{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T12:01:57Z","timestamp":1785499317778,"version":"3.56.0"},"reference-count":50,"publisher":"The Endocrine Society","issue":"1","license":[{"start":{"date-parts":[[2022,11,11]],"date-time":"2022-11-11T00:00:00Z","timestamp":1668124800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100000199","name":"USDA","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000199","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007917","name":"Agricultural Research Service","doi-asserted-by":"publisher","award":["3092-51000-060-01"],"award-info":[{"award-number":["3092-51000-060-01"]}],"id":[{"id":"10.13039\/100007917","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["DK-094616"],"award-info":[{"award-number":["DK-094616"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P30 DK-56338"],"award-info":[{"award-number":["P30 DK-56338"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["T32 DK007664"],"award-info":[{"award-number":["T32 DK007664"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["K01 DK129408"],"award-info":[{"award-number":["K01 DK129408"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Texas Medical Center Digestive Diseases Center"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,11,14]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>The influence of birth modality (scheduled cesarean or spontaneous vaginal) on the development of the newborn has been a source of controversy in neonatology. The impact of cesarean vs vaginal birth on the development of bile acid and fibroblast growth factor 19 (FGF19) signaling is unknown. Our aim was to determine the effect of birth modality and gestational age (preterm vs term) on plasma hormone levels, bile acid pool distribution, expression of genes in the bile acid-FXR-FGF19 pathway, and plasma levels of FGF19 at birth and on day 3 of life in neonatal pigs. Four sows underwent cesarean delivery on gestation day 105 (n = 2) and 114 (n = 2; term = 115 days), and 2 additional sows were allowed to farrow at term (gestation days 112 and 118). Piglets were euthanized at birth (Term-Vaginal n = 6; Term-Cesarean n = 8; Preterm n = 10) for tissue and blood collection, and the remaining pigs received total parenteral nutrition then were fed enterally on day 3 (Term-Vaginal n = 8; Term-Cesarean n = 10; Preterm n = 8), before blood and tissue were collected. Piglets born vaginally had a markedly (30-fold) higher plasma FGF19 at birth than term pigs born via cesarean delivery, and 70-fold higher than preterm pigs (P &amp;lt; 0.001). However, distal ileum FGF19 gene expression was similar in all groups (P &amp;gt; 0.05). Plasma FGF19 positively correlated with plasma cortisol (r = 0.58; P &amp;lt; 0.05) and dexamethasone treatment increased ileal FGF19 expression in cultured pig tissue explants and human enteroids. Our findings suggest that exposure to maternal or endogenous glucocorticoids in the perinatal period may upregulate the development of the bile acid\u2013FGF19 pathway.<\/jats:p>","DOI":"10.1210\/endocr\/bqac188","type":"journal-article","created":{"date-parts":[[2022,11,11]],"date-time":"2022-11-11T17:09:57Z","timestamp":1668186597000},"source":"Crossref","is-referenced-by-count":4,"title":["Increased Circulating Cortisol After Vaginal Birth Is Associated With Increased FGF19 Secretion in Neonatal Pigs"],"prefix":"10.1210","volume":"164","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9457-984X","authenticated-orcid":false,"given":"Caitlin","family":"Vonderohe","sequence":"first","affiliation":[{"name":"USDA-ARS Children\u2019s Nutrition Research Center; Pediatrics, Gastroenterology & Nutrition, Baylor College of Medicine , Houston, TX 77030 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7644-9582","authenticated-orcid":false,"given":"Gregory","family":"Guthrie","sequence":"additional","affiliation":[{"name":"USDA-ARS Children\u2019s Nutrition Research Center; Pediatrics, Gastroenterology & Nutrition, Baylor College of Medicine , Houston, TX 77030 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara","family":"Stoll","sequence":"additional","affiliation":[{"name":"USDA-ARS Children\u2019s Nutrition Research Center; Pediatrics, Gastroenterology & Nutrition, Baylor College of Medicine , Houston, TX 77030 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1113-105X","authenticated-orcid":false,"given":"Valeria Melendez","family":"Hebib","sequence":"additional","affiliation":[{"name":"USDA-ARS Children\u2019s Nutrition Research Center; Pediatrics, Gastroenterology & Nutrition, Baylor College of Medicine , Houston, TX 77030 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7648-9952","authenticated-orcid":false,"given":"Harry","family":"Dawson","sequence":"additional","affiliation":[{"name":"USDA-ARS, Beltsville Human Nutrition Research Center, Diet, Genomics & Immunology Laboratory , Beltsville, MD 20705-2350 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8792-3339","authenticated-orcid":false,"given":"Douglas","family":"Burrin","sequence":"additional","affiliation":[{"name":"USDA-ARS Children\u2019s Nutrition Research Center; Pediatrics, Gastroenterology & Nutrition, Baylor College of Medicine , Houston, TX 77030 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"80","published-online":{"date-parts":[[2022,11,11]]},"reference":[{"issue":"3","key":"2023111206535257500_bqac188-B1","doi-asserted-by":"crossref","first-page":"e640","DOI":"10.1542\/peds.2011-3379","article-title":"Preterm birth and body composition at term equivalent age: a systematic review and meta-analysis","volume":"130","author":"Johnson","year":"2012","journal-title":"Pediatrics"},{"issue":"3","key":"2023111206535257500_bqac188-B2","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1542\/peds.2009-2959","article-title":"Neonatal outcomes of extremely preterm infants from the NICHD neonatal research network","volume":"126","author":"Stoll","year":"2010","journal-title":"Pediatrics"},{"issue":"5","key":"2023111206535257500_bqac188-B3","doi-asserted-by":"crossref","first-page":"E839","DOI":"10.1152\/ajpendo.00151.2019","article-title":"Prematurity blunts the feeding-induced stimulation of translation initiation signaling and protein synthesis in muscle of neonatal piglets","volume":"317","author":"Naberhuis","year":"2019","journal-title":"Am J Physiol Endocrinol Metab"},{"issue":"3","key":"2023111206535257500_bqac188-B4","doi-asserted-by":"crossref","first-page":"E551","DOI":"10.1152\/ajpendo.00203.2020","article-title":"Prematurity blunts the insulin- and amino acid-induced stimulation of translation initiation and protein synthesis in skeletal muscle of neonatal pigs","volume":"320","author":"Rudar","year":"2021","journal-title":"Am J Physiol Endocrinol Metab"},{"issue":"6198","key":"2023111206535257500_bqac188-B5","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1126\/science.1251816","article-title":"Preterm labor: one syndrome, many causes","volume":"345","author":"Romero","year":"2014","journal-title":"Science"},{"issue":"1","key":"2023111206535257500_bqac188-B6","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1055\/s-0031-1285829","article-title":"Cesarean versus vaginal delivery: whose risks? Whose benefits?","volume":"29","author":"Gregory","year":"2012","journal-title":"Am J Perinatol"},{"issue":"6","key":"2023111206535257500_bqac188-B7","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1111\/j.1552-6909.2007.00196.x","article-title":"A review of issues surrounding medically elective cesarean delivery","volume":"36","author":"Miesnik","year":"2007","journal-title":"J Obstet Gynecol Neonatal Nurs"},{"issue":"1","key":"2023111206535257500_bqac188-B8","doi-asserted-by":"crossref","first-page":"G117","DOI":"10.1152\/ajpgi.00274.2021","article-title":"Tissue-specific mechanisms of bile acid homeostasis and activation of FXR-FGF19 signaling in preterm and term neonatal pigs","volume":"322","author":"Vonderohe","year":"2022","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"issue":"1","key":"2023111206535257500_bqac188-B9","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/S0167-4781(98)00255-3","article-title":"Structure and expression of a novel human FGF, FGF-19, expressed in the fetal brain","volume":"1444","author":"Nishimura","year":"1999","journal-title":"Biochim Biophys Acta"},{"key":"2023111206535257500_bqac188-B10","doi-asserted-by":"crossref","first-page":"118804","DOI":"10.1016\/j.lfs.2020.118804","article-title":"Role of the fibroblast growth factor 19 in the skeletal system","volume":"265","author":"Chen","year":"2021","journal-title":"Life Sci"},{"issue":"2","key":"2023111206535257500_bqac188-B11","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1016\/j.ydbio.2007.11.013","article-title":"Fgf19 is required for zebrafish lens and retina development","volume":"313","author":"Nakayama","year":"2008","journal-title":"Dev Biol"},{"issue":"1-2","key":"2023111206535257500_bqac188-B12","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.modgep.2006.05.003","article-title":"Fgf19 expression patterns in the developing chick inner ear","volume":"7","author":"S\u00e1nchez-Calder\u00f3n","year":"2007","journal-title":"Gene Expr Patterns"},{"issue":"5","key":"2023111206535257500_bqac188-B13","doi-asserted-by":"crossref","first-page":"e94","DOI":"10.1097\/MPG.0000000000002645","article-title":"Rapid postnatal upregulation of intestinal farnesoid X receptor-fibroblast growth factor 19 signaling in premature pigs","volume":"70","author":"Smith","year":"2020","journal-title":"J Pediatr Gastroenterol Nutr"},{"issue":"2","key":"2023111206535257500_bqac188-B14","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1007\/s13105-019-00675-7","article-title":"FGF19 Subfamily members: FGF19 and FGF21","volume":"75","author":"Dolegowska","year":"2019","journal-title":"J Physiol Biochem"},{"key":"2023111206535257500_bqac188-B15","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1007\/164_2019_235","article-title":"The enterokine fibroblast growth factor 15\/19 in bile acid metabolism","volume":"256","author":"Cariello","year":"2019","journal-title":"Handb Exp Pharmacol"},{"key":"2023111206535257500_bqac188-B16","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.semcdb.2015.09.021","article-title":"Metabolic fibroblast growth factors (FGFs): mediators of energy homeostasis","volume":"53","author":"Markan","year":"2016","journal-title":"Semin Cell Dev Biol"},{"issue":"8","key":"2023111206535257500_bqac188-B17","doi-asserted-by":"crossref","first-page":"990","DOI":"10.1038\/nm.4363","article-title":"Fibroblast growth factor 19 regulates skeletal muscle mass and ameliorates muscle wasting in mice","volume":"23","author":"Benoit","year":"2017","journal-title":"Nat Med"},{"issue":"6","key":"2023111206535257500_bqac188-B18","doi-asserted-by":"crossref","first-page":"2594","DOI":"10.1210\/en.2003-1671","article-title":"Fibroblast growth factor 19 increases metabolic rate and reverses dietary and leptin-deficient diabetes","volume":"145","author":"Fu","year":"2004","journal-title":"Endocrinology"},{"issue":"1","key":"2023111206535257500_bqac188-B19","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/j.jceh.2021.04.007","article-title":"Suppression of bile acid synthesis in a preterm infant receiving prolonged parenteral nutrition","volume":"12","author":"Memon","year":"2022","journal-title":"J Clin Exp Hepatol"},{"issue":"6","key":"2023111206535257500_bqac188-B20","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1080\/14767058.2018.1513483","article-title":"Developmental regulation of the gut-liver (FGF19-CYP7A1) axis in neonates","volume":"33","author":"Memon","year":"2020","journal-title":"J Matern Fetal Neonatal Med"},{"key":"2023111206535257500_bqac188-B21","doi-asserted-by":"crossref","first-page":"805722","DOI":"10.3389\/fendo.2021.805722","article-title":"Fibroblast growth factor 19 in gestational diabetes mellitus and fetal growth","volume":"12","author":"Yang","year":"2021","journal-title":"Front Endocrinol (Lausanne)"},{"issue":"10","key":"2023111206535257500_bqac188-B22","doi-asserted-by":"crossref","first-page":"4713","DOI":"10.2527\/jas.2013-6359","article-title":"Invited review: the preterm pig as a model in pediatric gastroenterology","volume":"91","author":"Sangild","year":"2013","journal-title":"J Anim Sci"},{"key":"2023111206535257500_bqac188-B23","doi-asserted-by":"crossref","first-page":"111617","DOI":"10.1016\/j.mce.2022.111617","article-title":"Fibroblast growth factor 15\/19 expression, regulation, and function: an overview","volume":"548","author":"Guthrie","year":"2022","journal-title":"Mol Cell Endocrinol"},{"issue":"3","key":"2023111206535257500_bqac188-B24","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1016\/j.jcmgh.2016.12.009","article-title":"GATA4 is sufficient to establish jejunal versus ileal identity in the small intestine","volume":"3","author":"Thompson","year":"2017","journal-title":"Cell Mol Gastroenterol Hepatol"},{"issue":"4","key":"2023111206535257500_bqac188-B25","doi-asserted-by":"crossref","first-page":"G638","DOI":"10.1152\/ajpgi.00198.2018","article-title":"Prematurity reduces citrulline-arginine-nitric oxide production and precedes the onset of necrotizing enterocolitis in piglets","volume":"315","author":"Robinson","year":"2018","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"issue":"9","key":"2023111206535257500_bqac188-B26","doi-asserted-by":"crossref","first-page":"e106888","DOI":"10.1371\/journal.pone.0106888","article-title":"Delayed initiation but not gradual advancement of enteral formula feeding reduces the incidence of necrotizing enterocolitis (NEC) in preterm pigs","volume":"9","author":"Ghoneim","year":"2014","journal-title":"PLoS One"},{"issue":"1","key":"2023111206535257500_bqac188-B27","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1186\/s40168-018-0498-0","article-title":"Metabolomic signatures distinguish the impact of formula carbohydrates on disease outcome in a preterm piglet model of NEC","volume":"6","author":"Call","year":"2018","journal-title":"Microbiome"},{"issue":"3","key":"2023111206535257500_bqac188-B28","doi-asserted-by":"crossref","first-page":"G270","DOI":"10.1152\/ajpgi.00177.2021","article-title":"Use of human tissue stem cell-derived organoid cultures to model enterohepatic circulation","volume":"321","author":"Blutt","year":"2021","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"2023111206535257500_bqac188-B29","article-title":"Plasma FGF19 and Insulin After Bolus Meal in Pigs on Day 3 of Life (Supplementary Figure\u00a01)","volume-title":"figshare","author":"Vonderohe"},{"issue":"7-8","key":"2023111206535257500_bqac188-B30","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1080\/00498250802040584","article-title":"Bile acid transporters in health and disease","volume":"38","author":"Kosters","year":"2008","journal-title":"Xenobiotica"},{"key":"2023111206535257500_bqac188-B31","article-title":"Expression of Bile Acid Transport Proteins in Liver and Distal Ileum of Pigs at Birth and on Day 3 of Life (Supplementary Figure\u00a02)","volume-title":"figshare","author":"Vonderohe"},{"key":"2023111206535257500_bqac188-B32","article-title":"Relative Expression of Fibroblast Growth Factor Receptors in the Gut and Liver of Neonatal Pigs (Supplementary Figure\u00a03)","volume-title":"figshare","author":"Vonderohe"},{"issue":"2","key":"2023111206535257500_bqac188-B33","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1203\/00006450-199502000-00014","article-title":"The prenatal development and glucocorticoid control of brush-border hydrolases in the pig small intestine","volume":"37","author":"Sangild","year":"1995","journal-title":"Pediatr Res"},{"key":"2023111206535257500_bqac188-B34","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1111\/j.2042-3306.1997.tb05077.x","article-title":"Systemic and luminal influences on the perinatal development of the gut","volume":"24","author":"Trahair","year":"1997","journal-title":"Equine Vet J Suppl"},{"issue":"4","key":"2023111206535257500_bqac188-B35","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1051\/rnd:2004043","article-title":"Hormones, IgG and lactose changes around parturition in plasma, and colostrum or saliva of multiparous sows","volume":"44","author":"Devillers","year":"2004","journal-title":"Reprod Nutr Dev"},{"key":"2023111206535257500_bqac188-B36","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/B978-0-323-62520-3.00005-1","volume-title":"Sperling Pediatric Endocrinology","author":"Mesiano","year":"2021","edition":"5th ed"},{"issue":"4","key":"2023111206535257500_bqac188-B37","first-page":"2953","article-title":"Regulation of Fgf15 expression in the intestine by glucocorticoid receptor","volume":"19","author":"Jia","year":"2019","journal-title":"Mol Med Rep"},{"issue":"9 Pt B","key":"2023111206535257500_bqac188-B38","doi-asserted-by":"crossref","first-page":"2927","DOI":"10.1016\/j.bbadis.2018.06.003","article-title":"Interaction of glucocorticoids with FXR\/FGF19\/FGF21-mediated ileum-liver crosstalk","volume":"1864","author":"Al-Aqil","year":"2018","journal-title":"Biochim Biophys Acta Mol Basis Dis"},{"issue":"3","key":"2023111206535257500_bqac188-B39","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1016\/S0016-5085(19)32473-4","article-title":"Bile salt metabolism in the human premature infant. Preliminary observations of pool size and synthesis rate following prenatal administration of dexamethasone and phenobarbital","volume":"69","author":"Watkins","year":"1975","journal-title":"Gastroenterology"},{"issue":"9","key":"2023111206535257500_bqac188-B40","doi-asserted-by":"crossref","first-page":"2673","DOI":"10.1093\/jn\/132.9.2673","article-title":"Preterm birth affects the intestinal response to parenteral and enteral nutrition in newborn pigs","volume":"132","author":"Sangild","year":"2002","journal-title":"J Nutr"},{"issue":"1","key":"2023111206535257500_bqac188-B41","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1146\/annurev-animal-020518-115142","article-title":"Translational advances in pediatric nutrition and gastroenterology: new insights from pig models","volume":"8","author":"Burrin","year":"2020","journal-title":"Annu Rev Anim Biosci"},{"issue":"2","key":"2023111206535257500_bqac188-B42","doi-asserted-by":"crossref","first-page":"e12914","DOI":"10.1111\/mcn.12914","article-title":"Neonatal weight loss and gain patterns in caesarean section born infants: integrative systematic review","volume":"16","author":"Kelly","year":"2020","journal-title":"Matern Child Nutr"},{"issue":"2","key":"2023111206535257500_bqac188-B43","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1177\/0890334411434177","article-title":"Weight loss in exclusively breastfed infants delivered by cesarean birth","volume":"28","author":"Preer","year":"2012","journal-title":"J Hum Lact"},{"issue":"2","key":"2023111206535257500_bqac188-B44","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/S0378-3782(03)00087-2","article-title":"The effect of antenatal corticosteroids on gut peptides of preterm infants\u2014a matched group comparison: corticosteroids and gut development","volume":"74","author":"Costalos","year":"2003","journal-title":"Early Hum Dev"},{"issue":"3","key":"2023111206535257500_bqac188-B45","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1159\/000371565","article-title":"Progesterone metabolites as farnesoid X receptor inhibitors","volume":"33","author":"Abu-Hayyeh","year":"2015","journal-title":"Dig Dis"},{"issue":"1-2","key":"2023111206535257500_bqac188-B46","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.mce.2012.10.027","article-title":"Nuclear receptors, bile acids and cholesterol homeostasis series\u2014bile acids and pregnancy","volume":"368","author":"Abu-Hayyeh","year":"2013","journal-title":"Mol Cell Endocrinol"},{"issue":"12","key":"2023111206535257500_bqac188-B47","doi-asserted-by":"crossref","first-page":"6496","DOI":"10.3390\/ijms23126496","article-title":"Maternal and fetal bile acid homeostasis regulated by sulfated progesterone metabolites through FXR signaling pathway in a pregnant sow model","volume":"23","author":"Wang","year":"2022","journal-title":"Int J Mol Sci"},{"issue":"1","key":"2023111206535257500_bqac188-B48","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1186\/s12884-020-03510-w","article-title":"Single-course antenatal corticosteroids is related to faster growth in very-low-birth-weight infant","volume":"21","author":"Jing","year":"2021","journal-title":"BMC Pregnancy Childbirth"},{"key":"2023111206535257500_bqac188-B49","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/j.jpeds.2018.10.004","article-title":"Effect of prophylaxis for early adrenal insufficiency using low-dose hydrocortisone in very preterm infants: an individual patient data meta-analysis","volume":"207","author":"Shaffer","year":"2019","journal-title":"J Pediatr"},{"issue":"1","key":"2023111206535257500_bqac188-B50","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1542\/peds.95.1.120","article-title":"Evidence of early adrenal insufficiency in babies who develop bronchopulmonary dysplasia","volume":"95","author":"Watterberg","year":"1995","journal-title":"Pediatrics"}],"container-title":["Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/endo\/advance-article-pdf\/doi\/10.1210\/endocr\/bqac188\/46988337\/bqac188.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/endo\/article-pdf\/164\/1\/bqac188\/51314253\/bqac188.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/endo\/article-pdf\/164\/1\/bqac188\/51314253\/bqac188.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,12]],"date-time":"2023-11-12T06:54:35Z","timestamp":1699772075000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/endo\/article\/doi\/10.1210\/endocr\/bqac188\/6823805"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11,11]]},"references-count":50,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2022,11,14]]}},"URL":"https:\/\/doi.org\/10.1210\/endocr\/bqac188","relation":{},"ISSN":["1945-7170"],"issn-type":[{"value":"1945-7170","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2023,1,1]]},"published":{"date-parts":[[2022,11,11]]},"article-number":"bqac188"}}