{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T15:12:49Z","timestamp":1789053169663,"version":"build-2803163510"},"reference-count":30,"publisher":"The Endocrine Society","issue":"7","license":[{"start":{"date-parts":[[2024,5,23]],"date-time":"2024-05-23T00:00:00Z","timestamp":1716422400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"Nano-Precision Medicine, Science, and Technology of Kanazawa University"},{"DOI":"10.13039\/501100001695","name":"JST","doi-asserted-by":"publisher","award":["JPMJFS2116"],"award-info":[{"award-number":["JPMJFS2116"]}],"id":[{"id":"10.13039\/501100001695","id-type":"DOI","asserted-by":"publisher"}]},{"name":"JSPS KAKENHI","award":["21K19503"],"award-info":[{"award-number":["21K19503"]}]},{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["JP20fk0210073"],"award-info":[{"award-number":["JP20fk0210073"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007449","name":"Takeda Science Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007449","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,5,27]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Leukocyte cell-derived chemotaxin 2 (LECT2) is a protein initially isolated as a neutrophil chemotactic factor. We previously found that LECT2 is an obesity-associated hepatokine that senses liver fat and induces skeletal muscle insulin resistance. In addition, hepatocyte-derived LECT2 activates macrophage proinflammatory activity by reinforcing the lipopolysaccharide (LPS)-induced c-Jun N-terminal kinase signaling. Based on these findings, we examined the effect of LECT2 deletion on nonalcoholic fatty liver disease\/nonalcoholic steatohepatitis (NAFLD\/NASH) caused by bacterial translocation. We created the bacterial translocation-mediated NAFLD\/NASH model using LECT2 knockout mice (LECT2 KO) with 28 times a low-dose LPS injection under high-fat diet feeding conditions. LECT2 deletion exacerbated steatosis and significantly reduced p38 phosphorylation in the liver. In addition, LECT2 deletion increased macrophage infiltration with decreased M1\/M2 ratios. LECT2 might contribute to protecting against lipid accumulation and macrophage activation in the liver under pathological conditions, which might be accomplished via p38 phosphorylation. This study provides novel aspects of LECT2 in the bacterial translocation-mediated NAFLD\/NASH model.<\/jats:p>","DOI":"10.1210\/endocr\/bqae059","type":"journal-article","created":{"date-parts":[[2024,5,23]],"date-time":"2024-05-23T18:32:56Z","timestamp":1716489176000},"source":"Crossref","is-referenced-by-count":9,"title":["LECT2 Deletion Exacerbates Liver Steatosis and Macrophage Infiltration in a Male Mouse Model of LPS-mediated NASH"],"prefix":"10.1210","volume":"165","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2609-6613","authenticated-orcid":false,"given":"Ryota","family":"Tanida","sequence":"first","affiliation":[{"name":"Department of Endocrinology and Metabolism, Kanazawa University Graduate School of Medical Sciences , Kanazawa, Ishikawa 920-8640 , Japan"},{"name":"Department of Nutrition, Faculty of Wellness, Shigakkan University , Obu 474-8651 , Japan"},{"name":"Arnie Charbonneau Cancer Institute, Departments of Biochemistry and Molecular Biology and Oncology, Cumming School of Medicine, University of Calgary , Calgary, AB T2N 4N1 , Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hisanori","family":"Goto","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism, Kanazawa University Graduate School of Medical Sciences , Kanazawa, Ishikawa 920-8640 , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4792-3868","authenticated-orcid":false,"given":"Hiroaki","family":"Takayama","sequence":"additional","affiliation":[{"name":"Life Sciences Division, Engineering and Technology Department, Kanazawa University Graduate School of Medical Sciences , Kanazawa, Ishikawa 920-8640 , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yujiro","family":"Nakano","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism, Kanazawa University Graduate School of Medical Sciences , Kanazawa, Ishikawa 920-8640 , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1155-9080","authenticated-orcid":false,"given":"Hein Ko","family":"Oo","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism, Kanazawa University Graduate School of Medical Sciences , Kanazawa, Ishikawa 920-8640 , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-8417-9906","authenticated-orcid":false,"given":"Cynthia Monserrat","family":"Galicia-Medina","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism, Kanazawa University Graduate School of Medical Sciences , Kanazawa, Ishikawa 920-8640 , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenta","family":"Takahashi","sequence":"additional","affiliation":[{"name":"Department of Human Pathology, Kanazawa University Graduate School of Medical Sciences , Kanazawa, Ishikawa 920-8640 , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kiyo-aki","family":"Ishii","sequence":"additional","affiliation":[{"name":"Department of Bone and Joint Disease, National Center for Geriatrics and Gerontology , Obu, Aichi 474-8511 , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arman Syah","family":"Goli","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism, Institute of Medicine, University of Tsukuba , Tsukuba, Ibaraki 305-8575 , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Matsuzaka","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism, Institute of Medicine, University of Tsukuba , Tsukuba, Ibaraki 305-8575 , Japan"},{"name":"Transborder Medical Research Center, University of Tsukuba , Tsukuba, Ibaraki 305-8575 , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenichi","family":"Harada","sequence":"additional","affiliation":[{"name":"Department of Human Pathology, Kanazawa University Graduate School of Medical Sciences , Kanazawa, Ishikawa 920-8640 , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4393-3244","authenticated-orcid":false,"given":"Toshinari","family":"Takamura","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism, Kanazawa University Graduate School of Medical Sciences , Kanazawa, Ishikawa 920-8640 , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"80","published-online":{"date-parts":[[2024,5,23]]},"reference":[{"issue":"1","key":"2024070101464165300_bqae059-B1","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1002\/hep.28431","article-title":"Global epidemiology of nonalcoholic fatty liver disease\u2014meta-analytic assessment of 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