{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T04:24:36Z","timestamp":1792211076909,"version":"4.4.0"},"reference-count":31,"publisher":"The Endocrine Society","issue":"5","license":[{"start":{"date-parts":[[2024,3,22]],"date-time":"2024-03-22T00:00:00Z","timestamp":1711065600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2021YFC2700200"],"award-info":[{"award-number":["2021YFC2700200"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100022963","name":"Key Research and Development Program of Zhejiang Province","doi-asserted-by":"publisher","award":["2023C03035"],"award-info":[{"award-number":["2023C03035"]}],"id":[{"id":"10.13039\/100022963","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100016692","name":"Key Research and Development Program of Ningxia Hui Autonomous Region","doi-asserted-by":"publisher","award":["2021BEG02029"],"award-info":[{"award-number":["2021BEG02029"]}],"id":[{"id":"10.13039\/100016692","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100016692","name":"Key Research and Development Program of Ningxia Hui Autonomous Region","doi-asserted-by":"publisher","award":["ZR2023QH491"],"award-info":[{"award-number":["ZR2023QH491"]}],"id":[{"id":"10.13039\/100016692","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007129","name":"Shandong Provincial Natural Science Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,3,29]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Seminal extracellular vesicles (EVs) contain different subgroups that have diverse effects on sperm function. However, the effect of seminal EVs\u2014especially their subgroups\u2014on endometrial receptivity is largely unknown. Here, we found that seminal EVs could be divided into high-density EVs (EV-H), medium density EVs, and low-density EVs after purification using iodixanol. We demonstrated that EV-H could promote the expression and secretion of leukemia inhibitor factor (LIF) in human endometrial cells. In EV-H\u2013treated endometrial cells, we identified 1274 differentially expressed genes (DEGs). DEGs were enriched in cell adhesion and AKT and STAT3 pathways. Therefore, we illustrated that EV-H enhanced the adhesion of human choriocarcinoma JAr cell spheroids to endometrial cells through the LIF-STAT3 pathway. Collectively, our findings indicated that seminal EV-H could regulate endometrial receptivity through the LIF pathway, which could provide novel insights into male fertility.<\/jats:p>","DOI":"10.1210\/endocr\/bqae035","type":"journal-article","created":{"date-parts":[[2024,3,20]],"date-time":"2024-03-20T19:17:28Z","timestamp":1710962248000},"source":"Crossref","is-referenced-by-count":18,"title":["Human Seminal Extracellular Vesicles Enhance Endometrial Receptivity Through Leukemia Inhibitory Factor"],"prefix":"10.1210","volume":"165","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9996-5114","authenticated-orcid":false,"given":"Hanshu","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Andrology, The Affiliated Hospital of Qingdao University , Qingdao 266000, Shandong Province , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Lin","sequence":"additional","affiliation":[{"name":"International Peace Maternity & Child Health Hospital, Shanghai Municipal Key Clinical Specialty, Institute of Embryo-Fetal Original Adult Disease, School of Medicine, Shanghai Jiao Tong University , Shanghai 200030 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rongrong","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Andrology, The Affiliated Hospital of Qingdao University , Qingdao 266000, Shandong Province , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Zhu","sequence":"additional","affiliation":[{"name":"Shanghai First Maternity and Infant Hospital, School of Medicine, Tongji University , Shanghai, 201204 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongqiang","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Andrology, The Affiliated Hospital of Qingdao University , Qingdao 266000, Shandong Province , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shengxian","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Andrology, The Affiliated Hospital of Qingdao University , Qingdao 266000, Shandong Province , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Andrology, The Affiliated Hospital of Qingdao University , Qingdao 266000, Shandong Province , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaishu","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Andrology, The Affiliated Hospital of Qingdao University , Qingdao 266000, Shandong Province , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yujie","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Andrology, The Affiliated Hospital of Qingdao University , Qingdao 266000, Shandong Province , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5103-7829","authenticated-orcid":false,"given":"Tao","family":"Jing","sequence":"additional","affiliation":[{"name":"Department of Andrology, The Affiliated Hospital of Qingdao University , Qingdao 266000, Shandong Province , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0870-8375","authenticated-orcid":false,"given":"Fei","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Urology and Andrology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine , Hangzhou 310020, Zhejiang , China"},{"name":"School of Basic Medical Sciences, Key Laboratory of Fertility Preservation and Maintenance of Ministry of Education, Ningxia Medical University , Yinchuan 750004 , 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