{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T15:13:52Z","timestamp":1791386032812,"version":"4.3.3"},"reference-count":72,"publisher":"The Endocrine Society","issue":"3","license":[{"start":{"date-parts":[[2024,1,9]],"date-time":"2024-01-09T00:00:00Z","timestamp":1704758400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2022YFC2702400"],"award-info":[{"award-number":["2022YFC2702400"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82101784"],"award-info":[{"award-number":["82101784"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82171648"],"award-info":[{"award-number":["82171648"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31988101"],"award-info":[{"award-number":["31988101"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"CAMS Innovation Fund for Medical Sciences","award":["2021-I2M-5-001"],"award-info":[{"award-number":["2021-I2M-5-001"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,1,16]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Repeated implantation failure (RIF) leads to a waste of high-quality embryos and remains a challenge in assisted reproductive technology. During early human placentation, the invasion of trophoblast cells into the decidua is an essential step for the establishment of maternal\u2013fetal interactions and subsequent successful pregnancy. Bone morphogenetic protein 2 (BMP2) has been reported to regulate endometrial receptivity and promote trophoblast invasion. However, whether there is dysregulation of endometrial BMP2 expression in patients with RIF remains unknown. Additionally, the molecular mechanisms underlying the effects of BMP2 on human trophoblast invasion and early placentation remain to be further elucidated.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Midluteal phase endometrial samples were biopsied from patients with RIF and from routine control in vitro fertilization followed by quantitative polymerase chain reaction and immunoblotting analyses. Human trophoblast organoids, primary human trophoblast cells, and an immortalized trophoblast cell line (HTR8\/SVneo) were used as study models.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>We found that BMP2 was aberrantly low in midluteal phase endometrial tissues from patients with RIF. Recombinant human BMP2 treatment upregulated integrin \u03b23 (ITGB3) in a SMAD2\/3-SMAD4 signaling-dependent manner in both HTR8\/SVneo cells and primary trophoblast cells. siRNA-mediated integrin \u03b23 downregulation reduced both basal and BMP2-upregulated trophoblast invasion and vascular mimicry in HTR8\/SVneo cells. Importantly, shRNA-mediated ITGB3 knockdown significantly decreased the formation ability of human trophoblast organoids.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Our results demonstrate endometrial BMP2 deficiency in patients with RIF. ITGB3 mediates both basal and BMP2-promoted human trophoblast invasion and is essential for early placentation. These findings broaden our knowledge regarding the regulation of early placentation and provide candidate diagnostic and therapeutic targets for RIF clinical management.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1210\/endocr\/bqae002","type":"journal-article","created":{"date-parts":[[2024,1,10]],"date-time":"2024-01-10T01:58:58Z","timestamp":1704851938000},"source":"Crossref","is-referenced-by-count":10,"title":["Endometrial BMP2 Deficiency Impairs ITGB3-Mediated Trophoblast Invasion in Women With Repeated Implantation Failure"],"prefix":"10.1210","volume":"165","author":[{"given":"Cuiping","family":"Hu","sequence":"first","affiliation":[{"name":"Institute of Women, Children and Reproductive Health, Shandong University , Jinan, Shandong, 250012 , China"},{"name":"State Key Laboratory of Reproductive Medicine and Offspring Health, Shandong University , Jinan, Shandong, 250012 , China"},{"name":"Medical Integration and Practice Center, Shandong University , Jinan, Shandong, 250012 , China"},{"name":"Key Laboratory of Reproductive Endocrinology (Shandong University), Ministry of Education , Jinan, Shandong, 250012 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianye","family":"Deng","sequence":"additional","affiliation":[{"name":"Institute of Women, Children and Reproductive Health, Shandong University , Jinan, Shandong, 250012 , China"},{"name":"Medical Integration and Practice Center, Shandong University , Jinan, Shandong, 250012 , China"},{"name":"Key Laboratory of Reproductive Endocrinology (Shandong University), Ministry of Education , Jinan, Shandong, 250012 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingxi","family":"Liu","sequence":"additional","affiliation":[{"name":"Institute of Women, Children and Reproductive Health, Shandong University , Jinan, Shandong, 250012 , China"},{"name":"Medical Integration and Practice Center, Shandong University , Jinan, Shandong, 250012 , China"},{"name":"Key Laboratory of Reproductive Endocrinology (Shandong University), Ministry of Education , Jinan, Shandong, 250012 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianxiang","family":"Ni","sequence":"additional","affiliation":[{"name":"Institute of Women, Children and Reproductive Health, Shandong University , Jinan, Shandong, 250012 , China"},{"name":"Key Laboratory of Reproductive Endocrinology (Shandong University), Ministry of Education , Jinan, Shandong, 250012 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6637-6631","authenticated-orcid":false,"given":"Zi-Jiang","family":"Chen","sequence":"additional","affiliation":[{"name":"Institute of Women, Children and Reproductive Health, Shandong University , Jinan, Shandong, 250012 , China"},{"name":"State Key Laboratory of Reproductive Medicine and Offspring Health, Shandong University , Jinan, Shandong, 250012 , China"},{"name":"Medical Integration and Practice Center, Shandong University , Jinan, Shandong, 250012 , China"},{"name":"Key Laboratory of Reproductive Endocrinology (Shandong University), Ministry of Education , Jinan, Shandong, 250012 , China"},{"name":"Research Unit of Gametogenesis and Health of ART-Offspring, Chinese Academy of Medical Sciences (No. 2021RU001) , Jinan, Shandong, 250012 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7110-8698","authenticated-orcid":false,"given":"Junhao","family":"Yan","sequence":"additional","affiliation":[{"name":"Institute of Women, Children and Reproductive Health, Shandong University , Jinan, Shandong, 250012 , China"},{"name":"Key Laboratory of Reproductive Endocrinology (Shandong University), Ministry of Education , Jinan, Shandong, 250012 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1813-8115","authenticated-orcid":false,"given":"Yan","family":"Li","sequence":"additional","affiliation":[{"name":"Institute of Women, Children and Reproductive Health, Shandong University , Jinan, Shandong, 250012 , China"},{"name":"Medical Integration and Practice Center, Shandong University , Jinan, Shandong, 250012 , China"},{"name":"Key Laboratory of Reproductive Endocrinology (Shandong University), Ministry of Education , Jinan, Shandong, 250012 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"80","published-online":{"date-parts":[[2024,1,9]]},"reference":[{"issue":"10178","key":"2024022011445120600_bqae002-B1","doi-asserted-by":"crossref","first-page":"1310","DOI":"10.1016\/S0140-6736(18)32843-5","article-title":"Frozen versus fresh single blastocyst transfer in ovulatory women: a multicentre, randomised controlled trial","volume":"393","author":"Wei","year":"2019","journal-title":"Lancet"},{"issue":"12","key":"2024022011445120600_bqae002-B2","doi-asserted-by":"crossref","first-page":"3036","DOI":"10.1093\/humrep\/del305","article-title":"Investigation and treatment of repeated implantation failure following IVF-ET","volume":"21","author":"Margalioth","year":"2006","journal-title":"Hum Reprod"},{"issue":"2","key":"2024022011445120600_bqae002-B3","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1093\/humrep\/deaa317","article-title":"Definition, diagnostic and therapeutic options in recurrent implantation failure: an international survey of clinicians and embryologists","volume":"36","author":"Cimadomo","year":"2021","journal-title":"Hum Reprod"},{"key":"2024022011445120600_bqae002-B4","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/j.omtn.2021.06.021","article-title":"CircSTK40 contributes to recurrent implantation failure via modulating the HSP90\/AKT\/FOXO1 axis","volume":"26","author":"Ni","year":"2021","journal-title":"Mol Ther Nucleic Acids"},{"issue":"5","key":"2024022011445120600_bqae002-B5","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1016\/j.fertnstert.2012.03.010","article-title":"Repeated implantation failure: clinical approach","volume":"97","author":"Simon","year":"2012","journal-title":"Fertil Steril"},{"issue":"6","key":"2024022011445120600_bqae002-B6","doi-asserted-by":"crossref","first-page":"1436","DOI":"10.1016\/j.fertnstert.2021.09.014","article-title":"A review of the pathophysiology of recurrent implantation failure","volume":"116","author":"Franasiak","year":"2021","journal-title":"Fertil Steril"},{"issue":"11","key":"2024022011445120600_bqae002-B7","doi-asserted-by":"crossref","first-page":"1227","DOI":"10.1007\/s10815-012-9861-4","article-title":"Assessment and treatment of repeated implantation failure (RIF)","volume":"29","author":"Simon","year":"2012","journal-title":"J Assist Reprod Genet"},{"issue":"1","key":"2024022011445120600_bqae002-B8","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1186\/s12958-018-0414-2","article-title":"Recurrent implantation failure-update overview on etiology, diagnosis, treatment and future directions","volume":"16","author":"Bashiri","year":"2018","journal-title":"Reprod Biol Endocrinol"},{"issue":"1","key":"2024022011445120600_bqae002-B9","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.rbmo.2013.08.011","article-title":"Recurrent implantation failure: definition and management","volume":"28","author":"Coughlan","year":"2014","journal-title":"Reprod Biomed Online"},{"issue":"32","key":"2024022011445120600_bqae002-B10","doi-asserted-by":"crossref","first-page":"eabj3725","DOI":"10.1126\/sciadv.abj3725","article-title":"Primary specification of blastocyst trophectoderm by scRNA-seq: new insights into embryo implantation","volume":"8","author":"Liu","year":"2022","journal-title":"Sci Adv"},{"issue":"5","key":"2024022011445120600_bqae002-B11","first-page":"1129","article-title":"Forskolin promotes vasculogenic mimicry and invasion via Notch-1-activated epithelial-to-mesenchymal transition in syncytiolization of trophoblast cells in choriocarcinoma","volume":"56","author":"Xue","year":"2020","journal-title":"Int J Oncol"},{"issue":"19","key":"2024022011445120600_bqae002-B12","doi-asserted-by":"crossref","first-page":"1400","DOI":"10.1056\/NEJMra000763","article-title":"Implantation and the survival of early pregnancy","volume":"345","author":"Norwitz","year":"2001","journal-title":"N Engl J Med"},{"issue":"1","key":"2024022011445120600_bqae002-B13","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1186\/1477-7827-3-56","article-title":"Human trophoblast function during the implantation process","volume":"3","author":"Staun-Ram","year":"2005","journal-title":"Reprod Biol Endocrinol"},{"issue":"6","key":"2024022011445120600_bqae002-B14","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1007\/s00018-022-04377-0","article-title":"Early human trophoblast development: from morphology to function","volume":"79","author":"Gauster","year":"2022","journal-title":"Cell Mol Life Sci"},{"issue":"4","key":"2024022011445120600_bqae002-B15","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1007\/s10815-021-02093-5","article-title":"Endometrial extracellular vesicles of recurrent implantation failure patients inhibit the proliferation, migration, and invasion of HTR8\/SVneo cells","volume":"38","author":"Liu","year":"2021","journal-title":"J Assist Reprod Genet"},{"issue":"18","key":"2024022011445120600_bqae002-B16","doi-asserted-by":"crossref","first-page":"10082","DOI":"10.3390\/ijms221810082","article-title":"Biomolecular markers of recurrent implantation failure-a review","volume":"22","author":"Mrozikiewicz","year":"2021","journal-title":"Int J Mol Sci"},{"issue":"3","key":"2024022011445120600_bqae002-B17","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/j.tem.2020.12.005","article-title":"Roles of TGF-beta superfamily proteins in extravillous trophoblast invasion","volume":"32","author":"Li","year":"2021","journal-title":"Trends Endocrinol Metab"},{"issue":"12","key":"2024022011445120600_bqae002-B18","doi-asserted-by":"crossref","first-page":"a022103","DOI":"10.1101\/cshperspect.a022103","article-title":"Structural biology and evolution of the TGF-\u03b2 family","volume":"8","author":"Hinck","year":"2016","journal-title":"Cold Spring Harb Perspect Biol"},{"issue":"6","key":"2024022011445120600_bqae002-B19","doi-asserted-by":"crossref","first-page":"1447","DOI":"10.1093\/humrep\/den110","article-title":"A distinct cohort of the TGFbeta superfamily members expressed in human endometrium regulate decidualization","volume":"23","author":"Stoikos","year":"2008","journal-title":"Hum Reprod"},{"issue":"11","key":"2024022011445120600_bqae002-B20","doi-asserted-by":"crossref","first-page":"15462","DOI":"10.1096\/fj.202000508R","article-title":"The regulation of IGFBP3 by BMP2 has a role in human endometrial remodeling","volume":"34","author":"Luo","year":"2020","journal-title":"FASEB J"},{"issue":"2","key":"2024022011445120600_bqae002-B21","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1038\/s41419-017-0230-1","article-title":"Bone morphogenetic protein 2 promotes human trophoblast cell invasion by upregulating N-cadherin via non-canonical SMAD2\/3 signaling","volume":"9","author":"Zhao","year":"2018","journal-title":"Cell Death Dis"},{"issue":"2","key":"2024022011445120600_bqae002-B22","doi-asserted-by":"crossref","first-page":"3151","DOI":"10.1096\/fj.201902168RR","article-title":"Bone morphogenetic protein 2 promotes human trophoblast cell invasion and endothelial-like tube formation through ID1-mediated upregulation of IGF binding protein-3","volume":"34","author":"Zhao","year":"2020","journal-title":"FASEB J"},{"issue":"7","key":"2024022011445120600_bqae002-B23","doi-asserted-by":"crossref","first-page":"2815","DOI":"10.1210\/en.2018-00301","article-title":"Bone morphogenetic protein 2 promotes human trophoblast cell invasion by inducing activin A production","volume":"159","author":"Zhao","year":"2018","journal-title":"Endocrinology"},{"issue":"1","key":"2024022011445120600_bqae002-B24","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1210\/me.2011-1196","article-title":"Research resource: interactome of human embryo implantation: identification of gene expression pathways, regulation, and integrated regulatory networks","volume":"26","author":"Altmae","year":"2012","journal-title":"Mol Endocrinol"},{"issue":"1","key":"2024022011445120600_bqae002-B25","doi-asserted-by":"crossref","first-page":"23","DOI":"10.3390\/ijms21010023","article-title":"Molecular signaling regulating endometrium-blastocyst crosstalk","volume":"21","author":"Massimiani","year":"2019","journal-title":"Int J Mol Sci"},{"issue":"3","key":"2024022011445120600_bqae002-B26","doi-asserted-by":"crossref","first-page":"a004994","DOI":"10.1101\/cshperspect.a004994","article-title":"Integrin structure, activation, and interactions","volume":"3","author":"Campbell","year":"2011","journal-title":"Cold Spring Harb Perspect Biol"},{"issue":"5","key":"2024022011445120600_bqae002-B27","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1186\/gb-2007-8-5-215","article-title":"The integrins","volume":"8","author":"Takada","year":"2007","journal-title":"Genome Biol"},{"issue":"2","key":"2024022011445120600_bqae002-B28","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1038\/s41580-022-00531-5","article-title":"Organization, dynamics and mechanoregulation of integrin-mediated cell-ECM adhesions","volume":"24","author":"Kanchanawong","year":"2023","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"1","key":"2024022011445120600_bqae002-B29","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1172\/JCI115565","article-title":"Distribution patterns of extracellular matrix components and adhesion receptors are intricately modulated during first trimester cytotrophoblast differentiation along the invasive pathway, in vivo","volume":"89","author":"Damsky","year":"1992","journal-title":"J Clin Invest"},{"issue":"6","key":"2024022011445120600_bqae002-B30","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1159\/000053942","article-title":"The role of integrins in human embryo implantation","volume":"16","author":"Merviel","year":"2001","journal-title":"Fetal Diagn Ther"},{"issue":"2","key":"2024022011445120600_bqae002-B31","doi-asserted-by":"crossref","first-page":"e21220","DOI":"10.1096\/fj.202001604R","article-title":"Activin A increases human trophoblast invasion by upregulating integrin beta1 through ALK4","volume":"35","author":"Zhu","year":"2021","journal-title":"FASEB J"},{"key":"2024022011445120600_bqae002-B32","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.placenta.2022.10.004","article-title":"Activin A promotes human trophoblast invasion by upregulating integrin beta3 via ALK4-SMAD4 signaling","volume":"129","author":"Sun","year":"2022","journal-title":"Placenta"},{"issue":"4","key":"2024022011445120600_bqae002-B33","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1016\/S0040-8166(03)00039-9","article-title":"Integrin receptors: the dynamic modulators of endometrial function","volume":"35","author":"Reddy","year":"2003","journal-title":"Tissue Cell"},{"issue":"10","key":"2024022011445120600_bqae002-B34","doi-asserted-by":"crossref","first-page":"3441","DOI":"10.1038\/s41596-020-0381-x","article-title":"Establishment and differentiation of long-term trophoblast organoid cultures from the human placenta","volume":"15","author":"Sheridan","year":"2020","journal-title":"Nat Protoc"},{"issue":"7735","key":"2024022011445120600_bqae002-B35","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1038\/s41586-018-0753-3","article-title":"Trophoblast organoids as a model for maternal-fetal interactions during human placentation","volume":"564","author":"Turco","year":"2018","journal-title":"Nature"},{"issue":"12","key":"2024022011445120600_bqae002-B36","doi-asserted-by":"crossref","first-page":"1754","DOI":"10.1038\/nm.3012","article-title":"Mechanisms of implantation: strategies for successful pregnancy","volume":"18","author":"Cha","year":"2012","journal-title":"Nat Med"},{"issue":"4","key":"2024022011445120600_bqae002-B37","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1002\/path.2948","article-title":"Specific and extensive endometrial deregulation is present before conception in IVF\/ICSI repeated implantation failures (IF) or recurrent miscarriages","volume":"225","author":"L\u00e9d\u00e9e","year":"2011","journal-title":"J Pathol"},{"key":"2024022011445120600_bqae002-B38","author":"Hu"},{"issue":"5","key":"2024022011445120600_bqae002-B39","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/0143-4004(95)90100-0","article-title":"Characteristic's of trophoblast cells migrating from first trimester chorionic villus explants and propagated in culture","volume":"16","author":"Irving","year":"1995","journal-title":"Placenta"},{"key":"2024022011445120600_bqae002-B40","doi-asserted-by":"crossref","first-page":"104664","DOI":"10.1016\/j.ebiom.2023.104664","article-title":"H3K27me3-modulated Hofbauer cell BMP2 signalling enhancement compensates for shallow trophoblast invasion in preeclampsia","volume":"93","author":"Deng","year":"2023","journal-title":"EBioMedicine"},{"issue":"5","key":"2024022011445120600_bqae002-B41","doi-asserted-by":"crossref","first-page":"e22319","DOI":"10.1096\/fj.202200081RR","article-title":"BMP2 suppresses the production of pentraxin 3 in human endometrial stromal and decidual stromal cells","volume":"36","author":"Zhang","year":"2022","journal-title":"FASEB J"},{"key":"2024022011445120600_bqae002-B42","doi-asserted-by":"crossref","first-page":"1090593","DOI":"10.3389\/fcell.2023.1090593","article-title":"ID3 mediates BMP2-induced downregulation of ICAM1 expression in human endometiral stromal cells and decidual cells","volume":"11","author":"Luo","year":"2023","journal-title":"Front Cell Dev Biol"},{"issue":"15","key":"2024022011445120600_bqae002-B43","doi-asserted-by":"crossref","first-page":"5468","DOI":"10.1128\/MCB.00342-07","article-title":"Bmp2 is critical for the murine uterine decidual response","volume":"27","author":"Lee","year":"2007","journal-title":"Mol Cell Biol"},{"issue":"11","key":"2024022011445120600_bqae002-B44","doi-asserted-by":"crossref","first-page":"e1003863","DOI":"10.1371\/journal.pgen.1003863","article-title":"Activin-like kinase 2 functions in peri-implantation uterine signaling in mice and humans","volume":"9","author":"Clementi","year":"2013","journal-title":"PLoS Genet"},{"issue":"7","key":"2024022011445120600_bqae002-B45","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1016\/0143-4004(77)90001-7","article-title":"Immunohistochemical examination of trophoblast populations in human first trimester and term placentae and of first trimester spiral arteries with the monoclonal antibody GZ 112","volume":"18","author":"Hartmann","year":"1997","journal-title":"Placenta"},{"issue":"5","key":"2024022011445120600_bqae002-B46","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1016\/j.placenta.2010.02.015","article-title":"Expression and localization of ATP binding cassette transporter A1 (ABCA1) in first trimester and term human placenta","volume":"31","author":"Bhattacharjee","year":"2010","journal-title":"Placenta"},{"key":"2024022011445120600_bqae002-B47","doi-asserted-by":"crossref","first-page":"208","DOI":"10.12688\/f1000research.22403.1","article-title":"Diagnostic and therapeutic options in recurrent implantation failure","volume":"9","author":"Moustafa","year":"2020","journal-title":"F1000Res"},{"issue":"6","key":"2024022011445120600_bqae002-B48","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1210\/er.2014-1045","article-title":"Cyclic decidualization of the human endometrium in reproductive health and failure","volume":"35","author":"Gellersen","year":"2014","journal-title":"Endocr Rev"},{"issue":"3","key":"2024022011445120600_bqae002-B49","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1677\/joe.0.1780357","article-title":"Cyclic AMP and progesterone receptor cross-talk in human endometrium: a decidualizing affair","volume":"178","author":"Gellersen","year":"2003","journal-title":"J Endocrinol"},{"key":"2024022011445120600_bqae002-B50","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.jare.2020.09.002","article-title":"Decreased PIBF1\/IL6\/p-STAT3 during the mid-secretory phase inhibits human endometrial stromal cell proliferation and decidualization","volume":"30","author":"Zhou","year":"2021","journal-title":"J Adv Res"},{"key":"2024022011445120600_bqae002-B51","doi-asserted-by":"crossref","first-page":"613277","DOI":"10.3389\/fcell.2021.613277","article-title":"Approaches to improve endometrial receptivity in case of repeated implantation failures","volume":"9","author":"Makrigiannakis","year":"2021","journal-title":"Front Cell Dev Biol"},{"issue":"1","key":"2024022011445120600_bqae002-B52","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1210\/en.2012-1585","article-title":"WNT4 acts downstream of BMP2 and functions via beta-catenin signaling pathway to regulate human endometrial stromal cell differentiation","volume":"154","author":"Li","year":"2013","journal-title":"Endocrinology"},{"issue":"12","key":"2024022011445120600_bqae002-B53","doi-asserted-by":"crossref","first-page":"a023010","DOI":"10.1101\/cshperspect.a023010","article-title":"Molecular cross-talk at the feto-maternal interface","volume":"5","author":"Lash","year":"2015","journal-title":"Cold Spring Harb Perspect Med"},{"issue":"6","key":"2024022011445120600_bqae002-B54","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1093\/oxfordjournals.humrep.a137430","article-title":"Granulated lymphocytes in human endometrium: histochemical and immunohistochemical studies","volume":"6","author":"Bulmer","year":"1991","journal-title":"Hum Reprod"},{"issue":"4","key":"2024022011445120600_bqae002-B55","doi-asserted-by":"crossref","first-page":"1438","DOI":"10.1095\/biolreprod.103.017574","article-title":"Dendritic cells in the human decidua","volume":"69","author":"Gardner","year":"2003","journal-title":"Biol Reprod"},{"issue":"5","key":"2024022011445120600_bqae002-B56","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1111\/j.8755-8920.2001.450505.x","article-title":"Characterization of NKT cells in human peripheral blood and decidual lymphocytes","volume":"45","author":"Tsuda","year":"2001","journal-title":"Am J Reprod Immunol"},{"issue":"4","key":"2024022011445120600_bqae002-B57","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1016\/j.ajog.2009.02.030","article-title":"The developmental role of natural killer cells at the fetal-maternal interface","volume":"201","author":"Yagel","year":"2009","journal-title":"Am J Obstet Gynecol"},{"issue":"7","key":"2024022011445120600_bqae002-B58","doi-asserted-by":"crossref","first-page":"1924","DOI":"10.1002\/eji.200737089","article-title":"A homodimeric complex of HLA-G on normal trophoblast cells modulates antigen-presenting cells via LILRB1","volume":"37","author":"Apps","year":"2007","journal-title":"Eur J Immunol"},{"issue":"8","key":"2024022011445120600_bqae002-B59","doi-asserted-by":"crossref","first-page":"e1396","DOI":"10.1038\/cddis.2014.335","article-title":"LIF upregulates poFUT1 expression and promotes trophoblast cell migration and invasion at the fetal-maternal interface","volume":"5","author":"Liu","year":"2014","journal-title":"Cell Death Dis"},{"issue":"7","key":"2024022011445120600_bqae002-B60","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1016\/j.placenta.2010.04.012","article-title":"Role of interleukin 8 in uterine natural killer cell regulation of extravillous trophoblast cell invasion","volume":"31","author":"De Oliveira","year":"2010","journal-title":"Placenta"},{"issue":"3","key":"2024022011445120600_bqae002-B61","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1038\/cmi.2013.67","article-title":"Decidual stromal cells recruit Th17 cells into decidua to promote proliferation and invasion of human trophoblast cells by secreting IL-17","volume":"11","author":"Wu","year":"2014","journal-title":"Cell Mol Immunol"},{"issue":"9341","key":"2024022011445120600_bqae002-B62","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.1016\/S0140-6736(02)11283-9","article-title":"Pre-eclampsia and expression of heparin-binding EGF-like growth factor","volume":"360","author":"Leach","year":"2002","journal-title":"Lancet"},{"issue":"8","key":"2024022011445120600_bqae002-B63","doi-asserted-by":"crossref","first-page":"1428","DOI":"10.1093\/humrep\/dez124","article-title":"Uterine spiral artery muscle dedifferentiation","volume":"34","author":"Robson","year":"2019","journal-title":"Hum Reprod"},{"issue":"4","key":"2024022011445120600_bqae002-B64","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1016\/j.cellsig.2010.10.003","article-title":"Bone morphogenetic proteins: a critical review","volume":"23","author":"Bragdon","year":"2011","journal-title":"Cell Signal"},{"issue":"6","key":"2024022011445120600_bqae002-B65","doi-asserted-by":"crossref","first-page":"5189","DOI":"10.1007\/s13277-014-1673-y","article-title":"Bone morphogenetic protein 2 inhibits hepatocellular carcinoma growth and migration through downregulation of the PI3K\/AKT pathway","volume":"35","author":"Zheng","year":"2014","journal-title":"Tumour Biol"},{"issue":"10","key":"2024022011445120600_bqae002-B66","doi-asserted-by":"crossref","first-page":"2481","DOI":"10.3390\/ijms20102481","article-title":"Phloretin suppresses bone morphogenetic protein-2-induced osteoblastogenesis and mineralization via inhibition of phosphatidylinositol 3-kinases\/Akt pathway","volume":"20","author":"Takeno","year":"2019","journal-title":"Int J Mol Sci"},{"key":"2024022011445120600_bqae002-B67","doi-asserted-by":"crossref","first-page":"773","DOI":"10.2147\/CMAR.S281969","article-title":"Inhibition of bone morphogenetic protein 2 suppresses the stemness maintenance of cancer stem cells in hepatocellular carcinoma via the MAPK\/ERK pathway","volume":"13","author":"Guo","year":"2021","journal-title":"Cancer Manag Res"},{"issue":"9","key":"2024022011445120600_bqae002-B68","doi-asserted-by":"crossref","first-page":"e21845","DOI":"10.1096\/fj.202100670RR","article-title":"Bone morphogenetic protein 2 upregulates SERPINE2 expression through noncanonical SMAD2\/3 and p38 MAPK signaling pathways in human granulosa-lutein cells","volume":"35","author":"Luo","year":"2021","journal-title":"FASEB J"},{"key":"2024022011445120600_bqae002-B69","doi-asserted-by":"crossref","first-page":"103676","DOI":"10.1016\/j.jri.2022.103676","article-title":"Understanding main pregnancy complications through animal models","volume":"153","author":"Aslanian-Kalkhoran","year":"2022","journal-title":"J Reprod Immunol"},{"issue":"6","key":"2024022011445120600_bqae002-B70","doi-asserted-by":"crossref","first-page":"1916","DOI":"10.1210\/en.2017-00103","article-title":"Tissue-specific ablation of the LIF receptor in the murine uterine epithelium results in implantation failure","volume":"158","author":"Cheng","year":"2017","journal-title":"Endocrinology"},{"key":"2024022011445120600_bqae002-B71","doi-asserted-by":"crossref","first-page":"e79794","DOI":"10.7554\/eLife.79794","article-title":"Innate immune signaling in trophoblast and decidua organoids defines differential antiviral defenses at the maternal-fetal interface","volume":"11","author":"Yang","year":"2022","journal-title":"Elife"},{"issue":"2","key":"2024022011445120600_bqae002-B72","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1016\/j.stemcr.2018.07.004","article-title":"Self-renewing trophoblast organoids recapitulate the developmental program of the early human placenta","volume":"11","author":"Haider","year":"2018","journal-title":"Stem Cell Reports"}],"container-title":["Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/endo\/advance-article-pdf\/doi\/10.1210\/endocr\/bqae002\/55275350\/bqae002.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/endo\/article-pdf\/165\/3\/bqae002\/56689801\/bqae002.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/endo\/article-pdf\/165\/3\/bqae002\/56689801\/bqae002.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,20]],"date-time":"2024-02-20T11:46:11Z","timestamp":1708429571000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/endo\/article\/doi\/10.1210\/endocr\/bqae002\/7513513"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1,9]]},"references-count":72,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2024,1,16]]}},"URL":"https:\/\/doi.org\/10.1210\/endocr\/bqae002","relation":{},"ISSN":["1945-7170"],"issn-type":[{"value":"1945-7170","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2024,3]]},"published":{"date-parts":[[2024,1,9]]},"article-number":"bqae002"}}