{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,2]],"date-time":"2026-08-02T23:46:39Z","timestamp":1785714399654,"version":"3.56.0"},"reference-count":64,"publisher":"The Endocrine Society","issue":"5","license":[{"start":{"date-parts":[[2022,4,6]],"date-time":"2022-04-06T00:00:00Z","timestamp":1649203200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/100009633","name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","doi-asserted-by":"publisher","award":["HD096057"],"award-info":[{"award-number":["HD096057"]}],"id":[{"id":"10.13039\/100009633","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009633","name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","doi-asserted-by":"publisher","award":["HD032067"],"award-info":[{"award-number":["HD032067"]}],"id":[{"id":"10.13039\/100009633","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000861","name":"Burroughs Wellcome Fund","doi-asserted-by":"publisher","award":["NGP10125"],"award-info":[{"award-number":["NGP10125"]}],"id":[{"id":"10.13039\/100000861","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,5,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The biological processes that control endometrial receptivity and embryo implantation are critical for the successful outcome of pregnancy. The endometrium is the complex inner lining of the uterine wall that is under the cyclical control of estrogen and progesterone and is a site of intimate contact between mother and blastocyst. The bone morphogenetic signaling (BMP) pathway is a highly conserved signaling pathway that controls key cellular processes throughout pregnancy and exerts intracellular effects via the SMAD1\/5 transcription factors. To delineate the endometrial compartment\u2013specific roles of BMP signaling, we generated mice with epithelial-specific conditional deletion of SMAD1\/5 using Lactoferrin-icre (Smad1flox\/flox;Smad5flox\/flox;Lactoferrin-cre, \u201cSmad1\/5 cKO\u201d). Histological analysis of the reproductive tracts showed that Smad1\/5 cKO mice were developmentally normal and displayed no defects in glandular morphology. In fertility analyses, single SMAD1 or SMAD5 deletion had no effect on fertility; however, double-conditional deletion of SMAD1 and SMAD5 resulted in severe subfertility. Timed mating analyses revealed endometrial receptivity defects in the Smad1\/5 cKO mice beginning at 3.5 days post coitum (dpc) that perturbed embryo implantation at 4.5 dpc, as demonstrated by the detection of unattached blastocysts in the uterus, decreased COX2 expression, and FOXO1 cytoplasmic mislocalization. We also found that defects that arose during peri-implantation adversely affected embryonic and decidual development at 5.5 and 6.5 dpc. Thus, uterine epithelial BMP\/SMAD1\/5 signaling is essential during early pregnancy and SMAD1\/5 epithelial-specific deletion has detrimental effects on stromal cell decidualization and pregnancy development.<\/jats:p>","DOI":"10.1210\/endocr\/bqac043","type":"journal-article","created":{"date-parts":[[2022,4,6]],"date-time":"2022-04-06T03:01:43Z","timestamp":1649214103000},"source":"Crossref","is-referenced-by-count":19,"title":["BMP\/SMAD1\/5 Signaling in the Endometrial Epithelium Is Essential for Receptivity and Early Pregnancy"],"prefix":"10.1210","volume":"163","author":[{"given":"Suni","family":"Tang","sequence":"first","affiliation":[{"name":"Department of Pathology & Immunology, Baylor College of Medicine , Houston, TX 77030 ,","place":["USA"]},{"name":"Center for Drug Discovery, Baylor College of Medicine , Houston, TX 77030 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominique I","family":"Cope","sequence":"additional","affiliation":[{"name":"Department of Pathology & Immunology, Baylor College of Medicine , Houston, TX 77030 ,","place":["USA"]},{"name":"Center for Drug Discovery, Baylor College of Medicine , Houston, TX 77030 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasmin M","family":"Vasquez","sequence":"additional","affiliation":[{"name":"Department of Pathology & Immunology, Baylor College of Medicine , Houston, TX 77030 ,","place":["USA"]},{"name":"Center for Drug Discovery, Baylor College of Medicine , Houston, TX 77030 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5660-6392","authenticated-orcid":false,"given":"Diana","family":"Monsivais","sequence":"additional","affiliation":[{"name":"Department of Pathology & Immunology, Baylor College of Medicine , Houston, TX 77030 ,","place":["USA"]},{"name":"Center for Drug Discovery, Baylor College of 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