{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T17:03:43Z","timestamp":1791133423510,"version":"4.1.0"},"reference-count":79,"publisher":"The Endocrine Society","issue":"1","license":[{"start":{"date-parts":[[2023,11,10]],"date-time":"2023-11-10T00:00:00Z","timestamp":1699574400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"National Center of Technology Innovation","award":["NCTIP-XD\/B03"],"award-info":[{"award-number":["NCTIP-XD\/B03"]}]},{"name":"National Center of Technology Innovation","award":["2022YFD1300301"],"award-info":[{"award-number":["2022YFD1300301"]}]},{"name":"National Center of Technology Innovation","award":["2022YFD1300304"],"award-info":[{"award-number":["2022YFD1300304"]}]},{"name":"Beijing Innovation Consortium"},{"name":"Livestock Research System","award":["BAIC05-2023"],"award-info":[{"award-number":["BAIC05-2023"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,11,20]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Decidualization is a progesterone-dependent cellular differentiation process that is essential for establishing pregnancy. Robust activation of glycolysis and lactate synthesis during decidualization is remarkable, but their developmental functions remain largely unknown. Herein, we identify that endometrial lactate production plays a critical role in establishing local histone lactylation, a newly identified histone modification, and is important for ensuring normal decidualization. Enhanced endometrial glycolysis is the hallmark metabolic change and is tightly coupled with H4K12la during decidualization. Inhibition of histone lactylation impaired decidualization, in either physiological conception or in vivo and in vitro induced decidualization models. Mechanistic study based on CUT&amp;Tag and ATAC-seq revealed that a transcriptional factor hypoxia-inducible factor 1 \u03b1 (Hif1\u03b1) is the critical regulatory target of H4K12la, and in turn forms an H4K12la\u2013Hif1\u03b1-glycolysis feedback loop to drive decidualization. Moreover, we demonstrate that the loop is directly activated by progesterone during decidualization. Our study not only advances the current knowledge of the role of lactate in regulating uterine function, but also establishes a novel functional link among the major endocrine factors, endometrial metabolic change, and epigenetic modification during endometrial remodeling. These findings present valuable clues to develop clinical intervention strategies to improve pregnancy outcomes following both natural conception and assisted reproduction.<\/jats:p>","DOI":"10.1210\/endocr\/bqad169","type":"journal-article","created":{"date-parts":[[2023,11,11]],"date-time":"2023-11-11T18:21:47Z","timestamp":1699726907000},"source":"Crossref","is-referenced-by-count":42,"title":["Progesterone Activates the Histone Lactylation\u2013Hif1\u03b1-glycolysis Feedback Loop to Promote Decidualization"],"prefix":"10.1210","volume":"165","author":[{"given":"Wei","family":"Zhao","sequence":"first","affiliation":[{"name":"State Key Laboratory of Animal Biotech Breeding, Key Laboratory of Animal Genetics, Breeding and Reproduction of the Ministry of Agriculture and Rural Affairs, National Engineering Laboratory for Animal Breeding, College of Animal Science and Technology, China Agricultural University , Beijing 1000193 , P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Wang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Animal Biotech Breeding, Key Laboratory of Animal Genetics, Breeding and Reproduction of the Ministry of Agriculture and Rural Affairs, National Engineering Laboratory for Animal Breeding, College of Animal Science and Technology, China Agricultural University , Beijing 1000193 , P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Liu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Animal Biotech Breeding, Key Laboratory of Animal Genetics, Breeding and Reproduction of the Ministry of Agriculture and Rural Affairs, National Engineering Laboratory for Animal Breeding, College of Animal Science and Technology, China Agricultural University , Beijing 1000193 , P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qianying","family":"Yang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Animal Biotech Breeding, Key Laboratory of Animal Genetics, Breeding and Reproduction of the Ministry of Agriculture and Rural Affairs, National Engineering Laboratory for Animal Breeding, College of Animal Science and Technology, China Agricultural University , Beijing 1000193 , P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuai","family":"Zhang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Animal Biotech Breeding, Key Laboratory of Animal Genetics, Breeding and Reproduction of the Ministry of Agriculture and Rural Affairs, National Engineering Laboratory for Animal Breeding, College of Animal Science and Technology, China Agricultural University , Beijing 1000193 , P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao","family":"Hu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Animal Biotech Breeding, Key Laboratory of Animal Genetics, Breeding and Reproduction of the Ministry of Agriculture and Rural Affairs, National Engineering Laboratory for Animal Breeding, College of Animal Science and Technology, China Agricultural University , Beijing 1000193 , P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhicheng","family":"Shi","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Animal Biotech Breeding, Key Laboratory of Animal Genetics, Breeding and Reproduction of the Ministry of Agriculture and Rural Affairs, National Engineering Laboratory for Animal Breeding, College of Animal Science and Technology, China Agricultural University , Beijing 1000193 , P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6376-875X","authenticated-orcid":false,"given":"Zhenni","family":"Zhang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Animal Biotech Breeding, Key Laboratory of Animal Genetics, Breeding and Reproduction of the Ministry of Agriculture and Rural Affairs, National Engineering Laboratory for Animal Breeding, College of Animal Science and Technology, China Agricultural University , Beijing 1000193 , P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4509-6336","authenticated-orcid":false,"given":"Jianhui","family":"Tian","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Animal Biotech Breeding, Key Laboratory of Animal Genetics, Breeding and Reproduction of the Ministry of Agriculture and Rural Affairs, National Engineering Laboratory for Animal Breeding, College of Animal Science and Technology, China Agricultural University , Beijing 1000193 , P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7254-948X","authenticated-orcid":false,"given":"Dapeng","family":"Chu","sequence":"additional","affiliation":[{"name":"Medical Center for Human Reproduction, Beijing Chao-Yang Hospital, Capital Medical University , Beijing 100020 , P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8509-2466","authenticated-orcid":false,"given":"Lei","family":"An","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Animal Biotech Breeding, Key Laboratory of Animal Genetics, Breeding and Reproduction of the Ministry of Agriculture and Rural Affairs, National Engineering Laboratory for Animal Breeding, College of Animal Science and Technology, China Agricultural University , Beijing 1000193 , P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"80","published-online":{"date-parts":[[2023,11,10]]},"reference":[{"issue":"19","key":"2023122315553784100_bqad169-B1","doi-asserted-by":"crossref","first-page":"1400","DOI":"10.1056\/NEJMra000763","article-title":"Implantation and the survival of early pregnancy","volume":"345","author":"Norwitz","year":"2001","journal-title":"N Engl J Med"},{"issue":"12","key":"2023122315553784100_bqad169-B2","doi-asserted-by":"crossref","first-page":"1754","DOI":"10.1038\/nm.3012","article-title":"Mechanisms of implantation: strategies for successful pregnancy","volume":"18","author":"Cha","year":"2012","journal-title":"Nat Med"},{"issue":"3","key":"2023122315553784100_bqad169-B3","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1038\/nrg1808","article-title":"Roadmap to embryo implantation: clues from mouse models","volume":"7","author":"Wang","year":"2006","journal-title":"Nat Rev Genet"},{"issue":"8","key":"2023122315553784100_bqad169-B4","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1038\/cr.2014.82","article-title":"Uterine Rbpj is required for embryonic-uterine orientation and decidual remodeling via Notch pathway-independent and -dependent mechanisms","volume":"24","author":"Zhang","year":"2014","journal-title":"Cell Res"},{"issue":"2-3-4","key":"2023122315553784100_bqad169-B5","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1387\/ijdb.130335gw","article-title":"Evolution of mammalian pregnancy and the origin of the decidual stromal cell","volume":"58","author":"Wagner","year":"2014","journal-title":"Int J Dev Biol"},{"issue":"1","key":"2023122315553784100_bqad169-B6","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1186\/s12958-017-0303-0","article-title":"TGF\u03b2 superfamily signaling and uterine decidualization","volume":"15","author":"Ni","year":"2017","journal-title":"Reprod Biol Endocrinol"},{"issue":"2","key":"2023122315553784100_bqad169-B7","doi-asserted-by":"crossref","first-page":"119","DOI":"10.4103\/2096-2924.320882","article-title":"Research progress on human endometrium decidualization in vitro cell models","volume":"5","author":"Tang","year":"2021","journal-title":"Reprod Dev Med"},{"issue":"3","key":"2023122315553784100_bqad169-B8","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1172\/JCI40051","article-title":"Uterine-specific p53 deficiency confers premature uterine senescence and promotes preterm birth in mice","volume":"120","author":"Hirota","year":"2010","journal-title":"J Clin Investig"},{"issue":"11","key":"2023122315553784100_bqad169-B9","doi-asserted-by":"crossref","first-page":"2091","DOI":"10.1007\/s00018-019-03395-9","article-title":"Epigenetic modifications working in the decidualization and endometrial receptivity","volume":"77","author":"Liu","year":"2020","journal-title":"Cell Mol Life Sci"},{"issue":"6","key":"2023122315553784100_bqad169-B10","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1038\/nrm3589","article-title":"TETonic shift: biological roles of TET proteins in DNA demethylation and transcription","volume":"14","author":"Pastor","year":"2013","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"1","key":"2023122315553784100_bqad169-B11","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.cell.2014.04.046","article-title":"A nuclear pyruvate dehydrogenase complex is important for the generation of acetyl-CoA and histone acetylation","volume":"158","author":"Sutendra","year":"2014","journal-title":"Cell"},{"key":"2023122315553784100_bqad169-B12","doi-asserted-by":"crossref","first-page":"784244","DOI":"10.3389\/fcell.2021.784244","article-title":"Vitamin C rescues in vitro embryonic development by correcting impaired active DNA demethylation","volume":"9","author":"Chu","year":"2021","journal-title":"Front Cell Dev Biol"},{"issue":"35","key":"2023122315553784100_bqad169-B13","doi-asserted-by":"crossref","first-page":"21280","DOI":"10.1074\/jbc.M115.656629","article-title":"Warburg-like glycolysis and lactate shuttle in mouse decidua during early pregnancy","volume":"290","author":"Zuo","year":"2015","journal-title":"J Biol Chem"},{"issue":"10","key":"2023122315553784100_bqad169-B14","doi-asserted-by":"crossref","first-page":"e1003900","DOI":"10.1371\/journal.pgen.1003900","article-title":"Acceleration of the glycolytic flux by steroid receptor coactivator-2 is essential for endometrial decidualization","volume":"9","author":"Kommagani","year":"2013","journal-title":"PLoS Genet"},{"issue":"1","key":"2023122315553784100_bqad169-B15","doi-asserted-by":"crossref","first-page":"3763","DOI":"10.1038\/s41467-019-11738-0","article-title":"Metabolic landscape of the tumor microenvironment at single cell resolution","volume":"10","author":"Xiao","year":"2019","journal-title":"Nat Commun"},{"issue":"1","key":"2023122315553784100_bqad169-B16","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1172\/JCI95937","article-title":"H3k27me3 dynamics dictate evolving uterine states in pregnancy and parturition","volume":"128","author":"Nancy","year":"2018","journal-title":"J Clin Investig"},{"issue":"4","key":"2023122315553784100_bqad169-B17","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1016\/j.cmet.2022.02.013","article-title":"Positive feedback regulation of microglial glucose metabolism by histone H4 lysine 12 lactylation in Alzheimer's disease","volume":"34","author":"Pan","year":"2022","journal-title":"Cell Metab"},{"issue":"7779","key":"2023122315553784100_bqad169-B18","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1038\/s41586-019-1678-1","article-title":"Metabolic regulation of gene expression by histone lactylation","volume":"574","author":"Zhang","year":"2019","journal-title":"Nature"},{"issue":"8","key":"2023122315553784100_bqad169-B19","doi-asserted-by":"crossref","first-page":"935","DOI":"10.3390\/genes11080935","article-title":"Comparative analysis of mouse decidualization models at the molecular level","volume":"11","author":"Wang","year":"2020","journal-title":"Genes (Basel)"},{"key":"2023122315553784100_bqad169-B20","author":"Zhao","year":"2023"},{"issue":"48","key":"2023122315553784100_bqad169-B21","doi-asserted-by":"crossref","first-page":"30628","DOI":"10.1073\/pnas.2009778117","article-title":"TLR signaling adapter BCAP regulates inflammatory to reparatory macrophage transition by promoting histone lactylation","volume":"117","author":"Irizarry-Caro","year":"2020","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"9","key":"2023122315553784100_bqad169-B22","doi-asserted-by":"crossref","first-page":"1660","DOI":"10.1016\/j.molcel.2022.02.033","article-title":"Lactylation-driven METTL3-mediated RNA m6A modification promotes immunosuppression of tumor-infiltrating myeloid cells","volume":"82","author":"Xiong","year":"2022","journal-title":"Mol Cell"},{"issue":"26","key":"2023122315553784100_bqad169-B23","doi-asserted-by":"crossref","first-page":"eabg3505","DOI":"10.1126\/sciadv.abg3505","article-title":"Lactate and IL6 define separable paths of inflammatory metabolic adaptation","volume":"7","author":"Dichtl","year":"2021","journal-title":"Sci Adv"},{"issue":"1","key":"2023122315553784100_bqad169-B24","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1038\/s41418-021-00841-9","article-title":"Lactate promotes macrophage HMGB1 lactylation, acetylation, and exosomal release in polymicrobial sepsis","volume":"29","author":"Yang","year":"2022","journal-title":"Cell Death Differ"},{"issue":"1","key":"2023122315553784100_bqad169-B25","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1165\/rcmb.2020-0360OC","article-title":"Lung myofibroblasts promote macrophage profibrotic activity through lactate-induced histone lactylation","volume":"64","author":"Cui","year":"2021","journal-title":"Am J Respir Cell Mol Biol"},{"issue":"8","key":"2023122315553784100_bqad169-B26","doi-asserted-by":"crossref","first-page":"3470","DOI":"10.7150\/ijbs.73398","article-title":"A positive feedback loop between inactive VHL-triggered histone lactylation and PDGFR\u03b2 signaling drives clear cell renal cell carcinoma progression","volume":"18","author":"Yang","year":"2022","journal-title":"Int J Biol Sci"},{"issue":"9","key":"2023122315553784100_bqad169-B27","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1038\/s42255-020-0267-9","article-title":"Glis1 facilitates induction of pluripotency via an epigenome\u2013metabolome\u2013epigenome signalling cascade","volume":"2","author":"Li","year":"2020","journal-title":"Nat Metab"},{"key":"2023122315553784100_bqad169-B28","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.bbrc.2022.05.028","article-title":"LDHA Promotes osteoblast differentiation through histone lactylation","volume":"615","author":"Nian","year":"2022","journal-title":"Biochem Biophys Res Commun"},{"issue":"3","key":"2023122315553784100_bqad169-B29","doi-asserted-by":"crossref","first-page":"548","DOI":"10.3390\/cells11030548","article-title":"Lactate activates germline and cleavage embryo genes in mouse embryonic stem cells","volume":"11","author":"Tian","year":"2022","journal-title":"Cells"},{"issue":"7","key":"2023122315553784100_bqad169-B30","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1038\/nmeth.2019","article-title":"Fiji: an open-source platform for biological-image analysis","volume":"9","author":"Schindelin","year":"2012","journal-title":"Nat Methods"},{"issue":"1","key":"2023122315553784100_bqad169-B31","doi-asserted-by":"crossref","first-page":"e85","DOI":"10.1002\/cpmb.85","article-title":"High-resolution chromatin profiling using CUT&RUN","volume":"126","author":"Hainer","year":"2019","journal-title":"Curr Protoc Mol Biol"},{"issue":"5","key":"2023122315553784100_bqad169-B32","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.1038\/nprot.2018.015","article-title":"Targeted in situ genome-wide profiling with high efficiency for low cell numbers","volume":"13","author":"Skene","year":"2018","journal-title":"Nat Protoc"},{"issue":"12","key":"2023122315553784100_bqad169-B33","doi-asserted-by":"crossref","first-page":"1213","DOI":"10.1038\/nmeth.2688","article-title":"Transposition of native chromatin for fast and sensitive epigenomic profiling of open chromatin, DNA-binding proteins and nucleosome position","volume":"10","author":"Buenrostro","year":"2013","journal-title":"Nat Methods"},{"key":"2023122315553784100_bqad169-B34","article-title":"FastQC: a quality control tool for high throughput sequence data","author":"Babraham Bioinformatics"},{"issue":"3","key":"2023122315553784100_bqad169-B35","doi-asserted-by":"crossref","first-page":"R25","DOI":"10.1186\/gb-2009-10-3-r25","article-title":"Ultrafast and memory-efficient alignment of short DNA sequences to the human genome","volume":"10","author":"Langmead","year":"2009","journal-title":"Genome Biol"},{"issue":"16","key":"2023122315553784100_bqad169-B36","doi-asserted-by":"crossref","first-page":"2078","DOI":"10.1093\/bioinformatics\/btp352","article-title":"The sequence alignment\/map format and SAMtools","volume":"25","author":"Li","year":"2009","journal-title":"Bioinformatics"},{"key":"2023122315553784100_bqad169-B37","author":"Picard Tools\u2014By Broad Institute"},{"issue":"W1","key":"2023122315553784100_bqad169-B38","doi-asserted-by":"crossref","first-page":"W160","DOI":"10.1093\/nar\/gkw257","article-title":"Deeptools2: a next generation web server for deep-sequencing data analysis","volume":"44","author":"Ram\u00edrez","year":"2016","journal-title":"Nucleic Acids Res"},{"issue":"9","key":"2023122315553784100_bqad169-B39","doi-asserted-by":"crossref","first-page":"R137","DOI":"10.1186\/gb-2008-9-9-r137","article-title":"Model-based analysis of ChIP-seq (MACS)","volume":"9","author":"Zhang","year":"2008","journal-title":"Genome Biol"},{"issue":"14","key":"2023122315553784100_bqad169-B40","doi-asserted-by":"crossref","first-page":"2382","DOI":"10.1093\/bioinformatics\/btv145","article-title":"ChIPseeker: an R\/bioconductor package for ChIP peak annotation, comparison and visualization","volume":"31","author":"Yu","year":"2015","journal-title":"Bioinformatics"},{"key":"2023122315553784100_bqad169-B41","author":"Stark"},{"issue":"6","key":"2023122315553784100_bqad169-B42","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1093\/bioinformatics\/btq033","article-title":"BEDTools: a flexible suite of utilities for comparing genomic features","volume":"26","author":"Quinlan","year":"2010","journal-title":"Bioinformatics"},{"issue":"12","key":"2023122315553784100_bqad169-B43","doi-asserted-by":"crossref","first-page":"e46255","DOI":"10.15252\/embr.201846255","article-title":"ChIP-Atlas: a data-mining suite powered by full integration of public ChIP-seq data","volume":"19","author":"Oki","year":"2018","journal-title":"EMBO Rep"},{"key":"2023122315553784100_bqad169-B44","article-title":"SEA: simple enrichment analysis of motifs","author":"Bailey","year":"2021","journal-title":"bioRxiv"},{"issue":"4","key":"2023122315553784100_bqad169-B45","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1016\/j.molcel.2010.05.004","article-title":"Simple combinations of lineage-determining transcription factors prime cis-regulatory elements required for macrophage and B cell identities","volume":"38","author":"Heinz","year":"2010","journal-title":"Mol Cell"},{"issue":"1","key":"2023122315553784100_bqad169-B46","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1113\/JP280572","article-title":"Regulation of glycolysis by the hypoxia-inducible factor (HIF): implications for cellular physiology","volume":"599","author":"Kierans","year":"2021","journal-title":"J Physiol"},{"issue":"8","key":"2023122315553784100_bqad169-B47","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1016\/j.placenta.2012.04.013","article-title":"Decidual vasculopathy and adverse perinatal outcome in preeclamptic pregnancy","volume":"33","author":"Stevens","year":"2012","journal-title":"Placenta"},{"issue":"1","key":"2023122315553784100_bqad169-B48","first-page":"1","article-title":"The high concentration of progesterone is harmful for endometrial receptivity and decidualization","volume":"8","author":"Liang","year":"2018","journal-title":"Sci Rep"},{"key":"2023122315553784100_bqad169-B49","doi-asserted-by":"crossref","first-page":"119222","DOI":"10.1016\/j.envpol.2022.119222","article-title":"BHPF Exposure impairs mouse and human decidualization","volume":"304","author":"Jin","year":"2022","journal-title":"Environ Pollut"},{"issue":"8-12","key":"2023122315553784100_bqad169-B50","doi-asserted-by":"crossref","first-page":"3333","DOI":"10.2741\/2316","article-title":"Rat ovulation, implantation and decidualization are severely compromised by COX-2 inhibitors","volume":"12","author":"Diao","year":"2007","journal-title":"Front Biosci"},{"key":"2023122315553784100_bqad169-B51","doi-asserted-by":"crossref","first-page":"640907","DOI":"10.3389\/fcell.2021.640907","article-title":"Illuminating the \u201cBlack Box\u201d of progesterone-dependent embryo implantation using engineered mice","volume":"9","author":"Maurya","year":"2021","journal-title":"Front Cell Dev Biol"},{"issue":"1-2","key":"2023122315553784100_bqad169-B52","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.mce.2011.10.028","article-title":"The progesterone receptor regulates implantation, decidualization, and glandular development via a complex paracrine signaling network","volume":"357","author":"Wetendorf","year":"2012","journal-title":"Mol Cell Endocrinol"},{"issue":"1","key":"2023122315553784100_bqad169-B53","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1172\/JCI92862","article-title":"Polycomb subunit BMI1 determines uterine progesterone responsiveness essential for normal embryo implantation","volume":"128","author":"Xin","year":"2018","journal-title":"J Clin Investig"},{"issue":"8","key":"2023122315553784100_bqad169-B54","doi-asserted-by":"crossref","first-page":"eabj2488","DOI":"10.1126\/sciadv.abj2488","article-title":"Fructose-1,6-bisphosphate prevents pregnancy loss by inducing decidual COX-2+ macrophage differentiation","volume":"8","author":"Zhou","year":"2022","journal-title":"Sci Adv"},{"issue":"12","key":"2023122315553784100_bqad169-B55","doi-asserted-by":"crossref","first-page":"2689","DOI":"10.1007\/s10815-022-02637-3","article-title":"Glucose and fatty acids catabolism during in vitro decidualization of human endometrial stromal cells","volume":"39","author":"Citrinovitz","year":"2022","journal-title":"J Assist Reprod Genet"},{"issue":"8","key":"2023122315553784100_bqad169-B56","doi-asserted-by":"crossref","first-page":"3885","DOI":"10.1210\/jc.2002-021890","article-title":"Glucose transporter proteins (GLUT) in human endometrium: expression, regulation, and function throughout the menstrual cycle and in early pregnancy","volume":"88","author":"von Wolff","year":"2003","journal-title":"J Clin Endocrinol Metab"},{"issue":"1","key":"2023122315553784100_bqad169-B57","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1095\/biolreprod.116.144451","article-title":"Acidification of uterine epithelium during embryo implantation in mice\u2020","volume":"96","author":"Xiao","year":"2017","journal-title":"Biol Reprod"},{"issue":"1","key":"2023122315553784100_bqad169-B58","doi-asserted-by":"crossref","first-page":"101456","DOI":"10.1016\/j.jbc.2021.101456","article-title":"A proteomic atlas of ligand\u2013receptor interactions at the ovine maternal\u2013fetal interface reveals the role of histone lactylation in uterine remodeling","volume":"298","author":"Yang","year":"2022","journal-title":"J Biol Chem"},{"issue":"1","key":"2023122315553784100_bqad169-B59","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1186\/2049-1891-3-23","article-title":"Uterine biology in pigs and sheep","volume":"3","author":"Bazer","year":"2012","journal-title":"J Animal Sci Biotechnol"},{"issue":"6","key":"2023122315553784100_bqad169-B60","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1530\/rep.1.00398","article-title":"Implantation mechanisms: insights from the sheep","volume":"128","author":"Spencer","year":"2004","journal-title":"Reproduction"},{"issue":"2","key":"2023122315553784100_bqad169-B61","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1095\/biolreprod.113.113217","article-title":"The fatty acid beta-oxidation pathway is important for decidualization of endometrial stromal cells in both humans and mice","volume":"90","author":"Tsai","year":"2014","journal-title":"Biol Reprod"},{"issue":"6","key":"2023122315553784100_bqad169-B62","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1038\/nri2974","article-title":"The outs and the ins of sphingosine-1-phosphate in immunity","volume":"11","author":"Spiegel","year":"2011","journal-title":"Nat Rev Immunol"},{"issue":"6349","key":"2023122315553784100_bqad169-B63","doi-asserted-by":"crossref","first-page":"eaaf9794","DOI":"10.1126\/science.aaf9794","article-title":"Kynurenines: Tryptophan's metabolites in exercise, inflammation, and mental health","volume":"357","author":"Cervenka","year":"2017","journal-title":"Science"},{"key":"2023122315553784100_bqad169-B64","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1016\/j.reprotox.2020.07.011","article-title":"Tryptophan and kynurenine stimulate human decidualization via activating aryl hydrocarbon receptor: short title: kynurenine action on human decidualization","volume":"96","author":"Wang","year":"2020","journal-title":"Reprod Toxicol"},{"issue":"5930","key":"2023122315553784100_bqad169-B65","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1126\/science.1160809","article-title":"Understanding the warburg effect: the metabolic requirements of cell proliferation","volume":"324","author":"Vander Heiden","year":"2009","journal-title":"Science"},{"issue":"1","key":"2023122315553784100_bqad169-B66","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1186\/s13059-021-02308-z","article-title":"Histone lactylation drives oncogenesis by facilitating m6A reader protein YTHDF2 expression in ocular melanoma","volume":"22","author":"Yu","year":"2021","journal-title":"Genome Biol"},{"issue":"1","key":"2023122315553784100_bqad169-B67","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1186\/s13072-021-00431-6","article-title":"Hypoxic in vitro culture reduces histone lactylation and impairs pre-implantation embryonic development in mice","volume":"14","author":"Yang","year":"2021","journal-title":"Epigenetics Chromatin"},{"key":"2023122315553784100_bqad169-B68","doi-asserted-by":"crossref","first-page":"786666","DOI":"10.3389\/fimmu.2021.786666","article-title":"Lactylated histone H3K18 as a potential biomarker for the diagnosis and predicting the severity of septic shock","volume":"12","author":"Chu","year":"2022","journal-title":"Front Immunol"},{"issue":"18","key":"2023122315553784100_bqad169-B69","doi-asserted-by":"crossref","first-page":"2266","DOI":"10.1101\/gad.9.18.2266","article-title":"Mice lacking progesterone receptor exhibit pleiotropic reproductive abnormalities","volume":"9","author":"Lydon","year":"1995","journal-title":"Genes Dev"},{"issue":"9","key":"2023122315553784100_bqad169-B70","doi-asserted-by":"crossref","first-page":"2687","DOI":"10.1242\/dev.122.9.2687","article-title":"Mechanisms of reduced fertility in Hoxa-10 mutant mice: uterine homeosis and loss of maternal Hoxa-10 expression","volume":"122","author":"Benson","year":"1996","journal-title":"Development"},{"issue":"4","key":"2023122315553784100_bqad169-B71","doi-asserted-by":"crossref","first-page":"1176","DOI":"10.1096\/fj.10-175349","article-title":"WNT4 Is a key regulator of normal postnatal uterine development and progesterone signaling during embryo implantation and decidualization in the mouse","volume":"25","author":"Franco","year":"2011","journal-title":"FASEB J"},{"issue":"15","key":"2023122315553784100_bqad169-B72","doi-asserted-by":"crossref","first-page":"5468","DOI":"10.1128\/MCB.00342-07","article-title":"Bmp2 is critical for the murine uterine decidual response","volume":"27","author":"Lee","year":"2007","journal-title":"Mol Cell Biol"},{"key":"2023122315553784100_bqad169-B73","doi-asserted-by":"crossref","first-page":"543148","DOI":"10.3389\/fphys.2020.543148","article-title":"Progesterone regulates glucose metabolism through glucose transporter 1 to promote endometrial receptivity","volume":"11","author":"Zhang","year":"2020","journal-title":"Front Physiol"},{"issue":"1","key":"2023122315553784100_bqad169-B74","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1093\/humrep\/deac240","article-title":"Single-cell profiling reveals mechanisms of uncontrolled inflammation and glycolysis in decidual stromal cell subtypes in recurrent miscarriage","volume":"38","author":"Bao","year":"2023","journal-title":"Hum Reprod"},{"issue":"3","key":"2023122315553784100_bqad169-B75","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1016\/j.fertnstert.2005.08.046","article-title":"Stromal cells from endometriotic lesions and endometrium from women with endometriosis have reduced decidualization capacity","volume":"85","author":"Klemmt","year":"2006","journal-title":"Fertil Steril"},{"issue":"1","key":"2023122315553784100_bqad169-B76","doi-asserted-by":"crossref","first-page":"E35","DOI":"10.1210\/jc.2011-1527","article-title":"Increased activation of the PI3K\/AKT pathway compromises decidualization of stromal cells from endometriosis","volume":"97","author":"Yin","year":"2012","journal-title":"J Clin Endocrinol Metab"},{"issue":"1","key":"2023122315553784100_bqad169-B77","doi-asserted-by":"crossref","first-page":"101456","DOI":"10.1016\/j.jbc.2021.101456","article-title":"A proteomic atlas of ligand-receptor interactions at the ovine maternal-fetal interface reveals the role of histone lactylation in uterine remodeling","volume":"298","author":"Yang","year":"2022","journal-title":"J Biol Chem"},{"key":"2023122315553784100_bqad169-B78","author":"GEO accession viewer"},{"key":"2023122315553784100_bqad169-B79","author":"GEO Accession viewer"}],"container-title":["Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/endo\/advance-article-pdf\/doi\/10.1210\/endocr\/bqad169\/53252721\/bqad169.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/endo\/article-pdf\/165\/1\/bqad169\/54729581\/bqad169.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/endo\/article-pdf\/165\/1\/bqad169\/54729581\/bqad169.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,12,23]],"date-time":"2023-12-23T16:01:06Z","timestamp":1703347266000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/endo\/article\/doi\/10.1210\/endocr\/bqad169\/7405349"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,11,10]]},"references-count":79,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2023,11,20]]}},"URL":"https:\/\/doi.org\/10.1210\/endocr\/bqad169","relation":{},"ISSN":["1945-7170"],"issn-type":[{"value":"1945-7170","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2024,1]]},"published":{"date-parts":[[2023,11,10]]},"article-number":"bqad169"}}