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However, with time, tumors may evolve and lead to disease progression; thus, there is a great interest in unraveling the mechanisms that drive tumor metastasis and endocrine resistance. In this review, we focus on one of the many pathways that have been involved in tumor progression, the fibroblast growth factor\/fibroblast growth factor receptor (FGFR) axis. We emphasize in data obtained from in vivo experimental models that we believe that in luminal BrCa, tumor growth relies in a crosstalk with the stromal tissue. We revisited the studies that illustrate the interaction between hormone receptors and FGFR. We also highlight the most frequent alterations found in BrCa cell lines and provide a short review on the trials that use FGFR inhibitors in combination with endocrine therapies. Analysis of these data suggests there are many players involved in this pathway that might be also targeted to decrease FGF signaling, in addition to specific FGFR inhibitors that may be exploited to increase their efficacy.<\/jats:p>","DOI":"10.1210\/endocr\/bqab265","type":"journal-article","created":{"date-parts":[[2022,1,3]],"date-time":"2022-01-03T09:16:46Z","timestamp":1641201406000},"source":"Crossref","is-referenced-by-count":9,"title":["New Insights in the Interaction of FGF\/FGFR and Steroid Receptor Signaling in Breast Cancer"],"prefix":"10.1210","volume":"163","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8405-2438","authenticated-orcid":false,"given":"Cecilia","family":"P\u00e9rez Pi\u00f1ero","sequence":"first","affiliation":[{"name":"Instituto de Biolog\u00eda y Medicina Experimental, IBYME CONICET, C1428ADN Ciudad de Buenos Aires, 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effect of antibody against basic fibroblast growth factor on androgen- or glucocorticoid-induced growth of Shionogi carcinoma 115 cells in serum-free culture","volume":"49","author":"Lu","year":"1989","journal-title":"Cancer Res."},{"issue":"8","key":"2022012121211447600_CIT0135","first-page":"2316","article-title":"Interaction of androgen-induced autocrine heparin-binding growth factor with fibroblast growth factor receptor on androgen-dependent Shionogi carcinoma 115 cells","volume":"50","author":"Nonomura","year":"1990","journal-title":"Cancer Res."},{"issue":"11","key":"2022012121211447600_CIT0136","first-page":"3006","article-title":"Proliferation of Shionogi carcinoma 115 cells by glucocorticoid-induced autocrine heparin-binding growth factor(s) in serum-free medium","volume":"51","author":"Yamanishi","year":"1991","journal-title":"Cancer 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