{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T21:16:12Z","timestamp":1789420572478,"version":"build-2803163510"},"reference-count":26,"publisher":"The Endocrine Society","issue":"5","license":[{"start":{"date-parts":[[2023,3,7]],"date-time":"2023-03-07T00:00:00Z","timestamp":1678147200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"crossref","award":["#1065854"],"award-info":[{"award-number":["#1065854"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"crossref","award":["2000732"],"award-info":[{"award-number":["2000732"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001728","name":"Swedish Foundation for International Cooperation in Research and Higher Education","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100001728","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100004359","name":"Swedish Research Council","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100006722","name":"Center for Clinical Research Dalarna","doi-asserted-by":"crossref","award":["#1159261"],"award-info":[{"award-number":["#1159261"]}],"id":[{"id":"10.13039\/501100006722","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100006722","name":"Center for Clinical Research Dalarna","doi-asserted-by":"crossref","award":["#1136418"],"award-info":[{"award-number":["#1136418"]}],"id":[{"id":"10.13039\/501100006722","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100006722","name":"Center for Clinical Research Dalarna","doi-asserted-by":"crossref","award":["#1146128"],"award-info":[{"award-number":["#1146128"]}],"id":[{"id":"10.13039\/501100006722","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100006722","name":"Center for Clinical Research Dalarna","doi-asserted-by":"crossref","award":["#1176922"],"award-info":[{"award-number":["#1176922"]}],"id":[{"id":"10.13039\/501100006722","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,3,13]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Background: Preeclampsia is a severe complication of pregnancy. Chemerin is an adipokine secreted from adipose tissue and highly expressed in placenta. This study evaluated the biomarker potential of circulating chemerin to predict preeclampsia.<\/jats:p><jats:p>Methods: Maternal plasma and placenta were collected from women with early-onset preeclampsia (&amp;lt;34 weeks), with preeclampsia and eclampsia, or before preeclampsia diagnosis (36 weeks). Human trophoblast stem cells were differentiated into syncytiotrophoblast or extravillous trophoblasts across 96\u2005hours. Cells were cultured in 1% O2 (hypoxia) or 5% O2 (normoxia). Chemerin was measured by enzyme-linked immunosorbent assay (ELISA) and RARRES2 (gene coding chemerin) by reverse transcription-quantitative polymerase chain reaction.<\/jats:p><jats:p>Results: Circulating chemerin was increased in 46 women with early-onset preeclampsia (&amp;lt;34 weeks) compared to 17 controls (P &amp;lt; .0006). Chemerin was increased in placenta from 43 women with early-onset preeclampsia compared to 24 controls (P &amp;lt; .0001). RARRES2 was reduced in placenta from 43 women with early-onset preeclampsia vs 24 controls (P &amp;lt; .0001).<\/jats:p><jats:p>Chemerin was increased in plasma from 26 women with established preeclampsia (P = .006), vs 15 controls. Circulating chemerin was increased in 23 women who later developed preeclampsia vs 182 who did not (P = 3.23 \u00d7 10\u22126).<\/jats:p><jats:p>RARRES2 was reduced in syncytiotrophoblast (P = .005) or extravillous trophoblasts (P &amp;lt; .0001). Hypoxia increased RARRES2 expression in syncytiotrophoblast (P = .01) but not cytotrophoblast cells.<\/jats:p><jats:p>Conclusions: Circulating chemerin was elevated in women with early-onset preeclampsia, established preeclampsia, and preceding preeclampsia diagnosis of preeclampsia. RARRES2 was dysregulated in placenta complicated by preeclampsia and may be regulated through hypoxia. Chemerin may have potential as a biomarker for preeclampsia but would need to be combined with other biomarkers.<\/jats:p>","DOI":"10.1210\/endocr\/bqad041","type":"journal-article","created":{"date-parts":[[2023,3,8]],"date-time":"2023-03-08T00:18:26Z","timestamp":1678234706000},"source":"Crossref","is-referenced-by-count":10,"title":["Circulating Chemerin Is Elevated in Women With Preeclampsia"],"prefix":"10.1210","volume":"164","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9150-6052","authenticated-orcid":false,"given":"Lucy A","family":"Bartho","sequence":"first","affiliation":[{"name":"Translational Obstetrics Group, The Department of Obstetrics and Gynaecology, Mercy Hospital for Women, University of Melbourne , Heidelberg, Victoria 3084 , Australia"},{"name":"Mercy Perinatal, Mercy Hospital for Women , Heidelberg, Victoria 3084 , 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Stellenbosch University , Cape Town 7505 , South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roxanne","family":"Hastie","sequence":"additional","affiliation":[{"name":"Translational Obstetrics Group, The Department of Obstetrics and Gynaecology, Mercy Hospital for Women, University of Melbourne , Heidelberg, Victoria 3084 , Australia"},{"name":"Mercy Perinatal, Mercy Hospital for Women , Heidelberg, Victoria 3084 , Australia"},{"name":"Department of Obstetrics and Gynecology, Stellenbosch University , Cape Town 7505 , South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lina","family":"Bergman","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Stellenbosch University , Cape Town 7505 , South Africa"},{"name":"Department of Women's and Children's Health, Uppsala University , Uppsala 751 85 , Sweden"},{"name":"Department of Obstetrics and Gynecology, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg , Gothenburg 405 30 , Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natasha","family":"Pritchard","sequence":"additional","affiliation":[{"name":"Translational Obstetrics Group, The Department of Obstetrics and Gynaecology, Mercy Hospital for Women, University of Melbourne , Heidelberg, Victoria 3084 , Australia"},{"name":"Mercy Perinatal, Mercy Hospital for Women , Heidelberg, Victoria 3084 , Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"Cannon","sequence":"additional","affiliation":[{"name":"Translational Obstetrics Group, The Department of Obstetrics and Gynaecology, Mercy Hospital for Women, University of Melbourne , Heidelberg, Victoria 3084 , Australia"},{"name":"Mercy Perinatal, Mercy Hospital for Women , Heidelberg, Victoria 3084 , Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tuong-Vi","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Translational Obstetrics Group, The Department of Obstetrics and Gynaecology, Mercy Hospital for Women, University of Melbourne , Heidelberg, Victoria 3084 , Australia"},{"name":"Mercy Perinatal, Mercy Hospital for Women , Heidelberg, Victoria 3084 , Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georgia P","family":"Wong","sequence":"additional","affiliation":[{"name":"Translational Obstetrics Group, The Department of Obstetrics and Gynaecology, Mercy Hospital for Women, University of Melbourne , Heidelberg, Victoria 3084 , Australia"},{"name":"Mercy Perinatal, Mercy Hospital for Women , Heidelberg, Victoria 3084 , Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teresa M","family":"MacDonald","sequence":"additional","affiliation":[{"name":"Translational Obstetrics Group, The Department of Obstetrics and Gynaecology, Mercy Hospital for Women, University of Melbourne , Heidelberg, Victoria 3084 , Australia"},{"name":"Mercy Perinatal, Mercy Hospital for Women , Heidelberg, Victoria 3084 , Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emerson","family":"Keenan","sequence":"additional","affiliation":[{"name":"Translational Obstetrics Group, The Department of Obstetrics and Gynaecology, Mercy Hospital for Women, University of Melbourne , Heidelberg, Victoria 3084 , Australia"},{"name":"Mercy Perinatal, Mercy Hospital for Women , Heidelberg, Victoria 3084 , Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalie J","family":"Hannan","sequence":"additional","affiliation":[{"name":"Translational Obstetrics Group, The Department of Obstetrics and Gynaecology, Mercy Hospital for Women, University of Melbourne , Heidelberg, Victoria 3084 , Australia"},{"name":"Mercy Perinatal, Mercy Hospital for Women , 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