factors in mammalian development: a regulatory network","volume":"19","author":"Maroulakou","year":"2000","journal-title":"Oncogene."},{"issue":"11","key":"2022010917551397200_CIT0052","doi-asserted-by":"crossref","first-page":"3100","DOI":"10.1002\/dvdy.21292","article-title":"ETS-family genes in pancreatic development","volume":"236","author":"Kobberup","year":"2007","journal-title":"Dev Dyn."},{"issue":"20","key":"2022010917551397200_CIT0053","doi-asserted-by":"crossref","first-page":"17533","DOI":"10.1074\/jbc.M009088200","article-title":"A pancreatic \u03b2-cell-specific enhancer in the human PDX-1 gene is regulated by hepatocyte nuclear factor 3\u03b2 (HNF-3\u03b2), HNF-1\u03b1, and SPs transcription factors","volume":"276","author":"Ben-Shushan","year":"2001","journal-title":"J Biol Chem."},{"issue":"8","key":"2022010917551397200_CIT0054","doi-asserted-by":"crossref","first-page":"1929","DOI":"10.2337\/db09-0070","article-title":"Identification of a novel beta-cell glucokinase (GCK) promoter mutation (\u201371G\u2005&gt;\u2005C) that modulates GCK gene expression through loss of allele-specific Sp1 binding causing mild fasting hyperglycemia in humans","volume":"58","author":"Gasper\u00edkov\u00e1","year":"2009","journal-title":"Diabetes."},{"issue":"23","key":"2022010917551397200_CIT0055","doi-asserted-by":"crossref","first-page":"3883","DOI":"10.1016\/j.febslet.2013.10.024","article-title":"Palmitate increases Nur77 expression by modulating ZBP89 and Sp1 binding to the Nur77 proximal promoter in pancreatic \u03b2-cells","volume":"587","author":"Mazuy","year":"2013","journal-title":"FEBS Lett."},{"issue":"8","key":"2022010917551397200_CIT0056","doi-asserted-by":"crossref","first-page":"1463","DOI":"10.7150\/ijbs.40834","article-title":"Transcription factor RREB1: from target genes towards biological functions","volume":"16","author":"Deng","year":"2020","journal-title":"Int J Biol Sci."},{"issue":"1","key":"2022010917551397200_CIT0057","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1038\/npp.2012.112","article-title":"DNA methylation and its basic function","volume":"38","author":"Moore","year":"2013","journal-title":"Neuropsychopharmacology."},{"issue":"18","key":"2022010917551397200_CIT0058","doi-asserted-by":"crossref","first-page":"8503","DOI":"10.1093\/nar\/gkt652","article-title":"Integrative analysis of tissue-specific methylation and alternative splicing identifies conserved transcription factor binding motifs","volume":"41","author":"Wan","year":"2013","journal-title":"Nucleic Acids Res."},{"issue":"5","key":"2022010917551397200_CIT0059","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1016\/j.molcel.2006.08.008","article-title":"CTCF-dependent chromatin insulator is linked to epigenetic remodeling","volume":"23","author":"Ishihara","year":"2006","journal-title":"Mol Cell."},{"issue":"6","key":"2022010917551397200_CIT0060","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1016\/j.cmet.2006.11.002","article-title":"PERK EIF2AK3 control of pancreatic beta cell differentiation and proliferation is required for postnatal glucose homeostasis","volume":"4","author":"Zhang","year":"2006","journal-title":"Cell Metab."},{"issue":"6","key":"2022010917551397200_CIT0061","doi-asserted-by":"crossref","first-page":"2301","DOI":"10.1096\/fj.12-226092","article-title":"The hydrolase DDAH2 enhances pancreatic insulin secretion by transcriptional regulation of secretagogin through a Sirt1-dependent mechanism in mice","volume":"27","author":"Hasegawa","year":"2013","journal-title":"FASEB J."},{"key":"2022010917551397200_CIT0062","doi-asserted-by":"crossref","first-page":"8872639","DOI":"10.1155\/2020\/8872639","article-title":"Nutrient sensor mTOR and OGT: orchestrators of organelle homeostasis in pancreatic \u03b2-cells","volume":"2020","author":"Esch","year":"2020","journal-title":"J Diabetes Res."},{"issue":"7154","key":"2022010917551397200_CIT0063","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1038\/nature05987","article-title":"DNMT3L connects unmethylated lysine 4 of histone H3 to de novo methylation of DNA","volume":"448","author":"Ooi","year":"2007","journal-title":"Nature."},{"issue":"8","key":"2022010917551397200_CIT0064","doi-asserted-by":"crossref","first-page":"a018747","DOI":"10.1101\/cshperspect.a018747","article-title":"Structural and functional coordination of DNA and histone methylation","volume":"6","author":"Cheng","year":"2014","journal-title":"Cold Spring Harb Perspect Biol."}],"container-title":["Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/endo\/advance-article-pdf\/doi\/10.1210\/endocr\/bqab251\/41725679\/bqab251.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/endo\/article-pdf\/163\/2\/bqab251\/42090670\/bqab251.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/endo\/article-pdf\/163\/2\/bqab251\/42090670\/bqab251.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,1,9]],"date-time":"2022-01-09T17:55:58Z","timestamp":1641750958000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/endo\/article\/doi\/10.1210\/endocr\/bqab251\/6459683"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,12,11]]},"references-count":64,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2022,2,1]]}},"URL":"https:\/\/doi.org\/10.1210\/endocr\/bqab251","relation":{},"ISSN":["0013-7227","1945-7170"],"issn-type":[{"value":"0013-7227","type":"print"},{"value":"1945-7170","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2022,2,1]]},"published":{"date-parts":[[2021,12,11]]},"article-number":"bqab251"}}