{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T02:45:36Z","timestamp":1788921936276,"version":"build-2803163510"},"reference-count":78,"publisher":"The Endocrine Society","issue":"11","license":[{"start":{"date-parts":[[2023,9,20]],"date-time":"2023-09-20T00:00:00Z","timestamp":1695168000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"Department of Molecular and Cellular Physiology at Louisiana State University Health Sciences Center\u2014Shreveport"},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Center for Redox Biology and Cardiovascular Disease"},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Center for Applied Immunology and Pathological Processes"},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,9,23]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Glucocorticoids acting via the glucocorticoid receptors (GR) are key regulators of metabolism and the stress response. However, uncontrolled or excessive GR signaling adversely affects adipose tissue, including endocrine, immune, and metabolic functions. Inflammation of the adipose tissue promotes systemic metabolic dysfunction; however, the molecular mechanisms underlying the role of adipocyte GR in regulating genes associated with adipose tissue inflammation are poorly understood. We performed in vivo studies using adipocyte-specific GR knockout mice in conjunction with in vitro studies to understand the contribution of adipocyte GR in regulating adipose tissue immune homeostasis. Our findings show that adipocyte-specific GR signaling regulates adipokines at both mRNA and plasma levels and immune regulatory (Coch, Pdcd1, Cemip, and Cxcr2) mRNA gene expression, which affects myeloid immune cell presence in white adipose tissue. We found that, in adipocytes, GR directly influences Cxcr2. This chemokine receptor promotes immune cell migration, indirectly affecting Pdcd1 and Cemip gene expression in nonadipocyte or stromal cells. Our findings suggest that GR adipocyte signaling suppresses inflammatory signals, maintaining immune homeostasis. We also found that GR signaling in adipose tissue in response to stress is sexually dimorphic. Understanding the molecular relationship between GR signaling and adipose tissue inflammation could help develop potential targets to improve local and systemic inflammation, insulin sensitivity, and metabolic health.<\/jats:p>","DOI":"10.1210\/endocr\/bqad143","type":"journal-article","created":{"date-parts":[[2023,9,22]],"date-time":"2023-09-22T18:42:20Z","timestamp":1695408140000},"source":"Crossref","is-referenced-by-count":4,"title":["Adipocyte Glucocorticoid Receptor Inhibits Immune Regulatory Genes to Maintain Immune Cell Homeostasis in Adipose Tissue"],"prefix":"10.1210","volume":"164","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-8190-7164","authenticated-orcid":false,"given":"Shripa","family":"Amatya","sequence":"first","affiliation":[{"name":"Department of Molecular and Cellular Physiology, Louisiana State University Health Sciences Center\u2014Shreveport , Shreveport, LA 71103 , USA"},{"name":"Center for Cardiovascular Diseases and Sciences and Center for Redox Biology and Cardiovascular Disease, Louisiana State University Health Sciences Center\u2014Shreveport , Shreveport, LA 71103 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dylan","family":"Tietje-Mckinney","sequence":"additional","affiliation":[{"name":"Department of Molecular and Cellular Physiology, Louisiana State University Health Sciences Center\u2014Shreveport , Shreveport, LA 71103 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Schaefer","family":"Mueller","sequence":"additional","affiliation":[{"name":"Department of Molecular and Cellular Physiology, Louisiana State University Health Sciences Center\u2014Shreveport , Shreveport, LA 71103 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5999-9355","authenticated-orcid":false,"given":"Maria G","family":"Petrillo","sequence":"additional","affiliation":[{"name":"Department of Health and Human Services, Signal Transduction Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health , Research Triangle Park, NC 27709 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8497-5838","authenticated-orcid":false,"given":"Matthew D","family":"Woolard","sequence":"additional","affiliation":[{"name":"Center for Cardiovascular Diseases and Sciences and Center for Redox Biology and Cardiovascular Disease, Louisiana State University Health Sciences Center\u2014Shreveport , Shreveport, LA 71103 , USA"},{"name":"Department of Microbiology and Immunology, Louisiana State University Health Sciences Center\u2014Shreveport , Shreveport, LA 71103 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0526-4705","authenticated-orcid":false,"given":"Sushma","family":"Bharrhan","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Louisiana State University Health Sciences Center\u2014Shreveport , Shreveport, LA 71103 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony Wayne","family":"Orr","sequence":"additional","affiliation":[{"name":"Center for Cardiovascular Diseases and Sciences and Center for Redox Biology and Cardiovascular Disease, Louisiana State University Health Sciences Center\u2014Shreveport , Shreveport, LA 71103 , USA"},{"name":"Department of Pathology and Translational Pathobiology, Louisiana State University Health Sciences Center\u2014Shreveport , Shreveport, LA 71103 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0863-7260","authenticated-orcid":false,"given":"Christopher G","family":"Kevil","sequence":"additional","affiliation":[{"name":"Center for Cardiovascular Diseases and Sciences and Center for Redox Biology and Cardiovascular Disease, Louisiana State University Health Sciences Center\u2014Shreveport , Shreveport, LA 71103 , USA"},{"name":"Department of Pathology and Translational Pathobiology, Louisiana State University Health Sciences Center\u2014Shreveport , Shreveport, LA 71103 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1420-0516","authenticated-orcid":false,"given":"John A","family":"Cidlowski","sequence":"additional","affiliation":[{"name":"Department of Health and Human Services, Signal Transduction Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health , Research Triangle Park, NC 27709 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6315-6027","authenticated-orcid":false,"given":"Diana","family":"Cruz-Topete","sequence":"additional","affiliation":[{"name":"Department of Molecular and Cellular Physiology, Louisiana State University Health Sciences Center\u2014Shreveport , Shreveport, LA 71103 , USA"},{"name":"Center for Cardiovascular Diseases and 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