{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T06:35:19Z","timestamp":1790836519609,"version":"4.1.0"},"reference-count":68,"publisher":"The Endocrine Society","issue":"11","license":[{"start":{"date-parts":[[2022,8,29]],"date-time":"2022-08-29T00:00:00Z","timestamp":1661731200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"Canadian Foundation for Innovation"},{"name":"Ontario Research Fund"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,10,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>The intestinal L-cell incretin, glucagon-like peptide-1 (GLP-1), exhibits a circadian pattern of secretion, thereby entraining diurnal insulin release. Secretagogin (Scgn), an actin-binding regulatory protein, is essential for the temporal peak of GLP-1 secretion in vitro. To interrogate the role of Scgn in diurnal GLP-1 secretion in vivo, peak and trough GLP-1 release were evaluated in knockout mice (Scgn\u2212\/\u2212, Gcg-CreERT2\/+; Scgnfl\/fl and Vil-CreERT2\/+; Scgnfl\/fl), and RNA sequencing (RNA-Seq) was conducted in Scgn knockdown L-cells. All 3 knockout models demonstrated loss of the diurnal rhythm of GLP-1 secretion in response to oral glucose. Gcg-CreERT2\/+; Scgnfl\/fl mice also lost the normal pattern in glucagon secretion, while Scgn\u2212\/\u2212 and Vil-CreERT2\/+; Scgnfl\/fl animals demonstrated impaired diurnal secretion of the related incretin, glucose-dependent insulinotrophic polypeptide. RNA-Seq of mGLUTag L-cells showed decreased pathways regulating vesicle transport, transport and binding, and protein-protein interaction at synapse, as well as pathways related to proteasome-mediated degradation including chaperone-mediated protein complex assembly following Scgn knockdown. Scgn is therefore essential for diurnal L-cell GLP-1 secretion in vivo, likely mediated through effects on secretory granule dynamics.<\/jats:p>","DOI":"10.1210\/endocr\/bqac142","type":"journal-article","created":{"date-parts":[[2022,8,29]],"date-time":"2022-08-29T12:48:57Z","timestamp":1661777337000},"source":"Crossref","is-referenced-by-count":6,"title":["The Cytoskeletal Transport Protein, Secretagogin, Is Essential for Diurnal Glucagon-like Peptide-1 Secretion in Mice"],"prefix":"10.1210","volume":"163","author":[{"given":"Andrew David","family":"Biancolin","sequence":"first","affiliation":[{"name":"Department of Physiology, University of Toronto , Toronto, Ontario M5S 1A8 , Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arjuna","family":"Srikrishnaraj","sequence":"additional","affiliation":[{"name":"Department of Physiology, University of Toronto , Toronto, Ontario M5S 1A8 , Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyerin","family":"Jeong","sequence":"additional","affiliation":[{"name":"Department of Physiology, University of Toronto , Toronto, Ontario M5S 1A8 , Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandre","family":"Martchenko","sequence":"additional","affiliation":[{"name":"Department of Physiology, University of Toronto , Toronto, Ontario M5S 1A8 , Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7908-788X","authenticated-orcid":false,"given":"Patricia Lee","family":"Brubaker","sequence":"additional","affiliation":[{"name":"Department of Physiology, University of Toronto , Toronto, Ontario M5S 1A8 , Canada"},{"name":"Department of Medicine, University of Toronto , Toronto, Ontario M5S 1A8 , Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"80","published-online":{"date-parts":[[2022,8,29]]},"reference":[{"issue":"3","key":"2022101708362665100_bqac142-B1","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.cmet.2006.01.004","article-title":"The biology of incretin hormones","volume":"3","author":"Drucker","year":"2006","journal-title":"Cell Metab"},{"key":"2022101708362665100_bqac142-B2","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.molmet.2019.09.010","article-title":"Glucagon-like peptide 1 (GLP-1)","volume":"30","author":"M\u00fcller","year":"2019","journal-title":"Mol Metab"},{"issue":"8","key":"2022101708362665100_bqac142-B3","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1038\/s41556-018-0143-y","article-title":"Enteroendocrine cells switch hormone expression along the crypt-to-villus BMP signalling gradient","volume":"20","author":"Beumer","year":"2018","journal-title":"Nat Cell Biol"},{"issue":"6","key":"2022101708362665100_bqac142-B4","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1016\/j.cmet.2013.04.008","article-title":"Pharmacology, physiology, and mechanisms of incretin hormone action","volume":"17","author":"Campbell","year":"2013","journal-title":"Cell Metab"},{"issue":"12","key":"2022101708362665100_bqac142-B5","doi-asserted-by":"crossref","first-page":"4217","DOI":"10.1172\/JCI97233","article-title":"Discovery, characterization, and clinical development of the glucagon-like peptides","volume":"127","author":"Drucker","year":"2017","journal-title":"J Clin Invest"},{"issue":"5","key":"2022101708362665100_bqac142-B6","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1007\/s00125-009-1288-9","article-title":"Circadian rhythms of GIP and GLP1 in glucose-tolerant and in type 2 diabetic patients after biliopancreatic diversion","volume":"52","author":"Mingrone","year":"2009","journal-title":"Diabetologia"},{"key":"2022101708362665100_bqac142-B7","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.molmet.2019.11.004","article-title":"The core clock gene, Bmal1, and its downstream target, the SNARE regulatory protein secretagogin, are necessary for circadian secretion of glucagon-like peptide-1","volume":"31","author":"Biancolin","year":"2020","journal-title":"Mol Metab"},{"issue":"12","key":"2022101708362665100_bqac142-B8","doi-asserted-by":"crossref","first-page":"2589","DOI":"10.2337\/db20-0262","article-title":"Circadian GLP-1 secretion in mice is dependent on the intestinal microbiome for maintenance of diurnal metabolic homeostasis","volume":"69","author":"Martchenko","year":"2020","journal-title":"Diabetes"},{"issue":"1","key":"2022101708362665100_bqac142-B9","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1146\/annurev-neuro-060909-153128","article-title":"Central and peripheral circadian clocks in mammals","volume":"35","author":"Mohawk","year":"2012","journal-title":"Annu Rev Neurosci"},{"issue":"2","key":"2022101708362665100_bqac142-B10","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/j.molcel.2012.06.026","article-title":"Clocks, metabolism, and the epigenome","volume":"47","author":"Feng","year":"2012","journal-title":"Mol Cell"},{"issue":"6315","key":"2022101708362665100_bqac142-B11","doi-asserted-by":"crossref","first-page":"994","DOI":"10.1126\/science.aah4965","article-title":"Circadian time signatures of fitness and disease","volume":"354","author":"Bass","year":"2016","journal-title":"Science."},{"issue":"45","key":"2022101708362665100_bqac142-B12","doi-asserted-by":"crossref","first-page":"16219","DOI":"10.1073\/pnas.1408886111","article-title":"A circadian gene expression atlas in mammals: implications for biology and medicine","volume":"111","author":"Zhang","year":"2014","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"4","key":"2022101708362665100_bqac142-B13","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1038\/nrgastro.2016.8","article-title":"Circadian rhythms of liver physiology and disease: experimental and clinical evidence","volume":"13","author":"Tahara","year":"2016","journal-title":"Nat Rev Gastroenterol Hepatol"},{"issue":"5","key":"2022101708362665100_bqac142-B14","doi-asserted-by":"crossref","first-page":"1074","DOI":"10.1210\/en.2017-00218","article-title":"Glucose homeostasis: regulation by peripheral circadian clocks in rodents and humans","volume":"158","author":"Gachon","year":"2017","journal-title":"Endocrinology"},{"issue":"2","key":"2022101708362665100_bqac142-B15","doi-asserted-by":"crossref","first-page":"399","DOI":"10.3945\/an.115.010777","article-title":"Circadian rhythms, metabolism, and chrononutrition in rodents and humans","volume":"7","author":"Johnston","year":"2016","journal-title":"Adv Nutr"},{"issue":"4","key":"2022101708362665100_bqac142-B16","doi-asserted-by":"crossref","first-page":"1250","DOI":"10.1053\/j.gastro.2007.07.009","article-title":"Clock gene expression in the murine gastrointestinal tract: endogenous rhythmicity and effects of a feeding regimen","volume":"133","author":"Hoogerwerf","year":"2007","journal-title":"Gastroenterology"},{"key":"2022101708362665100_bqac142-B17","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1111\/dom.12517","article-title":"Skeletal muscle functions around the clock","volume":"17","author":"Mayeuf-Louchart","year":"2015","journal-title":"Diabetes Obes Metab"},{"issue":"7306","key":"2022101708362665100_bqac142-B18","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1038\/nature09253","article-title":"Disruption of the clock components CLOCK and BMAL1 leads to hypoinsulinaemia and diabetes","volume":"466","author":"Marcheva","year":"2010","journal-title":"Nature"},{"issue":"2","key":"2022101708362665100_bqac142-B19","doi-asserted-by":"crossref","first-page":"e1000595","DOI":"10.1371\/journal.pbio.1000595","article-title":"Genome-wide and phase-specific DNA-binding rhythms of BMAL1 control circadian output functions in mouse liver","volume":"9","author":"Rey","year":"2011","journal-title":"PLoS Biol"},{"issue":"6105","key":"2022101708362665100_bqac142-B20","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1126\/science.1226339","article-title":"Transcriptional architecture and chromatin landscape of the core circadian clock in mammals","volume":"338","author":"Koike","year":"2012","journal-title":"Science."},{"issue":"1","key":"2022101708362665100_bqac142-B21","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1152\/physiolgenomics.00066.2007","article-title":"Identification of the circadian transcriptome in adult mouse skeletal muscle","volume":"31","author":"McCarthy","year":"2007","journal-title":"Physiol Genomics"},{"issue":"4","key":"2022101708362665100_bqac142-B22","doi-asserted-by":"crossref","first-page":"962","DOI":"10.2337\/diabetes.55.04.06.db05-0873","article-title":"Characterization of peripheral circadian clocks in adipose tissues","volume":"55","author":"Zvonic","year":"2006","journal-title":"Diabetes"},{"issue":"5","key":"2022101708362665100_bqac142-B23","doi-asserted-by":"crossref","first-page":"bqaa039","DOI":"10.1210\/endocr\/bqaa039","article-title":"Essential role of syntaxin-binding protein-1 in the regulation of glucagon-like peptide-1 secretion","volume":"161","author":"Campbell","year":"2020","journal-title":"Endocrinology"},{"issue":"5","key":"2022101708362665100_bqac142-B24","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.1002\/cne.25004","article-title":"The SNARE regulator Complexin3 is a target of the cone circadian clock","volume":"529","author":"Bhoi","year":"2021","journal-title":"J Comp Neurol"},{"issue":"9","key":"2022101708362665100_bqac142-B25","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1152\/physiolgenomics.00019.2016","article-title":"Circadian variation of the pancreatic islet transcriptome","volume":"48","author":"Rakshit","year":"2016","journal-title":"Physiol Genomics"},{"issue":"4","key":"2022101708362665100_bqac142-B26","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1101\/gad.290379.116","article-title":"Pancreatic \u03b1- and \u03b2-cellular clocks have distinct molecular properties and impact on islet hormone secretion and gene expression","volume":"31","author":"Petrenko","year":"2017","journal-title":"Genes Dev"},{"key":"2022101708362665100_bqac142-B27","doi-asserted-by":"crossref","first-page":"101340","DOI":"10.1016\/j.molmet.2021.101340","article-title":"L-cell Arntl is required for rhythmic glucagon-like peptide-1 secretion and maintenance of intestinal homeostasis","volume":"54","author":"Martchenko","year":"2021","journal-title":"Mol Metab"},{"issue":"11","key":"2022101708362665100_bqac142-B28","doi-asserted-by":"crossref","first-page":"3674","DOI":"10.2337\/db13-1501","article-title":"Circadian secretion of the intestinal hormone GLP-1 by the rodent L cell","volume":"63","author":"Gil-Lozano","year":"2014","journal-title":"Diabetes"},{"issue":"3","key":"2022101708362665100_bqac142-B29","doi-asserted-by":"crossref","first-page":"e0151927","DOI":"10.1371\/journal.pone.0151927","article-title":"Functional analysis of novel candidate regulators of insulin secretion in the MIN6 mouse pancreatic \u03b2 cell line","volume":"11","author":"Kobayashi","year":"2016","journal-title":"PLoS One"},{"issue":"12","key":"2022101708362665100_bqac142-B30","doi-asserted-by":"crossref","first-page":"1791","DOI":"10.1042\/BCJ20160137","article-title":"Secretagogin affects insulin secretion in pancreatic \u03b2-cells by regulating actin dynamics and focal adhesion","volume":"473","author":"Yang","year":"2016","journal-title":"Biochem J"},{"issue":"1","key":"2022101708362665100_bqac142-B31","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1038\/s41598-017-00344-z","article-title":"SUMOylation and calcium control syntaxin-1A and secretagogin sequestration by tomosyn to regulate insulin exocytosis in human \u00df cells","volume":"7","author":"Ferdaoussi","year":"2017","journal-title":"Sci Rep"},{"issue":"14","key":"2022101708362665100_bqac142-B32","doi-asserted-by":"crossref","first-page":"2107","DOI":"10.15252\/embj.201695347","article-title":"A TRPV1-to-secretagogin regulatory axis controls pancreatic \u03b2-cell survival by modulating protein turnover","volume":"36","author":"Malenczyk","year":"2017","journal-title":"EMBO J"},{"key":"2022101708362665100_bqac142-B33","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.molmet.2018.05.019","article-title":"Secretagogin protects Pdx1 from proteasomal degradation to control a transcriptional program required for \u03b2 cell specification","volume":"14","author":"Malenczyk","year":"2018","journal-title":"Mol Metab"},{"issue":"1","key":"2022101708362665100_bqac142-B34","doi-asserted-by":"crossref","first-page":"6976","DOI":"10.1038\/s41598-017-07072-4","article-title":"Calcium ion induced structural changes promote dimerization of secretagogin, which is required for its insulin secretory function","volume":"7","author":"Lee","year":"2017","journal-title":"Sci Rep"},{"key":"2022101708362665100_bqac142-B35","doi-asserted-by":"crossref","first-page":"e49910","DOI":"10.7554\/eLife.49910","article-title":"SCGN deficiency results in colitis susceptibility","volume":"8","author":"Sifuentes-Dominguez","year":"2019","journal-title":"Elife"},{"issue":"12","key":"2022101708362665100_bqac142-B36","doi-asserted-by":"crossref","first-page":"6559","DOI":"10.1073\/pnas.1919698117","article-title":"Structural and mechanistic insights into secretagogin-mediated exocytosis","volume":"117","author":"Qin","year":"2020","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"4","key":"2022101708362665100_bqac142-B37","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/j.tem.2019.01.007","article-title":"Veiled potential of secretagogin in diabetes: correlation or coincidence?","volume":"30","author":"Sharma","year":"2019","journal-title":"Trends Endocrinol Metab"},{"key":"2022101708362665100_bqac142-B38","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1016\/j.isci.2019.10.066","article-title":"Secretagogin regulates insulin signaling by direct insulin binding","volume":"21","author":"Sharma","year":"2019","journal-title":"iScience"},{"key":"2022101708362665100_bqac142-B39","article-title":"The cytoskeletal transport protein, secretagogin, is essential for diurnal glucagon-like peptide-1 secretion in mice.\u201d Uploaded August 12, 2022","author":"Brubaker"},{"issue":"3","key":"2022101708362665100_bqac142-B40","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1002\/gene.20042","article-title":"Tissue-specific and inducible cre-mediated recombination in the gut epithelium","volume":"39","author":"El Marjou","year":"2004","journal-title":"Genesis"},{"issue":"6","key":"2022101708362665100_bqac142-B41","doi-asserted-by":"crossref","first-page":"2166","DOI":"10.1053\/j.gastro.2011.09.014","article-title":"Loss of glucagon-like peptide-2-induced proliferation following intestinal epithelial insulin-like growth factor-1-receptor deletion","volume":"141","author":"Rowland","year":"2011","journal-title":"Gastroenterology"},{"issue":"9","key":"2022101708362665100_bqac142-B42","doi-asserted-by":"crossref","first-page":"2327","DOI":"10.2337\/db16-1403","article-title":"The SNARE protein syntaxin-1a plays an essential role in biphasic exocytosis of the incretin hormone glucagon-like peptide 1","volume":"66","author":"Wheeler","year":"2017","journal-title":"Diabetes"},{"issue":"2","key":"2022101708362665100_bqac142-B43","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1210\/en.2008-0726","article-title":"Insulin regulates glucagon-like peptide-1 secretion from the enteroendocrine L cell","volume":"150","author":"Lim","year":"2009","journal-title":"Endocrinology"},{"issue":"5","key":"2022101708362665100_bqac142-B44","doi-asserted-by":"crossref","first-page":"6628","DOI":"10.1096\/fj.202000169R","article-title":"Requirement for the intestinal epithelial insulin-like growth factor-1 receptor in the intestinal responses to glucagon-like peptide-2 and dietary fat","volume":"34","author":"Markovic","year":"2020","journal-title":"FASEB J"},{"issue":"3","key":"2022101708362665100_bqac142-B45","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1002\/ar.1092070305","article-title":"Cell production in mouse intestinal epithelium measured by stathmokinetic flow cytometry and coulter particle counting","volume":"207","author":"Cheng","year":"1983","journal-title":"Anat Rec"},{"issue":"4","key":"2022101708362665100_bqac142-B46","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2(\u2212Delta Delta C(T)) method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"issue":"4","key":"2022101708362665100_bqac142-B47","doi-asserted-by":"crossref","first-page":"e13007","DOI":"10.1111\/apha.13007","article-title":"Suppression of circadian secretion of glucagon-like peptide-1 by the saturated fatty acid, palmitate","volume":"222","author":"Martchenko","year":"2018","journal-title":"Acta Physiol"},{"issue":"5","key":"2022101708362665100_bqac142-B48","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1038\/nbt.3519","article-title":"Near-optimal probabilistic RNA-seq quantification","volume":"34","author":"Bray","year":"2016","journal-title":"Nat Biotechnol"},{"issue":"4","key":"2022101708362665100_bqac142-B49","doi-asserted-by":"crossref","first-page":"1521","DOI":"10.12688\/f1000research.7563.1","article-title":"Differential analyses for RNA-seq: transcript-level estimates improve gene-level inferences","volume":"30","author":"Soneson","year":"2015","journal-title":"F1000Res"},{"issue":"1","key":"2022101708362665100_bqac142-B50","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1093\/bioinformatics\/btp616","article-title":"Edger: a bioconductor package for differential expression analysis of digital gene expression data","volume":"26","author":"Robinson","year":"2010","journal-title":"Bioinformatics"},{"key":"2022101708362665100_bqac142-B51","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1007\/0-387-29362-0_23","volume-title":"Bioinformatics and Computational Biology Solutions Using R and Bioconductor","author":"Smyth","year":"2005"},{"issue":"2","key":"2022101708362665100_bqac142-B52","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1038\/s41596-018-0103-9","article-title":"Pathway enrichment analysis and visualization of omics data using g:Profiler, GSEA, Cytoscape and EnrichmentMap","volume":"14","author":"Reimand","year":"2019","journal-title":"Nat Protoc"},{"issue":"11","key":"2022101708362665100_bqac142-B53","doi-asserted-by":"crossref","first-page":"e13984","DOI":"10.1371\/journal.pone.0013984","article-title":"Enrichment map: a network-based method for gene-set enrichment visualization and interpretation","volume":"5","author":"Merico","year":"2010","journal-title":"PLoS One"},{"key":"2022101708362665100_bqac142-B54","doi-asserted-by":"crossref","first-page":"1717","DOI":"10.12688\/f1000research.9090.1","article-title":"AutoAnnotate: a cytoscape app for summarizing networks with semantic annotations","volume":"5","author":"Kucera","year":"2016","journal-title":"F1000Res"},{"key":"2022101708362665100_bqac142-B55","author":"E-MTAB-11683"},{"issue":"5","key":"2022101708362665100_bqac142-B56","doi-asserted-by":"crossref","first-page":"1158","DOI":"10.1016\/j.cell.2018.12.029","article-title":"Identification of enteroendocrine regulators by real-time single-cell differentiation mapping","volume":"176","author":"Gehart","year":"2019","journal-title":"Cell"},{"issue":"2","key":"2022101708362665100_bqac142-B57","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1159\/000091207","article-title":"Secretagogin is a novel marker for neuroendocrine differentiation","volume":"82","author":"Birkenkamp-Demtr\u00f6der","year":"2005","journal-title":"Neuroendocrinology"},{"issue":"4","key":"2022101708362665100_bqac142-B58","doi-asserted-by":"crossref","first-page":"1687","DOI":"10.1210\/endo.140.4.6643","article-title":"Role of the vagus nerve in mediating proximal nutrient-induced glucagon-like peptide-1 secretion","volume":"140","author":"Rocca","year":"1999","journal-title":"Endocrinology"},{"issue":"1","key":"2022101708362665100_bqac142-B59","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1042\/BJ20060918","article-title":"Binding of calcium ions and SNAP-25 to the hexa EF-hand protein secretagogin","volume":"401","author":"Rogstam","year":"2007","journal-title":"Biochem J"},{"key":"2022101708362665100_bqac142-B60","doi-asserted-by":"crossref","first-page":"29","DOI":"10.3389\/fnmol.2019.00029","article-title":"20 Years of secretagogin: exocytosis and beyond","volume":"12","author":"Maj","year":"2019","journal-title":"Front Mol Neurosci"},{"key":"2022101708362665100_bqac142-B61","doi-asserted-by":"crossref","first-page":"575595","DOI":"10.3389\/fmicb.2020.575595","article-title":"Regulation of enteroendocrine cell networks by the major human gut symbiont Bacteroides thetaiotaomicron","volume":"11","author":"Modasia","year":"2020","journal-title":"Front Microbiol"},{"issue":"4","key":"2022101708362665100_bqac142-B62","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1016\/j.cmet.2017.02.008","article-title":"The role of pancreatic preproglucagon in glucose homeostasis in mice","volume":"25","author":"Chambers","year":"2017","journal-title":"Cell Metab"},{"key":"2022101708362665100_bqac142-B63","doi-asserted-by":"crossref","first-page":"102285","DOI":"10.1016\/j.jbc.2022.102285","article-title":"Secretagogin is a Ca 2+-dependent stress-responsive chaperone that may also play a role in aggregation-based proteinopathies","volume":"298","author":"Chidananda","year":"2022","journal-title":"J Biol Chem"},{"issue":"9","key":"2022101708362665100_bqac142-B64","doi-asserted-by":"crossref","first-page":"bqac118","DOI":"10.1210\/endocr\/bqac118","article-title":"Disrupted and elevated circadian secretion of glucagon-like peptide-1 in a murine model of type 2 diabetes","volume":"163","author":"Biancolin","year":"2022","journal-title":"Endocrinology"},{"issue":"3","key":"2022101708362665100_bqac142-B65","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.1002\/cphy.c170055","article-title":"Glucagon-like peptide-2 and the regulation of intestinal growth and function","volume":"8","author":"Brubaker","year":"2018","journal-title":"Compr Physiol"},{"issue":"5","key":"2022101708362665100_bqac142-B66","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1016\/j.humpath.2010.10.004","article-title":"Expression of secretagogin in clear-cell renal cell carcinomas is associated with a high metastasis rate","volume":"42","author":"Ilhan","year":"2011","journal-title":"Hum Pathol"},{"issue":"3","key":"2022101708362665100_bqac142-B67","first-page":"2223","article-title":"Secretagogin, a marker for neuroendocrine cells, is more sensitive and specific in large cell neuroendocrine carcinoma compared with the markers CD56, CgA, Syn and Napsin A","volume":"19","author":"Dong","year":"2020","journal-title":"Oncol Lett"},{"issue":"1","key":"2022101708362665100_bqac142-B68","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1093\/abbs\/gmaa142","article-title":"A novel secretagogin\/ATF4 pathway is involved in oxidized LDL-induced endoplasmic reticulum stress and islet \u03b2-cell apoptosis","volume":"53","author":"Wu","year":"2021","journal-title":"Acta Biochim Biophys Sin (Shanghai)"}],"container-title":["Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/endo\/advance-article-pdf\/doi\/10.1210\/endocr\/bqac142\/45634172\/bqac142.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/endo\/article-pdf\/163\/11\/bqac142\/46542637\/bqac142.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/endo\/article-pdf\/163\/11\/bqac142\/46542637\/bqac142.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,10,17]],"date-time":"2022-10-17T08:39:09Z","timestamp":1665995949000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/endo\/article\/doi\/10.1210\/endocr\/bqac142\/6678475"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,8,29]]},"references-count":68,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2022,10,11]]}},"URL":"https:\/\/doi.org\/10.1210\/endocr\/bqac142","relation":{},"ISSN":["1945-7170"],"issn-type":[{"value":"1945-7170","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2022,11,1]]},"published":{"date-parts":[[2022,8,29]]},"article-number":"bqac142"}}