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Growth hormone\u2013releasing hormone (GHRH) is a crucial element in homeostasis maintenance, and regulates the release of growth hormone from the anterior pituitary gland. Accumulating evidence suggests that this neuropeptide can also promote malignancies, as well as inflammation. Our review is focused on the role of that 44 - amino acid peptide (GHRH) and its antagonists in inflammation and vascular function, summarizing recent findings in the corresponding field. Preclinical studies demonstrate the protective role of GHRH antagonists against endothelial barrier dysfunction, suggesting that the development of those peptides may lead to new therapies against pathologies related to vascular remodeling (eg, sepsis, acute respiratory distress syndrome). Targeted therapies for those diseases do not exist.<\/jats:p>","DOI":"10.1210\/endocr\/bqac209","type":"journal-article","created":{"date-parts":[[2022,12,12]],"date-time":"2022-12-12T08:07:19Z","timestamp":1670832439000},"source":"Crossref","is-referenced-by-count":32,"title":["Growth Hormone\u2013Releasing Hormone in Endothelial Inflammation"],"prefix":"10.1210","volume":"164","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8366-5099","authenticated-orcid":false,"given":"Nektarios","family":"Barabutis","sequence":"first","affiliation":[{"name":"School of Basic Pharmaceutical and Toxicological Sciences, College of Pharmacy, University of Louisiana Monroe , Monroe, LA , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad S","family":"Akhter","sequence":"additional","affiliation":[{"name":"School of Basic Pharmaceutical and Toxicological Sciences, College of Pharmacy, University of Louisiana Monroe , Monroe, LA , 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