{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,25]],"date-time":"2026-04-25T16:14:22Z","timestamp":1777133662824,"version":"3.51.4"},"reference-count":57,"publisher":"The Endocrine Society","issue":"2","license":[{"start":{"date-parts":[[2021,12,16]],"date-time":"2021-12-16T00:00:00Z","timestamp":1639612800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,2,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Noncoding RNAs (ncRNAs), including microRNAs (miRNAs) and circular RNAs (circRNAs), which are expressed with a daily rhythm in the rat pineal gland, are associated with the regulation of melatonin secretion and other biological functions. However, the mechanisms of these molecules in the rat pineal gland are not yet fully understood. In this study, we found that circR-WNK2 was highly expressed at night, which may be involved in the regulation of melatonin secretion through the competitive endogenous RNA (ceRNA) mechanism. By dual luciferase reporter, RNA pull-down, and fluorescence in situ hybridization (FISH) assays, we found that miR-328a-3p can target circR-WNK2 and the Aa-nat mRNA 3\u2032UTR. Transfection experiments indicated that circR-WNK2 could competitively bind to miR-328a-3p, reduce miR-328a-3p expression, and promote Aa-nat gene expression and melatonin secretion. And by constructing a superior cervical ganglionectomy (SCGx) rat model, we found that ncRNAs expression in the pineal gland was regulated by signals from the suprachiasmatic nucleus. This finding supports the hypothesis that these noncoding RNAs may interact to shape the circadian rhythm through transcriptional processing in melatonin synthesis.<\/jats:p>","DOI":"10.1210\/endocr\/bqab255","type":"journal-article","created":{"date-parts":[[2021,12,17]],"date-time":"2021-12-17T01:35:06Z","timestamp":1639704906000},"source":"Crossref","is-referenced-by-count":7,"title":["CircRNA-WNK2 Acts as a ceRNA for miR-328a-3p to Promote AANAT Expression in the Male Rat Pineal Gland"],"prefix":"10.1210","volume":"163","author":[{"given":"Yi","family":"Zheng","sequence":"first","affiliation":[{"name":"Department of Laboratory Animals, Jilin Provincial Key Laboratory of Animal Model, Jilin University, Changchun 130062, Jilin, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hao-Qi","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Laboratory Animals, Jilin Provincial Key Laboratory of Animal Model, Jilin University, Changchun 130062, Jilin, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hai-Xiang","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Laboratory Animals, Jilin Provincial Key Laboratory of Animal Model, Jilin University, Changchun 130062, Jilin, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heng-Li","family":"Xie","sequence":"additional","affiliation":[{"name":"Department of Laboratory Animals, Jilin Provincial Key Laboratory of Animal Model, Jilin University, Changchun 130062, Jilin, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei-Di","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Laboratory Animals, Jilin Provincial Key Laboratory of Animal Model, Jilin University, Changchun 130062, Jilin, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dong-Xu","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Laboratory Animals, Jilin Provincial Key Laboratory of Animal Model, Jilin University, Changchun 130062, Jilin, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2008-6166","authenticated-orcid":false,"given":"Hao","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Laboratory Animals, Jilin Provincial Key Laboratory of Animal Model, Jilin University, Changchun 130062, Jilin, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3490-0755","authenticated-orcid":false,"given":"Bao","family":"Yuan","sequence":"additional","affiliation":[{"name":"Department of Laboratory Animals, Jilin Provincial Key Laboratory of Animal Model, Jilin University, Changchun 130062, Jilin, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8533-4744","authenticated-orcid":false,"given":"Jia-Bao","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Laboratory Animals, Jilin Provincial Key Laboratory of Animal Model, Jilin University, Changchun 130062, Jilin, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"80","published-online":{"date-parts":[[2021,12,16]]},"reference":[{"issue":"Suppl 1","key":"2022011401103544800_CIT0001","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1159\/000125797","article-title":"Rhythmic release pattern of pineal melatonin in rodents","volume":"53","author":"Chan","year":"1991","journal-title":"Neuroendocrinology"},{"issue":"2","key":"2022011401103544800_CIT0002","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1124\/pr.55.2.2","article-title":"Generation of the melatonin endocrine message in mammals: a review of the complex regulation of melatonin synthesis by norepinephrine, peptides, and other pineal transmitters","volume":"55","author":"Simonneaux","year":"2003","journal-title":"Pharmacol Rev."},{"issue":"5","key":"2022011401103544800_CIT0003","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1016\/j.conb.2013.02.018","article-title":"Circadian timekeeping and output mechanisms in animals","volume":"23","author":"Hardin","year":"2013","journal-title":"Curr Opin Neurobiol."},{"issue":"2","key":"2022011401103544800_CIT0004","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/j.mce.2009.07.010","article-title":"Pineal function: impact of microarray analysis","volume":"314","author":"Klein","year":"2010","journal-title":"Mol Cell Endocrinol."},{"issue":"3","key":"2022011401103544800_CIT0005","first-page":"439","article-title":"Norepinephrine stimulation of pineal cyclic AMP response element-binding protein phosphorylation: primary role of a beta-adrenergic receptor\/cyclic AMP mechanism","volume":"47","author":"Roseboom","year":"1995","journal-title":"Mol Pharmacol."},{"issue":"9","key":"2022011401103544800_CIT0006","doi-asserted-by":"crossref","first-page":"3326","DOI":"10.1523\/JNEUROSCI.19-09-03326.1999","article-title":"Transcription factors in neuroendocrine regulation: rhythmic changes in pCREB and ICER levels frame melatonin synthesis","volume":"19","author":"Maronde","year":"1999","journal-title":"J Neurosci."},{"issue":"11","key":"2022011401103544800_CIT0007","doi-asserted-by":"crossref","first-page":"5194","DOI":"10.1210\/en.2004-0864","article-title":"Adrenergic regulation and diurnal rhythm of p38 mitogen-activated protein kinase phosphorylation in the rat pineal gland","volume":"145","author":"Chik","year":"2004","journal-title":"Endocrinology"},{"issue":"2-3","key":"2022011401103544800_CIT0008","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/S0014-2999(01)00823-8","article-title":"Characterisation of P2Y(1)-like receptor in cultured rat pineal glands","volume":"415","author":"Ferreira","year":"2001","journal-title":"Eur J Pharmacol."},{"issue":"11","key":"2022011401103544800_CIT0009","doi-asserted-by":"crossref","first-page":"6979","DOI":"10.1074\/jbc.272.11.6979","article-title":"The rat arylalkylamine N-acetyltransferase gene promoter. cAMP activation via a cAMP-responsive element-CCAAT complex","volume":"272","author":"Baler","year":"1997","journal-title":"J Biol Chem."},{"issue":"1-2","key":"2022011401103544800_CIT0010","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.lfs.2007.10.016","article-title":"Insulin modulates norepinephrine-mediated melatonin synthesis in cultured rat pineal gland","volume":"82","author":"Garcia","year":"2008","journal-title":"Life Sci."},{"issue":"3","key":"2022011401103544800_CIT0011","doi-asserted-by":"crossref","first-page":"1375","DOI":"10.1210\/endo.140.3.6552","article-title":"Photoneural regulation of rat pineal hydroxyindole-O-methyltransferase (HIOMT) messenger ribonucleic acid expression: an analysis of its complex relationship with HIOMT activity","volume":"140","author":"Ribelayga","year":"1999","journal-title":"Endocrinology"},{"issue":"14","key":"2022011401103544800_CIT0012","doi-asserted-by":"crossref","first-page":"8083","DOI":"10.1073\/pnas.141118798","article-title":"Role of a pineal cAMP-operated arylalkylamine N-acetyltransferase\/14-3-3-binding switch in melatonin synthesis","volume":"98","author":"Ganguly","year":"2001","journal-title":"Proc Natl Acad Sci USA."},{"key":"2022011401103544800_CIT0013","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1146\/annurev.pharmtox.40.1.617","article-title":"14-3-3 proteins: structure, function, and regulation","volume":"40","author":"Fu","year":"2000","journal-title":"Annu Rev Pharmacol Toxicol."},{"key":"2022011401103544800_CIT0014","first-page":"38","article-title":"Photoneural regulation of the mammalian pineal gland","volume":"117","author":"Klein","year":"1985","journal-title":"Ciba Found Symp"},{"issue":"30","key":"2022011401103544800_CIT0015","doi-asserted-by":"crossref","first-page":"25312","DOI":"10.1074\/jbc.M112.356733","article-title":"MicroRNAs in the pineal gland: miR-483 regulates melatonin synthesis by targeting arylalkylamine N-acetyltransferase","volume":"287","author":"Clokie","year":"2012","journal-title":"J Biol Chem."},{"issue":"2","key":"2022011401103544800_CIT0016","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.cell.2009.01.002","article-title":"MicroRNAs: target recognition and regulatory functions","volume":"136","author":"Bartel","year":"2009","journal-title":"Cell"},{"issue":"1","key":"2022011401103544800_CIT0017","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1101\/gr.082701.108","article-title":"Most mammalian mRNAs are conserved targets of microRNAs","volume":"19","author":"Friedman","year":"2009","journal-title":"Genome Res."},{"issue":"33","key":"2022011401103544800_CIT0018","doi-asserted-by":"crossref","first-page":"13319","DOI":"10.1073\/pnas.1207748109","article-title":"Circadian changes in long noncoding RNAs in the pineal gland","volume":"109","author":"Coon","year":"2012","journal-title":"Proc Natl Acad Sci USA."},{"issue":"1","key":"2022011401103544800_CIT0019","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.bbrc.2020.05.047","article-title":"The role of a lncRNA (TCONS_00044595) in regulating pineal CLOCK expression after neonatal hypoxia-ischemia brain injury","volume":"528","author":"Li","year":"2020","journal-title":"Biochem Biophys Res Commun."},{"issue":"2","key":"2022011401103544800_CIT0020","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1016\/j.cell.2018.05.022","article-title":"A network of noncoding regulatory RNAs acts in the mammalian brain","volume":"4","author":"Kleaveland","year":"2018","journal-title":"Cell"},{"issue":"1","key":"2022011401103544800_CIT0021","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.bbagrm.2015.07.007","article-title":"Circular RNAs: identification, biogenesis and function","volume":"1859","author":"Ebbesen","year":"2016","journal-title":"Biochim Biophys Acta."},{"key":"2022011401103544800_CIT0022","doi-asserted-by":"crossref","DOI":"10.1111\/age.12781","article-title":"Genome-wide identification and comparison of mRNAs, lncRNAs and circRNAs in porcine intramuscular, subcutaneous, retroperitoneal and mesenteric adipose tissues","author":"Liu","year":"2019","journal-title":"Anim Genet."},{"issue":"7441","key":"2022011401103544800_CIT0023","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1038\/nature11993","article-title":"Natural RNA circles function as efficient microRNA sponges","volume":"495","author":"Hansen","year":"2013","journal-title":"Nature"},{"issue":"5","key":"2022011401103544800_CIT0024","doi-asserted-by":"crossref","first-page":"1225","DOI":"10.7150\/ijms.51743","article-title":"Identifying daily changes in circRNAs and circRNA associated-ceRNA networks in the rat pineal gland","volume":"18","author":"Zhen","year":"2021","journal-title":"Int J Med Sci."},{"issue":"1","key":"2022011401103544800_CIT0025","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.jneumeth.2010.07.007","article-title":"A standardized surgical technique for rat superior cervical ganglionectomy","volume":"192","author":"Savastano","year":"2010","journal-title":"J Neurosci Methods."},{"issue":"5","key":"2022011401103544800_CIT0026","doi-asserted-by":"crossref","first-page":"1225","DOI":"10.7150\/ijms.51743","article-title":"Identifying daily changes in circRNAs and circRNA-associated-ceRNA networks in the rat pineal gland","volume":"18","author":"Zheng","year":"2021","journal-title":"Int J Med Sci."},{"key":"2022011401103544800_CIT0027","author":"Bao","year":"2021"},{"key":"2022011401103544800_CIT0028","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.05005","article-title":"Predicting effective microRNA target sites in mammalian mRNAs","volume":"4","author":"Agarwal","year":"2015","journal-title":"Elife."},{"issue":"7","key":"2022011401103544800_CIT0029","doi-asserted-by":"crossref","first-page":"1094","DOI":"10.1093\/bioinformatics\/btv656","article-title":"Specific identification and quantification of circular RNAs from sequencing data","volume":"32","author":"Cheng","year":"2016","journal-title":"Bioinformatics."},{"issue":"22","key":"2022011401103544800_CIT0030","doi-asserted-by":"crossref","first-page":"36553","DOI":"10.18632\/oncotarget.16615","article-title":"Roles of differential expression of microRNA-21-3p and microRNA-433 in FSH regulation in rat anterior pituitary cells","volume":"8","author":"Han","year":"2017","journal-title":"Oncotarget."},{"key":"2022011401103544800_CIT0031","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.neures.2014.03.005","article-title":"The in vitro maintenance of clock genes expression within the rat pineal gland under standard and norepinephrine-synchronized stimulation","volume":"81-82","author":"Andrade-Silva","year":"2014","journal-title":"Neurosci Res"},{"issue":"2","key":"2022011401103544800_CIT0032","doi-asserted-by":"crossref","first-page":"e12629","DOI":"10.1111\/jpi.12629","article-title":"Circadian regulation and molecular role of the Bsx homeobox gene in the adult pineal gland","volume":"68","author":"Carstensen","year":"2020","journal-title":"J Pineal Res."},{"issue":"9","key":"2022011401103544800_CIT0033","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1038\/nrg2843","article-title":"The widespread regulation of microRNA biogenesis, function and decay","volume":"11","author":"Krol","year":"2010","journal-title":"Nat Rev Genet."},{"issue":"1","key":"2022011401103544800_CIT0034","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21010132","article-title":"Systems and synthetic microRNA biology: from biogenesis to disease pathogenesis","author":"Matsuyama","year":"2019","journal-title":"Int J Mol Sci."},{"key":"2022011401103544800_CIT0035","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.brainres.2017.05.001","article-title":"Up-regulation of miR-325-3p suppresses pineal aralkylamine N-acetyltransferase (Aanat) after neonatal hypoxia-ischemia brain injury in rats","volume":"1668","author":"Yang","year":"2017","journal-title":"Brain Res."},{"issue":"4","key":"2022011401103544800_CIT0036","doi-asserted-by":"crossref","first-page":"e12693","DOI":"10.1111\/jpi.12693","article-title":"A meta-analysis of microRNA networks regulated by melatonin in cancer: portrait of potential candidates for breast cancer treatment","volume":"69","author":"Chuffa","year":"2020","journal-title":"J Pineal Res."},{"issue":"1","key":"2022011401103544800_CIT0037","doi-asserted-by":"crossref","first-page":"65","DOI":"10.2217\/epi-2020-0241","article-title":"Melatonin and regulation of miRNAs: novel targeted therapy for cancerous and noncancerous disease","volume":"13","author":"Pourhanifeh","year":"2021","journal-title":"Epigenomics."},{"key":"2022011401103544800_CIT0038","doi-asserted-by":"crossref","first-page":"546516","DOI":"10.1155\/2013\/546516","article-title":"Leptin modulates norepinephrine-mediated melatonin synthesis in cultured rat pineal gland","volume":"2013","author":"Peliciari-Garcia","year":"2013","journal-title":"Biomed Res Int."},{"issue":"3","key":"2022011401103544800_CIT0039","doi-asserted-by":"crossref","first-page":"e12552","DOI":"10.1111\/jpi.12552","article-title":"MicroRNA-7 inhibits melatonin synthesis by acting as a linking molecule between leptin and norepinephrine signaling pathways in pig pineal gland","volume":"66","author":"Qiu","year":"2019","journal-title":"J Pineal Res."},{"issue":"4","key":"2022011401103544800_CIT0040","doi-asserted-by":"crossref","first-page":"e12567","DOI":"10.1111\/jpi.12567","article-title":"Homeobox genes in melatonin-producing pinealocytes: Otx2 and Crx act to promote hormone synthesis in the mature rat pineal gland","volume":"66","author":"Rohde","year":"2019","journal-title":"J Pineal Res."},{"issue":"5355","key":"2022011401103544800_CIT0041","doi-asserted-by":"crossref","first-page":"1358","DOI":"10.1126\/science.279.5355.1358","article-title":"Melatonin production: proteasomal proteolysis in serotonin N-acetyltransferase regulation","volume":"279","author":"Gastel","year":"1998","journal-title":"Science."},{"issue":"17","key":"2022011401103544800_CIT0042","doi-asserted-by":"crossref","first-page":"4812","DOI":"10.1158\/0008-5472.CAN-18-0532","article-title":"CircNT5E acts as a sponge of miR-422a to promote glioblastoma tumorigenesis","volume":"78","author":"Wang","year":"2018","journal-title":"Cancer Res."},{"issue":"4","key":"2022011401103544800_CIT0043","doi-asserted-by":"crossref","first-page":"e1478","DOI":"10.1002\/wrna.1478","article-title":"A 360 degrees view of circular RNAs: from biogenesis to functions","volume":"9","author":"Wilusz","year":"2018","journal-title":"Wiley Interdiscip Rev RNA."},{"key":"2022011401103544800_CIT0044","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1007\/978-981-13-1426-1_19","article-title":"Circular RNA and Alzheimer\u2019s disease","volume":"1087","author":"Akhter","year":"2018","journal-title":"Adv Exp Med Biol."},{"issue":"7441","key":"2022011401103544800_CIT0045","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1038\/nature11928","article-title":"Circular RNAs are a large class of animal RNAs with regulatory potency","volume":"495","author":"Memczak","year":"2013","journal-title":"Nature."},{"key":"2022011401103544800_CIT0046","doi-asserted-by":"crossref","first-page":"11215","DOI":"10.1038\/ncomms11215","article-title":"Circular RNA profiling reveals an abundant circHIPK3 that regulates cell growth by sponging multiple miRNAs","volume":"7","author":"Zheng","year":"2016","journal-title":"Nat Commun."},{"issue":"4","key":"2022011401103544800_CIT0047","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1177\/0748730404267340","article-title":"The 2004 Aschoff\/Pittendrigh lecture: theory of the origin of the pineal gland--a tale of conflict and resolution","volume":"19","author":"Klein","year":"2004","journal-title":"J Biol Rhythms."},{"issue":"12","key":"2022011401103544800_CIT0048","doi-asserted-by":"crossref","first-page":"7606","DOI":"10.1074\/jbc.M808394200","article-title":"Night\/day changes in pineal expression of &gt;600 genes: central role of adrenergic\/cAMP signaling","volume":"284","author":"Bailey","year":"2009","journal-title":"J Biol Chem."},{"issue":"7","key":"2022011401103544800_CIT0049","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1038\/35081582","article-title":"Hypothalamic integration of central and peripheral clocks","volume":"2","author":"Buijs","year":"2001","journal-title":"Nat Rev Neurosci."},{"issue":"2","key":"2022011401103544800_CIT0050","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/0006-8993(79)90848-5","article-title":"Pineal N-acetyltransferase and hydroxyindole-O-methyltransferase: control by the retinohypothalamic tract and the suprachiasmatic nucleus","volume":"174","author":"Klein","year":"1979","journal-title":"Brain Res."},{"issue":"1","key":"2022011401103544800_CIT0051","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1046\/j.1460-9568.1998.00003.x","article-title":"Characterization of the multisynaptic neuronal control of the rat pineal gland using viral transneuronal tracing","volume":"10","author":"Larsen","year":"1998","journal-title":"Eur J Neurosci."},{"issue":"2","key":"2022011401103544800_CIT0052","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1046\/j.1471-4159.1996.66020748.x","article-title":"Norepinephrine release in the rat pineal gland: the input from the biological clock measured by in vivo microdialysis","volume":"66","author":"Drijfhout","year":"1996","journal-title":"J Neurochem."},{"issue":"9","key":"2022011401103544800_CIT0053","doi-asserted-by":"crossref","first-page":"e0137548","DOI":"10.1371\/journal.pone.0137548","article-title":"Neurotranscriptomics: the effects of neonatal stimulus deprivation on the rat pineal transcriptome","volume":"10","author":"Hartley","year":"2015","journal-title":"PLoS One."},{"issue":"8","key":"2022011401103544800_CIT0054","doi-asserted-by":"crossref","first-page":"3232","DOI":"10.1128\/MCB.25.8.3232-3246.2005","article-title":"Rhythmic serotonin N-acetyltransferase mRNA degradation is essential for the maintenance of its circadian oscillation","volume":"25","author":"Kim","year":"2005","journal-title":"Mol Cell Biol."},{"issue":"2","key":"2022011401103544800_CIT0055","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1046\/j.1460-9568.2003.02442.x","article-title":"Suprachiasmatic control of melatonin synthesis in rats: inhibitory and stimulatory mechanisms","volume":"17","author":"Perreau-Lenz","year":"2003","journal-title":"Eur J Neurosci."},{"key":"2022011401103544800_CIT0056","doi-asserted-by":"crossref","first-page":"370","DOI":"10.3389\/fendo.2017.00370","article-title":"Alterations in metabolism and diurnal rhythms following bilateral surgical removal of the superior cervical ganglia in rats","volume":"8","author":"Mul Fedele","year":"2017","journal-title":"Front Endocrinol (Lausanne)."},{"issue":"2","key":"2022011401103544800_CIT0057","doi-asserted-by":"crossref","first-page":"e12664","DOI":"10.1111\/jpi.12664","article-title":"Journal of pineal research guideline for authors: measuring melatonin in humans","volume":"69","author":"Lockley","year":"2020","journal-title":"J Pineal Res."}],"container-title":["Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/endo\/advance-article-pdf\/doi\/10.1210\/endocr\/bqab255\/41793088\/bqab255.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/endo\/article-pdf\/163\/2\/bqab255\/42184506\/bqab255.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/endo\/article-pdf\/163\/2\/bqab255\/42184506\/bqab255.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,1,14]],"date-time":"2022-01-14T01:12:28Z","timestamp":1642122748000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/endo\/article\/doi\/10.1210\/endocr\/bqab255\/6464229"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,12,16]]},"references-count":57,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2022,2,1]]}},"URL":"https:\/\/doi.org\/10.1210\/endocr\/bqab255","relation":{},"ISSN":["0013-7227","1945-7170"],"issn-type":[{"value":"0013-7227","type":"print"},{"value":"1945-7170","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2022,2,1]]},"published":{"date-parts":[[2021,12,16]]},"article-number":"bqab255"}}