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Although progesterone is the most abundant sex steroid in orchiectomized (ORX) male mice, the origins of progesterone in males are unclear.<\/jats:p>\n               <jats:p>To determine the origins of progesterone and androgens, we first determined the effect of ORX, adrenalectomy (ADX), or both (ORX + ADX) on progesterone levels in multiple male mouse tissues. As expected, intratissue androgen levels were mainly testicular derived. Interestingly, progesterone levels remained high after ORX and ORX + ADX with the highest levels in white adipose tissue and in the gastrointestinal tract. High progesterone levels were observed in mouse chow and exceptionally high progesterone levels were observed in food items such as dairy, eggs, and beef, all derived from female animals of reproductive age. To determine if orally ingested progesterone contributes to tissue levels of progesterone in males, we treated ORX + ADX and sham mice with isotope-labeled progesterone or vehicle by oral gavage. We observed a significant uptake of labeled progesterone in white adipose tissue and prostate, suggesting that dietary progesterone may contribute to tissue levels of progesterone. In conclusion, although adrenal-derived progesterone contributes to intratissue progesterone levels in males, nonadrenal progesterone sources also contribute. We propose that dietary progesterone is absorbed and contributes to intratissue progesterone levels in male mice. We speculate that food with high progesterone content could be a significant source of progesterone in males, possibly with consequences for men undergoing androgen deprivation therapy for prostate cancer.<\/jats:p>","DOI":"10.1210\/endocr\/bqad103","type":"journal-article","created":{"date-parts":[[2023,7,5]],"date-time":"2023-07-05T04:07:04Z","timestamp":1688530024000},"source":"Crossref","is-referenced-by-count":4,"title":["Dietary Progesterone Contributes to Intratissue Levels of Progesterone in Male Mice"],"prefix":"10.1210","volume":"164","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0814-9550","authenticated-orcid":false,"given":"Hannah","family":"Colld\u00e9n","sequence":"first","affiliation":[{"name":"Sahlgrenska Osteoporosis Centre at Institute of Medicine, Sahlgrenska Academy at University of Gothenburg , Gothenburg SE-405 30 , Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Malin","family":"Hagberg Thulin","sequence":"additional","affiliation":[{"name":"Sahlgrenska Osteoporosis Centre at Institute of Medicine, Sahlgrenska Academy at University of Gothenburg , Gothenburg SE-405 30 , Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Landin","sequence":"additional","affiliation":[{"name":"Department of Drug Treatment, Sahlgrenska University Hospital, Region V\u00e4stra G\u00f6taland , Gothenburg SE-413 45 , Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2082-4886","authenticated-orcid":false,"given":"Karin","family":"Horkeby","sequence":"additional","affiliation":[{"name":"Sahlgrenska Osteoporosis Centre at Institute of Medicine, Sahlgrenska Academy at University of Gothenburg , Gothenburg SE-405 30 , 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Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5276-6612","authenticated-orcid":false,"given":"Louise","family":"Grahnemo","sequence":"additional","affiliation":[{"name":"Sahlgrenska Osteoporosis Centre at Institute of Medicine, Sahlgrenska Academy at University of Gothenburg , Gothenburg SE-405 30 , Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8953-1734","authenticated-orcid":false,"given":"Matti","family":"Poutanen","sequence":"additional","affiliation":[{"name":"Sahlgrenska Osteoporosis Centre at Institute of Medicine, Sahlgrenska Academy at University of Gothenburg , Gothenburg SE-405 30 , Sweden"},{"name":"Research Centre for Integrative Physiology and Pharmacology, Institute of Biomedicine and Turku Center for Disease Modeling, University of Turku , Turku FI-20014 , Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henrik","family":"Ryberg","sequence":"additional","affiliation":[{"name":"Department of Clinical Chemistry, Sahlgrenska University Hospital , Gothenburg SE-413 45 , Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1712-6131","authenticated-orcid":false,"given":"Liesbeth","family":"Vandenput","sequence":"additional","affiliation":[{"name":"Sahlgrenska Osteoporosis Centre at Institute of Medicine, Sahlgrenska Academy at University of Gothenburg , Gothenburg SE-405 30 , Sweden"},{"name":"Mary McKillop Institute for Health Research, Australian Catholic University , Melbourne, VIC 3000 , Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9633-2805","authenticated-orcid":false,"given":"Claes","family":"Ohlsson","sequence":"additional","affiliation":[{"name":"Sahlgrenska Osteoporosis Centre at Institute of 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