{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T08:20:10Z","timestamp":1773303610897,"version":"3.50.1"},"reference-count":57,"publisher":"The Endocrine Society","issue":"9","license":[{"start":{"date-parts":[[2022,7,21]],"date-time":"2022-07-21T00:00:00Z","timestamp":1658361600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"Agencia Nacional de Promoci\u00f3n Cient\u00edfica y T\u00e9cnica, Buenos Aires, Argentina","award":["PICT 2016\u00a0N0252"],"award-info":[{"award-number":["PICT 2016\u00a0N0252"]}]},{"name":"Agencia Nacional de Promoci\u00f3n Cient\u00edfica y T\u00e9cnica, Buenos Aires, Argentina","award":["PICT 2017 N0072"],"award-info":[{"award-number":["PICT 2017 N0072"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Sex differences in the control of prolactin secretion are well documented. Sex-related differences in intrapituitary factors regulating lactotroph function have recently attracted attention. Sex differences in prolactinoma development are well documented in clinic, prolactinomas being more frequent in women but more aggressive in men, for poorly understood reasons. Kallikrein, the enzyme releasing kinins has been found in the pituitary, but there is no information on pituitary kinin receptors and their function. In the present work, we characterized pituitary bradykinin receptors (BRs) at the messenger RNA and protein levels in 2 mouse models of prolactinoma, Drd2 receptor gene inactivation and hCG\u03b2 gene overexpression, in both males and females, wild type or genomically altered. BR B2 (B2R) accounted for 97% or more of total pituitary BRs in both models, regardless of genotype, and was present in lactotrophs, somatotrophs, and gonadotrophs. Male pituitaries displayed higher level of B2R than females, regardless of genotype. Pituitary B2R gene expression was downregulated by estrogen in both males and females but only in females by dopamine. Activation of B1R or B2R by selective pharmacological agonists induced prolactin release in male pituitaries but inhibited prolactin secretion in female pituitaries. Increased B2R content was observed in pituitaries of mutated animals developing prolactinomas, compared to their respective wild-type controls. The present study documents a novel sex-related difference in the control of prolactin secretion and suggests that kinins are involved, through B2R activation, in lactotroph function and prolactinoma development.<\/jats:p>","DOI":"10.1210\/endocr\/bqac108","type":"journal-article","created":{"date-parts":[[2022,7,21]],"date-time":"2022-07-21T20:39:50Z","timestamp":1658435990000},"source":"Crossref","is-referenced-by-count":5,"title":["Sex-specific Regulation of Prolactin Secretion by Pituitary Bradykinin Receptors"],"prefix":"10.1210","volume":"163","author":[{"given":"Alejandra","family":"Abeledo-Machado","sequence":"first","affiliation":[{"name":"Laboratorio de Fisio-Patolog\u00eda Hormonal, Instituto de Biolog\u00eda y Medicina Experimental (IBYME), CONICET , Buenos Aires , Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Milagros","family":"Pe\u00f1a-Zanoni","sequence":"additional","affiliation":[{"name":"Laboratorio de Fisio-Patolog\u00eda Hormonal, 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Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Agustina","family":"Marcial","sequence":"additional","affiliation":[{"name":"Laboratorio de Endocrinolog\u00eda Molecular de la Reproducci\u00f3n, Instituto de Biolog\u00eda y Medicina Experimental (IBYME), CONICET , Buenos Aires , Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susana","family":"Rulli","sequence":"additional","affiliation":[{"name":"Laboratorio de Endocrinolog\u00eda Molecular de la Reproducci\u00f3n, Instituto de Biolog\u00eda y Medicina Experimental (IBYME), CONICET , Buenos Aires , Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francois","family":"Alhenc-Gelas","sequence":"additional","affiliation":[{"name":"INSERM U1138 , Universite Paris-Cite, Sorbonne Universite, Centre de Recherche des Cordeliers, Paris , 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Endocrinol."},{"issue":"2","key":"2022072611592508000_CIT0030","doi-asserted-by":"crossref","first-page":"1402","DOI":"10.1002\/jcp.26025","article-title":"Estrogen receptor beta regulates the tumoral suppressor PTEN to modulate pituitary cell growth","volume":"233","author":"Perez","year":"2018","journal-title":"J Cell Physiol."},{"issue":"7","key":"2022072611592508000_CIT0031","doi-asserted-by":"crossref","DOI":"10.1210\/en.2010-1464","article-title":"Active and total transforming growth factor-\u03b21 are differentially regulated by dopamine and estradiol in the pituitary","volume":"152","author":"Recouvreux","year":"2011","journal-title":"Endocrinology."},{"key":"2022072611592508000_CIT0032","article-title":"Supplemental Figure 1 for: Sex-specific regulation of prolactin secretion by pituitary bradykinin receptors","author":"Abeledo-Machado","year":"2022"},{"key":"2022072611592508000_CIT0033","article-title":"Supplemental Figure 2 for: Sex-specific regulation of prolactin secretion 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dopamine","author":"Kuan","year":"1990;127(4):1841-1848","journal-title":"Endocrinology."},{"key":"2022072611592508000_CIT0049","doi-asserted-by":"crossref","first-page":"E274","DOI":"10.1152\/ajpendo.1994.266.2.E274","article-title":"Effects of LHRH and ANG II on prolactin stimulation are mediated by hypophysial AT1 receptor subtype","volume":"266(2 Pt 1)","author":"Becu-Villalobos","year":"1994","journal-title":"Am J Physiol Endocrinol Metab."},{"key":"2022072611592508000_CIT0050","doi-asserted-by":"crossref","DOI":"10.1210\/edrv.22.6.0451","article-title":"Dopamine as a prolactin (PRL) inhibitor","author":"Ben-Jonathan","year":"2001;22(6):724-763","journal-title":"Endocr Rev."},{"key":"2022072611592508000_CIT0051","doi-asserted-by":"crossref","DOI":"10.1530\/ERC-18-0409","article-title":"MPRs represent a novel target for PRL inhibition in experimental prolactinomas","author":"Camilletti","year":"2019;26(5):497-510","journal-title":"Endocr Relat 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