{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T13:54:40Z","timestamp":1753883680887,"version":"3.41.2"},"reference-count":62,"publisher":"The Endocrine Society","issue":"5","license":[{"start":{"date-parts":[[2023,3,13]],"date-time":"2023-03-13T00:00:00Z","timestamp":1678665600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01DK112365"],"award-info":[{"award-number":["R01DK112365"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,3,13]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>1,25-Dihydroxyvitamin D3 (1,25(OH)2D3)-mediated intestinal calcium (Ca) absorption supplies Ca for proper bone mineralization during growth. We tested whether vitamin D receptor (VDR)-mediated 1,25(OH)2D3 signaling is critical for adult Ca absorption and bone by using mice with inducible Vdr gene knockout in the whole intestine (villin-CreERT2+\/\u2212\u2005\u00d7\u2005Vdrf\/f, WIK) or in the large intestine (Cdx2-CreERT2+\/\u2212\u2005\u00d7Vdrf\/f, LIK). At 4-month-old, Vdr alleles were recombined (0.05\u2005mg tamoxifen\/g BW, intraperitoneally [i.p.], 5 days) and mice were fed diets with either 0.5% (adequate) or 0.2% (low) Ca. Ca absorption was examined after 2 weeks while serum 1,25(OH)2D3, bone mass, and bone microarchitecture were examined after 16 weeks. Intestinal and renal gene expression was measured at both time points (n = 12\/genotype\/diet\/time point). On the 0.5% Ca diet, all phenotypes in WIK and LIK mice were similar to the controls. Control mice adapted to the 0.2% low-Ca diet by increasing renal Cyp27b1 mRNA (3-fold), serum 1,25(OH)2D3 level (1.9-fold), and Ca absorption in the duodenum (Dd, + 131%) and proximal colon (PCo, + 28.9%), which prevented bone loss. In WIK mice, low-Ca diet increased serum 1,25(OH)2D3 (4.4-fold) but Ca absorption remained unaltered in the Dd and PCo. Consequently, significant bone loss occurred in WIK mice (e.g., cortical thickness, Ct.Th, \u221233.7%). LIK mice adapted to the low-Ca diet in the Dd but not the PCo, and the effect on bone phenotypes was milder (e.g., Ct.Th, \u221213.1%). Our data suggest intestinal VDR in adult mice prevents bone loss under low Ca intake but is dispensable under adequate calcium intake.<\/jats:p>","DOI":"10.1210\/endocr\/bqad051","type":"journal-article","created":{"date-parts":[[2023,3,24]],"date-time":"2023-03-24T06:56:08Z","timestamp":1679640968000},"source":"Crossref","is-referenced-by-count":2,"title":["Intestinal Vitamin D Receptor Is Dispensable for Maintaining Adult Bone Mass in Mice With Adequate Calcium Intake"],"prefix":"10.1210","volume":"164","author":[{"given":"Heng","family":"Jiang","sequence":"first","affiliation":[{"name":"Department of Nutritional Sciences, Dell Pediatric Research Institute, University of Texas , Austin, TX 78723 , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Krittikan","family":"Chanpaisaeng","sequence":"additional","affiliation":[{"name":"Functional Ingredients and Food Innovation Research Group, National Center for Genetic Engineering and Biotechnology , Pathum Thani 12120 , Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sylvia","family":"Christakos","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Biochemistry and Molecular Genetics, Rutgers New Jersey Medical School , Newark, NJ 07103 , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0142-9517","authenticated-orcid":false,"given":"James C","family":"Fleet","sequence":"additional","affiliation":[{"name":"Department of Nutritional Sciences, Dell Pediatric Research Institute, University of Texas , Austin, TX 78723 , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"80","published-online":{"date-parts":[[2023,3,24]]},"reference":[{"issue":"12","key":"2023062109034333700_bqad051-B1","doi-asserted-by":"crossref","first-page":"3315","DOI":"10.1007\/s00198-017-4230-x","article-title":"Global dietary calcium intake among adults: a systematic review","volume":"28","author":"Balk","year":"2017","journal-title":"Osteoporos Int"},{"issue":"12","key":"2023062109034333700_bqad051-B2","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1007\/s001980070020","article-title":"Peak bone mass","volume":"11","author":"Heaney","year":"2000","journal-title":"Osteoporos Int"},{"issue":"1 Suppl","key":"2023062109034333700_bqad051-B3","doi-asserted-by":"crossref","first-page":"261S","DOI":"10.1093\/ajcn\/54.1.261S","article-title":"Calcium absorption efficiency and calcium requirements in children and adolescents","volume":"54","author":"Peacock","year":"1991","journal-title":"Am J Clin Nutr"},{"issue":"5","key":"2023062109034333700_bqad051-B4","doi-asserted-by":"crossref","first-page":"878","DOI":"10.1093\/ajcn\/52.5.878","article-title":"Factors that influence peak bone mass formation: a study of calcium balance and the inheritance of bone mass in adolescent females","volume":"52","author":"Matkovic","year":"1990","journal-title":"Am J Clin Nutr"},{"issue":"6","key":"2023062109034333700_bqad051-B5","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1530\/eje.0.1510759","article-title":"Does the response of bone mass to calcium supplements depend on calcium absorption efficiency?","volume":"151","author":"Smith","year":"2004","journal-title":"Eur J Endocrinol"},{"issue":"5","key":"2023062109034333700_bqad051-B6","doi-asserted-by":"crossref","first-page":"345","DOI":"10.7326\/0003-4819-132-5-200003070-00003","article-title":"Low fractional calcium absorption increases the risk for hip fracture in women with low calcium intake. 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in proximal colon with calcitriol glycosides and glucuronides","volume":"198","author":"Jiang","year":"2019","journal-title":"J Steroid Biochem Mol Biol"},{"issue":"5 Pt 1","key":"2023062109034333700_bqad051-B35","first-page":"G561","article-title":"An analysis of intestinal calcium transport across the rat intestine","volume":"250","author":"Bronner","year":"1986","journal-title":"Am J Physiol"},{"issue":"1 Pt 1","key":"2023062109034333700_bqad051-B36","first-page":"108","article-title":"Saturable and nonsaturable copper and calcium transport in mouse duodenum","volume":"249","author":"Bronner","year":"1985","journal-title":"Am J Physiol"},{"issue":"4","key":"2023062109034333700_bqad051-B37","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) 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mice","volume":"125","author":"Chanpaisaeng","year":"2019","journal-title":"Bone"},{"issue":"4","key":"2023062109034333700_bqad051-B41","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1172\/JCI107652","article-title":"Effects of dietary calcium restriction and chronic thyroparathyroidectomy on the metabolism of (3H)25-hydroxyvitamin D3 and the active transport of calcium by rat intestine","volume":"53","author":"Favus","year":"1974","journal-title":"J Clin Invest"},{"issue":"10","key":"2023062109034333700_bqad051-B42","doi-asserted-by":"crossref","first-page":"5576","DOI":"10.1210\/jc.2005-1021","article-title":"Relationships among vitamin D levels, parathyroid hormone, and calcium absorption in young adolescents","volume":"90","author":"Abrams","year":"2005","journal-title":"J Clin Endocrinol Metab"},{"issue":"4","key":"2023062109034333700_bqad051-B43","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1093\/ajcn\/63.4.579","article-title":"Increased efficiency of calcium absorption during short periods of inadequate calcium intake in girls","volume":"63","author":"O\u2019Brien","year":"1996","journal-title":"Am J Clin Nutr"},{"issue":"1","key":"2023062109034333700_bqad051-B44","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1210\/jcem-67-1-62","article-title":"Effect of lowering dietary calcium intake on fractional whole body calcium retention","volume":"67","author":"Dawson-Hughes","year":"1988","journal-title":"J Clin Endocrinol Metab"},{"issue":"7","key":"2023062109034333700_bqad051-B45","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1002\/jbmr.5650080702","article-title":"Calcium retention and hormone levels in black and white women on high- and low-calcium diets","volume":"8","author":"Dawson-Hughes","year":"1993","journal-title":"J Bone Min Res"},{"issue":"5","key":"2023062109034333700_bqad051-B46","doi-asserted-by":"crossref","first-page":"1118","DOI":"10.1172\/JCI109941","article-title":"Effect of age on the 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