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Primary aldosteronism, a typical model of a systemic aldosterone excess, may cause vision loss due to various ocular diseases, such as retinal vein occlusion, central serous chorioretinopathy, and, possibly glaucoma. RAAS components are present in various parts and types of cells present in the eye. Investigations of the local RAAS in various animal models of diabetic macular edema, retinal vein occlusion, retinopathy of prematurity, central serous chorioretinopathy, and glaucoma have found evidence that aldosterone or mineralocorticoid receptors may exacerbate the pathology of these disorders. Further studies are needed to elucidate whether the modulation of aldosterone or mineralocorticoid receptors is an effective treatment for preventing vision loss in patients with eye diseases.<\/jats:p>","DOI":"10.1210\/endocr\/bqac201","type":"journal-article","created":{"date-parts":[[2022,12,3]],"date-time":"2022-12-03T08:13:24Z","timestamp":1670055204000},"source":"Crossref","is-referenced-by-count":10,"title":["Aldosterone as a Possible Contributor to Eye Diseases"],"prefix":"10.1210","volume":"164","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9566-4587","authenticated-orcid":false,"given":"Tomomi","family":"Higashide","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, Kanazawa University Graduate School of Medical Sciences , Kanazawa , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2977-124X","authenticated-orcid":false,"given":"Kazuyuki","family":"Hirooka","sequence":"additional","affiliation":[{"name":"Ophthalmology and Visual Science, Graduate School of Biomedical Science, Hiroshima University , Hiroshima , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0461-3018","authenticated-orcid":false,"given":"Mitsuhiro","family":"Kometani","sequence":"additional","affiliation":[{"name":"Department of Health Promotion and Medicine of the Future, Kanazawa University Graduate School of Medical Sciences , Kanazawa , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuhisa","family":"Sugiyama","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Kanazawa University Graduate School of Medical Sciences , Kanazawa , 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