{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T22:12:32Z","timestamp":1783548752994,"version":"3.55.0"},"reference-count":55,"publisher":"The Endocrine Society","issue":"3","license":[{"start":{"date-parts":[[2023,12,29]],"date-time":"2023-12-29T00:00:00Z","timestamp":1703808000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R00-HD068130 04"],"award-info":[{"award-number":["R00-HD068130 04"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01-HD09551201A1"],"award-info":[{"award-number":["R01-HD09551201A1"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,1,16]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Hyperandrogenism and polycystic ovarian syndrome result from the imbalance or increase of androgen levels in females. Androgen receptor (AR) mediates the effects of androgens, and this study examines whether neuronal AR plays a role in reproduction under normal and increased androgen conditions in female mice. The neuron-specific AR knockout (KO) mouse (SynARKO) was generated from a female mouse (synapsin promoter driven Cre) and a male mouse (Ar fl\/y). Puberty onset and the levels of reproductive hormones such as LH, FSH, testosterone, and estradiol were comparable between the control and the SynARKO mice. There were no differences in cyclicity and fertility between the control and SynARKO mice, with similar impairment in both groups on DHT treatment. Neuronal AR KO, as in this SynARKO mouse model, did not alleviate the infertility associated with DHT treatment. These studies suggest that neuronal AR KO neither altered reproductive function under physiological androgen levels, nor restored fertility under hyperandrogenic conditions.<\/jats:p>","DOI":"10.1210\/endocr\/bqad199","type":"journal-article","created":{"date-parts":[[2023,12,29]],"date-time":"2023-12-29T13:08:05Z","timestamp":1703855285000},"source":"Crossref","is-referenced-by-count":4,"title":["Reproductive Profile of Neuronal Androgen Receptor Knockout Female Mice With a Low Dose of DHT"],"prefix":"10.1210","volume":"165","author":[{"given":"Vaibhave","family":"Ubba","sequence":"first","affiliation":[{"name":"Center for Metabolic Disease Research, Temple University School of Medicine , Philadelphia, PA, 19140 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Serene","family":"Joseph","sequence":"additional","affiliation":[{"name":"Center for Metabolic Disease Research, Temple University School of Medicine , Philadelphia, PA, 19140 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olubusayo","family":"Awe","sequence":"additional","affiliation":[{"name":"Department of Cellular and Molecular Physiology, Johns Hopkins University School of Medicine , Baltimore, MD, 21287 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dustin","family":"Jones","sequence":"additional","affiliation":[{"name":"Department of Cellular and Molecular Physiology, Johns Hopkins University School of Medicine , Baltimore, MD, 21287 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Milan K","family":"Dsilva","sequence":"additional","affiliation":[{"name":"Center for Metabolic Disease Research, Temple University School of Medicine , Philadelphia, PA, 19140 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingxiao","family":"Feng","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Johns Hopkins University School of Medicine , Baltimore, MD, 21087 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junjiang","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Johns Hopkins University School of Medicine , Baltimore, MD, 21087 , USA"},{"name":"Departments of Gastrointestinal Surgery and General Surgery, Guangdong Provincial People\u2019s Hospital, Southern Medical University , Guangzhou, 510080 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaomin","family":"Fu","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Johns Hopkins University School of Medicine , Baltimore, MD, 21087 , USA"},{"name":"Department of Endocrinology, The First Medical Center, Chinese PLA General Hospital , Beijing, 100853 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Razeen J","family":"Akbar","sequence":"additional","affiliation":[{"name":"Center for Metabolic Disease Research, Temple University School of Medicine , Philadelphia, PA, 19140 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brittany H","family":"Bodnar","sequence":"additional","affiliation":[{"name":"Center for Metabolic Disease Research, Temple University School of Medicine , Philadelphia, PA, 19140 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenhui","family":"Hu","sequence":"additional","affiliation":[{"name":"Center for Metabolic Disease Research, Temple University School of Medicine , Philadelphia, PA, 19140 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Wang","sequence":"additional","affiliation":[{"name":"Center for Metabolic Disease Research, Temple University School of Medicine , Philadelphia, PA, 19140 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaofeng","family":"Yang","sequence":"additional","affiliation":[{"name":"Center for Metabolic Disease Research, Temple University School of Medicine , Philadelphia, PA, 19140 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Medical Genetics & Molecular Biochemistry, Temple University School of Medicine , Philadelphia, PA, 19140 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peixin","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Obstetrics, Gynecology and Reproductive Sciences, University of Maryland School of Medicine , Baltimore, 21201 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bouchra","family":"Taib","sequence":"additional","affiliation":[{"name":"Department of Medicine, Johns Hopkins University School of Medicine , Baltimore, MD, 21287 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rexford","family":"Ahima","sequence":"additional","affiliation":[{"name":"Department of Medicine, Johns Hopkins University School of Medicine , Baltimore, MD, 21287 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Divall","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University of Washington, Seattle\u2019s Children\u2019s Hospital , Seattle, WA, 98145-5005 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2944-0475","authenticated-orcid":false,"given":"Sheng","family":"Wu","sequence":"additional","affiliation":[{"name":"Center for Metabolic Disease Research, Temple University School of Medicine , Philadelphia, PA, 19140 , USA"},{"name":"Department of Pediatrics, Johns Hopkins University School of Medicine , Baltimore, MD, 21087 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"80","published-online":{"date-parts":[[2023,12,29]]},"reference":[{"issue":"1-2","key":"2024022011443225500_bqad199-B1","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1007\/s11010-008-9928-9","article-title":"Generation and characterization of a complete null estrogen receptor \u03b1 mouse using Cre\/LoxP technology","volume":"321","author":"Chen","year":"2009","journal-title":"Mol Cell Biochem"},{"issue":"1","key":"2024022011443225500_bqad199-B2","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1095\/biolreprod35.1.27","article-title":"Synergism between granulosa and theca-interstitial cells in estrogen biosynthesis by gonadotropin-treated rat ovaries: studies on the two-cell, two-gonadotropin hypothesis using steroid antisera","volume":"35","author":"Liu","year":"1986","journal-title":"Biol Reprod"},{"key":"2024022011443225500_bqad199-B3","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.ddmod.2020.11.005","article-title":"Women\u2019s reproductive system as balanced estradiol and progesterone actions\u2014a revolutionary, paradigm-shifting concept in women\u2019s health","volume":"32","author":"Prior","year":"2020","journal-title":"Drug Discov Today Dis Models"},{"issue":"5","key":"2024022011443225500_bqad199-B4","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1210\/er.2015-1104","article-title":"The pathogenesis of polycystic ovary syndrome (PCOS): the hypothesis of PCOS as functional ovarian hyperandrogenism revisited","volume":"37","author":"Rosenfield","year":"2016","journal-title":"Endocr Rev"},{"issue":"1","key":"2024022011443225500_bqad199-B5","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1097\/md.0b013e3181946a2c","article-title":"Androgen dependence of hirsutism, acne, and alopecia in women: retrospective analysis of 228 patients investigated for hyperandrogenism","volume":"88","author":"Karrer-Voegeli","year":"2009","journal-title":"Medicine (Baltimore)"},{"issue":"3","key":"2024022011443225500_bqad199-B6","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1210\/en.2018-00966","article-title":"A hyperandrogenic environment causes intrinsic defects that are detrimental to follicular dynamics in a PCOS mouse model","volume":"160","author":"Bertoldo","year":"2019","journal-title":"Endocrinology"},{"key":"2024022011443225500_bqad199-B7","first-page":"58379","article-title":"A hyperandrogenic mouse model to study polycystic ovary syndrome","volume":"140","author":"Xue","year":"2018","journal-title":"J Vis Exp"},{"issue":"1","key":"2024022011443225500_bqad199-B8","first-page":"98","article-title":"Androgen receptor in the ovary theca cells plays a critical role in androgen-induced reproductive dysfunction","volume":"158","author":"Ma","year":"2017","journal-title":"Endocrinology"},{"issue":"8","key":"2024022011443225500_bqad199-B9","doi-asserted-by":"crossref","first-page":"3146","DOI":"10.1210\/en.2014-1196","article-title":"Characterization of reproductive, metabolic, and endocrine features of polycystic ovary syndrome in female hyperandrogenic mouse models","volume":"155","author":"Caldwell","year":"2014","journal-title":"Endocrinology"},{"issue":"1","key":"2024022011443225500_bqad199-B10","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1016\/j.theriogenology.2016.04.047","article-title":"Prenatal programming of neuroendocrine reproductive function","volume":"86","author":"Evans","year":"2016","journal-title":"Theriogenology"},{"issue":"1","key":"2024022011443225500_bqad199-B11","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/S0015-0282(01)02947-8","article-title":"Ovarian hyperandrogenism in adult female rhesus monkeys exposed to prenatal androgen excess","volume":"77","author":"Eisner","year":"2002","journal-title":"Fertil Steril"},{"issue":"1","key":"2024022011443225500_bqad199-B12","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1095\/biolreprod.108.067702","article-title":"Endocrine antecedents of polycystic ovary syndrome in fetal and infant prenatally androgenized female rhesus monkeys","volume":"79","author":"Abbott","year":"2008","journal-title":"Biol Reprod"},{"issue":"1","key":"2024022011443225500_bqad199-B13","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1095\/biolreprod.110.086686","article-title":"Developmental programming: impact of excess prenatal testosterone on intrauterine fetal endocrine milieu and growth in sheep","volume":"84","author":"Veiga-Lopez","year":"2011","journal-title":"Biol Reprod"},{"issue":"10","key":"2024022011443225500_bqad199-B14","doi-asserted-by":"crossref","first-page":"1670","DOI":"10.1210\/me.2014-1154","article-title":"Conditional knockout of the androgen receptor in gonadotropes reveals crucial roles for androgen in gonadotropin synthesis and surge in female mice","volume":"28","author":"Wu","year":"2014","journal-title":"Mol Endocrinol"},{"issue":"7","key":"2024022011443225500_bqad199-B15","doi-asserted-by":"crossref","first-page":"109557","DOI":"10.1016\/j.celrep.2021.109557","article-title":"Male fertility in mice requires classical and nonclassical androgen signaling","volume":"36","author":"Cooke","year":"2021","journal-title":"Cell Rep"},{"issue":"31","key":"2024022011443225500_bqad199-B16","doi-asserted-by":"crossref","first-page":"11209","DOI":"10.1073\/pnas.0404372101","article-title":"Subfertility and defective folliculogenesis in female mice lacking androgen receptor","volume":"101","author":"Hu","year":"2004","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"7","key":"2024022011443225500_bqad199-B17","doi-asserted-by":"crossref","first-page":"1393","DOI":"10.1210\/me.2010-0006","article-title":"Granulosa cell-specific androgen receptors are critical regulators of ovarian development and function","volume":"24","author":"Sen","year":"2010","journal-title":"Mol Endocrinol"},{"issue":"1","key":"2024022011443225500_bqad199-B18","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1073\/pnas.0506736102","article-title":"Premature ovarian failure in androgen receptor-deficient mice","volume":"103","author":"Shiina","year":"2006","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"17","key":"2024022011443225500_bqad199-B19","doi-asserted-by":"crossref","first-page":"e127817","DOI":"10.1172\/jci.insight.127817","article-title":"Gonadotrope androgen receptor mediates pituitary responsiveness to hormones and androgen-induced subfertility","volume":"5","author":"Wang","year":"2019","journal-title":"JCI Insight"},{"issue":"21","key":"2024022011443225500_bqad199-B20","doi-asserted-by":"crossref","first-page":"13498","DOI":"10.1073\/pnas.212474399","article-title":"Generation and characterization of androgen receptor knockout (ARKO) mice: an in vivo model for the study of androgen functions in selective tissues","volume":"99","author":"Yeh","year":"2002","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"7","key":"2024022011443225500_bqad199-B21","doi-asserted-by":"crossref","first-page":"3274","DOI":"10.1210\/en.2008-1750","article-title":"Subfertile female androgen receptor knockout mice exhibit defects in neuroendocrine signaling, intraovarian function, and uterine development but not uterine function","volume":"150","author":"Walters","year":"2009","journal-title":"Endocrinology"},{"issue":"16","key":"2024022011443225500_bqad199-B22","doi-asserted-by":"crossref","first-page":"E3334","DOI":"10.1073\/pnas.1616467114","article-title":"Neuroendocrine androgen action is a key extraovarian mediator in the development of polycystic ovary syndrome","volume":"114","author":"Caldwell","year":"2017","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"10","key":"2024022011443225500_bqad199-B23","doi-asserted-by":"crossref","first-page":"3684","DOI":"10.1210\/en.2017-00470","article-title":"Androgen action via the androgen receptor in neurons within the brain positively regulates muscle mass in male mice","volume":"158","author":"Davey","year":"2017","journal-title":"Endocrinology"},{"issue":"5","key":"2024022011443225500_bqad199-B24","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1016\/j.yhbeh.2007.12.013","article-title":"Neuroendocrine consequences of androgen excess in female rodents","volume":"53","author":"Foecking","year":"2008","journal-title":"Horm Behav"},{"issue":"35","key":"2024022011443225500_bqad199-B25","doi-asserted-by":"crossref","first-page":"26494","DOI":"10.1016\/S0021-9258(19)74341-5","article-title":"The 5\u2033Flanking region of the rat synapsin I gene directs neuron-specific and developmentally regulated reporter gene expression in transgenic mice","volume":"268","author":"Hoesche","year":"1993","journal-title":"J Biol Chem"},{"issue":"2","key":"2024022011443225500_bqad199-B26","doi-asserted-by":"crossref","first-page":"411","DOI":"10.2337\/db12-0135","article-title":"Neuronal androgen receptor regulates insulin sensitivity via suppression of hypothalamic NF-\u03baB-mediated PTP1B expression","volume":"62","author":"Yu","year":"2013","journal-title":"Diabetes"},{"issue":"10","key":"2024022011443225500_bqad199-B27","doi-asserted-by":"crossref","first-page":"e21921","DOI":"10.1096\/fj.202100961R","article-title":"Androgen-induced insulin resistance is ameliorated by deletion of hepatic androgen receptor in females","volume":"35","author":"Andrisse","year":"2021","journal-title":"FASEB J"},{"issue":"4","key":"2024022011443225500_bqad199-B28","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2-\u0394\u0394CT method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"issue":"1","key":"2024022011443225500_bqad199-B29","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1523\/JNEUROSCI.2974-10.2011","article-title":"Jak2 is necessary for neuroendocrine control of female reproduction","volume":"31","author":"Wu","year":"2011","journal-title":"J Neurosci"},{"issue":"3","key":"2024022011443225500_bqad199-B30","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1210\/en.2016-1553","article-title":"Low-dose dihydrotestosterone drives metabolic dysfunction via cytosolic and nuclear hepatic androgen receptor mechanisms","volume":"158","author":"Andrisse","year":"2017","journal-title":"Endocrinology"},{"issue":"11","key":"2024022011443225500_bqad199-B31","doi-asserted-by":"crossref","first-page":"3970","DOI":"10.1210\/jc.2017-00308","article-title":"Dysregulation of the anti-M\u00fcllerian hormone system by steroids in women with polycystic ovary syndrome","volume":"102","author":"Pierre","year":"2017","journal-title":"J Clin Endocrinol Metab"},{"issue":"6","key":"2024022011443225500_bqad199-B32","doi-asserted-by":"crossref","first-page":"2760","DOI":"10.1210\/jc.2002-021875","article-title":"Beyond adrenal and ovarian androgen generation: increased peripheral 5\u03b1-reductase activity in women with polycystic ovary syndrome","volume":"88","author":"Fassnacht","year":"2003","journal-title":"J Clin Endocrinol Metab"},{"issue":"5","key":"2024022011443225500_bqad199-B33","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1177\/1933719116669057","article-title":"RHOG-DOCK1-RAC1 signaling axis is perturbed in DHEA-induced polycystic ovary in rat model","volume":"24","author":"Ubba","year":"2017","journal-title":"Reprod Sci"},{"issue":"2","key":"2024022011443225500_bqad199-B34","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.brainres.2005.06.082","article-title":"Estrogen and progesterone do not activate Fos in AVPV or LHRH neurons in male rats","volume":"1054","author":"Hoffman","year":"2005","journal-title":"Brain Res"},{"key":"2024022011443225500_bqad199-B35","doi-asserted-by":"publisher","DOI":"10.6084\/m9.figshare.24084423","article-title":"Reproductive profile of neuronal androgen receptor knockout female mice with low dose of DHT","volume-title":"Figshare","author":"Ubba","year":"2023"},{"issue":"3","key":"2024022011443225500_bqad199-B36","doi-asserted-by":"crossref","first-page":"e1009483","DOI":"10.1371\/journal.pgen.1009483","article-title":"Androgens regulate ovarian gene expression by balancing Ezh2-Jmjd3 mediated H3K27me3 dynamics","volume":"17","author":"Roy","year":"2021","journal-title":"PLoS Genet"},{"issue":"7","key":"2024022011443225500_bqad199-B37","doi-asserted-by":"crossref","first-page":"2671","DOI":"10.1210\/en.2015-1998","article-title":"Disrupted leptin signaling in the lateral hypothalamus and ventral premammillary nucleus alters insulin and glucagon secretion and protects against diet-induced obesity","volume":"157","author":"Denroche","year":"2016","journal-title":"Endocrinology"},{"issue":"3","key":"2024022011443225500_bqad199-B38","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1002\/cne.10325","article-title":"Glial expression of estrogen and androgen receptors after rat brain injury","volume":"450","author":"Garc\u00eda-Ovejero","year":"2002","journal-title":"J Comp Neurol"},{"issue":"4","key":"2024022011443225500_bqad199-B39","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1002\/(SICI)1097-4695(19990915)40:4<446::AID-NEU3>3.0.CO;2-J","article-title":"Immunoreactivity for intracellular androgen receptors in identified subpopulations of neurons, astrocytes and oligodendrocytes in primate prefrontal cortex","volume":"40","author":"Finley","year":"1999","journal-title":"J Neurobiol"},{"issue":"2","key":"2024022011443225500_bqad199-B40","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/0960-0760(95)00165-V","article-title":"Immunocytochemical detection of androgen receptor in human temporal cortex: characterization and application of polyclonal androgen receptor antibodies in frozen and paraffin-embedded tissues","volume":"55","author":"Puy","year":"1995","journal-title":"J Steroid Biochem Mol Biol"},{"issue":"3-8","key":"2024022011443225500_bqad199-B41","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1016\/0960-0760(92)90394-X","article-title":"Demonstration of steroid hormone receptors and steroid action in primary cultures of rat glial cells","volume":"41","author":"Jung-Testas","year":"1992","journal-title":"J Steroid Biochem Mol Biol"},{"issue":"2","key":"2024022011443225500_bqad199-B42","doi-asserted-by":"crossref","first-page":"T41","DOI":"10.1530\/JOE-15-0113","article-title":"The hypothalamo-pituitary-gonadal axis","volume":"226","author":"Plant","year":"2015","journal-title":"J Endocrinol"},{"issue":"4","key":"2024022011443225500_bqad199-B43","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1159\/000487762","article-title":"The role of central androgen receptor actions in regulating the hypothalamic-pituitary-ovarian axis","volume":"106","author":"Walters","year":"2018","journal-title":"Neuroendocrinology"},{"issue":"9","key":"2024022011443225500_bqad199-B44","doi-asserted-by":"crossref","first-page":"3686","DOI":"10.1210\/en.2005-0488","article-title":"Regulation of Kiss1 gene expression in the brain of the female mouse","volume":"146","author":"Smith","year":"2005","journal-title":"Endocrinology"},{"issue":"17","key":"2024022011443225500_bqad199-B45","doi-asserted-by":"crossref","first-page":"9229","DOI":"10.3390\/ijms22179229","article-title":"Kisspeptin neurons and estrogen\u2013estrogen receptor \u03b1 signaling: unraveling the mystery of steroid feedback system regulating mammalian reproduction","volume":"22","author":"Uenoyama","year":"2021","journal-title":"Int J Mol Sci"},{"key":"2024022011443225500_bqad199-B46","doi-asserted-by":"crossref","first-page":"868572","DOI":"10.3389\/fendo.2022.868572","article-title":"Comparison of reproductive function between normal and hyperandrogenemia conditions in female mice with deletion of hepatic androgen receptor","volume":"13","author":"Feng","year":"2022","journal-title":"Front Endocrinol (Lausanne)"},{"issue":"6","key":"2024022011443225500_bqad199-B47","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1002\/ajhb.20555","article-title":"Menstrual cycle irregularities are associated with testosterone levels in healthy premenopausal women","volume":"18","author":"van Anders","year":"2006","journal-title":"Am J Hum Biol"},{"key":"2024022011443225500_bqad199-B48","doi-asserted-by":"crossref","first-page":"116940","DOI":"10.1016\/j.lfs.2019.116940","article-title":"Hyperandrogenemia and insulin resistance: the chief culprit of polycystic ovary syndrome","volume":"236","author":"Wang","year":"2019","journal-title":"Life Sci"},{"issue":"7","key":"2024022011443225500_bqad199-B49","first-page":"1","article-title":"Androgen action in adipose tissue and the brain are key mediators in the development of PCOS traits in a mouse model","volume":"161","author":"Cox","year":"2020","journal-title":"Endocrinology (United States)"},{"issue":"7","key":"2024022011443225500_bqad199-B50","doi-asserted-by":"crossref","first-page":"e141814","DOI":"10.1172\/jci.insight.141814","article-title":"Fatty acid binding protein 4 promotes autoimmune diabetes by recruitment and activation of pancreatic islet macrophages","volume":"6","author":"Xiao","year":"2021","journal-title":"JCI Insight"},{"issue":"2","key":"2024022011443225500_bqad199-B51","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1007\/s12020-011-9495-9","article-title":"Expression and regulation of adipocyte fatty acid binding protein in granulosa cells and its relation with clinical characteristics of polycystic ovary syndrome","volume":"40","author":"Hu","year":"2011","journal-title":"Endocrine"},{"issue":"5","key":"2024022011443225500_bqad199-B52","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1002\/cbin.10429","article-title":"Expression and function of fatty acid-binding protein 4 in epithelial cell of uterine endometrium","volume":"39","author":"Zhu","year":"2015","journal-title":"Cell Biol Int"},{"issue":"3","key":"2024022011443225500_bqad199-B53","doi-asserted-by":"crossref","first-page":"174","DOI":"10.4161\/isl.2.3.11454","article-title":"Expression of fatty acid binding proteins 3 and 5 genes in rat pancreatic islets and INS-1E cells: regulation by fatty acids and glucose","volume":"2","author":"Hyder","year":"2010","journal-title":"Islets"},{"issue":"12","key":"2024022011443225500_bqad199-B54","first-page":"bqab197","article-title":"Reproductive deficits induced by prenatal antim\u00fcllerian hormone exposure require androgen receptor in Kisspeptin cells","volume":"162","author":"Ho","year":"2021","journal-title":"Endocrinology (United States)"},{"issue":"1","key":"2024022011443225500_bqad199-B55","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.neuron.2020.01.008","article-title":"Optimizing nervous system-specific gene targeting with cre driver lines: prevalence of germline recombination and influencing factors","volume":"106","author":"Luo","year":"2020","journal-title":"Neuron"}],"container-title":["Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/endo\/advance-article-pdf\/doi\/10.1210\/endocr\/bqad199\/54920809\/bqad199.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/endo\/article-pdf\/165\/3\/bqad199\/56689769\/bqad199.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/endo\/article-pdf\/165\/3\/bqad199\/56689769\/bqad199.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,20]],"date-time":"2024-02-20T11:45:30Z","timestamp":1708429530000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/endo\/article\/doi\/10.1210\/endocr\/bqad199\/7503699"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,12,29]]},"references-count":55,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2024,1,16]]}},"URL":"https:\/\/doi.org\/10.1210\/endocr\/bqad199","relation":{},"ISSN":["1945-7170"],"issn-type":[{"value":"1945-7170","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2024,3]]},"published":{"date-parts":[[2023,12,29]]},"article-number":"bqad199"}}