{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T16:34:13Z","timestamp":1772382853321,"version":"3.50.1"},"reference-count":65,"publisher":"The Endocrine Society","issue":"9","license":[{"start":{"date-parts":[[2023,7,13]],"date-time":"2023-07-13T00:00:00Z","timestamp":1689206400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R21HD097498"],"award-info":[{"award-number":["R21HD097498"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01HD105699"],"award-info":[{"award-number":["R01HD105699"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["RO1HL70562"],"award-info":[{"award-number":["RO1HL70562"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R35GM145249"],"award-info":[{"award-number":["R35GM145249"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01GM074830"],"award-info":[{"award-number":["R01GM074830"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,8,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Uterine artery (UA) hydrogen sulfide (H2S) production is augmented in pregnancy and, on stimulation by systemic\/local vasodilators, contributes to pregnancy-dependent uterine vasodilation; however, how H2S exploits this role is largely unknown. S-sulfhydration converts free thiols to persulfides at reactive cysteine(s) on targeted proteins to affect the entire proteome posttranslationally, representing the main route for H2S to elicit its function. Here, we used Tag-Switch to quantify changes in sulfhydrated (SSH-) proteins (ie, sulfhydrome) in H2S-treated nonpregnant and pregnant human UA. We further used the low-pH quantitative thiol reactivity profiling platform by which paired sulfhydromes were subjected to liquid chromatography tandem mass spectrometry\u2013based peptide sequencing to generate site (cysteine)-specific pregnancy-dependent H2S-responsive human UA sulfhydrome. Total levels of sulfhydrated proteins were significantly greater in pregnant vs nonpregnant human UA and further stimulated by treatment with sodium hydrosulfide. We identified a total of 360 and 1671 SSH-peptides from 480 and 1186 SSH-proteins in untreated and sodium hydrosulfide\u2013treated human UA, respectively. Bioinformatics analyses identified pregnancy-dependent H2S-responsive human UA SSH peptides\/proteins, which were categorized to various molecular functions, pathways, and biological processes, especially vascular smooth muscle contraction\/relaxation. Pregnancy-dependent changes in these proteins were rectified by immunoblotting of the Tag-Switch labeled SSH proteins. Low-pH quantitative thiol reactivity profiling failed to identify low abundance SSH proteins such as KATP channels in human UA; however, immunoblotting of Tag-Switch\u2013labeled SSH proteins identified pregnancy-dependent upregulation of SSH-KATP channels without altering their total proteins. Thus, comprehensive analyses of human UA sulfhydromes influenced by endogenous and exogenous H2S inform novel roles of protein sulfhydration in uterine hemodynamics regulation.<\/jats:p>","DOI":"10.1210\/endocr\/bqad107","type":"journal-article","created":{"date-parts":[[2023,7,13]],"date-time":"2023-07-13T09:24:21Z","timestamp":1689240261000},"source":"Crossref","is-referenced-by-count":6,"title":["Mapping Pregnancy-dependent Sulfhydrome Unfolds Diverse Functions of Protein Sulfhydration in Human Uterine Artery"],"prefix":"10.1210","volume":"164","author":[{"given":"Jin","family":"Bai","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology, University of California , Irvine, CA 92697 , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fenglong","family":"Jiao","sequence":"additional","affiliation":[{"name":"Department of Physiology and Biophysics, University of California , Irvine, CA 92697 , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alejandra Garcia","family":"Salmeron","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, University of California , Irvine, CA 92697 , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shi","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Brown University , Providence, RI 02912 , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ming","family":"Xian","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Brown University , Providence, RI 02912 , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lan","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Physiology and Biophysics, University of California , Irvine, CA 92697 , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1067-6018","authenticated-orcid":false,"given":"Dong-bao","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, University of California , Irvine, CA 92697 , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"80","published-online":{"date-parts":[[2023,7,13]]},"reference":[{"issue":"3","key":"2023090207145531600_bqad107-B1","first-page":"H231","article-title":"Distribution of cardiac output in ovine pregnancy","volume":"232","author":"Rosenfeld","year":"1977","journal-title":"Am J Physiol"},{"issue":"6","key":"2023090207145531600_bqad107-B2","first-page":"1000","article-title":"Quantitative estimation of human uterine artery blood flow and pelvic blood flow redistribution in pregnancy","volume":"80","author":"Palmer","year":"1992","journal-title":"Obstet 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