{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T01:48:03Z","timestamp":1790732883051,"version":"4.1.0"},"reference-count":51,"publisher":"The Endocrine Society","issue":"7","license":[{"start":{"date-parts":[[2022,5,7]],"date-time":"2022-05-07T00:00:00Z","timestamp":1651881600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"Center for Metabolism and Mitochondrial Medicine"},{"DOI":"10.13039\/100000945","name":"Pittsburgh Foundation","doi-asserted-by":"publisher","award":["MR2020 109502"],"award-info":[{"award-number":["MR2020 109502"]}],"id":[{"id":"10.13039\/100000945","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["#82000816"],"award-info":[{"award-number":["#82000816"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,7,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Diabetes and related metabolic syndrome are common metabolic disorders. Gestational diabetes mellitus (GDM) is rather prevalent in the clinic. Although most GDM resolves after therapeutic intervention and\/or after delivery, the long-term health effect of GDM remains to be better understood. The constitutive androstane receptor (CAR), initially characterized as a xenobiotic receptor, was more recently proposed to be a therapeutic target for obesity and type 2 diabetes mellitus (T2DM). In this study, high-fat diet (HFD) feeding was used to induce GDM. Upon delivery, GDM mice were returned to chow diet until the metabolic parameters were normalized. Parous non-GDM control females or metabolically normalized GDM females were then subjected to HFD feeding to induce nongestational obesity and T2DM. Our results showed that GDM sensitized mice to metabolic abnormalities induced by a second hit of HFD. Treatment with the CAR agonist 1,4-bis [2-(3,5 dichloropyridyloxy)] benzene efficiently attenuated GDM-sensitized and HFD-induced obesity and T2DM, including decreased body weight, improved insulin sensitivity, inhibition of hyperglycemia and hepatic steatosis, increased oxygen consumption, and decreased adipocyte hypertrophy. In conclusion, our results have established GDM as a key risk factor for the future development of metabolic disease. We also propose that CAR is a therapeutic target for the management of metabolic disease sensitized by GDM.<\/jats:p>","DOI":"10.1210\/endocr\/bqac061","type":"journal-article","created":{"date-parts":[[2022,5,7]],"date-time":"2022-05-07T13:09:32Z","timestamp":1651928972000},"source":"Crossref","is-referenced-by-count":3,"title":["Gestational Diabetes Sensitizes Mice to Future Metabolic Syndrome That Can Be Relieved by Activating CAR"],"prefix":"10.1210","volume":"163","author":[{"given":"Ye","family":"Feng","sequence":"first","affiliation":[{"name":"Center for Pharmacogenetics and Department of Pharmaceutical Sciences, University of Pittsburgh , Pittsburgh, PA , 15261 USA"},{"name":"Department of Endocrinology and Metabolic Disease, The First Affiliated Hospital, Zhejiang University School of Medicine , Hangzhou , 310003 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Xu","sequence":"additional","affiliation":[{"name":"Center for Pharmacogenetics and Department of Pharmaceutical Sciences, University of Pittsburgh , Pittsburgh, PA , 15261 USA"},{"name":"Department of pharmacy, Zhongnan Hospital of Wuhan University, School of Pharmaceutical Sciences, Wuhan University , Wuhan 430071 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinran","family":"Cai","sequence":"additional","affiliation":[{"name":"Center for Pharmacogenetics and Department of Pharmaceutical Sciences, University of Pittsburgh , Pittsburgh, PA, 15261 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meishu","family":"Xu","sequence":"additional","affiliation":[{"name":"Center for Pharmacogenetics and Department of Pharmaceutical Sciences, University of Pittsburgh , Pittsburgh, PA, 15261 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wojciech G","family":"Garbacz","sequence":"additional","affiliation":[{"name":"Center for Pharmacogenetics and Department of Pharmaceutical Sciences, University of Pittsburgh , Pittsburgh, PA, 15261 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Songrong","family":"Ren","sequence":"additional","affiliation":[{"name":"Center for Pharmacogenetics and Department of Pharmaceutical Sciences, University of Pittsburgh , Pittsburgh, PA, 15261 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael J","family":"Jurczak","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Metabolism, Department of Medicine, University of Pittsburgh , Pittsburgh, PA, 15261 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4842-3646","authenticated-orcid":false,"given":"Chaohui","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, The First Affiliated Hospital, Zhejiang University School of Medicine , Hangzhou, 310003 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5300-8661","authenticated-orcid":false,"given":"Hui","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, School of Basic Medical Sciences, Wuhan University , Wuhan 430071 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3967-155X","authenticated-orcid":false,"given":"Wen","family":"Xie","sequence":"additional","affiliation":[{"name":"Center for Pharmacogenetics and Department of Pharmaceutical Sciences, University of Pittsburgh , Pittsburgh, PA , 15261 USA"},{"name":"Department of Pharmacology and Chemical Biology, University of Pittsburgh , Pittsburgh, PA 15261 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"80","published-online":{"date-parts":[[2022,5,7]]},"reference":[{"key":"2022061107522930500_CIT0001","volume-title":"Definition, Diagnosis and Classification of Diabetes Mellitus and its Complications: Report of a WHO Consultation. Part 1, Diagnosis and Classification of Diabetes Mellitus","author":"World Health O","year":"1999"},{"issue":"3","key":"2022061107522930500_CIT0002","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1053\/j.semperi.2007.03.006","article-title":"Recurrent gestational diabetes: risk factors, diagnosis, management, and implications","volume":"31","author":"Bottalico","year":"2007","journal-title":"Semin Perinatol."},{"issue":"3","key":"2022061107522930500_CIT0003","doi-asserted-by":"crossref","first-page":"579","DOI":"10.2337\/diacare.28.3.579","article-title":"Increasing prevalence of gestational diabetes mellitus (GDM) over time and by birth cohort: Kaiser Permanente of Colorado GDM Screening Program","volume":"28","author":"Dabelea","year":"2005","journal-title":"Diabetes Care."},{"issue":"5","key":"2022061107522930500_CIT0004","doi-asserted-by":"crossref","first-page":"319","DOI":"10.4158\/EP.11.5.319","article-title":"Polycystic ovary syndrome and severe nonalcoholic steatohepatitis: beneficial effect of modest weight loss and exercise on liver biopsy findings","volume":"11","author":"Brown","year":"2005","journal-title":"Endocr Pract."},{"issue":"3","key":"2022061107522930500_CIT0005","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1016\/S0002-9378(99)70500-4","article-title":"Effects of new criteria for type 2 diabetes on the rate of postpartum glucose intolerance in women with gestational diabetes","volume":"181","author":"Conway","year":"1999","journal-title":"Am J Obstet Gynecol."},{"issue":"4","key":"2022061107522930500_CIT0006","doi-asserted-by":"crossref","first-page":"404.e401","DOI":"10.1016\/j.ajog.2007.09.015","article-title":"Who returns for postpartum glucose screening following gestational diabetes mellitus?","volume":"198","author":"Hunt","year":"2008","journal-title":"Am J Obstet Gynecol."},{"issue":"10","key":"2022061107522930500_CIT0007","doi-asserted-by":"crossref","first-page":"2026","DOI":"10.2337\/dc08-0972","article-title":"Glucose intolerance in pregnancy and future risk of pre-diabetes or diabetes","volume":"31","author":"Retnakaran","year":"2008","journal-title":"Diabetes Care."},{"issue":"3","key":"2022061107522930500_CIT0008","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1111\/j.1464-5491.2010.03179.x","article-title":"Effect of subsequent pregnancies on the risk of developing diabetes following a first pregnancy complicated by gestational diabetes: a population-based study","volume":"28","author":"Retnakaran","year":"2011","journal-title":"Diabet Med."},{"issue":"4","key":"2022061107522930500_CIT0009","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1067\/mob.2002.121895","article-title":"Clinical predictors for a high risk for the development of diabetes mellitus in the early puerperium in women with recent gestational diabetes mellitus","volume":"186","author":"Schaefer-Graf","year":"2002","journal-title":"Am J Obstet Gynecol."},{"issue":"9677","key":"2022061107522930500_CIT0010","doi-asserted-by":"crossref","first-page":"1773","DOI":"10.1016\/S0140-6736(09)60731-5","article-title":"Type 2 diabetes mellitus after gestational diabetes: a systematic review and meta-analysis","volume":"373","author":"Bellamy","year":"2009","journal-title":"Lancet."},{"issue":"3","key":"2022061107522930500_CIT0011","first-page":"CD005102","article-title":"Dietary advice for the prevention of type 2 diabetes mellitus in adults","author":"Nield","year":"2008","journal-title":"Cochrane Database Syst Rev."},{"issue":"1","key":"2022061107522930500_CIT0012","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.amepre.2004.08.006","article-title":"Long-term effectiveness of weight-loss interventions in adults with pre-diabetes: a review","volume":"28","author":"Norris","year":"2005","journal-title":"Am J Prev Med."},{"issue":"3","key":"2022061107522930500_CIT0013","first-page":"CD003054","article-title":"Exercise or exercise and diet for preventing type 2 diabetes mellitus","author":"Orozco","year":"2008","journal-title":"Cochrane Database Syst Rev."},{"issue":"38","key":"2022061107522930500_CIT0014","doi-asserted-by":"crossref","first-page":"25984","DOI":"10.1074\/jbc.M109.016808","article-title":"The constitutive androstane receptor is an anti-obesity nuclear receptor that improves insulin sensitivity","volume":"284","author":"Gao","year":"2009","journal-title":"J Biol Chem."},{"issue":"44","key":"2022061107522930500_CIT0015","doi-asserted-by":"crossref","first-page":"18831","DOI":"10.1073\/pnas.0909731106","article-title":"Activation of nuclear receptor CAR ameliorates diabetes and fatty liver disease","volume":"106","author":"Dong","year":"2009","journal-title":"Proc Natl Acad Sci USA."},{"issue":"21","key":"2022061107522930500_CIT0016","doi-asserted-by":"crossref","first-page":"2715","DOI":"10.1128\/MCB.00138-16","article-title":"Hepatic overexpression of CD36 improves glycogen homeostasis and attenuates high-fat diet-induced hepatic steatosis and insulin resistance","volume":"36","author":"Garbacz","year":"2016","journal-title":"Mol Cell Biol."},{"issue":"7","key":"2022061107522930500_CIT0017","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1007\/BF00280883","article-title":"Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man","volume":"28","author":"Matthews","year":"1985","journal-title":"Diabetologia."},{"issue":"1","key":"2022061107522930500_CIT0018","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/S0021-9258(18)64849-5","article-title":"A simple method for the isolation and purification of total lipides from animal tissues","volume":"226","author":"Folch","year":"1957","journal-title":"J Biol Chem."},{"issue":"28","key":"2022061107522930500_CIT0019","doi-asserted-by":"crossref","first-page":"14695","DOI":"10.1074\/jbc.M115.707885","article-title":"Effect of hypertriglyceridemia on beta cell mass and function in ApoC3 transgenic mice","volume":"291","author":"Liu","year":"2016","journal-title":"J Biol Chem."},{"issue":"6","key":"2022061107522930500_CIT0020","doi-asserted-by":"crossref","first-page":"1543","DOI":"10.2337\/db11-1152","article-title":"Sex-specific effect of estrogen sulfotransferase on mouse models of type 2 diabetes","volume":"61","author":"Gao","year":"2012","journal-title":"Diabetes."},{"key":"2022061107522930500_CIT0021"},{"key":"2022061107522930500_CIT0022"},{"key":"2022061107522930500_CIT0023","author":"Feng"},{"issue":"2","key":"2022061107522930500_CIT0024","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1016\/j.apsb.2020.08.015","article-title":"Gadd45b is required in part for the anti-obesity effect of constitutive androstane receptor (CAR)","volume":"11","author":"Cai","year":"2021","journal-title":"Acta Pharm Sin B."},{"issue":"17","key":"2022061107522930500_CIT0025","doi-asserted-by":"crossref","first-page":"2721","DOI":"10.1007\/s00018-008-8104-4","article-title":"The role of the Agouti-related protein in energy balance regulation","volume":"65","author":"Ilnytska","year":"2008","journal-title":"Cell Mol Life Sci."},{"issue":"4","key":"2022061107522930500_CIT0026","doi-asserted-by":"crossref","first-page":"229","DOI":"10.5483\/BMBRep.2015.48.4.272","article-title":"Network of hypothalamic neurons that control appetite","volume":"48","author":"Sohn","year":"2015","journal-title":"BMB Rep."},{"issue":"9","key":"2022061107522930500_CIT0027","doi-asserted-by":"crossref","first-page":"1653","DOI":"10.2337\/dc16-er09","article-title":"Classification and diagnosis of diabetes. Sec. 2. In Standards of Medical Care in Diabetes-2016. Diabetes Care 2016;39(Suppl. 1):S13-S22","volume":"39","author":"Erratum","year":"2016","journal-title":"Diabetes Care."},{"issue":"1","key":"2022061107522930500_CIT0028","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1007\/s11892-011-0238-3","article-title":"Gestational diabetes: implications for cardiovascular health","volume":"12","author":"Sullivan","year":"2012","journal-title":"Curr Diab Rep."},{"issue":"6","key":"2022061107522930500_CIT0029","doi-asserted-by":"crossref","first-page":"1502","DOI":"10.2337\/db07-0140","article-title":"(How) can we prevent type 2 diabetes?","volume":"56","author":"Buchanan","year":"2007","journal-title":"Diabetes."},{"issue":"12","key":"2022061107522930500_CIT0030","doi-asserted-by":"crossref","first-page":"4774","DOI":"10.1210\/jc.2008-0772","article-title":"Prevention of diabetes in women with a history of gestational diabetes: effects of metformin and lifestyle interventions","volume":"93","author":"Ratner","year":"2008","journal-title":"J Clin Endocrinol Metab."},{"issue":"6","key":"2022061107522930500_CIT0031","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1056\/NEJMoa012512","article-title":"Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin","volume":"346","author":"Knowler","year":"2002","journal-title":"N Engl J Med."},{"key":"2022061107522930500_CIT0032","doi-asserted-by":"crossref","first-page":"4235","DOI":"10.2147\/DMSO.S270935","article-title":"Research progress on the experimental animal model of gestational diabetes mellitus","volume":"13","author":"He","year":"2020","journal-title":"Diabetes Metab Syndr Obes."},{"issue":"2","key":"2022061107522930500_CIT0033","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1007\/s00125-007-0886-7","article-title":"The mechanisms of alloxan- and streptozotocin-induced diabetes","volume":"51","author":"Lenzen","year":"2008","journal-title":"Diabetologia."},{"key":"2022061107522930500_CIT0034","doi-asserted-by":"crossref","first-page":"5.47.41","DOI":"10.1002\/0471141755.ph0547s70","article-title":"Streptozotocin-induced diabetic models in mice and rats","volume":"70","author":"Furman","year":"2015","journal-title":"Curr Protoc Pharmacol."},{"issue":"11","key":"2022061107522930500_CIT0035","first-page":"7287","article-title":"Effects of miR-22-3p targeted regulation of Socs3 on the hepatic insulin resistance in mice with gestational diabetes mellitus","volume":"12","author":"Zhang","year":"2020","journal-title":"Am J Transl Res."},{"issue":"3","key":"2022061107522930500_CIT0036","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1016\/j.amjms.2020.06.032","article-title":"Effects of miR-152-mediated targeting of SOCS3 on hepatic insulin resistance in gestational diabetes mellitus mice","volume":"361","author":"Li","year":"2021","journal-title":"Am J Med Sci."},{"issue":"2","key":"2022061107522930500_CIT0037","doi-asserted-by":"crossref","first-page":"E293","DOI":"10.1152\/ajpendo.00167.2012","article-title":"Treatment with constitutive androstane receptor ligand during pregnancy prevents insulin resistance in offspring from high-fat diet-induced obese pregnant mice","volume":"303","author":"Masuyama","year":"2012","journal-title":"Am J Physiol Endocrinol Metab."},{"issue":"1-2","key":"2022061107522930500_CIT0038","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1007\/s11010-016-2772-4","article-title":"Dimethylesculetin ameliorates maternal glucose intolerance and fetal overgrowth in high-fat diet-fed pregnant mice via constitutive androstane receptor","volume":"419","author":"Masuyama","year":"2016","journal-title":"Mol Cell Biochem."},{"issue":"9","key":"2022061107522930500_CIT0039","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1007\/s40618-016-0607-5","article-title":"Gestational diabetes mellitus: an updated overview","volume":"40","author":"Chiefari","year":"2017","journal-title":"J Endocrinol Invest."},{"issue":"6806","key":"2022061107522930500_CIT0040","doi-asserted-by":"crossref","first-page":"920","DOI":"10.1038\/35038112","article-title":"The nuclear receptor CAR mediates specific xenobiotic induction of drug metabolism","volume":"407","author":"Wei","year":"2000","journal-title":"Nature."},{"issue":"19","key":"2022061107522930500_CIT0041","doi-asserted-by":"crossref","first-page":"19832","DOI":"10.1074\/jbc.M313601200","article-title":"The nuclear receptor CAR is a regulator of thyroid hormone metabolism during caloric restriction","volume":"279","author":"Maglich","year":"2004","journal-title":"J Biol Chem."},{"issue":"1","key":"2022061107522930500_CIT0042","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1093\/toxsci\/69.1.79","article-title":"Evaluation of a 15-day screening assay using intact male rats for identifying steroid biosynthesis inhibitors and thyroid modulators","volume":"69","author":"O\u2019Connor","year":"2002","journal-title":"Toxicol Sci."},{"issue":"6","key":"2022061107522930500_CIT0043","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1530\/EC-20-0189","article-title":"Regulation of type 3 deiodinase in rodent liver and adipose tissue during fasting","volume":"9","author":"de Vries","year":"2020","journal-title":"Endocr Connect."},{"issue":"10","key":"2022061107522930500_CIT0044","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1016\/j.tips.2012.07.003","article-title":"Targeting xenobiotic receptors PXR and CAR for metabolic diseases","volume":"33","author":"Gao","year":"2012","journal-title":"Trends Pharmacol Sci."},{"issue":"12","key":"2022061107522930500_CIT0045","doi-asserted-by":"crossref","first-page":"2091","DOI":"10.1124\/dmd.110.035568","article-title":"Pregnane X receptor and constitutive androstane receptor at the crossroads of drug metabolism and energy metabolism","volume":"38","author":"Gao","year":"2010","journal-title":"Drug Metab Dispos."},{"issue":"6","key":"2022061107522930500_CIT0046","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/j.tem.2009.03.003","article-title":"PXR and CAR in energy metabolism","volume":"20","author":"Wada","year":"2009","journal-title":"Trends Endocrinol Metab."},{"issue":"5","key":"2022061107522930500_CIT0047","doi-asserted-by":"crossref","first-page":"1004","DOI":"10.1002\/hep.20953","article-title":"The CAR nuclear receptor and hepatocyte proliferation","volume":"42","author":"Costa","year":"2005","journal-title":"Hepatology."},{"issue":"4","key":"2022061107522930500_CIT0048","doi-asserted-by":"crossref","first-page":"1302","DOI":"10.1002\/hep.22475","article-title":"C-Myc and its target FoxM1 are critical downstream effectors of constitutive androstane receptor (CAR) mediated direct liver hyperplasia","volume":"48","author":"Blanco-Bose","year":"2008","journal-title":"Hepatology."},{"issue":"20","key":"2022061107522930500_CIT0049","doi-asserted-by":"crossref","first-page":"7197","DOI":"10.1158\/0008-5472.CAN-04-1459","article-title":"The orphan nuclear receptor constitutive active\/androstane receptor is essential for liver tumor promotion by phenobarbital in mice","volume":"64","author":"Yamamoto","year":"2004","journal-title":"Cancer Res."},{"issue":"6","key":"2022061107522930500_CIT0050","doi-asserted-by":"crossref","first-page":"1646","DOI":"10.1210\/me.2004-0520","article-title":"Xenobiotic stress induces hepatomegaly and liver tumors via the nuclear receptor constitutive androstane receptor","author":"Huang","year":"2005","journal-title":"Mol Endocrinol."},{"issue":"12","key":"2022061107522930500_CIT0051","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1161\/CIRCULATIONAHA.120.046464","article-title":"Hyperglycemia induces trained immunity in macrophages and their precursors and promotes atherosclerosis","volume":"144","author":"Edgar","year":"2021","journal-title":"Circulation."}],"container-title":["Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/endo\/advance-article-pdf\/doi\/10.1210\/endocr\/bqac061\/43615239\/bqac061.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/endo\/article-pdf\/163\/7\/bqac061\/44022108\/bqac061.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/endo\/article-pdf\/163\/7\/bqac061\/44022108\/bqac061.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,21]],"date-time":"2023-11-21T05:44:57Z","timestamp":1700545497000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/endo\/article\/doi\/10.1210\/endocr\/bqac061\/6582264"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,5,7]]},"references-count":51,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2022,7,1]]}},"URL":"https:\/\/doi.org\/10.1210\/endocr\/bqac061","relation":{},"ISSN":["0013-7227","1945-7170"],"issn-type":[{"value":"0013-7227","type":"print"},{"value":"1945-7170","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2022,7,1]]},"published":{"date-parts":[[2022,5,7]]},"article-number":"bqac061"}}