{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T10:37:29Z","timestamp":1792406249086,"version":"4.4.0"},"reference-count":90,"publisher":"The Endocrine Society","issue":"9","license":[{"start":{"date-parts":[[2022,7,14]],"date-time":"2022-07-14T00:00:00Z","timestamp":1657756800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/100005825","name":"National Institute of Food and Agriculture","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005825","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009633","name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009633","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>High follicle-stimulating hormone (FSH) doses during ovarian stimulation protocols for assisted reproductive technologies (ART) are detrimental to ovulatory follicle function and oocyte quality. However, the mechanisms are unclear. In a small ovarian reserve heifer model, excessive FSH doses lead to phenotypic heterogeneity of ovulatory size follicles, with most follicles displaying signs of premature luteinization and a range in severity of abnormalities. By performing whole transcriptome analyses of granulosa cells, cumulus cells, and oocytes from individual follicles of animals given standard or excessive FSH doses, we identified progressive changes in the transcriptomes of the 3 cell types, with increasing severity of follicular abnormality with the excessive doses. The granulosa and cumulus cells each diverged progressively from their normal phenotypes and became highly similar to each other in the more severely affected follicles. Pathway analysis indicates a possible dysregulation of the final stages of folliculogenesis, with processes characteristic of ovulation and luteinization occurring concurrently rather than sequentially in the most severely affected follicles. These changes were associated with disruptions in key pathways in granulosa and cumulus cells, which may account for previously reported reduced estradiol production, enhanced progesterone and oxytocin production and diminished ovulation rates. Predicted deficiencies in oocyte survival, stress response, and fertilization suggest likely reductions in oocyte health, which could further compromise oocyte quality and ART outcomes.<\/jats:p>","DOI":"10.1210\/endocr\/bqac100","type":"journal-article","created":{"date-parts":[[2022,7,14]],"date-time":"2022-07-14T09:37:09Z","timestamp":1657791429000},"source":"Crossref","is-referenced-by-count":23,"title":["Follicular Hyperstimulation Dysgenesis: New Explanation for Adverse Effects of Excessive FSH in Ovarian Stimulation"],"prefix":"10.1210","volume":"163","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2942-9447","authenticated-orcid":false,"given":"Zaramasina L","family":"Clark","sequence":"first","affiliation":[{"name":"Reproductive and Developmental Sciences Program and the Department of Animal Science, Michigan State University , East Lansing, MI 48824 , USA"},{"name":"School of Biological Sciences, Victoria University of Wellington , Wellington , New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4303-1491","authenticated-orcid":false,"given":"Meghan L","family":"Ruebel","sequence":"additional","affiliation":[{"name":"Reproductive and Developmental Sciences Program and the Department of Animal Science, Michigan State University , East Lansing, MI 48824 , USA"},{"name":"USDA-ARS Arkansas Children\u2019s Nutrition Center 15 Children\u2019s Way Little Rock , AR 72202 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1016-6998","authenticated-orcid":false,"given":"Peter Z","family":"Schall","sequence":"additional","affiliation":[{"name":"Reproductive and Developmental Sciences Program and the Department of Animal Science, Michigan State University , East Lansing, MI 48824 , USA"},{"name":"University of Michigan Medical School, Department of Human Genetics , Ann Arbor, Michigan , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9584-8036","authenticated-orcid":false,"given":"Kaitlin R","family":"Karl","sequence":"additional","affiliation":[{"name":"Reproductive and Developmental Sciences Program and the Department of Animal Science, Michigan State University , East Lansing, MI 48824 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5923-8000","authenticated-orcid":false,"given":"James J","family":"Ireland","sequence":"additional","affiliation":[{"name":"Reproductive and Developmental Sciences Program and the Department of Animal Science, Michigan State University , East Lansing, MI 48824 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1206-9059","authenticated-orcid":false,"given":"Keith E","family":"Latham","sequence":"additional","affiliation":[{"name":"Reproductive and Developmental Sciences Program and 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