{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T14:46:53Z","timestamp":1791557213940,"version":"4.3.4"},"reference-count":65,"publisher":"The Endocrine Society","issue":"7","license":[{"start":{"date-parts":[[2023,5,26]],"date-time":"2023-05-26T00:00:00Z","timestamp":1685059200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100001843","name":"Science and Engineering Research Board","doi-asserted-by":"publisher","award":["CRG\/2019\/003467"],"award-info":[{"award-number":["CRG\/2019\/003467"]}],"id":[{"id":"10.13039\/501100001843","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,6,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Hyperprolactinemia is prevalent in up to 16% of infertile males. Although the prolactin receptor (PRLR) is present on various testicular cells, the physiological role of this receptor in spermatogenesis remains elusive. The aim of this study is to delineate prolactin actions in rat testicular tissue. Serum prolactin, developmental expression of PRLR, signaling pathways associated, and gene transcription regulation in the testes were investigated. Serum prolactin and testicular PRLR expression was found to be significantly increased at pubertal and adult ages as compared to prepubertal. Further, PRLR activated the JAK2\/STAT5 pathway, but not the MAPK\/ERK and PI3K\/AKT pathway in the testicular cells. Gene expression profiling following prolactin treatment in seminiferous tubule culture resulted in a total of 692 differentially expressed genes, of which 405 were upregulated and 287 were downregulated. Enrichment map analysis showed that prolactin target genes are involved in processes such as cell cycle, male reproduction, chromatin remodeling, and cytoskeletal organization. Novel gene targets of prolactin whose role in testes is unexplored were obtained and validated by qPCR. Additionally, 10 genes involved in cell cycle process were also validated; 6 genes (Ccna1, Ccnb1, Ccnb2, Cdc25a, Cdc27, Plk1) were found to be significantly upregulated, whereas 4 genes (Ccar2, Nudc, Tuba1c, Tubb2a) were found to be significantly downregulated in testes after treatment with prolactin. Taken together, the findings from this study suggest a crucial role of prolactin in male reproduction and identified target genes regulated by prolactin in the testes.<\/jats:p>","DOI":"10.1210\/endocr\/bqad072","type":"journal-article","created":{"date-parts":[[2023,5,26]],"date-time":"2023-05-26T10:24:20Z","timestamp":1685096660000},"source":"Crossref","is-referenced-by-count":10,"title":["Prolactin Regulates Testicular Gene Expression and Cell Cycle Processes Predominantly via JAK2\/STAT5 Pathway in the Male Rat"],"prefix":"10.1210","volume":"164","author":[{"given":"Sanketa","family":"Raut","sequence":"first","affiliation":[{"name":"Department of Neuroendocrinology, ICMR-National Institute for Research in Reproductive and Child Health , Mumbai 400012 , India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kushaan","family":"Khambata","sequence":"additional","affiliation":[{"name":"Department of Gamete Immunobiology, ICMR- National Institute for Research in Reproductive and Child Health , Mumbai 400012 , India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent","family":"Goffin","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris Cit\u00e9, INSERM UMR-S1151, CNRS UMR-S8253, Institut Necker Enfants Malades , F-75015 Paris , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9937-7518","authenticated-orcid":false,"given":"Nafisa","family":"Balasinor","sequence":"additional","affiliation":[{"name":"Department of Neuroendocrinology, ICMR-National Institute for Research in Reproductive and Child Health , Mumbai 400012 , India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"80","published-online":{"date-parts":[[2023,5,26]]},"reference":[{"issue":"12 Suppl","key":"2023070611302398200_bqad072-B1","first-page":"1075","article-title":"Guidelines for the diagnosis and treatment of 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